Duration: 5 years (start date November 2021)
Funder: British Society for Antimicrobial Chemotherapy
Chief investigators: Professor Gary Macfarlane, Professor Gareth Jones
Other co-investigators: Professor Patrice Forget, Dr Callum Kaye (NHS Grampian), Dr Noha El Sakka (NHS Grampian)
Study coordinators: Laura Moir, Rebecca Parr
Project assistant: Jay Woods
Effective antimicrobial agents are a crucial component of modern medicine allowing the elimination or inhibition of growth of all microorganisms. However, their effectiveness is threatened by evolutionary development of certain microbes. According to the WHO, antimicrobial resistance is increasing world-wide, and compromising our ability to treat infectious diseases and undermining many other advances in health and medicine. The purpose of the UKAR is to answer a broad set of research questions around novel anti-microbial agents. It will allow us to describe the use of such novel agents throughout the UK and to quantify the clinical outcomes and safety profile associated with their use in a real world setting.
Enquiries about the study can be emailed to email@example.com.
You can find out more about the registry, including the latest study news, at the BSAC study webpages.
If you are a clinician who is interested in antimicrobial resistance, please follow the link or QR code below to the UKAR Study Expression of Interest form:
Participating hospital sites
FANTASTIC NEWS! The #UKARStudy team are delighted to welcome @MFTnhs and #Pharmacist PI @francesgarragh1 to the @BSACandJAC UK Antimicrobial Registry. We look forward to working with you as we move toward a better understanding of #antimicrobialresistance. https://t.co/4HxE4GOw9G— UoAEpidemiology (@UoAEpi) September 15, 2023
First Recruit Friday! The #UKARStudy are delighted to have our first recruit @Leic_hospital. Thank you to the team, PI David Jenkins @NatalieAyton & @corrinea5h. To learn more about how to #getinvolved in the @BSACandJAC study follow the link #AMR https://t.co/4HxE4GOw9G— UoAEpidemiology (@UoAEpi) September 8, 2023
22/08/2023 - The British Society for Antimicrobial Chemotherapy (BSAC) is collaborating with the University of Aberdeen Epidemiology Group to develop the first UK Antimicrobial Registry (UKAR) to provide information about the safety and efficacy of new antimicrobials in real-world use.
The #UKARStudy is looking forward to working with @AnnaCTGordon of @NHS_Lothian who has registered with the @NIHRresearch Associate Principal Investigator scheme @NIHRcommunity. The scheme is a great way to #getinvolvedinresearch and develop your clinical research career. #AMR https://t.co/n2ZvkBbZnK— UoAEpidemiology (@UoAEpi) August 24, 2023
Great article from @BSACandJAC featuring the #UKARStudy, which represents an opportunity for pharmacists to #getinvolvedinresearch as Principal Investigators and @NIHRcommunity Associate Principal Investigators on an observational study looking into #AMRhttps://t.co/k40f100Bzg— UoAEpidemiology (@UoAEpi) August 22, 2023
Exciting News! Join us in celebrating a groundbreaking moment for #UKAR_Study & @UoAEpi! Thrilled to announce @southernHSCT as the FIRST site in Northern Ireland to join in almost 20 years of studies. #HealthResearch #NI #Milestone @BSACandJAC Thanks to everyone involved! https://t.co/wziu0Fvy0f— UoAEpidemiology (@UoAEpi) August 9, 2023
Want to get involved in research?#nihr #AssociatePI scheme. The UKAR Study provides a great training opportunity. Work alongside the Local PI on an NIHR portfolio study, find out more here: https://t.co/tp8pauPIXs.— UoAEpidemiology (@UoAEpi) August 2, 2023
Welcome to our newest #NIHR #AssociatePI @corrinea5h #UKARStudy pic.twitter.com/kQI7yUCQ48
Fantastic to see the #UKARStudy on https://t.co/7umPF2XpXO. Thank you to the team @ResearchAwaren1. Coincidentally, today we have our first participant @NHSGrampian Many thanks to PI @Micro_tweeter and the UKAR Study team. #AMR #antimicrobialresistance #getinvolvedinresearch https://t.co/smAevD058O— UoAEpidemiology (@UoAEpi) July 20, 2023
Are you interested in antimicrobial resistance?— UoAEpidemiology (@UoAEpi) July 13, 2023
Do you want to be involved in UK-wide research into the effective use of new-to-market antibiotics?
The UK Antimicrobial Registry would like to hear from you. Learn more https://t.co/XC2SwFJUef @BSACandJAC#UKARStudy #AMR pic.twitter.com/aLUnLJ90Y8
Great news! Green Light Day for the #UKARStudy and Royal Cornwall Hospitals Trust @RCHTWeCare @neilthepcist We look forward to working with you on the UK Antimicrobial Registry Study @BSACandJAC#UKARStudy #AMR #antimicrobialresistance #antimicrobialstewardship pic.twitter.com/g2dBT0KL1K— UoAEpidemiology (@UoAEpi) July 11, 2023
Congratulations to @KettGeneral for recruiting their first #UKARStudy participant. It only took 4 days from #GreenLight to recruit #1. Many thanks to the site study team for a great job. #AMR #AntimicrobialResistance #antimicrobialstewardship #getinvolvedinresearch @BSACandJAC pic.twitter.com/cJIb6phYn2— UoAEpidemiology (@UoAEpi) July 4, 2023
FANTASTIC NEWS! Green Light Day for the #UKARStudy and @KettGeneral Thank you to PI Ryan Hamilton and all the team – you guys are worthy of a ROSE Award. Looking forward to working together @BSACandJAC #AMR #antimicrobialresistance #antimicrobialstewardship #getinvolvedinresearch pic.twitter.com/klO4EPXiJ3— UoAEpidemiology (@UoAEpi) June 30, 2023
Fantastic Friday update - @NHSGGC have recruited 3 more participants to the #UKARStudy study this week. Many thanks to everyone involved; @raseaton66 you have a great team. #getinvolvedinresearch #antimicrobialresistance #AMR pic.twitter.com/UxoroxvJNw— UoAEpidemiology (@UoAEpi) June 23, 2023
The #UKARStudy is registered for the NIHR Associate PI scheme @NIHRcommunity. To find out how trainees in your NHS trust/board can be included, please email the team (firstname.lastname@example.org) and visit the link #getinvolvedinresearch #AMR #antimicrobialresistance https://t.co/iNXytbrGhf— UoAEpidemiology (@UoAEpi) June 19, 2023
Today the #UKARStudy team says goodbye to "Flemmy"! Many thanks to all the delegates from the @BSACandJAC Spring Conference that entered the "Guess the Antibiotic Emoji" quiz. All entrants got full marksCongrats to @Vaitehi who was the lucky winner to be pulled out of the#AMR pic.twitter.com/D2n5siYxZ8— UoAEpidemiology (@UoAEpi) June 14, 2023
30/05/2023 - The University of Aberdeen Epidemiology Group is collaborating with BSAC to develop the first UK Antimicrobial Registry (UKAR). The UKAR Study team is delighted to announce that NHS Grampian and NHS Greater Glasgow and Clyde are open for recruitment of participants to the UK Antimicrobial Registry.
GREAT NEWS! Green Light Day for the #UKARStudy and @NHSGGC. Today we are happy give the Green Light to PI @raseaton66 and the team at NHS Greater Glasgow and Clyde to start recruiting participants to the @BSACandJAC #UKARStudy. #AMR #antimicrobialresistance #getinvolvedinresearch pic.twitter.com/6c8AyF0fbk— UoAEpidemiology (@UoAEpi) May 23, 2023
BIG NEWS! Green Light Day for the #UKARStudy and @NHSGrampian. Today we are happy to Green Light NHS Grampian and our PI @Micro_tweeter to start recruiting participants to the @BSACandJAC #UKARStudy. #AMR #antimicrobialresistance #antimicrobialstewardship #getinvolvedinresearch pic.twitter.com/o8xMw1e1Of— UoAEpidemiology (@UoAEpi) May 19, 2023
Are you a clinician who's passionate about tackling #AMR? If you're at the #BSACSpring2023 today, come and have a chat with the excellent @UoAEpi #UKARStudy team to discuss how you can get involved with the UK Antimicrobial Registry. https://t.co/ujZ6nAYkzF pic.twitter.com/Cpf3E0YrgM— BSAC (@BSACandJAC) May 18, 2023
Group members @hteraG_senoJ, Laura Moir and @reb_parr are in London today to represent the#UKARStudy team at #BSACSpring2023 with the latest from the @BSACandJAC— UoAEpidemiology (@UoAEpi) May 18, 2023
UK Antimicrobial Registry #AntimicrobialResistance #AMR - pop along and say hello if you're in attendance! https://t.co/wbbPIVEcLX
Great to watch @jacquisneddons of @BSACandJAC discussing the importance of the #UKARStudy. For more information visit the UKAR Study websites at https://t.co/E8TH24xCqH and https://t.co/FZA7A4q8ig #AntimicrobialResistance #AMR https://t.co/EcU6lRgK0o— UoAEpidemiology (@UoAEpi) May 4, 2023
- Why is this research important?
Antibiotics are a vital part of modern medicine as they stop the growth of bacteria that cause infection. The UKAR Study will help us look how widely these medicines are used across the UK, why they are being prescribed, and how effective they are.
Bacteria are becoming resistant to treatment with commonly used antibiotics. This means that it is becoming difficult to successfully treat some bacterial infections. It is estimated that, worldwide, deaths due to antimicrobial resistance are on the same scale as deaths due to major diseases such as HIV/AIDS and malaria (Lancet, 2022: Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis).
Links to Resources about AMR / antibiotics:
- What will this research involve?
We will ask that patients give us their consent to allow us access to their medical records and allow us to collect clinical data from their notes. No further participation is required, as the study does not include any participant surveys or questionnaires.
Clinical data will be collected during treatment with the antibiotics included in the study, and then at 28 days, 6 months, and 12 months afterwards. We will collect information about the infections that the antibiotics are being used to treat, why these antibiotics were chosen and how effective they are at treating the infection.
The antibiotics included in the study are listed below:
All of the information that we collect will be analysed so that we can better understand how effective the antibiotics are at treating infections and tackling antimicrobial resistance. Participants will not be identifiable in any of the findings published from this research.
- Who can take part in the study?
To be included in the UKAR Study, a patient must be 18 years old or older, and have been prescribed one of the 11 study antibiotics during their current stay in a participating hospital:
The drug must have been prescribed within the last 60 days and the patient must have been treated with the drug for at least 24 hours.
As we are collecting health information, the study will ask for informed consent from patients. If a patient does not have the capacity to consent for themselves, an appropriate person will be asked to act on behalf of the patient.
If you have any questions about who can take part in the study, please email the UKAR Study team: email@example.com
- How will the research benefit patients and society?
Being part of the UKAR Study does not affect the treatment that a patient receives. Therefore, individual patients do not directly benefit from participating in the study. However, the UKAR Study will provide important information about the study drugs. The study will help us see how often these drugs are used across the UK, and to look at how safe and effective they are. Lessons learnt from the registry will help doctors across the country decide how best to treat patients in the future.
What is required of a participant in the UKAR Study?
We will ask the patient to give their consent for us to access their hospital notes. We will not ask anything further from the patient, as there are no participant surveys or questionnaires.
How will my information be used?
No personal or identifiable information about participants in the UKAR Study will be available to anyone outside of the UKAR Study team. Personal, identifiable information will be removed from the data before it is analysed.
Which drugs are included in the UKAR Study?
Gram negative agents: Gram positive agents:
How many participants does a site need to recruit?
A site will need to recruit a minimum of 20 patients over the course of the study, which is expected to be recruiting participants through to May 2026
How does my site become involved in the study?
To get involved in the UKAR Study, please complete the UKAR Expression of Interest (EOI) form which can be accessed from on the website or using the QR code:
What are the requirements of my site?
- Prescription of the any of the antibiotics included in the study.
- A way to identify patients who are prescribed antibiotics included in the study.
- Someone able to receive informed consent from participants.
- A Principal Investigator to take responsibility for running the UKAR Study at site.
The UKAR Study is registered with the NIHR Associate PI scheme - Associate Principal Investigator Scheme
Fran Garraghan @francesgarragh1, Consultant Pharmacist & Antibiotic angel, is the UKAR Study Principal Investigator at Manchester University NHS Foundation Trust. Fran has made this video about setting up the study at site.
- How can I get involved?
- Study team
The following team will be responsible for delivering the study:
Professor Gary Macfarlane - Chief investigator – UKAR Virtual Registry
Professor Gareth Jones – Chief Investigator – UKAR Hospital Registry
Mrs Laura Moir – Study Coordinator
Dr Rebecca Parr – Assistant Study Coordinator
Mr Jay Woods – Project Assistant
- Who is funding this study?
The UKAR Study is funded by The British Society for Antimicrobial Chemotherapy
To find out more visit Home - UK Antimicrobial Registry (bsac-ukar.org)
- What we have found so far
We are currently setting up our 4 pilot sites across the UK.
We will update you with findings once we have trialled the study at our pilot sites.
- Patient Stories
If you are a patient involved in the UKAR study and would like to share your experiences, please contact us at firstname.lastname@example.org .
- Contact details
If you are interested to learn more about the UKAR Study, please contact the team; email@example.com
Chemotherapy – The use of chemicals (drugs) as therapy (treatment) against disease.
Microbe – a microorganism (such as bacteria) that can only be seen using a microscope.
Antimicrobial – Something (a drug) that works against microbes (such as bacteria).
Antimicrobial resistance – Microbes (such as bacteria) that have developed the ability to survive treatment with antimicrobial drugs (such as antibiotics).