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The Institute of Medical Sciences

Dr Felix Grassmann

Dr Felix Grassmann
Dr Felix Grassmann
Dr Felix Grassmann

Honorary Senior Lecturer

About
Email Address
felix.grassmann@abdn.ac.uk
Office Address
Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition
Personal Website

Biography

I received my PhD in the field of human genetics from the University of Regensburg, Germany. I spent several years as a postdoctoral researcher at the Karolinska Institute in Stockholm, Sweden and was appointed as Senior Lecturer of Bioinformatics and Biostatistics at the Institute of Medical Sciences. Currently, I am a Professor of Epidemiology and the Health and Medical University in Potsdam, Germany as well as a Honorary Senior Lecturer at the IMS in Aberdeen.

Prizes and Awards

2018               Leopoldina Postdoc Fellowship

2016               Travel Grant “RD Meeting Travel Grant” 2016 (Kyoto, Japan)

2016               Pro Retina “Makula-Forschungspreis” (Excellence in Visual Science Award)

2015               Distinguished PhD-Thesis Award (University of Regensburg)

2015              Travel Grant “ARVO Travel Grant“ 2015 (Denver, Colorado, USA)

2012             ProRetina Travel Award (RD Meeting 2012)

2009             Alumni Award University of Regensburg

2009             ProRetina Poster Award

Research

Research Overview

The main focus of my research is to understand the inherited and acquired genetics in complex diseases. To this end, I am working with public datasets as well as consortia to generate the largest datasets for each disease of interest. I am particularly interested in diseases with a significant individual and societal burden in aging populations such as age-related macular degeneration, breast cancer and cardiometabolic diseases. My group uses the full spectrum of high-throughput omics tools available to understand the underlying biology behind those diseases with the potential to uncover novel ways to treat of prevent them.

Research Areas

Biomedical Sciences

Supervising
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Applied Health Sciences

Supervising
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Research Specialisms

  • Bioinformatics
  • Biomedical Sciences
  • Epidemiology
  • Human Genetics
  • Statistics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

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  • Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study

    Brandl, C., Breinlich, V., Stark, K. J., Enzinger, S., Aenmacher, M., Olden, M., Grassmann, F., Graw, J., Heier, M., Peters, A., Helbig, H., Küchenhoff, H., Weber, B. H., Heid, I. M.
    PloS ONE, vol. 11, no. 11, e0167181
    Contributions to Journals: Articles

  • Distinct genetic risk profile of the rapidly progressing diffuse-trickling subtype of geographic atrophy in age-related macular degeneration (AMD)

    Fleckenstein, M., Grassmann, F., Lindner, M., Pfau, M., Czauderna, J., Strunz, T., von Strachwitz, C., Schmitz-Valckenberg, S., Holz, F. G., Weber, B. H.
    Investigative Ophthalmology and Visual Science, vol. 57, no. 6, pp. 2463-2471
    Contributions to Journals: Articles

  • Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)

    Grassmann, F., Cantsilieris, S., Schulz-Kuhnt, A. S., White, S. J., Richardson, A. J., Hewitt, A. W., Vote, B. J., Schmied, D., Guymer, R. H., Weber, B. H., Baird, P. N.
    Journal of Neuroinflammation, vol. 13, 81
    Contributions to Journals: Articles

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

    Fritsche, L. G., Igl, W., Bailey, J. N., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P., Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. o., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., Yates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H., Abecasis, G. R., Heid, I. M.
    Nature Genetics, vol. 48, pp. 134-143
    Contributions to Journals: Articles

  • Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-βsignaling

    Friedrich, U., Datta, S., Schubert, T., Plössl, K., Schneider, M., Grassmann, F., Fuchshofer, R., Tiefenbach, K. J., Längst, G., Weber, B. H.
    Human Molecular Genetics, vol. 24, no. 22, pp. 6361-6373
    Contributions to Journals: Articles

  • Genetisches Risiko bei der altersabhängigen Makuladegeneration

    Grassmann, F., Loss, J., Heid, I. M., Weber, B. H.
    BioSpektrum, vol. 21, no. 7, pp. 703-705
    Contributions to Journals: Articles

  • What Does Genetics Tell Us About Age-Related Macular Degeneration?

    Grassmann, F., Ach, T., Brandl, C., Heid, I., Weber, B.
    Annual review of vision science, vol. 1, pp. 73-96
    Contributions to Journals: Articles

  • The genetics of age-related macular degeneration (AMD) - Novel targets for designing treatment options?

    Grassmann, F., Fauser, S., Weber, B. H.
    European Journal of Pharmaceutics and Biopharmaceutics, vol. 95, no. Part B, pp. 194-202
    Contributions to Journals: Articles

  • A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)

    Grassmann, F., Friedrich, U., Fauser, S., Schick, T., Milenkovic, A., Schulz, H. L., von Strachwitz, C. N., Bettecken, T., Lichtner, P., Meitinger, T., Arend, N., Wolf, A., Haritoglou, C., Rudolph, G., Chakravarthy, U., Silvestri, G., McKay, G. J., Freitag-Wolf, S., Krawczak, M., Smith, R. T., Merriam, J. C., Merriam, J. E., Allikmets, R., Heid, I. M., Weber, B. H.
    NeuroMolecular Medicine, vol. 17, no. 2, pp. 111-120
    Contributions to Journals: Articles

  • Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

    Grassmann, F., Fleckenstein, M., Chew, E. Y., Strunz, T., Schmitz-Valckenberg, S., Göbel, A. P., Klein, M. L., Ratnapriya, R., Swaroop, A., Holz, F. G., Weber, B. H.
    PloS ONE, vol. 10, no. 5, e0126636
    Contributions to Journals: Articles
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