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Professor Gary Macfarlane

Professor Gary Macfarlane
Professor Gary Macfarlane
Professor Gary Macfarlane

BSc (Hons), MBChB, PhD, CStat, MD (Hons), FFPHM, DSc

Clinical Chair in Epidemiology, Dean of Interdisciplinary Research and Research Impact

About
Email Address
g.j.macfarlane@abdn.ac.uk
Office Address
106 Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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Biography

Gary Macfarlane is Dean for Interdisciplinary Research and Research Impact. He has also held the Chair in Epidemiology (Clinical) at The University of Aberdeen since 2005 and previously held the same post at The University of Manchester from 1999. He is an Honorary Consultant in the Department of Public Health in NHS Grampian. Professor Macfarlane is Co-Director of the Versus Arthritis/Medical Research Council Centre for Musculoskeletal Health and Work and holds a Visiting Professor position at the University of Southampton. He trained in Statistics/ Computing Science and then Medicine at The University of Glasgow before undertaking his PhD at The University of Bristol. He worked at the Division of Epidemiology and Biostatistics at the European Institute of Oncology in Milan before leading a programme of chronic pain research at the Arthritis Research UK Epidemiology Unit at the University of Manchester.

He leads the Epidemiology group at the University of Aberdeen which focusses its research in Rheumatic and Musculoskeletal Diseases (RMD). The RMD programme has programmes of research on: mechanisms of disease onset and outcome (observational epidemiology), identifying effective management for RMDs (Clinical trials and evidence synthesis),  and designing optimal delivery of care (health services research). The clinical focus is on common complex conditions (including musculoskeletal pain and fatigue, fibromyalgia, and early osteoarthritis), inflammatory conditions, and rare diseases. He currently has 11 active grants (4 as Chief Investigator, 2 as Deputy Chief Investigator) worth £11.1m. The group runs the British Society of Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR-AS) and the BSR register in Psoriatic Arthritis (BSR-PsA).  Professor Macfarlane is a Chartered Statistician of the Royal Statistical Society and a Fellow of the Faculty of Public Health Medicine. 

Qualifications

  • BSc (Hons) Statistics and Computing Science 
    1985 - University of Glasgow 
  • MBChB Medicine and Surgery 
    1990 - University of Glasgow 
  • PhD Epidemiology 
    1993 - University of Bristol 

    The Epidemiology of Oral Cancer

  • MD (Hons) Medicine (Epidemiology) 
    2003 - University of Glasgow 
  • DSc Medicine 
    2021 - University of Glasgow 
  • CStat Statistics 
    1999 - Royal Statistical Society 
  • FFPH Public Health 
    2009 - Faculty of Public Health 

External Memberships

  • British Society for Rheumatology Board Member and Trustee; Chair of Heberden Committee
  • Scottish Pain Research Community (SPaRC): Member of Steering Group 
Research

Research Overview

My major research interests are in the Epidemiology of Rheumatic and Musculoskleletal Disorders (RMD) with a particular focus on pain (including fibromyalgia), fatigue and axial Spondyloarthritis (axSpA). I also undertake work in cancer epidemiology.

Research Specialisms

  • Epidemiology
  • Medical Statistics
  • Medicine
  • Environmental and Public Health

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR-AS)

Funder: British Society for Rheumatology (who receive funds from AbbVie, Pfizer and UCB) 2012-18

CI: Professor Gary J Macfarlane

This is a  UK-wide cohort study of biologic therapy-naïve patients with axial Spondyloarthritis (axSpA according to ASAS criteria). There are two sub-cohorts: patients recruited as they are about to start anti-Tumour Necrosis Factor (TNF) therapy, and those that are remaining on traditional DMARDs. Patients are followed for up to 5 years. The primary outcome of the study is safety but secondary outcomes include disease indices, quality of life and work. The study also allows the opportunity to study the epidemiology of axSpA. In December 2016 the study had recruited 2200 subjects across over 80 centres. More details of this and other related studies in Ankylosing Spondylitis are available through our RMD theme webpages.

 

MAMmOTH study: investigating the prevention of chronic widespread pain and fibromyalgia

Funder: Arthritis Research UK (with treatment costs from NHS Grampian, Highland and Greater Glasgow and Clyde health boards) 2015-19

CI: Professor Gary J Macfarlane

This is the first ever randomised clinical trial being conducted which aims to prevent the onset of chronic widespread pain (the characteristic feature of fibromyalgia). We are recruiting persons at high risk of developing CWP and they are randomly allocated to receive either usual care or 8 sessions of Cognitive Behaviour Therapy (CBT) delivered by telephone. Potentially eligible subjects are beimg identified through a large-scale population survey.


TRIO-POPULAR: Predicting the outcome of patients undergoing knee arthroplasty

Funder: Arthritis Research UK 2012-2017

CI: Professor Gary J Macfarlane

TRIO-POPULAR is a prospective cohort study of persons scheduled to undergo total knee arthroplasty (knee replacement). Patients are recruited prior to their operation when individual, clinical and psychosocial factors are collected. They are then followed-up for two years after their operation to identify which have done well/poorly in terms of knee pain and function. The aim is to determine whether information collected prior to operation could help identify those patients most likely to benefit. This type of study can inform decision by clinicians in offering patients the most appropriate management from which they are likely to benefit. Part of this study is nested within a randomised controlled trial of total knee arthroplasty testing whether, amongst people with pain and poor function post-operatively, intensive physiotherapy improves outcome.

Fibromyalgia: Optimal Management in patients with Axial Spondyloarthritis (FOMAxS)

Funder: Arthritis Research UK 2017-18

CI: Professor Gary J Macfarlane

FOMAxS is a study which ultimately aims to provide optinal management for patients whohave both axial Spondyloarthritis (AxSpA) and fibromyalgia (FM). Fibromyalgia has been shown to be more common in patients with AxSpA (and other inflammatory rheumatic arthritides), it may result in distortion of axSpA disease indices and result in inappropriate management. This study undertakes preparatory work for a future trial with the aims of a) assessing criteria for FM amongst patients with AxSpA, b) determining how common FM occurs in patients with AxSpA, c) developing and evaluating management using a cognitive behavioural approach for patients with co-morbid FM and AxSpA.

Research programme

You can read about our research programme, including studies underway, research outputs and plain language summaries here: https://www.abdn.ac.uk/iahs/research/epidemiology/research-107.php

Collaborations

Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Health and Work

Professor Macfarlane principal investigator for the Aberdeen spoke of this centre, which is based at the University of Southampton. Coordinated by the University of Southampton, the centre brings together fifteen different academic institutions across the UK, with interest and expertise in rheumatic and musculoskeletal disease, and its relation to occupation, to identify effective and cost-effective ways to minimise the adverse impacts of musculoskeletal disorders in the workplace. The work at the University of Aberdeen is focussed on investigating: media campaigns for low back pain; axial spondyloarthritis; pain management. 

European League Against Rheumatism (EULAR) revised guidelines for the management of fibromyalgia

Professor Macfarlane chaired an international group of clinicians, allied health professionals and scientists from 12 countries across Europe, in revising EULAR guidelines for the management of fibromyalgia. Since the original EULAR fibromyalgia guidelines, more than fifty randomised controlled trials have been published concerned with the phramcological or non-pharmacological management of the conditions. The revised guidelines were published, in 2016, in the Annals of the Rheumatic Diseases: http://ard.bmj.com/content/early/2016/07/04/annrheumdis-2016-209724.full

UK-RiME : UK Research in Musculoskeletal Epidemiology

The UK Research in Musculoskeletal Epidemiology (UK-RiME) partnership is a national collaboration between eight epidemiology centres in the United Kingdom including Aberdeen. The partnership seeks to develop a co-ordinated training programme facilitated by exchanges between departments at PhD, post-doctoral, NIHR academic clinical fellow, clinical fellow and international trainee levels.  UK-RiME facilitates access to one another’s cohorts and share analytical expertise with each other and the UK musculoskeletal research community.

 

 

Teaching

Teaching Responsibilities

 

Postgraduate (PhD) research students

The Epidemiology group welcomes applications in our research areas of interest.

External courses

Professor Macfarlane established a week-long Intensive Course in Applied Epidemiology (ICAE) at the University of Aberdeen.  This course has been run here since 2007, having previously been run for 15 years at the University of Manchester.  The course is highly rated by attendees, with attendees from Europe, Asia, the Americas and Australasia.  The course is annual and starts on the first Monday in March. For further details and / or to register for the next course please see our ICAE web page.

The Epidemiology Group has also put on shorter courses at external locations including Warsaw and Bucharest and also runs courses focussed on specific clinical disciplines such as  "Essentials in Epidemiology for Reproductive Health".

 

Publications

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  • The Natural History of Ankylosing Spondylitis: Results from the Scotland and Ireland Registry for Ankylosing Spondylitis

    Dean, L. E., Macfarlane, G. J., MacDonald, A. G., Jones, G. T.
    Rheumatology, vol. 53, no. suppl 1, pp. i43-i44
    Contributions to Journals: Articles

  • Smoking addiction and the risk of upper-aerodigestive- tract cancer in a multicenter case-control study

    Lee, Y. A., Zugna, D., Richiardi, L., Merletti, F., Marron, M., Ahrens, W., Pohlabeln, H., Lagiou, P., Trichopoulos, D., Agudo, A., Castellsague, X., Betka, J., Holcatova, I., Kjaerheim, K., Macfarlane, G. J., MacFarlane, T., Talamini, R., Barzan, L., Canova, C., Simonato, L., Conway, D. I., McKinney, P. A., Thomson, P., Znaor, A., Healy, C. M., McCartan, B. E., Boffetta, P., Brennan, P., Hashibe, M.
    International Journal of Cancer, vol. 133, no. 11, pp. 2688-2695
    Contributions to Journals: Articles

  • A randomised controlled trial (RCT) of telephone delivered cognitive behaviour therapy (TCBT) and exercise in the management of chronic widespread pain (CWP): Identifying long-term outcome and who benefits from which treatment

    Macfarlane, G. J., Beasley, M., Keeley, P., Lovell, K., Hannaford, P., Symmons, D. P. M., Woby, S., Prescott, G. J., MUSICIAN Study team, Prescott, G. J.
    77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals, pp. S1221
    Contributions to Journals: Abstracts

  • Ankylosing Spondylitis Is Associated With An Increased Likelihood Of Cardiovascular Disease: A Nationwide Matched Cohort Study In Primary Care

    Dean, L. E., Macfarlane, G. J., MacDonald, A. G., Jones, G. T., Dean, L. E.
    77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals, pp. S1187-S1187
    Contributions to Journals: Abstracts

  • Do patients with ankylosing spondylitis have an excess prevalence of chronic widespread pain?: Results from the Scotland and Ireland Registry for Ankylosing Spondylitis (SIRAS) and the MUSICIAN study

    Atzeni, F., Beasley, M., Dean, L. E., Jones, G., Gibson, J., Sarzi-Puttini, P., Macfarlane, G.
    77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals, pp. S652-S652
    Contributions to Journals: Abstracts

  • Explaining fatigue in ANCA-associated vasculitis

    Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., Little, M. A., Jayne, D. R. W., Flossmann, O., McLaren, J., Kumar, V., Erwig, L. P., Reid, D. M., Macfarlane, G. J., Jones, G. T.
    Rheumatology, vol. 52, no. 9, pp. 1680-1685
    Contributions to Journals: Articles

  • Fatigue-related brain white matter changes in granulomatosis with polyangiitis

    Basu, N., Murray, A. D., Jones, G. T., Reid, D. M., Macfarlane, G. J., Waiter, G. D.
    Rheumatology, vol. 52, no. 8, pp. 1429-1434
    Contributions to Journals: Articles

  • Modest Association of Joint Hypermobility With Disabling and Limiting Musculoskeletal Pain: Results From a Large-Scale General Population–Based Survey

    Mulvey, M. R., Macfarlane, G. J., Beasley, M., Symmons, D. P., Lovell, K., Keeley, P., Woby, S., McBeth, J.
    Arthritis Care & Research, vol. 65, no. 8, pp. 1325-1333
    Contributions to Journals: Articles

  • Alternative population sampling frames produced important differences in estimates of association: a case-control study of vasculitis

    Macfarlane, G. J., Jones, G. T., Swafe, L., Reid, D. M., Basu, N.
    Journal of Clinical Epidemiology, vol. 66, no. 6, pp. 675-680
    Contributions to Journals: Articles

  • Does primary care management of low-back pain differ in older persons?: Results from the MUSICIAN study

    Beasley, M., Schild von Spannenberg, S., Jones, G., Macfarlane, G.
    Annals of the Rheumatic Diseases, vol. 72, no. Suppl. 3, pp. 1040
    Contributions to Journals: Abstracts

  • Long-Term Effects of Cognitive Behaviour Therapy and Exercise for Chronic Widespread Pain

    Beasley, M., Prescott, G., McBeth, J., Scotland, G., Lovell, K., Keeley, P., Hannaford, P., McNamee, P., Symmons, D. P. M., Woby, S., Gkazinou, C., Macfarlane, G. J.
    Annals of the Rheumatic Diseases, vol. 72, pp. 1057
    Contributions to Journals: Abstracts

  • Long-term effects of cognitive behaviour therapy and exercise for chronic widespread pain

    Beasley, M., Prescott, G., McBeth, J., Scotland, G., Lovell, K., Keeley, P., Hannaford, P., McNamee, P., Symmons, D. P. M., Woby, S., Gkazinou, C., Macfarlane, G. J.
    Annals of the Rheumatic Diseases, vol. 72, no. Suppl3, pp. 131
    Contributions to Journals: Abstracts

  • Multiple somatic symptoms predict impaired health status in functional somatic syndromes

    Creed, F. H., Tomenson, B., Chew-Graham, C., MacFarlane, G. J., Davies, I., Jackson, J., Littlewood, A., McBeth, J.
    International Journal of Behavioral Medicine, vol. 20, no. 2, pp. 194-205
    Contributions to Journals: Articles

  • Current evidence of methotrexate efficacy in childhood chronic uveitis: A systematic review and meta-analysis approach

    Simonini, G., Paudyal, P., Jones, G. T., Cimaz, R., Macfarlane, G. J.
    Rheumatology, vol. 52, no. 5, pp. 825-831
    Contributions to Journals: Articles

  • Low back pain among textile workers: A cross-sectional study

    Paudyal, P., Ayres, J. G., Semple, S., Macfarlane, G. J.
    Occupational Medicine, vol. 63, no. 2, pp. 129-134
    Contributions to Journals: Articles

  • Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

    Peters, M. J., Broer, L., Willemen, H. L. D. M., Eiriksdottir, G., Hocking, L. J., Holliday, K. L., Horan, M. A., Meulenbelt, I., Neogi, T., Popham, M., Schmidt, C. O., Soni, A., Valdes, A. M., Amin, N., Dennison, E. M., Eijkelkamp, N., Harris, T. B., Hart, D. J., Hofman, A., Huygen, F. J. P. M., Jameson, K. A., Jones, G. T., Launer, L. J., Kerkhof, H. J. M., de Kruijf, M., McBeth, J., Kloppenburg, M., Ollier, W. E., Oostra, B., Payton, A., Rivadeneira, F., Smith, B. H., Smith, A. V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A. G., Wang, K., van Wingerden, S. H., Arden, N. K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G. J., Pendleton, N., Slagboom, P. E., Spector, T. D., Völzke, H., Kavelaars, A., van Duijn, C. M., Williams, F. M. K., van Meurs, J. B. J.
    Annals of the Rheumatic Diseases, vol. 72, no. 3, pp. 427-436
    Contributions to Journals: Articles

  • Investigating the role of pain-modulating pathway genes in musculoskeletal pain

    Holliday, K. L., McBeth, J., MacFarlane, G., Huhtaniemi, I. T., Bartfai, G., Casanueva, F. F., Forti, G., Kula, K., Punab, M., Vanderschueren, D., Wu, F. C., Thomson, W.
    European Journal of Pain (United Kingdom), vol. 17, no. 1, pp. 28-34
    Contributions to Journals: Articles

  • Does primary care management of low-back pain differ in older persons: Results from the MUSICIAN study

    Beasley, M., Schild von Spannenberg, S., Jones, G., Macfarlane, G.
    Scottish Pain Research Community 3rd Annual Scientific Meeting
    Contributions to Conferences: Abstracts

  • OP34 Assessing the Social Determinants of Teenage Pregnancy: A Time-Space Analysis using an Obstetric Database from 1950-2010

    McCall, S. J., Bhattacharya, S., Macfarlane, G., Okpo, E.
    Journal of Epidemiology and Community Health, vol. 67, no. Suppl 1, pp. A18
    Contributions to Journals: Abstracts

  • The Prevalence Of Fibromyalgia In The General Population - a Comparison Of The ACR 1990, 2010 and Modified 2010 Classification Criteria

    Jones, G., Beasley, M., Atzeni, F., Fluss, E., Sarzi-Puttini, P., Macfarlane, G.
    Arthritis & Rheumatism, vol. 65, no. S10, pp. S358
    Contributions to Journals: Abstracts

  • The characterisation and determinants of quality of life in ANCA associated vasculitis

    Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., Little, M. A., Jayne, D. R., Flossmann, O., McLaren, J., Kumar, V., Erwig, L. P., Reid, D. M., Jones, G. T., Macfarlane, G. J.
    Annals of the Rheumatic Diseases, vol. 73, no. 1, pp. 207-211
    Contributions to Journals: Articles

  • A systematic review of evidence for the effectiveness of practitioner-based complementary and alternative therapies in the management of rheumatic diseases: Osteoarthritis

    Macfarlane, G. J., Paudyal, P., Doherty, M., Ernst, E., Lewith, G., MacPherson, H., Sim, J., Jones, G. T.
    Rheumatology, vol. 51, no. 12, pp. 2224-2233
    Contributions to Journals: Articles

  • Systematic review and meta-analysis of the evidence for flexible sigmoidoscopy as a screening method for the prevention of colorectal cancer

    Littlejohn, C., Hilton, S., MacFarlane, G. J., Phull, P.
    British Journal of Surgery, vol. 99, no. 11, pp. 1488-1500
    Contributions to Journals: Articles

  • Bath Ankylosing Spondylitis Functional Index (BASFI) is a better indicator of poor quality of life than Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in ankylosing spondylitis: results from SIRAS - the Scotland and Ireland Registry for Ankylosing Spondylitis

    Jones, G. T., Dean, L. E., Macfarlane, G. J., Scotland Ireland Registry
    76th Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) 2012, pp. S261
    Contributions to Journals: Abstracts

  • The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility

    Holliday, K. L., Thomson, W., Neogi, T., Felson, D. T., Wang, K., Wu, F. C., Huhtaniemi, I. T., Bartfai, G., Casanueva, F., Forti, G., Kula, K., Punab, M., Vanderschueren, D., Macfarlane, G. J., Horan, M. A., Ollier, W., Payton, A., Pendleton, N., McBeth, J.
    Molecular Pain, vol. 8, 72
    Contributions to Journals: Articles

  • A systematic review of evidence for the effectiveness of practitioner-based complementary and alternative therapies in the management of rheumatic diseases: Rheumatoid arthritis

    Macfarlane, G. J., Paudyal, P., Doherty, M., Ernst, E., Lewith, G., Macpherson, H., Sim, J., Jones, G. T.
    Rheumatology, vol. 51, no. 9, pp. 1707-1713
    Contributions to Journals: Articles

  • A high tender point count is associated with the presence of multiple idiopathic pain disorders: Results from a population study

    Aggarwal, V. R., MacFarlane, G. J., McBeth, J.
    European Journal of Pain (United Kingdom), vol. 16, no. 8, pp. 1195-1203
    Contributions to Journals: Articles

  • Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain

    Barakat, A., Vogelzangs, N., Licht, C. M., Geenen, R., MacFarlane, G. J., De Geus, E. J., Smit, J. H., Penninx, B. W., Dekker, J.
    Arthritis Care and Research, vol. 64, no. 8, pp. 1209-1216
    Contributions to Journals: Articles

  • Fatigue: prevalence, correlates and consequences: results from the Scotland and Ireland Registry for Ankylosing Spondylitis (SIRAS)

    Morton, L., Jones, G. T., Lambert, C. M., Richmond, R., MacDonald, A. G., Jones, E. A., Sturrock, R. D., Hunter, J., Macfarlane, G. J.
    Scottish Medical Journal, vol. 57, no. 3, pp. 163-164
    Contributions to Journals: Abstracts

  • The natural history of ankylosing spondylitis before and after commencing biological therapy

    Downham, C., Dean, L., Jones, E. A., Davidson, L., MacDonald, A. G., Macfarlane, G. J., Jones, G. T.
    Scottish Medical Journal, vol. 57, no. 3, pp. 164
    Contributions to Journals: Abstracts

  • Somatization and health anxiety as predictors of health care use

    Tomenson, B., McBeth, J., Chew-Graham, C. A., MacFarlane, G., Davies, I., Jackson, J., Littlewood, A., Creed, F. H.
    Psychosomatic Medicine, vol. 74, no. 6, pp. 656-664
    Contributions to Journals: Articles

  • BASFI is a better indicator of low quality of life than BASDAI in ankylosing spondylitis: results from the Scotland and Ireland Registry for Ankylosing Spondylitis (SIRAS)

    Dean, L. E., Macfarlane, G. J., Jones, G. T., SIRAS
    Clinical and Experimental Rheumatology, vol. 30, no. 4, pp. 621-621
    Contributions to Journals: Abstracts

  • Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case–control study

    Marron, M., Boffetta, P., Møller, H., Ahrens, W., Pohlabeln, H., Benhamou, S., Bouchardy, C., Lagiou, P., Lagiou, A., Slámová, A., Schejbalová, M., Merletti, F., Richiardi, L., Kjaerheim, K., Agudo, A., Castellsague, X., MacFarlane, T., Macfarlane, G., Talamini, R., Barzan, L., Canova, C., Simonato, L., Biggs, A., Thomson, P., Conway, D. I., McKinney, P. A., Znaor, A., Healy, C. M., McCartan, B. E., Brennan, P., Hashibe, M.
    European Journal of Epidemiology, vol. 27, no. 7, pp. 499-517
    Contributions to Journals: Articles

  • The prevalence and burden of ankylosing spondylitis in Europe: a systematic review

    Morton, L., Jones, G. T., MacDonald, A. G., Downham, C., Macfarlane, G. J.
    Rheumatology, vol. 51, no. suppl 3, pp. 19-20
    Contributions to Journals: Abstracts

  • Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study

    MacFarlane, T., Macfarlane, G. J., Thakker, N. S., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A., Castellsague, X., Agudo, A., Slamova, A., Plzak, J., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Canova, C., Simonato, L., Conway, D. I., McKinney, P. A., Thomson, P., Sloan, P., Znaor, A., Healy, C. M., McCartan, B. E., Marron, M., Brennan, P.
    Annals of Oncology, vol. 23, no. 4, pp. 1053-1060
    Contributions to Journals: Articles

  • The epidemiology of multiple somatic symptoms

    Creed, F. H., Davies, I., Jackson, J., Littlewood, A., Chew-Graham, C., Tomenson, B., Macfarlane, G., Barsky, A., Katon, W., McBeth, J.
    Journal of Psychosomatic Research, vol. 72, no. 4, pp. 311-317
    Contributions to Journals: Articles

  • Predicting OA progression to total hip replacement: can we do better than risk factors alone using active shape modelling as an imaging biomarker?

    Barr, R. J., Gregory, J. S., Reid, D. M., Aspden, R. M., Yoshida, K., Hosie, G., Silman, A. J., Alesci, S., Macfarlane, G. J.
    Rheumatology, vol. 51, no. 3, pp. 562-570
    Contributions to Journals: Articles

  • Organising a World Congress of Epidemiology (WCE): Reflections and lessons from the XIX WCE, Scotland

    Bhopal, R. S., Smith, W. C., McEwen, J., MacFarlane, G., McCallum, A., Pattison, D., Bhala, N., Peto, R., Pell, J. P.
    Public Health, vol. 126, no. 3, pp. 265-270
    Contributions to Journals: Articles

  • Cognitive behavior therapy, exercise, or both for treating chronic widespread pain

    McBeth, J., Prescott, G., Scotland, G., Lovell, K., Keeley, P., Hannaford, P., McNamee, P., Symmons, D. P. M., Woby, S., Gkazinou, C., Beasley, M., Macfarlane, G. J.
    JAMA Internal Medicine, vol. 172, no. 1, pp. 48-57
    Contributions to Journals: Articles

  • The prevalence and management of low back pain across adulthood: Results from a population-based cross-sectional study (the MUSICIAN study)

    Macfarlane, G. J., Beasley, M., Jones, E. A., Prescott, G. J., Docking, R., Keeley, P., McBeth, J., Jones, G. T., MUSICIAN Study team
    Pain, vol. 153, no. 1, pp. 27-32
    Contributions to Journals: Articles

  • Back pain

    Macfarlane, G. J., Beasley, M., Jones, E. A., Lovell, K., Prescott, G. J., Keeley, P., McBeth, J., Jones, G. T., MUSICIAN Study team
    75th Annual Scientific Meeting of the American-College-of-Rheumatology/46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, pp. S345-S346
    Contributions to Journals: Abstracts

  • Maternal and perinatal risk factors and childhood cancer

    Beasley, M., Bhattacharya, S., Pang, D., Macfarlane, G.
    Society for Social Medicine 55th Annual Scientific Meeting
    Contributions to Conferences: Posters

  • Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer

    Anantharaman, D., Marron, M., Lagiou, P., Samoli, E., Ahrens, W., Pohlabeln, H., Slamova, A., Schejbalova, M., Merletti, F., Richiardi, L., Kjaerheim, K., Castellsague, X., Agudo, A., Talamini, R., Barzan, L., MacFarlane, T., Tickle, M., Simonato, L., Canova, C., Conway, D. I., McKinney, P. A., Thomson, P., Znaor, A., Healy, C. M., McCartan, B. E., Hashibe, M., Brennan, P., Macfarlane, G. J.
    Oral Oncology, vol. 47, no. 8, pp. 725-731
    Contributions to Journals: Articles

  • A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

    McKay, J. D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G. J., MacFarlane, T., Simonato, L., Canova, C., Agudo, A., Castellsagué, X., Lowry, R., Conway, D. I., McKinney, P. A., Healy, C. M., Toner, M. E., Znaor, A., Curado, M. P., Koifman, S., Menezes, A., Wünsch-Filho, V., Neto, J. E., Garrote, L. F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A. F., Weissler, M. C., Funkhouser, W. K., Luo, J., Lubiński, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S. M., Chen, C., Fish, S., Doody, D. R., Muscat, J. E., Lazarus, P., Gallagher, C. J., Chang, S., Zhang, Z., Wei, Q., Sturgis, E. M., Wang, L., Franceschi, S., Herrero, R., Kelsey, K. T., McClean, M. D., Marsit, C. J., Nelson, H. H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J. J., Peters, W. H. M., Hung, R. J., McLaughlin, J., Vatten, L., Njølstad, I., Goodman, G. E., Field, J. K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., González, C. A., Quirós, J. R., Martínez, C., Navarro, C., Ardanaz, E., Larrañaga, N., Khaw, K., Key, T., Bueno-de-Mesquita, H. B., Peeters, P. H. M., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad, K., Tjønneland, A., Kumle, M., Riboli, E., Välk, K., Vooder, T., Voodern, T., Metspalu, A., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Blanché, H., Gut, I. G., Galan, P., Heath, S., Hashibe, M., Hayes, R. B., Boffetta, P., Lathrop, M., Brennan, P.
    PLoS Genetics, vol. 7, no. 3, e1001333
    Contributions to Journals: Articles

  • Life-course influences on chronic pain in adults

    Macfarlane, G. J.
    Chronic Pain Epidemiology: From Aetiology to Public Health. Oxford University Press (OUP)
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Hypothalamic-Pituitary-Adrenal Axis Response to Mental Stress Predicts Chronic Widespread Pain Onset: Results from the SPICE Study

    Jones, G., Waiter, G. D., Beasley, M., Gkazinou, C., Macfarlane, G.
    Arthritis & Rheumatism, vol. 62, no. S10, pp. 649
    Contributions to Journals: Abstracts

  • Fatigue: A principal contributor to impaired quality of life in ANCA-associated vasculitis

    Basu, N., Jones, G., Fluck, N., MacDonald, A. G., Pang, D., Dospinescu, P., Reid, D. M., Macfarlane, G.
    Rheumatology, vol. 49, no. 7, pp. 1383-1390
    Contributions to Journals: Articles

  • Few clinical parameters mark out anti-TNF use among patients with ankylosing spondylitis: Data from the Scotland and Ireland registry for ankylosing spondylitis (SIRAS)

    Jones, G., Beasley, M., Marshall, D., Gibson, J., Steven, M. M., Sturrock, R. D., Macfarlane, G. J., SIRAS Steering Comm
    Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. 621
    Contributions to Journals: Abstracts

  • Fibromyalgia (FM) is not a clinical characteristic of ANCA-Associated Vasculitis (AAV) in Northern Scotland

    Basu, N., Dospinescu, P., Macdonald, A., Fluck, N., Jones, G., Reid, D., Macfarlane, G.
    APMIS, vol. 117, no. s127, pp. 161
    Contributions to Journals: Abstracts

  • Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality (vol 48, pg 74, 2009): corrigendum

    McBeth, J., Symmons, D. P., Silman, A. J., Allison, T., Webb, R., Brammah, T., Macfarlane, G. J.
    Rheumatology, vol. 48, no. 4, pp. 459
    Contributions to Journals: Articles

  • Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality

    McBeth, J., Symmons, D. P., Silman, A. J., Allison, T., Webb, R., Brammah, T., Macfarlane, G. J.
    Rheumatology, vol. 48, no. 1, pp. 74-77
    Contributions to Journals: Articles

  • Unexplained orofacial pain - Is an early diagnosis possible?

    Aggarwal, V. R., McBeth, J., Zakrzewska, J. M., MacFarlane, G. J.
    British Dental Journal, vol. 205, no. 3
    Contributions to Journals: Articles

  • Active exercise, education, and cognitive behavioral therapy for persistent disabling low back pain: a randomized controlled trial

    Johnson, R. E., Jones, G. T., Wiles, N. J., Chaddock, C., Potter, R. G., Roberts, C., Symmons, D. P. M., Watson, P. J., Torgerson, D. J., Macfarlane, G. J.
    Spine, vol. 32, no. 15, pp. 1578-1585
    Contributions to Journals: Articles

  • Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study

    Purandare, N., Burns, A., Daly, K. J., Hardicre, J., Morris, J., MacFarlane, G. J., McCollum, C.
    British Medical Journal, vol. 332, pp. 1119-1124
    Contributions to Journals: Editorials

  • Managing low back pain presenting to primary care: where do we go from here?

    MacFarlane, G. J., Jones, G. T., Hannaford, P. C.
    Pain, vol. 122, no. 3, pp. 219-222
    Contributions to Journals: Articles

  • Predicting persistent disabling low back pain in general practice: a prospective cohort study

    Jones, G., Johnson, R. E., Wiles, N. J., Chaddock, C., Potter, R. G., Roberts, C., Symmons, D. P. M., MacFarlane, G. J.
    The British Journal of General Practice, vol. 56, no. 526, pp. 334-41
    Contributions to Journals: Articles

  • Predictors of persistent neck pain after whiplash injury

    Atherton, K., Wiles, N., Lecky, F. E., Hawes, S. J., Silman, A. J., MacFarlane, G. J., Jones, G. T.
    Emergency Medicine Journal, vol. 23, no. 3, pp. 195-201
    Contributions to Journals: Editorials

  • Does physical trauma lead to an increase in the risk of new onset widespread pain?

    Wynne-Stones, G., Macfarlane, G. J., Silman, A. J., Jones, G. T.
    Annals of the Rheumatic Diseases, vol. 65, no. 3, pp. 391-393
    Contributions to Journals: Articles

  • Predicting New Onset of Widespread Pain Following a Motor Vehicle Collision

    Wynn, J., Jones, G. T., Wiles, N., Silman, A. J., MacFarlane, G. J.
    Journal of Rheumatology, vol. 33, no. 5, pp. 968-974
    Contributions to Journals: Editorials

  • The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?

    Aggarwal, V. R., McBeth, J., Zakrzewska, J. M., Lunt, M., MacFarlane, G. J.
    International Journal of Epidemiology, vol. 35, pp. 468-476
    Contributions to Journals: Editorials

  • Who Will Develop Chronic Pain and Why? The Epidemiological Evidence

    MacFarlane, G. J.
    Proceedings of the 11th World Congress on Pain, pp. 529-541, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Comment on Hendriks et al.: prognostic factors for poor recovery in acute whiplash patients. Pain 2005;114:408-416

    Wynne-Jones, G., Jones, G., Atherton, K., Wiles, N. J., Silman, A. J., Macfarlane, G.
    Pain, vol. 119, no. 1-3, pp. 247-248
    Contributions to Journals: Articles

  • Long-term mortality amongst Gulf War Veterans: is there a relationship with experiences during deployment and subsequent morbidity?

    MacFarlane, G. J., Hotopf, M., Maconochie, N., Blatchley, N., Richards, A., Lunt, M.
    British Medical Journal, vol. 34, no. 6, pp. 1403-1408
    Contributions to Journals: Editorials

  • Onset of neck pain after a motor vehicle accident: a case-control study

    Wiles, N. J., Jones, G., Silman, A. J., Macfarlane, G.
    Journal of Rheumatology, vol. 32, no. 8, pp. 1576-83
    Contributions to Journals: Articles

  • Epidemiology of low back pain in children and adolescents

    Jones, G., MacFarlane, G. J.
    Archives of Disease in Childhood, vol. 90, no. 3, pp. 312-316
    Contributions to Journals: Editorials

  • Is musculoskeletal pain more common now than 40 years ago? : two population-based cross-sectional studies

    Harkness, E. F., MacFarlane, G. J., Silman, A. J., McBeth, J.
    Rheumatology
    Contributions to Journals: Editorials

  • Primary care consultation predictors in men and women: a cohort study

    Kapur, N., Hunt, I., Lunt, M., McBeth, J., Creed, F., MacFarlane, G. J.
    The British Journal of General Practice, vol. 55, pp. 108-113
    Contributions to Journals: Editorials

  • An excess of widespread pain among South Asians: are low levels of vitamin D implicated?

    MacFarlane, G. J., Palmer, B., Roy, D., Afzal, C., Silman, A. J., O'Neill, T.
    Annals of the Rheumatic Diseases, vol. 64, pp. 1217-1219
    Contributions to Journals: Editorials

  • Association between pain in the hip region and radiographic changes of osteoarthritis: results from a population-based study

    Birrell, F., Lunt, M., MacFarlane, G. J., Silman, A. J.
    Rheumatology, vol. 44, pp. 337-341
    Contributions to Journals: Editorials

  • Chronic Widespread Pain and Fibromyalgia: Should Reports of Increased Mortality Influence Management

    MacFarlane, G. J.
    Current Rheumatology Reports, vol. 7, pp. 339-341
    Contributions to Journals: Editorials

  • Defining hip pain for population studies

    Birrell, F., Lunt, M., MacFarlane, G. J., Silman, A. J.
    Annals of the Rheumatic Diseases, vol. 64, pp. 95-98
    Contributions to Journals: Editorials

  • Development and validation of the Manchester oro-facial pain disability scale.

    Aggarwal, V. R., MacFarlane, T., Lunt, M., Zakrzewska, J. M., MacFarlane, G. J.
    Community Dentistry and Oral Epidemiology, vol. 33, pp. 141-149
    Contributions to Journals: Articles

  • Do strong opioids have a role in the early management of back pain? Recommendations from a European expert panel

    Kalso, E., Allan, L., Dobrogowski, J., Johnson, M., Krcevski-Skvarc, N., MacFarlane, G. J., Mick, G., Ortolani, S., Perrot, S., Perucho, A., Semmons, I., Sorensen, J.
    Current Medical Research and Opinion, vol. 21, no. 11, pp. 1819-1828
    Contributions to Journals: Editorials

  • Epidemiology of Pain in Older Persons

    Jones, G. T., MacFarlane, G. J.
    British Journal of Anaesthesia, vol. 35
    Contributions to Journals: Editorials

  • Looking back: development in our understanding of the occurrence, aetiology and prognosis of chronic pain 1954-2004

    MacFarlane, G. J.
    Rheumatology, vol. 44, no. 4, pp. 23-26
    Contributions to Journals: Editorials

  • Poor sleep and depression are independently associated with a reduced pain threshold.Results of a population based study

    Chiu, Y. H., Silman, A. J., MacFarlane, G. J., Ray, D., Gupta, A., Dickens, C., Morriss, R., McBeth, J.
    Pain, vol. 115, pp. 316-321
    Contributions to Journals: Editorials

  • Parental pain is not associated with pain in the child: a population based study

    Jones, G., Silman, A. J., Macfarlane, G.
    Annals of the Rheumatic Diseases, vol. 63, no. 9, pp. 1152-1154
    Contributions to Journals: Articles

  • Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire?

    MacFarlane, T., Blinkhorn, A. S., Craven, R., Zakrzewska, J. M., Atkin, P., Escudier, M. P., Rooney, C. A., Aggarwal, V., MacFarlane, G. J.
    Pain, vol. 111, pp. 270-277
    Contributions to Journals: Articles

  • DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma

    Hewitt, C., Wilson, P., McGlinn, E., Macfarlane, G., Papageorgiou, A., Woodwards, R. T. M., Sloan, P., Gollin, S. M., Paterson, I., Parkinson, K. K., Read, A. P., Thakker, N.
    Cancer Letters, vol. 209, no. 2, pp. 207-213
    Contributions to Journals: Articles

  • Childhood experience and health care in adulthood

    Kapur, N., Hunt, I., MacFarlane, G. J., McBeth, J., Creed, F.
    British Journal of Clinical Psychology, vol. 185, pp. 134-139
    Contributions to Journals: Editorials

  • Mechanical injury and psychosocial factors in the work place predict the onset of widespread body pain: a two-year prospective study among cohorts of newly employed workers

    Harkness, E. F., MacFarlane, G. J., Nahit, E., Silman, A. J., McBeth, J.
    Arthritis & Rheumatism, vol. 50, no. 5, pp. 1655-1664
    Contributions to Journals: Editorials

  • Psychosocial and illness related predictors of consultation rates in primary care - a cohort study

    Kapur, N., Hunt, I., Lunt, M., McBeth, J., Creed, F., MacFarlane, G. J.
    Psychological Medicine, vol. 34, no. 4, pp. 719-728
    Contributions to Journals: Editorials

  • The Cheshire Foot Pain and Disability Survey: a population survey assessing prevalence and associations

    Garrow, A. P., Silman, A. J., MacFarlane, G. J.
    Pain, vol. 110, pp. 378-384
    Contributions to Journals: Editorials

  • Occurrence of Raynaud's phenomenon in children ages 12-15 years: prevalence and association with other common symptoms

    Jones, G., Herrick, A. L., Woodham, S. E., Baildam, E. M., Macfarlane, G., Silman, A. J.
    Arthritis & Rheumatism, vol. 48, no. 12, pp. 3518-3521
    Contributions to Journals: Articles

  • Incidence of cancer among UK Gulf war veterans:cohort study

    MacFarlane, G. J., Biggs, A. M., Maconochie, N., Hotopf, M., Doyle, P., Lunt, M.
    Journal of Epidemiology and Community Health, vol. 327, pp. 1373-1375
    Contributions to Journals: Editorials

  • Predictors of low back pain in British schoolchildren: A population-based prospective cohort study

    Jones, G. T., Watson, K. D., Silman, A. J., Symmons, D. P. M., MacFarlane, G. J.
    Pediatrics, vol. 111, no. 4, pp. 822-828
    Contributions to Journals: Editorials

  • Why is pain more common amongst people living in areas of low socio-economic status? A population-based cross-sectional study.

    Aggarwal, V. R., MacFarlane, T., MacFarlane, G. J.
    British Dental Journal, vol. 194, pp. 383-387
    Contributions to Journals: Articles

  • Association of widespread body pain with an increased risk of cancer and reduced cancer survival

    McBeth, J., Silman, A. J., MacFarlane, G. J.
    Arthritis & Rheumatism, vol. 48, pp. 1686-1692
    Contributions to Journals: Editorials

  • Effects of psychosocial and individual psychological factors on the onset of musculoskeletal pain: common and site specific effects

    Nahit, E., Hunt, I., Lunt, M., Dunn, G., Silman, A. J., MacFarlane, G. J.
    Annals of the Rheumatic Diseases, vol. 62, pp. 755-760
    Contributions to Journals: Editorials

  • Generalised estimating equations and low back pain

    Harkness, E. F., Nahit, E., MacFarlane, G. J., Silman, A. J., Dunn, G., McBeth, J.
    Occupational and Environmental Medicine, vol. 60, pp. 378-382
    Contributions to Journals: Editorials

  • Hip pain onset in relation to cumulative workplace and leisure time mechanical load: a population-based case-control study

    Pope, D. P., Hunt, I., Birrell, F., Silman, A. J., MacFarlane, G. J.
    Annals of the Rheumatic Diseases, vol. 62, pp. 322-326
    Contributions to Journals: Editorials

  • Low back pain in schoolchildren: the role of mechanical and psychosocial factors

    Watson, K. D., Papageorgiou, A., Jones, G. T., Taylor, S., Symmons, D. P. M., Silman, A. J., MacFarlane, G. J.
    Archives of Disease in Childhood, vol. 88, no. 1, pp. 12-17
    Contributions to Journals: Editorials

  • Mechanical and psychosocial factors predict new onset shoulder pain: a prospective cohort study of newly employed workers

    Harkness, E. F., MacFarlane, G. J., Nahit, E., Silman, A. J., McBeth, J.
    Occupational and Environmental Medicine, vol. 60, pp. 850-857
    Contributions to Journals: Editorials

  • National Study of Cause-Specific Mortality in Rheumatoid Arthritis, Juvenile Chronic Arthritis, and other Rheumatic Conditions: a 20 year follow-up study

    Thomas, E., Symmons, D. P. M., Brewster, D. H., Black, R. J., MacFarlane, G. J.
    Journal of Rheumatology, vol. 30, no. 5, pp. 958-965
    Contributions to Journals: Editorials

  • Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing?

    Robinson, K. L., MacFarlane, G. J.
    Oral Oncology, vol. 39, pp. 31-36
    Contributions to Journals: Articles

  • Predicting the onset of forearm pain: A prospective study across 12 occupational groups

    Nahit, E., Taylor, S., Hunt, I., Silman, A. J., MacFarlane, G. J.
    Arthritis Care & Research, vol. 49, pp. 519-525
    Contributions to Journals: Editorials

  • Predicting the onset of widespread body pain among children

    Jones, G. T., Silman, A. J., MacFarlane, G. J.
    Arthritis & Rheumatism, vol. 48, no. 9, pp. 2615-2621
    Contributions to Journals: Editorials

  • Predictors of hip joint replacement in new attenders in primary care with hip pain

    Birrell, F., Afzal, C., Nahit, E., Lunt, M., MacFarlane, G. J., Cooper, C., Croft, P., Hosie, G., Silman, A. J.
    The British Journal of General Practice, vol. 53, pp. 26-30
    Contributions to Journals: Editorials

  • Risk factors for new-onset low back pain amongst cohorts of newly employed workers

    Harkness, E. F., MacFarlane, G. J., Nahit, E., Silman, A. J., McBeth, J.
    Rheumatology, vol. 42, pp. 959-968
    Contributions to Journals: Editorials

  • Syndrome of symptomatic adult acetabular dysplasia (SAAD Syndrome)

    Birrell, F., Silman, A. J., Croft, P., Cooper, C., Hosie, G., MacFarlane, G. J., PCR Hip Study Group
    Annals of the Rheumatic Diseases, vol. 62, pp. 356-358
    Contributions to Journals: Editorials
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