BSc (Hons), MLitt, PhD
Senior Trial Manager
- About
-
- Email Address
- s.c.cotton@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438178
- Office Address
Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU in 2007 as a trial manager. I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007. Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed). I also worked as trial manager on a number of CHaRT trials, including TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Qualifications
- BSc Health Sciences1993 - University of Aberdeen
- MLitt by research1994 - University of Aberdeen
- PhD Public Health2008 - University of Aberdeen
- Research
-
Research Overview
Trial methodology & trial management
Research Areas
Applied Health Sciences
Nutrition and Health
Current Research
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Past Research
Since joining the Unit I have worked on a number of trials that have now been completed.
TWICS - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.
CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;
NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;
FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery
REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.
The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.
I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.
- Teaching
-
Teaching Responsibilities
I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.
Non-course Teaching Responsibilities
Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).
- Publications
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A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology
Cytopathology, vol. 26, no. 3, pp. 178-187Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cyt.12173
- [ONLINE] View publication in Scopus
Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial
Health Technology Assessment, vol. 19, no. 27, pp. 1-342Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta19270
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4430/1/CLASS.pdf
Management of women with low grade cytology: how reassuring is a normal colposcopy examination?
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, pp. 380-386Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.12932
Normative data for the Hospital Anxiety and Depression Scale
Quality of Life Research, vol. 24, no. 2, pp. 391-398Contributions to Journals: ArticlesMeasuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM)
Health and Quality of Life Outcomes, vol. 12, 154Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12955-014-0154-8
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4927/1/TOMBOLA_HQLO_FApaper.pdf
Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial
British Journal of Surgery, vol. 101, no. 12, pp. 1532-1540Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bjs.9595
A randomized trial comparing treatments for varicose veins
The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227Contributions to Journals: ArticlesIntravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
European Heart Journal, vol. 35, no. 19, pp. 1255-1262Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/eurheartj/ehu096
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4482/1/Siddiqi_2014.pdf
The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance
Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/LGT.0b013e31829c97d8
Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation
Trials, vol. 15, 62Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-15-62
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3317/1/Gillies_2014.pdf
Nitrites in Acute Myocardial Infarction
Circulation, vol. 128, no. 24, pp. 2705Contributions to Journals: AbstractsImpact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy
European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejogrb.2013.02.006
Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)
Health Technology Assessment, vol. 17, no. 22, pp. 1-166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta17220
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2867/1/Grant_2013.pdf
Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
Journal of translational medicine, vol. 11, 116Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1479-5876-11-116
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3089/1/Siddiqi_2013.pdf
Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)
BMJ, vol. 346, f1908Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.f1908
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2865/1/Grant_2013.pdf
Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial
Cytopathology, vol. 23, no. 3, pp. 150-160Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2303.2011.00848.x
A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study
Critical Care, vol. 15, no. 6, R296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/cc10592
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2650/1/Cuthbertson_2011.pdf
Analysis of patient information leaflets (PILs), used in clinical trials using the Informed Consent Evaluation instrument (ICEi)
Trials, vol. 12, no. Suppl 1, pp. A121Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-12-S1-A121
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2523/1/Gillies_2011.pdf
Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status
PloS ONE, vol. 6, no. 6, e21046Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0021046
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3553/1/Human_pap.pdf
Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial
British Journal of Cancer, vol. 104, no. 2, pp. 255-264Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6606042
The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 117, no. 6, pp. 645-659Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1471-0528.2010.02519.x
Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery
Edinburgh, United Kingdom: Chief Scientist Office. 7 pagesBooks and Reports: Commissioned ReportsAfter-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 11, pp. 1506-1514Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1471-0528.2009.02263.x
Comprehensive cancer control-research & development: Knowing what we do and doing what we know
Tumori, vol. 95, no. 5, pp. 610-622Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial
British Medical Journal, vol. 339, b2548Contributions to Journals: ArticlesCytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial
British Medical Journal, vol. 339, b2546Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b2546
Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study
British Medical Journal, vol. 339, no. -, b2549Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b2549
Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
British Journal of Nutrition, vol. 99, no. 2, pp. 379-389Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0007114507801073
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2173/1/MTHFR_Bvits_CRC.pdf
Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women
British Journal of Cancer, vol. 97, no. 1, pp. 133-139Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6603822
Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1
International Journal of Cancer, vol. 119, no. 9, pp. 2155-2164Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.22093
Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)
Clinical Trials, vol. 3, pp. 431-442Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1740774506070812
Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design
Contemporary Clinical Trials, vol. 27, no. 5, pp. 449-471Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cct.2006.04.001
Enclosing a pen with a postal questionnaire can significantly increase the response rate
Journal of Clinical Epidemiology, vol. 59, no. 7, pp. 747-754Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jclinepi.2005.10.014
Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors
British Journal of Cancer, vol. 94, pp. 1253-1262Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6603086
Refining the management of low-grade cervical abnormailities in the UK National Health Service and defining the potential for human papillomavirus testing: A commentary on emerging evidence
Journal of Lower Genital Tract Disease, vol. 10, no. 1, pp. 26-38Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/01.lgt.0000192695.93172.75
Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) trial.
Quality of Life Research, vol. 14, no. 6, pp. 1553-1562Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s11136-004-8146-5
Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review
American Journal of Epidemiology, vol. 161, no. 10, pp. 901-915Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/aje/kwi121
CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review
American Journal of Epidemiology, vol. 160, no. 8, pp. 729-740Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/aje/kwh287
Are lifestyle factors associated with infection with high risk human papilloma virus? results from TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)
Journal of Epidemiology and Community Health, vol. 58, no. Supplement IIContributions to Journals: ArticlesDietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population based case-control study in Scotland
The Journal of Nutrition, vol. 132 Supplement 11Contributions to Journals: ArticlesWomen’s experiences of having an abnormal smear result: qualitative analyses from TOMBOLA
Journal of Obstetrics and Gynaecology, vol. 22, pp. 107-111Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/01443610211113
Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study
Journal of Epidemiology and Community Health, vol. 55, no. Supplement 1Contributions to Journals: ArticlesGlutathione S-transferase polymorphisms and colorectal cancer: A HuGE review
American Journal of Epidemiology, vol. 151, pp. 732Contributions to Journals: Literature ReviewsN-Acetyltransferase polymorphisms and colorectal cancer: A HuGE review
American Journal of Epidemiology, vol. 151, pp. 846-861Contributions to Journals: Literature ReviewsSEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history
Paediatric and Perinatal Epidemiology, vol. 13, no. 3, pp. 325-341Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-3016.1999.00195.x
- [ONLINE] View publication in Scopus
Partnerships in purchasing: Development of consortium-based purchasing among GP fundholders
Health Services Management Research, vol. 10, no. 4, pp. 245-254Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1177/095148489701000405
- [ONLINE] View publication in Scopus
Patterns of inter-organizational purchasing: Evolution of consortia-based purchasing amongst GP fundholders
European Journal of Purchasing and Supply Management, vol. 3, no. 2, pp. 83-91Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0969-7012(96)00020-2
- [ONLINE] View publication in Scopus
The Adenoma-Carcinoma Sequence and Prospects for the Prevention of Colorectal Neoplasia
Critical Reviews in Oncogenesis, vol. 7, no. 5-6, pp. 293-342Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Purchasing health care services: Information sources and decisional criteria
Journal of Marketing Management, vol. 12, no. 8, pp. 719-734Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/0267257X.1996.9964449
- [ONLINE] View publication in Scopus
Towards an understanding of health care purchasing: The purchasing behaviour of general practice fundholders
Journal of Marketing Management, vol. 11, no. 6, pp. 583-600Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/0267257X.1995.9964369
- [ONLINE] View publication in Scopus