Professor Graeme MacLennan

Professor Graeme MacLennan

Director (CHaRT)

Professor Graeme MacLennan
Professor Graeme MacLennan

Contact Details


I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  


MSc, Applied Statistics Sheffield Hallam University 2004
BSc, Mathematics University of Aberdeen 1997

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here


Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.



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  • Outcomes of a Noninferiority Randomised Controlled Trial of Surgery for Men with Urodynamic Stress Incontinence After Prostate Surgery (MASTER)

    Abrams, P., Constable, L. D., Cooper, D., MacLennan, G., Drake, M. J., Harding, C., Mundy, A., McCormack, K., McDonald, A., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Glazener, C.

    European Urology, vol. 79, no. 6, pp. 812-823

    Contributions to Journals: Articles

  • Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)

    King, A., Hudson, J., Fernie, G., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., MacLennan, G., King, A., Agrawal, P., Stead, R., Broadway, D. C., Strouthidis, N., Chew, S., Sng, C., Toth, M., Gazzard, G., Elkarmouty, A., Nikita, E., Triolo, G., Aguilar-Munoa, S., Goyal, S., Lim, S., Sung, V., Masood, I., Wride, N., Sandhu, A., Hill, E., Sparrow, J., Grey, F., Bourne, R., Nithyanandarajah, G., Willshire, C., Bloom, P., Ahmed, F., Cordeiro, F., Crawley, L., Normando, E., Ameen, S., Tryfinopoulou, J., Porteous, A., Azuara-Blanco, A., Sidiki, S., TAGS Study Group

    BMJ, vol. 373, n1014

    Contributions to Journals: Articles

  • The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

    Nielsen, M. E., Edison, E., McGrath, J., Nkwam, N., MacKenzie, K., olivier, J., Jefferies, M., Burnhope, T., Uçar, T., Nambiar, A. K., Lal, A., Lillaz, B., Assmus, M., Downey, A., Chuchu, N., Zimmermann, E., Takwoingi, Y., Gómez Rivas, J., Moore, S., Gao, C., MacLennan, G., Marra, G., Boltri, M., Clarke, H., Claps, F., Tanasescu, G., Gillams, K., Mannas, M., Kasivisvanathan, V., Gallagher, K. M., Antón-Juanilla, M., Lau, D., Boxall, N., O'Rourke, J., Crockett, M., Lee, T., Shah, T. T., Khadhouri, S., The IDENTIFY Study Group

    BJU International

    Contributions to Journals: Articles

  • Selective caries removal in permanent teeth (script) for the treatment of deep caries lesions: A randomised controlled clinical trial in primary care

    Clarkson, J. E., Ramsay, C., Ricketts, D. N. J., Banerjee, A., Deery, C., Lamont, T. J., Boyers, D., Marshman, Z., Goulao, B., Bannister, K., Conway, D. I., Dawett, B., Baker, S. R., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H. J., Fee, P. A., Forrest, M., Gouick, J., Mitchell, F. E., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.

    BMC Oral Health

    Contributions to Journals: Articles

  • Shockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Thomas, R., N'Dow, J., Norrie, J., Anson, K., Keeley Jr, F. X., MacLennan, S., Starr, K., McClinton, S.

    European Urology

    Contributions to Journals: Articles

  • Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis

    Norman, J. E., Norrie, J., MacLennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Mei, X. W., Smith, J. B. E., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., group, o. b. o. t. S. c.

    PLoS Medicine, vol. 18, no. 3, e1003506

    Contributions to Journals: Articles

  • Protocol for a randomised controlled trial comparing laparoscopic cholecystectomy with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones (C-Gall trial)

    Ahmed, I., Innes, K., Brazzelli, M., Gillies, K., Newlands, R., Avenell, A., Hernández, R., Blazeby, J., Croal, B., Hudson, J., MacLennan, G., McCormack, K., McDonald, A., Murchie, P., Ramsay, C.

    BMJ Open, vol. 11, no. 3, e039781

    Contributions to Journals: Articles

  • Why trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework

    Newlands, R., Duncan, E., Presseau, J., Treweek, S., Lawrie, L., Bower, P., Elliott, J., Francis, J. J., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.

    Journal of Clinical Epidemiology

    Contributions to Journals: Articles

  • Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT

    Morrison, A. P., Pyle, M., Byrne, R., Broome, M., Freeman, D., Johns, L., James, A., Husain, N., Whale, R., MacLennan, G., Norrie, J., Hudson, J., Peters, S., Davies, L., Bowe, S., Smith, J., Shiers, D., Joyce, E., Jones, W., Hollis, C., Maughan, D.

    Health technology assessment (Winchester, England), vol. 25, no. 4, pp. 1-124

    Contributions to Journals: Articles

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