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The Institute of Medical Sciences

Dr Anke Roelofs

Dr Anke Roelofs
Dr Anke Roelofs
Dr Anke Roelofs

MSc, PhD, FHEA

Senior Lecturer

About
Email Address
a.roelofs@abdn.ac.uk
Office Address

Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I completed my MSc in Medical Biology at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford where I obtained my DPhil in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).

Qualifications

  • MSc Medical Biology 
    2003 - University of Groningen 
  • DPhil Medical Sciences 
    2007 - University of Oxford 
Research

Current Research

My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.

Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.

Teaching

Programmes

Courses

Publications

Page 2 of 2 Results 26 to 43 of 43

  • Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field

    Zhao, Z., Watt, C., Karystinou, A., Roelofs, A. J., McCaig, C. D., Gibson, I. R., De Bari, C.
    European Cells & Materials, vol. 22, no. -, pp. 344-358
    Contributions to Journals: Articles

  • Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs

    Sun, S., Blazewska, K. M., Kashemirov, B. A., Roelofs, A. J., Coxon, F. P., Rogers, M. J., Ebetino, F. H., Mckenna, M. J., Mckenna, C. E.
    Phosphorus, Sulfur and SIlicon and the Related Elements, vol. 186, no. 4, pp. 970-971
    Contributions to Journals: Articles

  • Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

    Roelofs, A. J., Thompson, K., Ebetino, F., Rogers, M. J., Coxon, F.
    Current Pharmaceutical Design, vol. 16, no. 27, pp. 2950-2960
    Contributions to Journals: Review articles

  • A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells

    Ford, L. A., Roelofs, A. J., Anavi-Goffer, S., Mowat, L., Simpson, D. G., Irving, A. J., Rogers, M. J., Rajnicek, A. M., Ross, R. A.
    British Journal of Pharmacology, vol. 160, no. 3, pp. 762-771
    Contributions to Journals: Articles

  • Bisphosphonates: mechanisms of action

    Roelofs, A. J., Rogers, M.
    Handbook of Cancer-Related Bone Disease. Coleman, R. E., Abrahamsson, P. A., Hadji, P. (eds.). BioScientifica, pp. 71-89, 19 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

    Roelofs, A. J., Coxon, F., Ebetino, F. H., Lundy, M. W., Henneman, Z. J., Nancollas, G. H., Sun, S., Blazewska, K. M., Lynn F Bala, J., Kashemirov, B. A., Khalid, A. B., McKenna, C. E., Rogers, M. J.
    Journal of Bone and Mineral Research, vol. 25, no. 3, pp. 606-616
    Contributions to Journals: Articles

  • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation

    Guenther, A., Gordon, S., Tiemann, M., Burger, R., Bakker, F., Green, J. R., Baum, W., Roelofs, A. J., Rogers, M. J., Gramatzki, M.
    International Journal of Cancer, vol. 126, no. 1, pp. 239-246
    Contributions to Journals: Articles

  • Activation of γδ T Cells by Bisphosphonates

    Thompson, K., Roelofs, A. J., Jauhiainen, M., Mönkkönen, H., Mönkkönen, J., Rogers, M. J.
    Advances in Experimental Medicine and Biology, vol. 658, pp. 11-20
    Contributions to Journals: Review articles

  • The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

    Hirbe, A. C., Roelofs, A. J., Floyd, D. H., Deng, H., Becker, S. N., Lanigan, L. G., Apicelli, A. J., Xu, Z., Prior, J. L., Eagleton, M. C., Piwnica-Worms, D., Rogers, M. J., Weilbaecher, K.
    Bone, vol. 44, no. 5, pp. 908-916
    Contributions to Journals: Articles

  • Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP

    Roelofs, A. J., Jauhiainen, M., Monkkonen, H., Rogers, M. J., Monkkonen, J., Thompson, K.
    British Journal of Haematology, vol. 144, no. 2, pp. 245-250
    Contributions to Journals: Articles

  • Fluorescently labeled risedronate and related analogues: “Magic Linker” Synthesis

    Kashemirov, B. A., Bala, J. L. F., Chen, X., Ebetino, F. H., Xia, Z., Russell, R. G. G., Coxon, F., Roelofs, A. J., Rogers, M. J., McKenna, C. E.
    Bioconjugate Chemistry, vol. 19, no. 12, pp. 2308-2310
    Contributions to Journals: Articles

  • Bisphosphonates: Mechanisms of action

    Roelofs, A. J., Frank H Ebetino, F. H., Reszka, A. A., Russell, R. G. G., Rogers, M.
    Principles of Bone Biology: Volume 2. Bilezikian, J. P., Raisz, L. G., Martin, T. J. (eds.). 3 edition. Academic Press, pp. 1737-1767
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

    Coxon, F., Thompson, K., Roelofs, A. J., Ebetino, F. H., Rogers, M. J.
    Bone, vol. 42, no. 5, pp. 848-860
    Contributions to Journals: Articles

  • Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase

    Roelofs, A. J., Edwards, C. M., Graham, R., Russell, G., Ebetino, F. H., Rogers, M. J., Hulley, P. A.
    Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 1, pp. 228-235
    Contributions to Journals: Articles

  • Differential Effects of Stress on Adult Hippocampal Cell Proliferation in Low and High Aggressive Mice

    Veenema, A. H., De Kloet, E. R., De Wilde, M. C., Roelofs, A. J., Kawata, M., Buwalda, B., Neumann, I. D., Koolhaas, J. M., Lucassen, P. J.
    Journal of Neuroendocrinology, vol. 19, no. 7, pp. 489-498
    Contributions to Journals: Articles

  • Apomine (TM), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo

    Edwards, C. M., Mueller, G., Roelofs, A. J., Chantry, A., Perry, M., Russell, R. G. G., Van Camp, B., Guyon-Gellin, Y., Niesor, E. J., Bentzen, C. L., Vanderkerken, K., Croucher, P. I.
    International Journal of Cancer, vol. 120, no. 8, pp. 1657-1663
    Contributions to Journals: Articles

  • Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells

    Roelofs, A. J., Hulley, P. A., Meijer, A., Ebetino, F. H., Russell, R. G. G., Shipman, C. M.
    International Journal of Cancer, vol. 119, no. 6, pp. 1254-1261
    Contributions to Journals: Articles

  • Molecular mechanisms of action of bisphosphonates: current status

    Roelofs, A. J., Thompson, K., Gordon, S. A., Rogers, M. J.
    Clinical Cancer Research, vol. 12, no. 20 PT 2, pp. 6222S-6230S
    Contributions to Journals: Review articles
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