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MT5029: TOXICOLOGY (2022-2023)

Last modified: 31 May 2022 13:30


Course Overview

This course will cover the principles of toxicology including molecular toxicology and target organ toxicity, mechanisms of cell death, molecular carcinogenesis and safety evaluation of carcinogens, adverse outcome pathways (AOPs) and new alternative methods (NAMs). These elements will be taught around the processes involved in drug discovery and development and will include advanced learning on drug metabolism and drug transporters.  The course will also provide the principles and practice of risk assessment and regulatory toxicology.  External experts are invited to provide their unique expertise on a range of topics, which include regulatory aspects as well as an industrial perspective on the drug discovery process.

Course Details

Study Type Postgraduate Level 5
Term First Term Credit Points 15 credits (7.5 ECTS credits)
Campus Aberdeen Sustained Study No
Co-ordinators
  • Professor Heather Wallace

What courses & programmes must have been taken before this course?

  • Any Postgraduate Programme

What other courses must be taken with this course?

None.

What courses cannot be taken with this course?

Are there a limited number of places available?

No

Course Description

Topics - Principles of toxicology; target organ toxicity and oxidative stress; molecular toxicology; mechanisms of cell death; molecular and chemical carcinogenesis; use of biomarkers; safety evaluation of carcinogens; drug metabolism and transporters; Risk Assessment; regulatory toxicology.


Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

More Information about Week Numbers


Details, including assessments, may be subject to change until 30 August 2024 for 1st term courses and 20 December 2024 for 2nd term courses.

Summative Assessments

Viva

Assessment Type Summative Weighting 10
Assessment Weeks Feedback Weeks

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualEvaluateDescribe various types of biomarkers particularly in relation to cancer and cancer therapies
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity
ReflectionCreateimproved scientific communication
ReflectionEvaluateEvaluating industrial drug research and development and risk assessment

Essay

Assessment Type Summative Weighting 35
Assessment Weeks Feedback Weeks

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualEvaluateDescribe various types of biomarkers particularly in relation to cancer and cancer therapies
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity

Portfolio

Assessment Type Summative Weighting 40
Assessment Weeks 15,17 Feedback Weeks 17,19

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Toxicology scenarios

There are 2 scenarios and one write up on the methods used in the scenarios. The scenarios have 5 questions for short answers. The write up will select 2 methods used in the scenarios and provide a review of the advantages and disadvantages of these 2 methods.

Learning Outcomes
Knowledge LevelThinking SkillOutcome
ConceptualEvaluateDescribe various types of biomarkers particularly in relation to cancer and cancer therapies
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity
ReflectionCreateimproved scientific communication
ReflectionEvaluateEvaluating industrial drug research and development and risk assessment

Editorial

Assessment Type Summative Weighting 15
Assessment Weeks Feedback Weeks

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity

Formative Assessment

There are no assessments for this course.

Course Learning Outcomes

Knowledge LevelThinking SkillOutcome
ConceptualEvaluateDescribe various types of biomarkers particularly in relation to cancer and cancer therapies
ReflectionCreateimproved scientific communication
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity
ReflectionEvaluateEvaluating industrial drug research and development and risk assessment

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