Professor Graeme MacLennan
Health Services Research Unit
2nd Floor Health Sciences Building
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
A complete list of the CHaRT RCT portolio is available by clicking here
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Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases: a multi-centre randomised controlled parallel open-label group trial (LIFT)The Lancet RheumatologyContributions to Journals: Articles
Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: results from the IDENTIFY Collaborative StudyEuropean Urology FocusContributions to Journals: Articles
Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trialThe Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592Contributions to Journals: Articles
Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCTEfficacy and Mechanism Evaluation, vol. 9, no. 4Contributions to Journals: Articles
The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)Trials, vol. 23, no. 1, 384Contributions to Journals: Articles
ScotCap - A large observational cohort studyColorectal Disease, vol. 24, no. 4, pp. 411-421Contributions to Journals: Articles
Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)Trials, vol. 23, no. 1, 307Contributions to Journals: Articles
Correction to: Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study (Pilot and Feasibility Studies, (2022), 8, 1, (77), 10.1186/s40814-022-01029-9)Pilot and Feasibility Studies, vol. 8, 82Contributions to Journals: Comments and Debates
The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trialsTrials, vol. 23, no. 1, 268Contributions to Journals: Articles
Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility studyPilot and Feasibility Studies, vol. 8, 77Contributions to Journals: Articles