We are particularly well equipped for research in the two main research themes of Biomolecular Chemistry and Medicinal Chemistry.

Facilities for Biomolecular Chemistry research include 250, 400 and 600 MHz NMR, electrospray MS, GC-MS and LC-MS, and a unique collection of instruments for environmental analysis and speciation. Facilities for Materials Chemistry Research include X-ray single crystal and powder diffraction, electron microscopy, solid state NMR, XPS, EPR, FTIR and Raman microprobes, impedance spectroscopy, gas sorption analysis and a comprehensive suite of thermal analysis instruments (including high pressure DSC).

Chemistry staff also make extensive use of Central Facilities such as synchrotrons and neutron sources both in the UK and Europe, and through the ScotChem network of Scottish Chemistry Institutions access facilities in other Scottish universities.

The database of facilities available through ScotChem can be found here

 

Elemental Analysis

High resolution continuum source graphite furnace and flame atomic absorption spectrometry (HR CS-AAS), ContrA700 Analytic Jena

Graphite furnace AAS with autosampler.

This instrument is usually use for the determination of non-metals such as fluorine, chlorine, sulfur and phosphorous by using CS-MAS (molecular absorption spectrometry)

high ppb to ppm range

For any information related to the instruments above please contact:

Microwave Induced Plasma – Atomic Emission Spectrometry (MIP-AES) MP4200 Agilent

Simultaneous determination of elements, sensitivity between AAS and ICP-MS depending on the analyte, with autosampler, also used for undergraduate teaching;

For any information related to the instruments above please contact:

Inductively coupled plasma mass spectrometry (ICP-MS)

Different Agilent series, all with autosampler and possibility to couple with HPLC, and/or Molecular Mass Spectrometry, GC or Laser Ablation.

Agilent 7500c - can be coupled to

  • laser ablation system (NewWave 213 nm),
  • HPLC-molecular mass spectrometer (1100-Agilent XCT) or
  • GC-system (Agilent 6890).

 

Agilent 7900 - can be coupled to

  • laser ablation system (NewWave 213 nm), 
  • HPLC-molecular mass spectrometer (1100-Agilent XCT);
  • suitable for use with organic solvents (MeOH, Xylene, THF).

 

Agilent 8800  triple-quad instrument; can be coupled with

  • HPLC (Agilent 1290) and molecular mass spectrometer (Bruker Maxis II or Thermo Orbitrap LTQ), suitable for use with organic solvents, suitable for sulphur and phosphorus determination

ICP-MS Sensitivity ppt to low ppm range (depending on the element); Agilent 8800 to be used in collision and/or reaction mode to suppress  molecular interferences

For any information related to the instruments above please contact:

Atomic Fluorescence Spectrometry (AFS)
  • PSA Millennium; ultra-trace Hg determination, with autosampler.
  • PSA Millennium; ultra-trace Hg determination and speciation with preconcentration for Methylmercury in ppq levels;
  • PSA Millenium; AFS with Autosampler for total Arsenic determination and Arsenic speciation; possibility for Se, Bi, Te, determination

For any information related to the instruments above please contact:

Molecular Analysis

NMR
  • 300 NMR

From Bruker Daltonics: for routine analysis of 1H, 13C and DEPT spectra, also used for undergraduate teaching; equipped with 1H/13C probe with gradients.

 

  • Advance III HD 400 NMR

From Bruker Daltonics: equipped with 60-sample changer for automated analysis of routine samples (1H, 13C, DEPT, standard 2D experiments)

Equipped with a Double-resonance broadband multinuclear (BBFO) SmartProbe for observation of nuclei in frequency range 15N to 31P plus 19F, with 1H decoupling/ observation and 2H lock, standard 5mm sample diameter.

Equipped with shielded z-gradient coils for gradient spectroscopy (GRASP) and automatic tuning and matching accessory (ATM)

 

  • Advance III HD 600 NMR

From Bruker Daltonics: equipped with 24-sample changer and a low-temperature probe, capable of advanced 2D NMR techniques, selective 1D experiments, DOSY, etc.

Equipped with a Prodigy TCI Cryoprobe optimised for 1H observation with pulsing/decoupling of 13C and 15N with 2H lock channel, standard 5mm sample diameter.

Equipped with shielded z-gradient coils and cooled preamplifiers for 1H and 13C plus automatic tuning and matching accessory.

For any information related to the NMR instruments please contact:

Gas Chromatography – mass spectrometry (GC-MS)

Agilent 7820A with MSD Agilent 5977E, equipped with autosampler.

For any information related to the instrument please contact:

Orbitrap LTQ

From Thermo-Scientific; with HPLC-system, ESI and APCI head, resolution: 7500 to 70.000 Da, high mass accuracy.

For any information related to the instruments please contact:

Maxis II q-TOF

From Bruker Daltronics; with HPLC-system, ESI-head, resolution: < 70.000 (depending on m/z, TOF-system), high mass accuracy.

For any information related to the instruments please contact:

XCT-ion-trap

From Agilent; with HPLC-system, ESI and APCI head, low resolution.

any information related to the instrument please contact:

Separation Systems

Asymmetric Flow Field Flow Fractionation

Asymmetric flow field flow fractionation (AF4)

  •   AF4: suitable for separation of nanoparticles in a variety of matrices
  •   AF4 system: Postnova including UV and MALS (multi-angle light scattering) detector
  •   can be additionally coupled to ICP-MS

For information related to the instrument please contact Dr. Eva Krupp

 

 

Gas Chromatography – Flame Ionisation Detection (GC-FID)
  • Gas Chromatography coupled to ICP-MS (GC-ICPMS)
  • Agilent 7820A, manual injection; also used for undergraduate teaching
  • Agilent 6890 with autosampler; suitable for cryo-trapping

For any information related to the instrument please contact:

     

Gas chromatograph coupled with MSD

Gas chromatograph coupled with MSD

  • Gas chromatograph (Agilent technologies 7820A) coupled with a MSD system
  • Agilent technologies 5977E: GC-MS system equipped with split/splitless liner and a 16-vial automatic liquid sampler, also used for undergraduate teaching

For any information related to the instrument please contact:

HPLC-systems
  • 1100-HPLC system

from Agilent with cooled autosampler, analytical fraction collector, DAD-detector and fluorescence detector; can be used in combination with 7500c ICP-MS (Agilent) and/or XCT-ion-trap MS (Agilent)

 

  • 1200-HPLC-system

From Agilent; manual injection, single wavelength UV-detector and fluorescence detector, also used for undergraduate teaching

For any information related to the instruments above please contact:

 

  • 1290-HPLC-system

From Agilent; with cooled autosampler and DAD-detector; can be used in combination with 8800 ICP-MS (Agilent) and/or MaxisII (Bruker Daltronics) or Orbitrap LTQ (Thermo)

For any information related to the instruments above please contact:

 

  • Preparative HPLC systems-1260 Infinity

From Agilent with autosampler, fraction collector, DAD-detector.

For any information related to the instruments please contact:

Ion Chromatograph (IC) Metrohm 882
  • From Metrohm

With anion exchange column and x detector, suitable for detection and quantification of anions in liquid samples; also used for undergraduate teaching.

For any information related to the instruments above please contact:

Gel-electrophoresis-systems

Diverse, suitable for mini-gels and blotting of mini-gels.

Imaging Systems

Elemental Imaging - Laser-ablation-system

From NewWave, 213nm; can be combined with 7500c ICP-MS (Agilent) or 7900 ICP-MS (Agilent); suitable for elemental imaging of samples.

For any information related to the instrument please contact:

Gel-imaging

For any information related to the instrument please contact:

Thermal Analysis

Thermo-Mechanical Analysis (TMA)
  • Mettler Toledo TMA/SDTA 840. Studies of fusion, glass transitions, softening of materials, viscoelastic behaviour, expansion and contraction.
  • Thermogravimetry and Thermogravimetry/Mass Spectrometry (TG/MS)
  • Mettler Toledo TGA/SDTA 851 (25 to 1600ºC), coupled to Balzars mass spectrometer, which can measure up to 300 a.m.u. For analysis of evaporation, desorption, vaporisation, thermal decomposition, composition.
  • Thermogravimetry (TG) Stanton Redcroft TG/DTA (30-1600ºC) for analysis of thermal stability, phase decomposition, oxygen content, water content.
  • Dynamic Mechanical Thermal Analysis (DMTA) Rheometric Scientific DMTA Mark III (-130 to 500ºC, 0.01-200 Hz) for analysis of glass transitions, softening, thermal stability, modulus measurements (shear and bending), ageing, expansion and contraction.
Differential Scanning Calorimeter
  • 1 x DSC1 (-50-600C), 1 x DSC3 (-50-600C) from Mettler Toledo

Used for temperature and energy determination of phase transitions, crystallising points, and melting points.

Dynamic Mechanical Analyser
  • DMA1 (-150-600C) from Mettler Toledo

Used to determine the stiffness of samples via a variety of methods / factors:

  • Fixed Temp / Fixed Frequency
  • Multi Temp / Fixed Frequency
  • Fixed Temp / Multi Frequency
  • Multi Temp / Multi Frequency

All of the above can be performed in the following modes;

  • Single Cantilever Bending
  • Dual Cantilever Bending
  • Three Point Bending
  • Shear
  • Compression
  • Tension
TGA - MS
  • TGA2 (25-1000C) from Mettler Toledo coupled to Balzers ThermoStar MS

Used to determine the stability / degeneration of samples over a temperature range in either a reactive or inert atmosphere. When coupled to the MS, residual gas analysis can inform the products released during degeneration.

For any information related to the Thermal Analysis Suite of instruments please contact:

Diffractometers

Panalytical Empyrean X-ray Powder Diffractometer

High-resolution X-ray diffractometer Cu Ka1 system equipped with a Johannson monoochromator for general phase identification and Rietveld analysis.

The diffractometer has a PIXcel 1D detector and can be equipped with incident and diffracted beam 0.02 or 0.04 RAD Soller slits. Dedicated small angle scattering (SAXS) slits are also available.

For any information related to the instrument please contact:

Panalytical X'Pert X-ray Powder diffractometer

X-ray powder diffractometer with Cu Ka1/Ka2 radiation for general phase analysis

The diffractometer has a PIXcel 1D detector and 0.04 RAD Soller slits. The diffractometer PC contains the highscore software linked to the ICDD pdf2 database for search/match of phases.

For any information related to the instrument please contact:

Microscopy

Polarised Light Microscopes

Polarised light microscopes from Olympus equipped with Linkam and Mettler-Toledo heating/cooling stages and Infinity Lite video capture camera

Heated stage microscopy allows the heating or cooling of samples to observe transitional phases over a temperature range and record structural alignment via video capture. Still photographs can also be obtained from the video footage.

For any information related to the instrument please contact:

FT Raman Microscope
  • From Renishaw inVia confocal Raman microscope.
AFM
  • NanoObserver from CSI

Allows AFM imaging of surfaces in the following modes: Contact, AC and Force Modulation. Can scan areas up to 100 x 100 m2. Topographic images in all three modes, friction mapping in contact mode, elastic and viscoelastic mapping of surfaces in Force-Modulation and AC modes, respectively.

For any information related to the instrument please contact:

Others

Microbiological Laboratories

Bacterial laboratory

For culture work with E.coli and Streptomyces suitable for protein, genetic and metabolic work, equipped with fermenters (1L), incubators and xx (gel reader)

For any information related to this Laboratory please contact:  

Fungal and bacterial laboratory

Biosafety level 2 laboratory for work with environmental bacteria and fungi, equipped with autoclave, incubator, clean bench dedicated to bacterial work, and clean bench for fungal work.

For any information related to this Laboratory please contact: