Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Advanced Research Fellow
- About
-
- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
- Internal Memberships
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Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
- External Memberships
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Member of the Royal Society of Chemistry (RSC) https://www.rsc.org/
Member of European Society for Molecular Imaging (ESMI) https://e-smi.eu/
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) http://www.sinapse.ac.uk/
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental PhysiologyContributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: ArticlesGuanidinoneomycin-Maleimide Molecular Transporter: Synthesis, Chemistry and Cellular Uptake
Organic & Biomolecular Chemistry, vol. 19, no. 29, pp. 6513-6520Contributions to Journals: ArticlesClinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Insights into Imaging, vol. 12, no. 1, 90Contributions to Journals: Articles
- Research
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Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
- Teaching
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Courses
Course coordinator
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Publications
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The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental PhysiologyContributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: ArticlesGuanidinoneomycin-Maleimide Molecular Transporter: Synthesis, Chemistry and Cellular Uptake
Organic & Biomolecular Chemistry, vol. 19, no. 29, pp. 6513-6520Contributions to Journals: ArticlesClinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Insights into Imaging, vol. 12, no. 1, 90Contributions to Journals: ArticlesSynthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR
European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439Contributions to Journals: Articles4,4,16-Trifluoropalmitate: design, synthesis, tritiation, radiofluorination and pre-clinical PET imaging studies on myocardial fatty acid oxidation
ChemMedChem, vol. 15, no. 23, pp. 2317-2331Contributions to Journals: ArticlesDesign, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers
Bioconjugate Chemistry, vol. 31, no. 9, pp. 2201-2210Contributions to Journals: ArticlesWidespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: ArticlesDesign, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
ChemMedChem, vol. 15, no. 16, pp. 1579-1590Contributions to Journals: Articles
