Dr Anke Roelofs

Dr Anke Roelofs
MSc, PhD
Senior Lecturer
- About
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Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZDBiography
I completed my MSc in Medical Biology at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford where I obtained my DPhil in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).
Qualifications
- MSc Medical Biology2003 - University of Groningen
- DPhil Medical Sciences2007 - University of Oxford
- Research
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Current Research
My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.
Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.
- Teaching
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Programmes
- Postgraduate, 3 stage, September start
Programme coordinator
Teaching Responsibilities
Programme Coordinator
Course Coordinator
MB5517 (Masters course: Genome-Enabled Medicine)
Other Contributions to Teaching
Undergraduate
SM1501 (The Cell) - Lectures on cell growth, cell death, cell differentiation, embryonic development, evolution of multicellular life, inheritance, and sexual reproduction.
MBChB Medicine year 1 (Student Selected Component) - Tutorials.
SM2001 (Foundation Skills for Medical Sciences) - Workshops.
BC4314 (Honours Biochemistry Option 2) - Lectures on stem cells, cancer and ageing.
Honours projects - Supervision of research projects.
Masters
MB5517 (Genome-Enabled Medicine) - Lectures and workshop on genome technologies for the study of stem cells.
BT5509 (Biologic Drug Discovery) - Lectures on biologics in rheumatology.
MB5526 (Genes and Immunity) - Lecture on stem cell transplantation.
Research projects - Supervision of research projects.
- Publications
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Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Annals of the Rheumatic DiseasesContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard-2021-221682
Cellular therapy and tissue engineering for cartilage repair
Osteoarthritis and CartilageContributions to Journals: Review articlesTargeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
Annals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224Contributions to Journals: ArticlesHuman Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model
Cells, vol. 10, no. 8, 1999Contributions to Journals: ArticlesIL-6 ACTIVATES YES-ASSOCIATED PROTEIN (YAP) IN FIBROBLASTS AND INDUCES YAP-SNAIL COMPLEX FORMATION TO DRIVE SYNOVIAL LINING PATHOLOGY IN INFLAMMATORY ARTHRITIS
European Congress of Rheumatology, pp. 19-19Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1136/annrheumdis-2021-eular.2530
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis
Annals of the Rheumatic Diseases, vol. 79, no. 12, pp. 1625-1634Contributions to Journals: ArticlesAgrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Science translational medicine, vol. 12, no. 559, eaax9086Contributions to Journals: ArticlesStem and progenitor cells in synovium
Encyclopedia of Bone Biology. Zaidi, M. (ed.). Elsevier, pp. 96-108, 13 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-801238-3.11160-2
- [ONLINE] View publication in Scopus
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
Scientific Reports, vol. 10, 157Contributions to Journals: ArticlesThe burden of metabolic syndrome on osteoarthritic joints
Arthritis Research & Therapy, vol. 21, 289Contributions to Journals: Review articles