Dr Daniel Berg

Dr Daniel Berg
BSc in Biology (Uppsala University, 2006), PhD (Karolinska Institutet, 2012)


Dr Daniel Berg
Dr Daniel Berg

Contact Details

work +44 (0)1224 437332
The University of Aberdeen University of Aberdeen
Institute of Medical Sciences 
School of Medicine,
Medical Sciences & Nutrition
Foresterhill Health Campus
Scotland, UK


BSc in Biology, Uppsala University, Sweden (2006).

PhD. (2007-2012). Karolinska Institutet, Sweden. Studied brain regeneration in the Red-spotted Newt with Professor András Simon.

Postdoctoral Fellow. The Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA. (2012-2017). Studied adult neurogenesis under the supervision of Professor Hongjun Song (Funded by EMBO Long-Term Fellowships and Swedish research council international postdoc scholarship).  

Research Associate, The Department of Neuroscience, Perelman School of Medicine, The University of Pennsylvania. (2017-2020). Continued to work with Professor Hongjun Song and studied the embryonic origin of the adult neural stem cells. 


Research Overview

Daniel Berg received his biology undergraduate degree from Uppsala University in his hometown Uppsala, Sweden. For his PhD, he joined the lab of Dr. András Simon at the Karolinska Institute in Stockholm, Sweden, where he studied adult neurogenesis, i.e. the generation of functional neurons in the adult brain, using the Red-spotted Newt as a model organism. Unlike mammals, many amphibians are able to regenerate body parts, including their brain, after injury.  In his PhD work, Daniel identified the neural stem cells that fuel regeneration in the newt brain and examined signaling pathways that control the proliferation of these stem cells.

Neural Stem cells in the adult dentate gyrusThe dentate gyrus of mouse hippocampus at postnatal day 7, blue is nuclei marker, green is progeny of HOPX-expressing progenitor cells, and red is marker of cell proliferation.

Daniel then joined the lab of Dr. Hongjun Song, first at the Johns Hopkins University, Baltimore and then at the University of Pennsylvania, Philadelphia as a postdoctoral fellow. In the Song lab Daniel studied adult neurogenesis in the mouse brain and attempted to identify the different types of neural stem cells that reside in the adult mammalian brain. He also examined the developmental origin of the adult neural stem cells. 


Dentate DevelopmentNeural stem cells in the Dentate gyrus labeled at different stages of development.

As a lecturer at The Institute of Medical Sciences, Daniel plans to study neural stem cells, both during development and in adulthood using mammalian and amphibian model systems. The overall aim of his research will be to identify mechanisms to activate endogenous neural stem cells to repair the brain after injury and disease. He will use techniques such as lineage tracing, in vivo genetic manipulation and single cell RNA-sequencing. 



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  • A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

    Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., Epstein, J. A., Wu, Q. F., Canzar, S., Ming, G. L., Song, H., Bond, A. M.

    Cell, vol. 177, no. 3, pp. 654-668 and e1-e15

    Contributions to Journals: Articles

  • Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

    Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D., Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H., Ming, G. L.

    Cell, vol. 165, no. 5, pp. 1238-1254

    Contributions to Journals: Articles

  • Diversity of neural precursors in the adult mammalian brain

    Bonaguidi, M. A., Stadel, R. P., Berg, D. A., Sun, J., Ming, G. L., Song, H.

    Cold Spring Harbor perspectives in biology, vol. 8, no. 4, a018838

    Contributions to Journals: Articles

  • Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain

    Hameed, L. S., Berg, D. A., Belnoue, L., Jensen, L. D., Cao, Y., Simon, A.

    eLife, vol. 4, no. OCTOBER2015, e08422

    Contributions to Journals: Articles

  • Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

    Shin, J., Berg, D. A., Zhu, Y., Shin, J. Y., Song, J., Bonaguidi, M. A., Enikolopov, G., Nauen, D. W., Christian, K. M., Ming, G. L., Song, H.

    Cell Stem Cell, vol. 17, no. 3, pp. 360-372

    Contributions to Journals: Articles

  • Tbr2-expressing intermediate progenitor cells in the adult mouse hippocampus are unipotent neuronal precursors with limited amplification capacity under homeostasis

    Berg, D. A., Yoon, K. J., Will, B., Xiao, A. Y., Kim, N. S., Christian, K. M., Song, H., Ming, G. l.

    Frontiers in Biology, vol. 10, no. 3, pp. 262-271

    Contributions to Journals: Articles

  • Progenitor cell dynamics in the newt telencephalon during homeostasis and neuronal regeneration

    Kirkham, M., Hameed, L. S., Berg, D. A., Wang, H., Simon, A.

    Stem Cell Reports, vol. 2, no. 4, pp. 507-519

    Contributions to Journals: Articles

  • Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

    Berg, D. A., Belnoue, L., Song, H., Simon, A.

    Development (Cambridge), vol. 140, no. 12, pp. 2548-2561

    Contributions to Journals: Review articles

  • Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons

    Berg, D. A., Kirkham, M., Wang, H., Frisén, J., Simon, A.

    Cell Stem Cell, vol. 8, no. 4, pp. 426-433

    Contributions to Journals: Articles

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