Professor Graeme MacLennan
Professor Graeme MacLennan

Professor Graeme MacLennan

Director (CHaRT)


Health Services Research Unit
2nd Floor Health Sciences Building
AB25 2ZD


I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  


  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here


Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.


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  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease
    Contributions to Journals: Articles
  • How common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial

    Reid, F. M., Elders, A., Breeman, S., Freeman, R. M., Glazener, C. M., Hemming, C., Cooper, K. G., Smith, A. R., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., the PROSPECT study group
    BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189
    Contributions to Journals: Articles
  • Male synthetic sling or artificial urinary sphincter (AUS) for men with urodynamic stress incontinenceafter prostate surgery: the MASTER non-inferiority randomised controlled trial

    Constable, L., Abrams, P., Cooper, D., Kilonzo, M., Cotterill, N., Harding, C. K., Drake, M. J., Pardoe, M. N., McDonald, A., Smith, R., Norrie, J., McCormack, K., Ramsay, C., Uren, A., Mundy, T., Glazener, C., MacLennan, G.
    Health Technology Assessment
    Contributions to Journals: Articles
  • Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms

    Abdel-fattah, M., Chapple, C., Guerrero, K., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M. J., Gammie, A., Mostafa, A., Bladder Health, U. K., Breeman, S., Cooper, D., MacLennan, G., Norrie, J.
    Trials, vol. 22, no. 1, 745
    Contributions to Journals: Articles
  • A multicentre open label randomised clinical trial using exhaled nitric oxide in addition to standard care to reduce asthma attacks in children

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation
    Contributions to Journals: Articles
  • The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

    Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A. K., Mannas, M., Lee, T., Marra, G., Lillaz, B., Gómez Rivas, J., olivier, J., Assmus, M., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N., Downey, A., Lal, A., Antón-Juanilla, M., Clarke, H., Lau, D., Gillams, K., Crockett, M., Nielsen, M. E., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., McGrath, J., Kasivisvanathan, V., The IDENTIFY Study Group
    BJU International, vol. 128, no. 4, pp. 440-450
    Contributions to Journals: Articles
  • Why trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework

    Newlands, R., Duncan, E., Presseau, J., Treweek, S., Lawrie, L., Bower, P., Elliott, J., Francis, J. J., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.
    Journal of Clinical Epidemiology, vol. 137, pp. P1-13
    Contributions to Journals: Articles
  • Selective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care

    Clarkson, J. E., Ramsay, C. R., Ricketts, D., Banerjee, A., Deery, C., Lamont, T., Boyers, D., Marshman, Z., Goulao, B., Banister, K., Conway, D., Dawett, B., Baker, S., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H., Fee, P., Forrest, M., Gouick, J., Mitchell, F., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.
    BMC Oral Health, vol. 21, 336
    Contributions to Journals: Articles
  • Have you had bleeding from your gums?: Self-report to Identify giNGival inflammation (The SING diagnostic accuracy and diagnostic model development study)

    Goulao, B., MacLennan, G., Ramsay, C.
    Journal of Journal of Clinical Periodontology, vol. 48, no. 7, pp. 919-928
    Contributions to Journals: Articles
  • Shockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial

    Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Thomas, R., N'Dow, J., Norrie, J., Anson, K., Keeley Jr, F. X., MacLennan, S., Starr, K., McClinton, S.
    European Urology, vol. 80, no. 1, pp. 46-54
    Contributions to Journals: Articles
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Books and Reports

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals