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Health Services Research Unit

Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis

    Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.
    BMJ, vol. 359, j4849
    Contributions to Journals: Articles

  • Bayesian clinical trial designs: Another option for trauma trials?

    Jansen, J. O., Pallmann, P., MacLennan, G., Campbell, M. K., UK-REBOA Trial Investigators
    The journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741
    Contributions to Journals: Articles

  • THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial

    Lenguerrand, E., Winter, C., Innes, K., MacLennan, G., Siassakos, D., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T., Thistle group
    BMC Pregnancy and Childbirth, vol. 17, 294
    Contributions to Journals: Articles

  • The SIMS trial: adjustable anchored single-incision mini-slings versus standard tension-free midurethral slings in the surgical management of female stress urinary incontinence. A study protocol for a pragmatic, multicentre, non-inferiority randomised controlled trial

    Abdel-Fattah, M., Maclennan, G., Kilonzo, M., Assassa, R. P., McCormack, K., Davidson, T., McDonald, A., N'Dow, J., Wardle, J., Norrie, J.
    BMJ Open, vol. 7, no. 8, pp. 1-18
    Contributions to Journals: Articles

  • Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study

    Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H., PRISM-EZ Trial Group
    Journal of Bone and Mineral Research, vol. 32, no. 6, pp. 1165-1173
    Contributions to Journals: Articles

  • Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree

    Sylvester, R. J., Canfield, S. E., Lam, T. B. L., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernandez, V., Plass, K., Van Poppel, H., N'Dow, J.
    European Urology, vol. 71, no. 5, pp. 811-819
    Contributions to Journals: Articles

  • The BJUI's clinical trials initiative

    Davis, J. W., MacLennan, G.
    BJU International, vol. 119, no. 4, pp. 503
    Contributions to Journals: Editorials

  • Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)

    Glazener, C. M. A., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R. B., Reid, F., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    The Lancet, vol. 389, no. 10067, pp. 381–392
    Contributions to Journals: Articles

  • The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

    Cook, J. A., Beard, D. J., Cook, J. R., MacLennan, G. S.
    Pilot & Feasibility Studies, vol. 2, 73
    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study

    Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K., Freeman, R., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 20, no. 95, pp. 1-452
    Contributions to Journals: Articles

  • Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?

    Fielding, S., Ogbuagu, A., Sivasubramaniam, S., MacLennan, G., Ramsay, C. R.
    Quality of Life Research, vol. 25, no. 12, pp. 2977-2983
    Contributions to Journals: Articles

  • Breast pumps as an incentive for breastfeeding: a mixed methods study of acceptability

    Crossland, N., Thomson, G., Morgan, H., MacLennan, G., Campbell, M., Dykes, F., Hoddinott, P.
    Maternal and Child Nutrition, vol. 12, no. 4, pp. 726-739
    Contributions to Journals: Articles

  • Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

    Pyle, M., Norrie, J., Schwannauer, M., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., Morrison, A. P.
    BMC Psychiatry, vol. 16, pp. 1-12
    Contributions to Journals: Articles

  • A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials

    Gardner, H. R., Fraser, C., MacLennan, G., Treweek, S.
    Systematic reviews , vol. 5, 131
    Contributions to Journals: Articles

  • Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

    Cruickshank, M., Henderson, L., MacLennan, G., Fraser, C., Campbell, M., Blackwood, B., Gordon, A., Brazzelli, M.
    Health Technology Assessment, vol. 20, no. 25, pp. 0-120
    Contributions to Journals: Literature Reviews

  • Behavioural recovery after treatment for varicose veins

    Cotton, S. C., MacLennan, G., Brittenden, J., Prior, M., Francis, J.
    British Journal of Surgery, vol. 103, no. 4, pp. 374-381
    Contributions to Journals: Articles

  • The ethics of future trials: qualitative analysis of physicians' decision making

    Webster, F., Weijer, C., Todd, L., Grimshaw, J. M., Marshall, A. P., Cook, D., MacLennan, G., Cuthbertson, B. H., Francis, J. J., SuDDICU International Study Group
    Trials, vol. 17, pp. 1-8
    Contributions to Journals: Articles

  • Mindfulness-Based Stress Reduction for Veterans With PTSD

    Goulao, B., MacLennan, G. S.
    JAMA, vol. 315, no. 1, pp. 87-88
    Contributions to Journals: Letters

  • Kurzdarstellung aktueller publikationen: Begünstigt eine muskelrelaxierende therapie den uretersteinabgang?

    Pickard, R., Starr, K., MacLennan, G., Lam, T., Thomas, R., Burr, J., McPherson, G., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, T., Kilonzo, M., Gillies, K., Shearer, K., Boachie, C., Cameron, S., Norrie, J., McClinton, S.
    Nieren- und Hochdruckkrankheiten, vol. 45, no. 1, pp. 38
    Contributions to Journals: Articles

  • Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial): study protocol for a randomised controlled trial

    Stephenson, R., Carnell, S., Johnson, N., Brown, R., Wilkinson, J., Mundy, A., Payne, S., Watkin, N., N'Dow, J., Sinclair, A., Rees, R., Barclay, S., Cook, J. A., Goulao, B., MacLennan, G., McPherson, G., Jackson, M., Rapley, T., Shen, J., Vale, L., Norrie, J., McColl, E., Pickard, R.
    Trials, vol. 16, 600
    Contributions to Journals: Articles

  • Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study

    Hoddinott, P., Thomson, G., Morgan, H., Crossland, N., MacLennan, G. S., Dykes, F., Stewart, F., Bauld, L., Campbell, M. K.
    Maternal and Child Nutrition, vol. 11, no. Supplement S2, pp. 113
    Contributions to Journals: Abstracts

  • Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study

    Hoddinott, P., Thomson, G., Morgan, H., Crossland, N., MacLennan, G., Dykes, F., Stewart, F., Bauld, L., Campbell, M. K.
    BMJ Open, vol. 5, no. 11, e008492
    Contributions to Journals: Articles

  • Ureteric colic and clinical evidence - Authors' reply

    Pickard, R., MacLennan, G., Norrie, J., McClinton, S.
    The Lancet, vol. 386, no. 10006, pp. 1823
    Contributions to Journals: Comments and Debates

  • Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial)

    Pickard, R., Starr, K., MacLennan, G., Kilonzo, M., Lam, T., Thomas, R. E., Burr, J., Norrie, J., McPherson, G., McDonald, A., Shearer, K., Gillies, K., Anson, K., Boachie, C., N'Dow, J., Burgess, N., Clark, T., Cameron, S., McClinton, S.
    Health Technology Assessment, vol. 19, no. 63, pp. 1-171
    Contributions to Journals: Articles

  • Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial

    Pickard, R., Starr, K., MacLennan, G., Lam, T. B. L., Thomas, R., Burr, J., McPherson, G., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, T., Kilonzo, M., Gillies, K., Shearer, K., Boachie, C., Cameron, S., Norrie, J., McClinton, S.
    The Lancet, vol. 386, no. 9991, pp. 341-349
    Contributions to Journals: Articles

  • Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation

    Ramsay, C. R., Adewuyi, T. E., Gray, J., Hislop, J., Shirley, M. D., Jayakody, S., MacLennan, G., Fraser, C., MacLennan, S., Brazzelli, M., N'Dow, J., Pickard, R., Robertson, C., Rothnie, K., Rushton, S. P., Vale, L., Lam, T. B.
    Health Technology Assessment, vol. 19, no. 49, pp. 1-524
    Contributions to Journals: Articles

  • A systematic review of the use of an expertise-based randomised controlled trial design

    Cook, J. A., Elders, A., Boachie, C., Bassinga, T., Fraser, C. M., Altman, D., Boutron, I., Ramsay, C. R., MacLennan, G. S.
    Trials, vol. 16, 241
    Contributions to Journals: Articles

  • STOPPIT Baby Follow-Up Study: The Effect of Prophylactic Progesterone in Twin Pregnancy on Childhood Outcome

    McNamara, H. C., Wood, R., Chalmers, J., Marlow, N., Norrie, J., MacLennan, G., McPherson, G., Boachie, C., Norman, J. E.
    PloS ONE, vol. 10, no. 4, e0122341
    Contributions to Journals: Articles

  • Benefits of incentives for breastfeeding and smoking cessation in pregnancy (BIBS): a mixed methods study to inform trial design

    Morgan, H., Hoddinott, P., Thomson, G., Crossland, N., Farrar, S., Yi, D., Hislop, J. M., Hall Moran, V., MacLennan, G. S., Dombrowski, S. U., Rothnie, K. J., Stewart, F., Bauld, L., Ludbrook, A., Dykes, F., Sniehotta, F. F., Tappin, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 30, pp. 1-564
    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial

    Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., Bolsover, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 27, pp. 1-342
    Contributions to Journals: Articles

  • Incentives to Promote Breastfeeding: A Systematic Review

    Hall Moran, V., Morgan, H., Rothnie, K., MacLennan, G., Stewart, F., Thomson, G., Crossland, N., Tappin, D., Campbell, M., Hoddinott, P.
    Pediatrics, vol. 135, no. 3, pp. e687-702
    Contributions to Journals: Articles

  • Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy: a randomized controlled trial

    Ahmed, I., Cook, J. A., Duncan, A., Krukowski, Z. H., Malik, M., MacLennan, G., McCormack, K., SCARLESS Study Group
    Surgical Endoscopy, vol. 29, no. 1, pp. 77-85
    Contributions to Journals: Articles

  • Non-compliance with randomised allocation and missing outcome data in randomised controlled trials evaluating surgical interventions: a systematic review

    Adewuyi, T. E., MacLennan, G., Cook, J. A.
    BMC Research Notes, vol. 8, 403
    Contributions to Journals: Articles

  • The push me, pull you of financial incentives and health inequalities: a mixed methods study investigating smoking cessation in pregnancy and breastfeeding

    Hoddinott, P., Morgan, H., Thomson, G., Crossland, N., Farrar, S., Yi, D., Hislop, J., Hall Moran, V., MacLennan, G. S., Dombrowski, S. U., Rothnie, K., Stewart, F., Bauld, L., Ludbrook, A., Dykes, F., Sniehotta, F. F., Tappin, D., Campbell, M. K.
    European Public Health Science Conference, pp. S37
    Contributions to Journals: Abstracts

  • Observational study of current use of selective decontamination of the digestive tract in UK critical care units

    Canter, R. R., Harvey, S. E., Harrison, D. A., Campbell, M. K., M Rowan, K., Cuthbertson, B. H., Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators, Duncan, E., Prior, M. E., Bellingan, G., Eccles, M., Johnston, M., MacLennan, G. S., Ramsay, C. R., Rose, L., Shulman, R., Dombrowski, S.
    British Journal of Anaesthesia, vol. 113, no. 4, pp. 610-617
    Contributions to Journals: Articles

  • Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis

    Ford, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M., RECORD Trial Group
    The American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 746-755
    Contributions to Journals: Articles

  • Public acceptability of financial incentives for smoking cessation in pregnancy and breastfeeding

    Hoddinott, P., Morgan, H., MacLennan, G., Sewel, K., Thomson, G., Bauld, L., Yi, D., Ludbrook, A., Campbell, M. K.
    International Journal of Behavioral Medicine, vol. 21, no. 1 Suppl., S194
    Contributions to Journals: Abstracts

  • Public acceptability of financial incentives for smoking cessation in pregnancy and breast feeding: a survey of the British public

    Hoddinott, P., Morgan, H., MacLennan, G., Sewel, K., Thomson, G., Bauld, L., Yi, D., Ludbrook, A., Campbell, M. K.
    BMJ Open, vol. 4, no. 7, e005524
    Contributions to Journals: Articles

  • Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin): study protocol for a randomized controlled trial

    McClinton, S., Starr, K., Thomas, R., MacLennan, G. S., McPherson, G., McDonald, A., Lam, T., N'Dow, J., Kilonzo, M., Pickard, R., Anson, K., Burr, J., SUSPEND Study Group
    Trials, vol. 15, no. 1, 238
    Contributions to Journals: Articles

  • Comparison of four methods for assessing the importance of attitudinal beliefs: An international Delphi study in intensive care settings

    Francis, J. J., Duncan, E. M., Prior, M. E., Maclennan, G., Marshall, A. P., Wells, E. C., Todd, L., Rose, L., Campbell, M. K., Webster, F., Eccles, M. P., Bellingan, G., Seppelt, I. M., Grimshaw, J. M., Cuthbertson, B. H., SuDDICU study groups
    British Journal of Health Psychology, vol. 19, no. 2, pp. 274-291
    Contributions to Journals: Articles

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators
    European Heart Journal, vol. 35, no. 19, pp. 1255-1262
    Contributions to Journals: Articles

  • Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study)

    J Francis, J., M Duncan, E., Prior, M. E., S Maclennan, G., Dombrowski, S. U., Bellingan, G., Campbell, M. K., P Eccles, M., Rose, L., M Rowan, K., Shulman, R., Peter R Wilson, A., H Cuthbertson, B.
    Health Technology Assessment, vol. 18, no. 25, pp. 1-170
    Contributions to Journals: Articles

  • Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis

    Price, R., MacLennan, G., Glen, J., SuDDICU Collaboration
    BMJ, vol. 348, g2197
    Contributions to Journals: Articles

  • A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT)

    Murray, D. W., MacLennan, G. S., Breeman, S., Dakin, H. A., Johnston, L., Campbell, M. K., Gray, A. M., Fiddian, N., Fitzpatrick, R., Morris, R. W., Grant, A. M., KAT group
    Health Technology Assessment, vol. 18, no. 19, pp. 1-235, vii-viii
    Contributions to Journals: Articles

  • Paper-based and web-based intervention modeling experiments identified the same predictors of general practitioners' antibiotic-prescribing behavior

    Treweek, S., Bonetti, D., Maclennan, G., Barnett, K., Eccles, M. P., Jones, C., Pitts, N. B., Ricketts, I. W., Sullivan, F., Weal, M., Francis, J. J.
    Journal of Clinical Epidemiology, vol. 67, no. 3, pp. 296-304
    Contributions to Journals: Articles

  • Advance telephone calls ahead of reminder questionnaires increase response rate in non-responders compared to questionnaire reminders only: The RECORD phone trial

    Maclennan, G., McDonald, A., McPherson, G., Treweek, S., Avenell, A., RECORD Trial Group
    Trials, vol. 15, 13
    Contributions to Journals: Articles

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.
    Circulation, vol. 128, no. 24, pp. 2705
    Contributions to Journals: Abstracts

  • Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study

    Cuthbertson, B. H., Campbell, M. K., Maclennan, G., Duncan, E. M., Marshall, A. P., Wells, E. C., Prior, M. E., Todd, L., Rose, L., Seppelt, I. M., Bellingan, G., Francis, J. J.
    Critical Care, vol. 17, no. 6, R266
    Contributions to Journals: Articles

  • Systematic Review of Adrenalectomy and Lymph Node Dissection in Locally Advanced Renal Cell Carcinoma

    Bekema, H. J., Maclennan, S., Imamura, M., Lam, T. B. L., Stewart, F., Scott, N., Maclennan, G., McClinton, S., Griffiths, T. R. L., Skolarikos, A., Maclennan, S. J., Sylvester, R., Ljungberg, B., N'dow, J.
    European Urology, vol. 64, no. 5, pp. 799-810
    Contributions to Journals: Articles

  • Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials

    Bristow, S. M., Bolland, M. J., Maclennan, G. S., Avenell, A., Grey, A., Gamble, G. D., Reid, I. R.
    British Journal of Nutrition, vol. 110, no. 8, pp. 1384-1393
    Contributions to Journals: Articles
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