Generation of antibody or peptide hits through phage display is an invaluable tool for biological research as these recombinant antibodies/peptides bind specifically to their targets and can be easily expressed in bacterial or mammalian systems.
Using phage display, the antigen binding regions of an antibody (variable heavy and light chain genes) and conveniently reformatted into soluble antibody fragments or full monoclonal antibodies. These biological ligands can be used in a number of applications including;
- Disease marker discovery
- Drug target validation
- Diagnostics (clinical to environmental samples)
- In vivo imaging
- Therapeutic candidates