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Professor Graeme MacLennan

Professor Graeme MacLennan

Director (CHaRT)

Overview
Professor Graeme MacLennan
Professor Graeme MacLennan

Contact Details

Telephone
work +44 (0)1224 438147
Fax
fax +44 (0)1224 554580
Email
Address
The University of Aberdeen Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD
Other Profiles
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Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

MSc, Applied Statistics Sheffield Hallam University 2004
BSc, Mathematics University of Aberdeen 1997
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

Publications 

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  • The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

    Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A. K., Mannas, M., Lee, T., Marra, G., Lillaz, B., Gómez Rivas, J., olivier, J., Assmus, M., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N., Downey, A., Lal, A., Antón-Juanilla, M., Clarke, H., Lau, D., Gillams, K., Crockett, M., Nielsen, M. E., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., McGrath, J., Kasivisvanathan, V., The IDENTIFY Study Group

    BJU International

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1111/bju.15483

  • Why trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework

    Newlands, R., Duncan, E., Presseau, J., Treweek, S., Lawrie, L., Bower, P., Elliott, J., Francis, J. J., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.

    Journal of Clinical Epidemiology, vol. 137, pp. 1-13

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1016/j.jclinepi.2021.03.007

  • Selective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care

    Clarkson, J. E., Ramsay, C. R., Ricketts, D., Banerjee, A., Deery, C., Lamont, T., Boyers, D., Marshman, Z., Goulao, B., Banister, K., Conway, D., Dawett, B., Baker, S., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H., Fee, P., Forrest, M., Gouick, J., Mitchell, F., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.

    BMC Oral Health, vol. 21, no. 1, 336

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1186/s12903-021-01637-6
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/16955/1/Clarkson_etal_BMC_Selective_caries_removal_VOR.pdf
    Additional Links
    View publication in Scopus

  • Shockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Thomas, R., N'Dow, J., Norrie, J., Anson, K., Keeley Jr, F. X., MacLennan, S., Starr, K., McClinton, S.

    European Urology, vol. 80, no. 1, pp. 46-54

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1016/j.eururo.2021.02.044

  • The arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: The STOPPIT 2 RCT

    Norman, J. E., Norrie, J., Maclennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Neilson, A. R., Mei, X. W., Smith, J. B., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., on behalf of the STOPPIT collaborative group

    NIHR Health Technology Assessment programme. 94 pages

    Books and Reports: Other Reports

    Digital Object Identifier
    https://doi.org/10.3310/hta25440
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/17001/1/Norman_etal_HTA_The_Arabin_pessary_VOR.pdf
    Additional Links
    View publication in Scopus

  • Outcomes of a non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery (MASTER)

    Abrams, P., Constable, L., Cooper, D., MacLennan, G., Drake, M. J., Harding, C., Mundy, A., McCormack, K., McDonald, A., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Glazener, C., MASTER trial team

    European Urology, vol. 79, no. 6, pp. 812-823

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1016/j.eururo.2021.01.024
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/17064/1/Abrams_etal_EU_outcomes_of_a_VOR.pdf
    Additional Links
    View publication in Scopus

  • Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT

    Booth, J., Aucott, L., Cotton, S., Davis, B., Fenocchi, L., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D., Surr, C., Treweek, S.

    Health technology assessment (Winchester, England), vol. 25, no. 41

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.3310/hta25410
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/16754/1/Booth_etal_HTA_Tibial_nerve_Stimulation_VoR.pdf

  • Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)

    King, A., Hudson, J., Fernie, G., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., MacLennan, G., King, A., Agrawal, P., Stead, R., Broadway, D. C., Strouthidis, N., Chew, S., Sng, C., Toth, M., Gazzard, G., Elkarmouty, A., Nikita, E., Triolo, G., Aguilar-Munoa, S., Goyal, S., Lim, S., Sung, V., Masood, I., Wride, N., Sandhu, A., Hill, E., Sparrow, J., Grey, F., Bourne, R., Nithyanandarajah, G., Willshire, C., Bloom, P., Ahmed, F., Cordeiro, F., Crawley, L., Normando, E., Ameen, S., Tryfinopoulou, J., Porteous, A., Azuara-Blanco, A., Sidiki, S., TAGS Study Group

    BMJ, vol. 373, n1014

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1136/bmj.n1014
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/16479/1/bmj-373-bmj-n1014.pdf

  • Selective caries removal in permanent teeth (script) for the treatment of deep caries lesions: A randomised controlled clinical trial in primary care

    Clarkson, J. E., Ramsay, C., Ricketts, D. N. J., Banerjee, A., Deery, C., Lamont, T. J., Boyers, D., Marshman, Z., Goulao, B., Bannister, K., Conway, D. I., Dawett, B., Baker, S. R., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H. J., Fee, P. A., Forrest, M., Gouick, J., Mitchell, F. E., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.

    BMC Oral Health

    Contributions to Journals: Articles

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