Dr Anke Roelofs
I completed my MSc in Medical Biology at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford where I obtained my DPhil in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).
- MSc Medical Biology2003 - University of Groningen
- DPhil Medical Sciences2007 - University of Oxford
My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.
Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.
- Postgraduate, 3 stage, September start
MB5517 (Masters course: Genome-Enabled Medicine)
Other Contributions to Teaching
SM1501 (The Cell) - Lectures on cell growth, cell death, cell differentiation, embryonic development, evolution of multicellular life, inheritance, and sexual reproduction.
MBChB Medicine year 1 (Student Selected Component) - Tutorials.
SM2001 (Foundation Skills for Medical Sciences) - Workshops.
BC4314 (Honours Biochemistry Option 2) - Lectures on stem cells, cancer and ageing.
Honours projects - Supervision of research projects.
MB5517 (Genome-Enabled Medicine) - Lectures and workshop on genome technologies for the study of stem cells.
BT5509 (Biologic Drug Discovery) - Lectures on biologics in rheumatology.
MB5526 (Genes and Immunity) - Lecture on stem cell transplantation.
Research projects - Supervision of research projects.
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Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolutionAnnals of the Rheumatic DiseasesContributions to Journals: Articles
Cellular therapy and tissue engineering for cartilage repairOsteoarthritis and CartilageContributions to Journals: Review articles
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritisAnnals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224Contributions to Journals: Articles
Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury ModelCells, vol. 10, no. 8, 1999Contributions to Journals: Articles
IL-6 ACTIVATES YES-ASSOCIATED PROTEIN (YAP) IN FIBROBLASTS AND INDUCES YAP-SNAIL COMPLEX FORMATION TO DRIVE SYNOVIAL LINING PATHOLOGY IN INFLAMMATORY ARTHRITISEuropean Congress of Rheumatology, pp. 19-19Contributions to Journals: Abstracts
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritisAnnals of the Rheumatic Diseases, vol. 79, no. 12, pp. 1625-1634Contributions to Journals: Articles
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesisScience translational medicine, vol. 12, no. 559, eaax9086Contributions to Journals: Articles
Stem and progenitor cells in synoviumEncyclopedia of Bone Biology. Zaidi, M. (ed.). Elsevier, pp. 96-108, 13 pagesChapters in Books, Reports and Conference Proceedings: Chapters
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritisScientific Reports, vol. 10, 157Contributions to Journals: Articles
The burden of metabolic syndrome on osteoarthritic jointsArthritis Research & Therapy, vol. 21, 289Contributions to Journals: Review articles