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Health Services Research Unit

Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Effect of day and time of admission on mortality in an intensive care unit

    Jansen, J. O., Maclennan, G. S., Cuthbertson, B. H.
    Journal of the Intensive Care Society, vol. 14, no. 4, pp. 294-298
    Contributions to Journals: Articles

  • Management of the open abdomen: A national study of clinical outcome and safety of negative pressure wound therapy

    Carlson, G. L., Patrick, H., Amin, A. I., McPherson, G., Maclennan, G., Afolabi, E., Mowatt, G., Campbell, B.
    Annals of Surgery, vol. 257, no. 6, pp. 1154-1159
    Contributions to Journals: Articles

  • Authors' reply - Assessing catheter-associated urinary tract infection

    Pickard, R., MacLennan, G., Norrie, J., N'Dow, J.
    The Lancet, vol. 381, no. 9877, pp. 1536
    Contributions to Journals: Letters

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.
    Journal of translational medicine, vol. 11, 116
    Contributions to Journals: Articles

  • Mortality and quality of life in the five years after severe sepsis

    Cuthbertson, B. H., Elders, A., Hall, S., Taylor, J., Maclennan, G., Mackirdy, F., Mackenzie, S. J., Scottish Critical Care Trials Group and the Scottish Intensive Care Society Audit Group
    Critical Care, vol. 17, no. 2, R70
    Contributions to Journals: Articles

  • Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement

    Breeman, S., Campbell, M. K., Dakin, H., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Johnston, L., MacLennan, G. S., Morris, R. W., Murray, D. W., KAT Trial Group
    Journal of Bone & Joint Surgery (US Volume), vol. 95-B, no. 4, pp. 486-492
    Contributions to Journals: Articles

  • Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial

    Pickard, R., Lam, T., Maclennan, G., Starr, K., Kilonzo, M., McPherson, G., Gillies, K., McDonald, A., Walton, K., Buckley, B., Glazener, C., Boachie, C., Burr, J., Norrie, J., Vale, L., Grant, A., N'Dow, J.
    The Lancet, vol. 380, no. 9857, pp. 1927-1935
    Contributions to Journals: Articles

  • Systematic review of perioperative and quality-of-life outcomes following surgical management of localised renal cancer

    MacLennan, S., Imamura, M., Lapitan, M. C., Omar, M. I., Lam, T. B. L., Hilvano-Cabungcal, A. M., Royle, P., Stewart, F., MacLennan, G., MacLennan, S. J., Dahm, P., Canfield, S. E., McClinton, S., Griffiths, T. R. L., Ljungberg, B., N'Dow, J., UCAN Systematic Review Reference Group
    European Urology, vol. 62, no. 6, pp. 1097-1117
    Contributions to Journals: Articles

  • Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation: multicentre randomised controlled trial and economic evaluation of antimicrobial- and antiseptic-impregnated urethral catheters (the CATHETER trial)

    Pickard, R., Lam, T., Maclennan, G., Starr, K., Kilonzo, M., McPherson, G., Gillies, K., McDonald, A., Walton, K., Buckley, B., Glazener, C. M. A., Boachie, C., Burr, J., Norrie, J., Vale, L., Grant, A. M., N'dow, J.
    Health Technology Assessment, vol. 16, no. 47, pp. 1-197
    Contributions to Journals: Articles

  • Explaining clinical behaviors using multiple theoretical models

    Eccles, M. P., Grimshaw, J. M., MacLennan, G., Bonetti, D., Glidewell, L., Pitts, N. B., Steen, N., Thomas, R. E., Walker, A., Johnston, M.
    Implementation Science, vol. 7, 99
    Contributions to Journals: Articles

  • Using shared goal setting to improve access and equity: a mixed methods study of the Good Goals intervention in children's occupational therapy

    Kolehmainen, N., Maclennan, G., Ternent, L., Duncan, E. A. S., Duncan, E. M., Ryan, S. B., McKee, L., Francis, J.
    Implementation Science, vol. 7, 76
    Contributions to Journals: Articles

  • Do incentives, reminders or reduced burden improve healthcare professional response rates in postal questionnaires?: two randomised controlled trials

    Glidewell, L., Thomas, R., MacLennan, G., Bonetti, D., Johnston, M., Eccles, M. P., Edlin, R., Pitts, N. B., Clarkson, J., Steen, N., Grimshaw, J. M.
    BMC Health Services Research, vol. 12, 250
    Contributions to Journals: Articles

  • Corrigendum to "systematic review of oncological outcomes following surgical management of localised renal cancer" [Eur Urol 2012;61:972-93]

    MaClennan, S., Imamura, M., Lapitan, M. C., Omar, M. I., Lam, T. B., Hilvano-Cabungcal, A. M., Royle, P., Stewart, F., MaClennan, G., MaClennan, S. J., Canfield, S. E., McClinton, S., Griffiths, T. R., Ljungberg, B., N'Dow, J.
    European Urology, vol. 62, no. 1
    Contributions to Journals: Comments and Debates

  • E-mail invitations to general practitioners were as effective as postal invitations and were more efficient

    Treweek, S., Barnett, K., Maclennan, G., Bonetti, D., Eccles, M. P., Francis, J. J., Jones, C., Pitts, N. B., Ricketts, I. W., Weal, M., Sullivan, F.
    Journal of Clinical Epidemiology, vol. 65, no. 7, pp. 793-797
    Contributions to Journals: Articles

  • Systematic review of oncological outcomes following surgical management of localised renal cancer

    MacLennan, S., Imamura, M., Lapitan, M. C. M., Omar, M. I., Lam, T. B. L., Hilvano-Cabungcal, A., Royle, P., Stewart, F., MacLennan, G. S., MacLennan, S., Canfield, S., McClinton, S., Griffiths, T. R. L., Ljungberg, B., N'Dow, J. M. O.
    European Urology, vol. 61, no. 5, pp. 972-993
    Contributions to Journals: Articles

  • Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD trial)

    Avenell, A., Maclennan, G. S., Jenkinson, D. J., McPherson, G. C., McDonald, A. M., Pant, P. R., Grant, A. M., Campbell, M. K., Anderson, F. H., Cooper, C., Francis, R. M., Gillespie, W. J., Robinson, C. M., Torgerson, D. J., Wallace, W. A., RECORD Trial Group
    Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 614-622
    Contributions to Journals: Articles

  • Rationing of total knee replacement: a cost-effectiveness analysis on a large trial data set

    Dakin, H., Gray, A., Fitzpatrick, R., Maclennan, G., Murray, D., KAT Trial Group
    BMJ Open, vol. 2, no. 1, e000332
    Contributions to Journals: Articles

  • Clustering in surgical trials: database of intracluster correlations

    Cook, J. A., Bruckner, T., MacLennan, G. S., Seiler, C. M.
    Trials, vol. 13, no. -, 2
    Contributions to Journals: Articles

  • Identifying active ingredients in complex behavioural interventions for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: a systematic review

    Dombrowski, S. U., Sniehotta, F., Avenell, A., Johnston, M., MacLennan, G. S., Araujo-Soares, V.
    Health Psychology Review, vol. 6, no. 1, pp. 7-32
    Contributions to Journals: Articles

  • Process evaluation for the FEeding Support Team (FEST) randomised controlled feasibility trial of proactive and reactive telephone support for breastfeeding women living in disadvantaged areas

    Hoddinott, P., Craig, L., Maclennan, G., Boyers, D., Vale, L., On behalf of the NHS Grampian and the University of Aberdeen FEST project team
    BMJ Open, vol. 2, no. 2, e001039
    Contributions to Journals: Articles

  • The FEeding Support Team (FEST) randomised, controlled feasibility trial of proactive and reactive telephone support for breastfeeding women living in disadvantaged areas

    Hoddinott, P., Craig, L., Maclennan, G., Boyers, D., Vale, L., On behalf of the NHS Grampian and the University of Aberdeen FEST project team
    BMJ Open, vol. 2, no. 2, e000652
    Contributions to Journals: Articles

  • Surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer: a systematic review

    Robertson, C., Ragupathy, S. K. A., Boachie, C., Fraser, C., Heys, S. D., Maclennan, G., Mowatt, G., Thomas, R. E., Gilbert, F. J., Mammographic Surveillance Health Technology Assessment Group
    European Radiology, vol. 21, no. 12, pp. 2484-2491
    Contributions to Journals: Articles

  • Assessing risk of bias in non-randomised studies and incorporating GRADE: Initial experience with a new Cochrane ‘risk of bias’ tool under development

    MacLennan, S., Imamura, M., Dahm, P., Nueberger, M., Reeves, B. C., MacLennan, G. S., Omar, M. I., McClinton, S., Griffiths, T. R. L., N'Dow, J. M. O.
    Contributions to Conferences: Papers

  • The hazards of extracting hazard ratios from survival curves for meta-analyses in observational studies

    Imamura, M., MacLennan, S., Dahm, P., Nueberger, M., Omar, M. I., MacLennan, G. S.
    Contributions to Conferences: Papers

  • Evidence for partial nephrectomy

    Lam, T. B. L., MacLennan, S., Imamura, M., Omar, M. I., MacLennan, G.
    Contributions to Conferences: Papers

  • Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial

    Breeman, S., Campbell, M., Dakin, H., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Johnston, L., Maclennan, G., Morris, R., Murray, D., KAT Trial Group
    The Journal of Bone & Joint Surgery. American Volume, vol. 93, no. 16, pp. 1473-1481
    Contributions to Journals: Articles

  • The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer: systematic reviews registry database analyses and economic evaluation

    Robertson, C., Arcot Ragupathy, S. K., Boachie, C., Dixon, J. M., Fraser, C., Hernández, R., Heys, S., Jack, W., Kerr, G. R., Lawrence, G., MacLennan, G., Maxwell, A., McGregor, J., Mowatt, G., Pinder, S., Ternent, L., Thomas, R. E., Vale, L., Wilson, R., Zhu, S., Gilbert, F. J.
    Health Technology Assessment, vol. 15, no. 34, pp. v-vi, 1-322
    Contributions to Journals: Articles

  • Further use for the harvest plot: a novel method for quantitative and qualitative data synthesis

    Crowther, M., Avenell, A., MacLennan, G. S., Mowatt, G.
    Research Synthesis Methods, vol. 2, no. 2, pp. 79-83
    Contributions to Journals: Articles

  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of lumbar spine x-ray for low back pain in UK primary care practice

    Grimshaw, J. M., Eccles, M. P., Steen, N., Johnston, M., Pitts, N. B., Glidewell, E., Maclennan, G., Thomas, R. E., Bonetti, D. L., Walker, A. E.
    Implementation Science, vol. 6, pp. 55
    Contributions to Journals: Articles

  • Developing and evaluating interventions to reduce inappropriate prescribing by general practitioners of antibiotics for upper respiratory tract infections: a randomised controlled trial to compare paper-based and web-based modelling experiments

    Treweek, S. P., Ricketts, I. W., Francis, J., Eccles, M., Bonetti, D., Pitts, N. B., Maclennan, G., Sullivan, F., Jones, C., Weal, M., Barnett, K.
    Implementation Science, vol. 6, no. 1, pp. 16
    Contributions to Journals: Articles

  • Calcium and heart attacks: Authors' reply

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., Reid, I. R., MacLennan, G. S., Gamble, G. D.
    BMJ (Online), vol. 341, no. 7773, pp. 569
    Contributions to Journals: Letters

  • Clinicians' caseload management behaviours as explanatory factors in patients' length of time on caseloads: a predictive multilevel study in paediatric community occupational therapy

    Kolehmainen, N., MacLennan, G., Francis, J. J., Duncan, E. A. S.
    BMC Health Services Research, vol. 10, no. 249, 249
    Contributions to Journals: Articles

  • Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., MacLennan, G. S., Gamble, G. D., Reid, I. R.
    British Medical Journal, vol. 341, no. -, c3691
    Contributions to Journals: Articles

  • Study of progesterone for the prevention of preterm birth in twins (STOPPIT): findings from a trial-based cost-effectiveness analysis

    Eddama, O., Petrou, S., Regier, D., Norrie, J., MacLennan, G., MacKenzie, F., Norman, J. E.
    International Journal of Technology Assessment in Health Care, vol. 26, no. 2, pp. 141-148
    Contributions to Journals: Articles

  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of placing preventive fissure sealants

    Bonetti, D., Johnston, M., Clarkson, J. E., Grimshaw, J., Pitts, N. B., Eccles, M., Steen, N., Thomas, R., Maclennan, G., Glidewell, E., Walker, A. E.
    Implementation Science, vol. 5, pp. 25
    Contributions to Journals: Articles

  • The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trials

    Lourenco, T., Shaw, M., Fraser, C. M., MacLennan, G. S., N'Dow, J. M. O., Pickard, R.
    World Journal of Urology, vol. 28, no. 1, pp. 23-32
    Contributions to Journals: Articles

  • Quality of life in the five years after intensive care: a cohort study

    Cuthbertson, B., Roughton, S., Jenkinson, D. J., MacLennan, G. S., Vale, L. D.
    Critical Care, vol. 14, no. 1, R6
    Contributions to Journals: Articles

  • Factors Influencing the Participation of Older People in Clinical Trials: Data Analysis from the MAVIS Trial

    Fearn, P., Avenell, A., McCann, S. K., Milne, A. C., MacLennan, G. S., MAVIS Trial Group
    Journal of Nutrition, Health & Aging, vol. 14, no. 1, pp. 51-56
    Contributions to Journals: Articles

  • Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone

    Langston, A. L., Campbell, M. K., Fraser, W. D., MacLennan, G. S., Selby, P. L., Ralston, S. H., PRISM Trial Group
    Journal of Bone and Mineral Research, vol. 25, no. 1, pp. 20-31
    Contributions to Journals: Articles

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hernández, R. A.
    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages
    Books and Reports: Commissioned Reports

  • Surveillance following breast cancer: is it cost-effective?

    Ternent, L., MacLennan, G., Heys, S. D., Gilbert, F., Vale, L., Mammographic Surveillance HTA Group
    Breast Cancer Research, vol. 12, no. Suppl. 3, pp. 5-6
    Contributions to Journals: Articles

  • Development and exploratory cluster-randomised opportunistic trial of a theory-based intervention to enhance physical activity among adolescents

    Araujo-Soares, V., McIntyre, T., MacLennan, G. S., Sniehotta, F.
    Psychology & Health, vol. 24, no. 7, pp. 805-822
    Contributions to Journals: Articles

  • Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)

    Avenell, A., Cook, J. A., MacLennan, G. S., McPherson, G. C., RECORD Trial Group
    Age and Ageing, vol. 38, no. 5, pp. 606-609
    Contributions to Journals: Articles

  • Uric acid levels and outcome from coronary artery bypass grafting

    Hillis, G. S., Cuthbertson, B. H., Gibson, P. H., McNeilly, J. D., Maclennan, G. S., Jeffrey, R. R., Buchan, K. G., El-Shafei, H., Gibson, G., Croal, B. L.
    Journal of Thoracic and Cardiovascular Surgery, vol. 138, no. 1, pp. 200-205
    Contributions to Journals: Articles

  • Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis

    Norman, J. E., Mackenzie, F., Owen, P., Mactier, H., Hanretty, K., Cooper, S., Calder, A., Mires, G., Danielian, P., Sturgiss, S., MacLennan, G., Tydeman, G., Thornton, S., Martin, B., Thornton, J. G., Neilson, J. P., Norrie, J.
    The Lancet, vol. 373, no. 9680, pp. 2034-2040
    Contributions to Journals: Articles

  • Meaning behind measurement: self-comparisons affect responses to health-related quality of life questionnaires

    Robertson, C., Langston, A. L., Stapley, S., McColl, E., Campbell, M. K., Fraser, W. D., MacLennan, G., Selby, P. L., Ralston, S. H., Fayers, P. M., PRISM Trial Group
    Quality of Life Research, vol. 18, no. 2, pp. 221-230
    Contributions to Journals: Articles

  • The Knee Arthroplasty Trial (KAT): design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement

    Campbell, M., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Morris, R., Murray, D., Rowley, D., Johnston, L., MacLennan, G., McCormack, K., Ramsay, C., Walker, A., KAT Trial Group
    The Journal of Bone & Joint Surgery. American Volume, vol. 91, no. 1, pp. 134-141
    Contributions to Journals: Articles

  • Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement

    Lourenco, T., Armstrong, N., N'Dow, J., Nabi, G., Deverill, M., Pickard, R., Vale, L., MacLennan, G., Fraser, C., McClinton, S., Wong, S., Coutts, A., Mowatt, G., Grant, A.
    Health Technology Assessment, vol. 12, no. 35, pp. 1-168
    Contributions to Journals: Literature Reviews

  • Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trials

    Lourenco, T., Pickard, R., Vale, L., Grant, A., Fraser, C., MacLennan, G., N'Dow, J., The Benign Prostatic Enlargement Team
    British Medical Journal, vol. 337, a1662
    Contributions to Journals: Articles

  • A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes

    Fielding, S., MacLennan, G. S., Cook, J. A., Ramsay, C. R.
    Trials, vol. 9, 51
    Contributions to Journals: Articles
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