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Health Services Research Unit

Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis

    Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.
    BMJ, vol. 359, j4849
    Contributions to Journals: Articles

  • Bayesian clinical trial designs: Another option for trauma trials?

    Jansen, J. O., Pallmann, P., MacLennan, G., Campbell, M. K., UK-REBOA Trial Investigators
    The journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741
    Contributions to Journals: Articles

  • THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial

    Lenguerrand, E., Winter, C., Innes, K., MacLennan, G., Siassakos, D., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T., Thistle group
    BMC Pregnancy and Childbirth, vol. 17, 294
    Contributions to Journals: Articles

  • The SIMS trial: adjustable anchored single-incision mini-slings versus standard tension-free midurethral slings in the surgical management of female stress urinary incontinence. A study protocol for a pragmatic, multicentre, non-inferiority randomised controlled trial

    Abdel-Fattah, M., Maclennan, G., Kilonzo, M., Assassa, R. P., McCormack, K., Davidson, T., McDonald, A., N'Dow, J., Wardle, J., Norrie, J.
    BMJ Open, vol. 7, no. 8, pp. 1-18
    Contributions to Journals: Articles

  • Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study

    Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H., PRISM-EZ Trial Group
    Journal of Bone and Mineral Research, vol. 32, no. 6, pp. 1165-1173
    Contributions to Journals: Articles

  • Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree

    Sylvester, R. J., Canfield, S. E., Lam, T. B. L., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernandez, V., Plass, K., Van Poppel, H., N'Dow, J.
    European Urology, vol. 71, no. 5, pp. 811-819
    Contributions to Journals: Articles

  • The BJUI's clinical trials initiative

    Davis, J. W., MacLennan, G.
    BJU International, vol. 119, no. 4, pp. 503
    Contributions to Journals: Editorials

  • Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)

    Glazener, C. M. A., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R. B., Reid, F., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    The Lancet, vol. 389, no. 10067, pp. 381–392
    Contributions to Journals: Articles

  • The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

    Cook, J. A., Beard, D. J., Cook, J. R., MacLennan, G. S.
    Pilot & Feasibility Studies, vol. 2, 73
    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study

    Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K., Freeman, R., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 20, no. 95, pp. 1-452
    Contributions to Journals: Articles

  • Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?

    Fielding, S., Ogbuagu, A., Sivasubramaniam, S., MacLennan, G., Ramsay, C. R.
    Quality of Life Research, vol. 25, no. 12, pp. 2977-2983
    Contributions to Journals: Articles

  • Breast pumps as an incentive for breastfeeding: a mixed methods study of acceptability

    Crossland, N., Thomson, G., Morgan, H., MacLennan, G., Campbell, M., Dykes, F., Hoddinott, P.
    Maternal and Child Nutrition, vol. 12, no. 4, pp. 726-739
    Contributions to Journals: Articles

  • Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

    Pyle, M., Norrie, J., Schwannauer, M., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., Morrison, A. P.
    BMC Psychiatry, vol. 16, pp. 1-12
    Contributions to Journals: Articles

  • A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials

    Gardner, H. R., Fraser, C., MacLennan, G., Treweek, S.
    Systematic reviews , vol. 5, 131
    Contributions to Journals: Articles

  • Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

    Cruickshank, M., Henderson, L., MacLennan, G., Fraser, C., Campbell, M., Blackwood, B., Gordon, A., Brazzelli, M.
    Health Technology Assessment, vol. 20, no. 25, pp. 0-120
    Contributions to Journals: Literature Reviews

  • Behavioural recovery after treatment for varicose veins

    Cotton, S. C., MacLennan, G., Brittenden, J., Prior, M., Francis, J.
    British Journal of Surgery, vol. 103, no. 4, pp. 374-381
    Contributions to Journals: Articles

  • The ethics of future trials: qualitative analysis of physicians' decision making

    Webster, F., Weijer, C., Todd, L., Grimshaw, J. M., Marshall, A. P., Cook, D., MacLennan, G., Cuthbertson, B. H., Francis, J. J., SuDDICU International Study Group
    Trials, vol. 17, pp. 1-8
    Contributions to Journals: Articles

  • Mindfulness-Based Stress Reduction for Veterans With PTSD

    Goulao, B., MacLennan, G. S.
    JAMA, vol. 315, no. 1, pp. 87-88
    Contributions to Journals: Letters

  • Kurzdarstellung aktueller publikationen: Begünstigt eine muskelrelaxierende therapie den uretersteinabgang?

    Pickard, R., Starr, K., MacLennan, G., Lam, T., Thomas, R., Burr, J., McPherson, G., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, T., Kilonzo, M., Gillies, K., Shearer, K., Boachie, C., Cameron, S., Norrie, J., McClinton, S.
    Nieren- und Hochdruckkrankheiten, vol. 45, no. 1, pp. 38
    Contributions to Journals: Articles

  • Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial): study protocol for a randomised controlled trial

    Stephenson, R., Carnell, S., Johnson, N., Brown, R., Wilkinson, J., Mundy, A., Payne, S., Watkin, N., N'Dow, J., Sinclair, A., Rees, R., Barclay, S., Cook, J. A., Goulao, B., MacLennan, G., McPherson, G., Jackson, M., Rapley, T., Shen, J., Vale, L., Norrie, J., McColl, E., Pickard, R.
    Trials, vol. 16, 600
    Contributions to Journals: Articles

  • Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study

    Hoddinott, P., Thomson, G., Morgan, H., Crossland, N., MacLennan, G. S., Dykes, F., Stewart, F., Bauld, L., Campbell, M. K.
    Maternal and Child Nutrition, vol. 11, no. Supplement S2, pp. 113
    Contributions to Journals: Abstracts

  • Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study

    Hoddinott, P., Thomson, G., Morgan, H., Crossland, N., MacLennan, G., Dykes, F., Stewart, F., Bauld, L., Campbell, M. K.
    BMJ Open, vol. 5, no. 11, e008492
    Contributions to Journals: Articles

  • Ureteric colic and clinical evidence - Authors' reply

    Pickard, R., MacLennan, G., Norrie, J., McClinton, S.
    The Lancet, vol. 386, no. 10006, pp. 1823
    Contributions to Journals: Comments and Debates

  • Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial)

    Pickard, R., Starr, K., MacLennan, G., Kilonzo, M., Lam, T., Thomas, R. E., Burr, J., Norrie, J., McPherson, G., McDonald, A., Shearer, K., Gillies, K., Anson, K., Boachie, C., N'Dow, J., Burgess, N., Clark, T., Cameron, S., McClinton, S.
    Health Technology Assessment, vol. 19, no. 63, pp. 1-171
    Contributions to Journals: Articles

  • Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial

    Pickard, R., Starr, K., MacLennan, G., Lam, T. B. L., Thomas, R., Burr, J., McPherson, G., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, T., Kilonzo, M., Gillies, K., Shearer, K., Boachie, C., Cameron, S., Norrie, J., McClinton, S.
    The Lancet, vol. 386, no. 9991, pp. 341-349
    Contributions to Journals: Articles

  • Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation

    Ramsay, C. R., Adewuyi, T. E., Gray, J., Hislop, J., Shirley, M. D., Jayakody, S., MacLennan, G., Fraser, C., MacLennan, S., Brazzelli, M., N'Dow, J., Pickard, R., Robertson, C., Rothnie, K., Rushton, S. P., Vale, L., Lam, T. B.
    Health Technology Assessment, vol. 19, no. 49, pp. 1-524
    Contributions to Journals: Articles

  • A systematic review of the use of an expertise-based randomised controlled trial design

    Cook, J. A., Elders, A., Boachie, C., Bassinga, T., Fraser, C. M., Altman, D., Boutron, I., Ramsay, C. R., MacLennan, G. S.
    Trials, vol. 16, 241
    Contributions to Journals: Articles

  • STOPPIT Baby Follow-Up Study: The Effect of Prophylactic Progesterone in Twin Pregnancy on Childhood Outcome

    McNamara, H. C., Wood, R., Chalmers, J., Marlow, N., Norrie, J., MacLennan, G., McPherson, G., Boachie, C., Norman, J. E.
    PloS ONE, vol. 10, no. 4, e0122341
    Contributions to Journals: Articles

  • Benefits of incentives for breastfeeding and smoking cessation in pregnancy (BIBS): a mixed methods study to inform trial design

    Morgan, H., Hoddinott, P., Thomson, G., Crossland, N., Farrar, S., Yi, D., Hislop, J. M., Hall Moran, V., MacLennan, G. S., Dombrowski, S. U., Rothnie, K. J., Stewart, F., Bauld, L., Ludbrook, A., Dykes, F., Sniehotta, F. F., Tappin, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 30, pp. 1-564
    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial

    Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., Bolsover, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 27, pp. 1-342
    Contributions to Journals: Articles

  • Incentives to Promote Breastfeeding: A Systematic Review

    Hall Moran, V., Morgan, H., Rothnie, K., MacLennan, G., Stewart, F., Thomson, G., Crossland, N., Tappin, D., Campbell, M., Hoddinott, P.
    Pediatrics, vol. 135, no. 3, pp. e687-702
    Contributions to Journals: Articles

  • Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy: a randomized controlled trial

    Ahmed, I., Cook, J. A., Duncan, A., Krukowski, Z. H., Malik, M., MacLennan, G., McCormack, K., SCARLESS Study Group
    Surgical Endoscopy, vol. 29, no. 1, pp. 77-85
    Contributions to Journals: Articles

  • Non-compliance with randomised allocation and missing outcome data in randomised controlled trials evaluating surgical interventions: a systematic review

    Adewuyi, T. E., MacLennan, G., Cook, J. A.
    BMC Research Notes, vol. 8, 403
    Contributions to Journals: Articles

  • The push me, pull you of financial incentives and health inequalities: a mixed methods study investigating smoking cessation in pregnancy and breastfeeding

    Hoddinott, P., Morgan, H., Thomson, G., Crossland, N., Farrar, S., Yi, D., Hislop, J., Hall Moran, V., MacLennan, G. S., Dombrowski, S. U., Rothnie, K., Stewart, F., Bauld, L., Ludbrook, A., Dykes, F., Sniehotta, F. F., Tappin, D., Campbell, M. K.
    European Public Health Science Conference, pp. S37
    Contributions to Journals: Abstracts

  • Observational study of current use of selective decontamination of the digestive tract in UK critical care units

    Canter, R. R., Harvey, S. E., Harrison, D. A., Campbell, M. K., M Rowan, K., Cuthbertson, B. H., Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators, Duncan, E., Prior, M. E., Bellingan, G., Eccles, M., Johnston, M., MacLennan, G. S., Ramsay, C. R., Rose, L., Shulman, R., Dombrowski, S.
    British Journal of Anaesthesia, vol. 113, no. 4, pp. 610-617
    Contributions to Journals: Articles

  • Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis

    Ford, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M., RECORD Trial Group
    The American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 746-755
    Contributions to Journals: Articles

  • Public acceptability of financial incentives for smoking cessation in pregnancy and breastfeeding

    Hoddinott, P., Morgan, H., MacLennan, G., Sewel, K., Thomson, G., Bauld, L., Yi, D., Ludbrook, A., Campbell, M. K.
    International Journal of Behavioral Medicine, vol. 21, no. 1 Suppl., S194
    Contributions to Journals: Abstracts

  • Public acceptability of financial incentives for smoking cessation in pregnancy and breast feeding: a survey of the British public

    Hoddinott, P., Morgan, H., MacLennan, G., Sewel, K., Thomson, G., Bauld, L., Yi, D., Ludbrook, A., Campbell, M. K.
    BMJ Open, vol. 4, no. 7, e005524
    Contributions to Journals: Articles

  • Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin): study protocol for a randomized controlled trial

    McClinton, S., Starr, K., Thomas, R., MacLennan, G. S., McPherson, G., McDonald, A., Lam, T., N'Dow, J., Kilonzo, M., Pickard, R., Anson, K., Burr, J., SUSPEND Study Group
    Trials, vol. 15, no. 1, 238
    Contributions to Journals: Articles

  • Comparison of four methods for assessing the importance of attitudinal beliefs: An international Delphi study in intensive care settings

    Francis, J. J., Duncan, E. M., Prior, M. E., Maclennan, G., Marshall, A. P., Wells, E. C., Todd, L., Rose, L., Campbell, M. K., Webster, F., Eccles, M. P., Bellingan, G., Seppelt, I. M., Grimshaw, J. M., Cuthbertson, B. H., SuDDICU study groups
    British Journal of Health Psychology, vol. 19, no. 2, pp. 274-291
    Contributions to Journals: Articles

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators
    European Heart Journal, vol. 35, no. 19, pp. 1255-1262
    Contributions to Journals: Articles

  • Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study)

    J Francis, J., M Duncan, E., Prior, M. E., S Maclennan, G., Dombrowski, S. U., Bellingan, G., Campbell, M. K., P Eccles, M., Rose, L., M Rowan, K., Shulman, R., Peter R Wilson, A., H Cuthbertson, B.
    Health Technology Assessment, vol. 18, no. 25, pp. 1-170
    Contributions to Journals: Articles

  • Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis

    Price, R., MacLennan, G., Glen, J., SuDDICU Collaboration
    BMJ, vol. 348, g2197
    Contributions to Journals: Articles

  • A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT)

    Murray, D. W., MacLennan, G. S., Breeman, S., Dakin, H. A., Johnston, L., Campbell, M. K., Gray, A. M., Fiddian, N., Fitzpatrick, R., Morris, R. W., Grant, A. M., KAT group
    Health Technology Assessment, vol. 18, no. 19, pp. 1-235, vii-viii
    Contributions to Journals: Articles

  • Paper-based and web-based intervention modeling experiments identified the same predictors of general practitioners' antibiotic-prescribing behavior

    Treweek, S., Bonetti, D., Maclennan, G., Barnett, K., Eccles, M. P., Jones, C., Pitts, N. B., Ricketts, I. W., Sullivan, F., Weal, M., Francis, J. J.
    Journal of Clinical Epidemiology, vol. 67, no. 3, pp. 296-304
    Contributions to Journals: Articles

  • Advance telephone calls ahead of reminder questionnaires increase response rate in non-responders compared to questionnaire reminders only: The RECORD phone trial

    Maclennan, G., McDonald, A., McPherson, G., Treweek, S., Avenell, A., RECORD Trial Group
    Trials, vol. 15, 13
    Contributions to Journals: Articles

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.
    Circulation, vol. 128, no. 24, pp. 2705
    Contributions to Journals: Abstracts

  • Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study

    Cuthbertson, B. H., Campbell, M. K., Maclennan, G., Duncan, E. M., Marshall, A. P., Wells, E. C., Prior, M. E., Todd, L., Rose, L., Seppelt, I. M., Bellingan, G., Francis, J. J.
    Critical Care, vol. 17, no. 6, R266
    Contributions to Journals: Articles

  • Systematic Review of Adrenalectomy and Lymph Node Dissection in Locally Advanced Renal Cell Carcinoma

    Bekema, H. J., Maclennan, S., Imamura, M., Lam, T. B. L., Stewart, F., Scott, N., Maclennan, G., McClinton, S., Griffiths, T. R. L., Skolarikos, A., Maclennan, S. J., Sylvester, R., Ljungberg, B., N'dow, J.
    European Urology, vol. 64, no. 5, pp. 799-810
    Contributions to Journals: Articles

  • Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials

    Bristow, S. M., Bolland, M. J., Maclennan, G. S., Avenell, A., Grey, A., Gamble, G. D., Reid, I. R.
    British Journal of Nutrition, vol. 110, no. 8, pp. 1384-1393
    Contributions to Journals: Articles

  • Effect of day and time of admission on mortality in an intensive care unit

    Jansen, J. O., Maclennan, G. S., Cuthbertson, B. H.
    Journal of the Intensive Care Society, vol. 14, no. 4, pp. 294-298
    Contributions to Journals: Articles

  • Management of the open abdomen: A national study of clinical outcome and safety of negative pressure wound therapy

    Carlson, G. L., Patrick, H., Amin, A. I., McPherson, G., Maclennan, G., Afolabi, E., Mowatt, G., Campbell, B.
    Annals of Surgery, vol. 257, no. 6, pp. 1154-1159
    Contributions to Journals: Articles

  • Authors' reply - Assessing catheter-associated urinary tract infection

    Pickard, R., MacLennan, G., Norrie, J., N'Dow, J.
    The Lancet, vol. 381, no. 9877, pp. 1536
    Contributions to Journals: Letters

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.
    Journal of translational medicine, vol. 11, 116
    Contributions to Journals: Articles

  • Mortality and quality of life in the five years after severe sepsis

    Cuthbertson, B. H., Elders, A., Hall, S., Taylor, J., Maclennan, G., Mackirdy, F., Mackenzie, S. J., Scottish Critical Care Trials Group and the Scottish Intensive Care Society Audit Group
    Critical Care, vol. 17, no. 2, R70
    Contributions to Journals: Articles

  • Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement

    Breeman, S., Campbell, M. K., Dakin, H., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Johnston, L., MacLennan, G. S., Morris, R. W., Murray, D. W., KAT Trial Group
    Journal of Bone & Joint Surgery (US Volume), vol. 95-B, no. 4, pp. 486-492
    Contributions to Journals: Articles

  • Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial

    Pickard, R., Lam, T., Maclennan, G., Starr, K., Kilonzo, M., McPherson, G., Gillies, K., McDonald, A., Walton, K., Buckley, B., Glazener, C., Boachie, C., Burr, J., Norrie, J., Vale, L., Grant, A., N'Dow, J.
    The Lancet, vol. 380, no. 9857, pp. 1927-1935
    Contributions to Journals: Articles

  • Systematic review of perioperative and quality-of-life outcomes following surgical management of localised renal cancer

    MacLennan, S., Imamura, M., Lapitan, M. C., Omar, M. I., Lam, T. B. L., Hilvano-Cabungcal, A. M., Royle, P., Stewart, F., MacLennan, G., MacLennan, S. J., Dahm, P., Canfield, S. E., McClinton, S., Griffiths, T. R. L., Ljungberg, B., N'Dow, J., UCAN Systematic Review Reference Group
    European Urology, vol. 62, no. 6, pp. 1097-1117
    Contributions to Journals: Articles

  • Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation: multicentre randomised controlled trial and economic evaluation of antimicrobial- and antiseptic-impregnated urethral catheters (the CATHETER trial)

    Pickard, R., Lam, T., Maclennan, G., Starr, K., Kilonzo, M., McPherson, G., Gillies, K., McDonald, A., Walton, K., Buckley, B., Glazener, C. M. A., Boachie, C., Burr, J., Norrie, J., Vale, L., Grant, A. M., N'dow, J.
    Health Technology Assessment, vol. 16, no. 47, pp. 1-197
    Contributions to Journals: Articles

  • Explaining clinical behaviors using multiple theoretical models

    Eccles, M. P., Grimshaw, J. M., MacLennan, G., Bonetti, D., Glidewell, L., Pitts, N. B., Steen, N., Thomas, R. E., Walker, A., Johnston, M.
    Implementation Science, vol. 7, 99
    Contributions to Journals: Articles

  • Using shared goal setting to improve access and equity: a mixed methods study of the Good Goals intervention in children's occupational therapy

    Kolehmainen, N., Maclennan, G., Ternent, L., Duncan, E. A. S., Duncan, E. M., Ryan, S. B., McKee, L., Francis, J.
    Implementation Science, vol. 7, 76
    Contributions to Journals: Articles

  • Do incentives, reminders or reduced burden improve healthcare professional response rates in postal questionnaires?: two randomised controlled trials

    Glidewell, L., Thomas, R., MacLennan, G., Bonetti, D., Johnston, M., Eccles, M. P., Edlin, R., Pitts, N. B., Clarkson, J., Steen, N., Grimshaw, J. M.
    BMC Health Services Research, vol. 12, 250
    Contributions to Journals: Articles

  • Corrigendum to "systematic review of oncological outcomes following surgical management of localised renal cancer" [Eur Urol 2012;61:972-93]

    MaClennan, S., Imamura, M., Lapitan, M. C., Omar, M. I., Lam, T. B., Hilvano-Cabungcal, A. M., Royle, P., Stewart, F., MaClennan, G., MaClennan, S. J., Canfield, S. E., McClinton, S., Griffiths, T. R., Ljungberg, B., N'Dow, J.
    European Urology, vol. 62, no. 1
    Contributions to Journals: Comments and Debates

  • E-mail invitations to general practitioners were as effective as postal invitations and were more efficient

    Treweek, S., Barnett, K., Maclennan, G., Bonetti, D., Eccles, M. P., Francis, J. J., Jones, C., Pitts, N. B., Ricketts, I. W., Weal, M., Sullivan, F.
    Journal of Clinical Epidemiology, vol. 65, no. 7, pp. 793-797
    Contributions to Journals: Articles

  • Systematic review of oncological outcomes following surgical management of localised renal cancer

    MacLennan, S., Imamura, M., Lapitan, M. C. M., Omar, M. I., Lam, T. B. L., Hilvano-Cabungcal, A., Royle, P., Stewart, F., MacLennan, G. S., MacLennan, S., Canfield, S., McClinton, S., Griffiths, T. R. L., Ljungberg, B., N'Dow, J. M. O.
    European Urology, vol. 61, no. 5, pp. 972-993
    Contributions to Journals: Articles

  • Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD trial)

    Avenell, A., Maclennan, G. S., Jenkinson, D. J., McPherson, G. C., McDonald, A. M., Pant, P. R., Grant, A. M., Campbell, M. K., Anderson, F. H., Cooper, C., Francis, R. M., Gillespie, W. J., Robinson, C. M., Torgerson, D. J., Wallace, W. A., RECORD Trial Group
    Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 614-622
    Contributions to Journals: Articles

  • Rationing of total knee replacement: a cost-effectiveness analysis on a large trial data set

    Dakin, H., Gray, A., Fitzpatrick, R., Maclennan, G., Murray, D., KAT Trial Group
    BMJ Open, vol. 2, no. 1, e000332
    Contributions to Journals: Articles

  • Clustering in surgical trials: database of intracluster correlations

    Cook, J. A., Bruckner, T., MacLennan, G. S., Seiler, C. M.
    Trials, vol. 13, no. -, 2
    Contributions to Journals: Articles

  • Identifying active ingredients in complex behavioural interventions for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: a systematic review

    Dombrowski, S. U., Sniehotta, F., Avenell, A., Johnston, M., MacLennan, G. S., Araujo-Soares, V.
    Health Psychology Review, vol. 6, no. 1, pp. 7-32
    Contributions to Journals: Articles

  • Process evaluation for the FEeding Support Team (FEST) randomised controlled feasibility trial of proactive and reactive telephone support for breastfeeding women living in disadvantaged areas

    Hoddinott, P., Craig, L., Maclennan, G., Boyers, D., Vale, L., On behalf of the NHS Grampian and the University of Aberdeen FEST project team
    BMJ Open, vol. 2, no. 2, e001039
    Contributions to Journals: Articles

  • The FEeding Support Team (FEST) randomised, controlled feasibility trial of proactive and reactive telephone support for breastfeeding women living in disadvantaged areas

    Hoddinott, P., Craig, L., Maclennan, G., Boyers, D., Vale, L., On behalf of the NHS Grampian and the University of Aberdeen FEST project team
    BMJ Open, vol. 2, no. 2, e000652
    Contributions to Journals: Articles

  • Surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer: a systematic review

    Robertson, C., Ragupathy, S. K. A., Boachie, C., Fraser, C., Heys, S. D., Maclennan, G., Mowatt, G., Thomas, R. E., Gilbert, F. J., Mammographic Surveillance Health Technology Assessment Group
    European Radiology, vol. 21, no. 12, pp. 2484-2491
    Contributions to Journals: Articles

  • Assessing risk of bias in non-randomised studies and incorporating GRADE: Initial experience with a new Cochrane ‘risk of bias’ tool under development

    MacLennan, S., Imamura, M., Dahm, P., Nueberger, M., Reeves, B. C., MacLennan, G. S., Omar, M. I., McClinton, S., Griffiths, T. R. L., N'Dow, J. M. O.
    Contributions to Conferences: Papers

  • The hazards of extracting hazard ratios from survival curves for meta-analyses in observational studies

    Imamura, M., MacLennan, S., Dahm, P., Nueberger, M., Omar, M. I., MacLennan, G. S.
    Contributions to Conferences: Papers

  • Evidence for partial nephrectomy

    Lam, T. B. L., MacLennan, S., Imamura, M., Omar, M. I., MacLennan, G.
    Contributions to Conferences: Papers

  • Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial

    Breeman, S., Campbell, M., Dakin, H., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Johnston, L., Maclennan, G., Morris, R., Murray, D., KAT Trial Group
    The Journal of Bone & Joint Surgery. American Volume, vol. 93, no. 16, pp. 1473-1481
    Contributions to Journals: Articles

  • The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer: systematic reviews registry database analyses and economic evaluation

    Robertson, C., Arcot Ragupathy, S. K., Boachie, C., Dixon, J. M., Fraser, C., Hernández, R., Heys, S., Jack, W., Kerr, G. R., Lawrence, G., MacLennan, G., Maxwell, A., McGregor, J., Mowatt, G., Pinder, S., Ternent, L., Thomas, R. E., Vale, L., Wilson, R., Zhu, S., Gilbert, F. J.
    Health Technology Assessment, vol. 15, no. 34, pp. v-vi, 1-322
    Contributions to Journals: Articles

  • Further use for the harvest plot: a novel method for quantitative and qualitative data synthesis

    Crowther, M., Avenell, A., MacLennan, G. S., Mowatt, G.
    Research Synthesis Methods, vol. 2, no. 2, pp. 79-83
    Contributions to Journals: Articles

  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of lumbar spine x-ray for low back pain in UK primary care practice

    Grimshaw, J. M., Eccles, M. P., Steen, N., Johnston, M., Pitts, N. B., Glidewell, E., Maclennan, G., Thomas, R. E., Bonetti, D. L., Walker, A. E.
    Implementation Science, vol. 6, pp. 55
    Contributions to Journals: Articles

  • Developing and evaluating interventions to reduce inappropriate prescribing by general practitioners of antibiotics for upper respiratory tract infections: a randomised controlled trial to compare paper-based and web-based modelling experiments

    Treweek, S. P., Ricketts, I. W., Francis, J., Eccles, M., Bonetti, D., Pitts, N. B., Maclennan, G., Sullivan, F., Jones, C., Weal, M., Barnett, K.
    Implementation Science, vol. 6, no. 1, pp. 16
    Contributions to Journals: Articles

  • Calcium and heart attacks: Authors' reply

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., Reid, I. R., MacLennan, G. S., Gamble, G. D.
    BMJ (Online), vol. 341, no. 7773, pp. 569
    Contributions to Journals: Letters

  • Clinicians' caseload management behaviours as explanatory factors in patients' length of time on caseloads: a predictive multilevel study in paediatric community occupational therapy

    Kolehmainen, N., MacLennan, G., Francis, J. J., Duncan, E. A. S.
    BMC Health Services Research, vol. 10, no. 249, 249
    Contributions to Journals: Articles

  • Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., MacLennan, G. S., Gamble, G. D., Reid, I. R.
    British Medical Journal, vol. 341, no. -, c3691
    Contributions to Journals: Articles

  • Study of progesterone for the prevention of preterm birth in twins (STOPPIT): findings from a trial-based cost-effectiveness analysis

    Eddama, O., Petrou, S., Regier, D., Norrie, J., MacLennan, G., MacKenzie, F., Norman, J. E.
    International Journal of Technology Assessment in Health Care, vol. 26, no. 2, pp. 141-148
    Contributions to Journals: Articles

  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of placing preventive fissure sealants

    Bonetti, D., Johnston, M., Clarkson, J. E., Grimshaw, J., Pitts, N. B., Eccles, M., Steen, N., Thomas, R., Maclennan, G., Glidewell, E., Walker, A. E.
    Implementation Science, vol. 5, pp. 25
    Contributions to Journals: Articles

  • The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trials

    Lourenco, T., Shaw, M., Fraser, C. M., MacLennan, G. S., N'Dow, J. M. O., Pickard, R.
    World Journal of Urology, vol. 28, no. 1, pp. 23-32
    Contributions to Journals: Articles

  • Quality of life in the five years after intensive care: a cohort study

    Cuthbertson, B., Roughton, S., Jenkinson, D. J., MacLennan, G. S., Vale, L. D.
    Critical Care, vol. 14, no. 1, R6
    Contributions to Journals: Articles

  • Factors Influencing the Participation of Older People in Clinical Trials: Data Analysis from the MAVIS Trial

    Fearn, P., Avenell, A., McCann, S. K., Milne, A. C., MacLennan, G. S., MAVIS Trial Group
    Journal of Nutrition, Health & Aging, vol. 14, no. 1, pp. 51-56
    Contributions to Journals: Articles

  • Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone

    Langston, A. L., Campbell, M. K., Fraser, W. D., MacLennan, G. S., Selby, P. L., Ralston, S. H., PRISM Trial Group
    Journal of Bone and Mineral Research, vol. 25, no. 1, pp. 20-31
    Contributions to Journals: Articles

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hernández, R. A.
    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages
    Books and Reports: Commissioned Reports

  • Surveillance following breast cancer: is it cost-effective?

    Ternent, L., MacLennan, G., Heys, S. D., Gilbert, F., Vale, L., Mammographic Surveillance HTA Group
    Breast Cancer Research, vol. 12, no. Suppl. 3, pp. 5-6
    Contributions to Journals: Articles

  • Development and exploratory cluster-randomised opportunistic trial of a theory-based intervention to enhance physical activity among adolescents

    Araujo-Soares, V., McIntyre, T., MacLennan, G. S., Sniehotta, F.
    Psychology & Health, vol. 24, no. 7, pp. 805-822
    Contributions to Journals: Articles

  • Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)

    Avenell, A., Cook, J. A., MacLennan, G. S., McPherson, G. C., RECORD Trial Group
    Age and Ageing, vol. 38, no. 5, pp. 606-609
    Contributions to Journals: Articles

  • Uric acid levels and outcome from coronary artery bypass grafting

    Hillis, G. S., Cuthbertson, B. H., Gibson, P. H., McNeilly, J. D., Maclennan, G. S., Jeffrey, R. R., Buchan, K. G., El-Shafei, H., Gibson, G., Croal, B. L.
    Journal of Thoracic and Cardiovascular Surgery, vol. 138, no. 1, pp. 200-205
    Contributions to Journals: Articles

  • Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis

    Norman, J. E., Mackenzie, F., Owen, P., Mactier, H., Hanretty, K., Cooper, S., Calder, A., Mires, G., Danielian, P., Sturgiss, S., MacLennan, G., Tydeman, G., Thornton, S., Martin, B., Thornton, J. G., Neilson, J. P., Norrie, J.
    The Lancet, vol. 373, no. 9680, pp. 2034-2040
    Contributions to Journals: Articles

  • Meaning behind measurement: self-comparisons affect responses to health-related quality of life questionnaires

    Robertson, C., Langston, A. L., Stapley, S., McColl, E., Campbell, M. K., Fraser, W. D., MacLennan, G., Selby, P. L., Ralston, S. H., Fayers, P. M., PRISM Trial Group
    Quality of Life Research, vol. 18, no. 2, pp. 221-230
    Contributions to Journals: Articles

  • The Knee Arthroplasty Trial (KAT): design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement

    Campbell, M., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Morris, R., Murray, D., Rowley, D., Johnston, L., MacLennan, G., McCormack, K., Ramsay, C., Walker, A., KAT Trial Group
    The Journal of Bone & Joint Surgery. American Volume, vol. 91, no. 1, pp. 134-141
    Contributions to Journals: Articles

  • Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement

    Lourenco, T., Armstrong, N., N'Dow, J., Nabi, G., Deverill, M., Pickard, R., Vale, L., MacLennan, G., Fraser, C., McClinton, S., Wong, S., Coutts, A., Mowatt, G., Grant, A.
    Health Technology Assessment, vol. 12, no. 35, pp. 1-168
    Contributions to Journals: Literature Reviews

  • Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trials

    Lourenco, T., Pickard, R., Vale, L., Grant, A., Fraser, C., MacLennan, G., N'Dow, J., The Benign Prostatic Enlargement Team
    British Medical Journal, vol. 337, a1662
    Contributions to Journals: Articles

  • A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes

    Fielding, S., MacLennan, G. S., Cook, J. A., Ramsay, C. R.
    Trials, vol. 9, 51
    Contributions to Journals: Articles
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