Professor Claude Wischik | The Institute of Medical Sciences

Assays for the Screening and Characterization of Tau Aggregation Inhibitors
2016 - Published
Rickard, J. E., Horsley, D., Wischik, C. M., Harrington, C. R.
Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer, pp. 129-140, 12 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-6598-4_8
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
2016 - Published
Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
The Lancet, vol. 388, no. 10062, pp. 2873-2884
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(16)31275-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8639/3/Gauthier_et_al_R2_19July2016_FINAL_CLEAN.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8639/2/Gauthier_et_al_R2_Supplementary_tables_19July2016.docx
Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease
2016 - Published
Wischik, C. M., Storey, J. M. D., Wischik, D. J., Harrington, C. R.
Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., pp. 385-436, 52 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-802173-6.00015-0
- [ONLINE] View publication in Scopus
Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease
2016 - Published
Lai, R. Y. K., Harrington, C. R., Wischik, C. M.
Biomolecules, vol. 6, no. 2, pp. 1-19
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biom6020019
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5864/1/biomolecules_06_00019_v2.pdf
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
2016 - Published
Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., Wischik, C., Hof, P. R.
Biomolecules, vol. 6, no. 1, 6
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.3390/biom6010006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8985/1/biomolecules_06_00006_v2.pdf
- [ONLINE] View publication in Scopus
Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis
2016 - Published
Vuksanovic, V., Staff, R., Ahearn, T., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.
SINAPSE Annual Scientific Meeting (2016)
Contributions to Conferences: Abstracts
Phenothiazine compounds for treating mild cognitive impairment
2015 - Published
Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D., Staff, R. T.
Patents: Patents
Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration
2015 - Published
Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G., Theuring, F.
Cellular and Molecular Life Sciences, vol. 72, no. 11, pp. 2199-2222
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00018-014-1804-z
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4567/1/art_3A10.1007_2Fs00018_014_1804_z.pdf
Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models
2015 - Published
Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
Behavioural Pharmacology, vol. 26, no. 4, pp. 353-368
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1097/FBP.0000000000000133
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4568/1/Effects_of_oxidized_and_reduced_forms_of.4.pdf
Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease
2015 - Published
Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.
The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1074/jbc.M114.616029
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4569/1/J._Biol._Chem._2015_Harrington_10862_75.pdf
The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease
2015 - Published
Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B., Luna-Muñoz, J.
Frontiers in Neuroscience, vol. 9, 33
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnins.2015.00033
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4290/1/fnins_09_00033.pdf
Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease
2015 - Published
Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A., Harrington, C. R.
Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-142874
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4205/1/fulltext.pdf
Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease
2015 - Published
Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1124/jpet.114.219352
Tau-aggregation inhibitor therapy for Alzheimer's disease
2014 - Published
Wischik, C. M., Harrington, C. R., Storey, J. M. D.
Biochemical Pharmacology, vol. 88, no. 4, pp. 529-539
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.bcp.2013.12.008
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4208/1/1_s2.0_S0006295213007612_main.pdf
TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX
2014 - Published
Wischik, C. M., Harrington, C. R., Storey, J. M. D.
13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, pp. S26
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1016/j.neurobiolaging.2014.01.128
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
2012 - Published
Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
Patents: Patents
Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease
2011 - Published
Reilly, T. J., Staff, R. T., Ahearn, T. S., Bentham, P., Wischik, C. M., Murray, A. D.
Behavioural Brain Research, vol. 222, no. 2, pp. 375-379
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2011.04.003
The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease
2011 - Published
Staff, R., Ahearn, T. S., Phillips, L. H., Cooper, C. L., Mowat, D., Wischik, C. M., Whalley, L. J., Murray, A. D.
Neuroscience & Medicine, vol. 2, no. 1, pp. 6-13
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.4236/nm.2011.21002
3,7-diamino-10H-phenothiazine salts and their use: WO2007110627
2011 - Published
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4352/1/WO2007110627.pdf
Stripline resonator and preamplifier for preclinical magnetic resonance imaging at 4.7 T
2011 - Published
Lavdas, I., Seton, H., Harrington, C. R., Wischik, C. M.
Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 24, no. 6, pp. 331-337
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s10334-011-0273-8
3,6-Disubstituted xanthylium salts
2010 - Published
Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.
Patents: Patents
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds
2010 - Published
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
Patents: Patents
Ligands for aggregated tau molecules: WO2010034982
2010 - Published
Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4351/1/WO2010034982.pdf
Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies
2010 - Published
Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
- [ONLINE] DOI: https://doi.org/10.1039/9781849731065
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4066/1/Wischik_2010_RSC_Chapter.pdf
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe
2009 - Published
Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M., CC75C Collaboration Group
The Scientific World Journal, vol. 9, pp. 1463-1475
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1100/tsw.2009.151
Therapeutic Use of Diaminophenothiazines: WO2009044127
2009 - Published
Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.
Patents: Patents
- [ONLINE] http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009044127
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4353/1/WO2009044127.pdf
Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine
2009 - Published
Deiana, S., Harrington, C. R., Wischik, C. M., Riedel, G.
Psychopharmacology, vol. 202, no. 1-3, pp. 53-65
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00213-008-1394-2
Methods of synthesis and/or purification of diaminophenothiazinium compounds
2009 - Published
Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
Patents: Patents
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints
2008 - Published
Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M., Mena, R.
Acta Neuropathologica, vol. 116, no. 5, pp. 507-515
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00401-008-0431-x
Inhibitors of protein aggregation: WO2007110629
2007 - Published
Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4488/1/WO2007110629.pdf
A55 A rCBF study of hallucinations in dementia.
2006 - Published
Staff, R. T., Benjamin, K. D., Murray, A. D., Gemmell, H. G., Wischik, C. M.
Nuclear Medicine Communications, vol. 27, no. 3, 295
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1097/00006231-200603000-00066
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
2006 - Published
Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.
Patents: Patents
Inhibition of tau-tau-association
2005 - Published
Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.
Patents: Patents
Alzheimer's disease
2004 - Published
Wischik, C. M., Harrington, C. R., Roth, M.
The Oxford Companion to The Mind. Gregory, R. (ed.). 2 edition. Oxford University Press, pp. 24-27, 4 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
Naphthoquinone-type inhibitors of protein aggregation
2003 - Published
Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.
Patents: Patents
Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002059150
2002 - Published
Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4355/1/WO2002059150.pdf
Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics
2002 - Published
Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.
Neuroscience Letters, vol. 317, no. 3, pp. 161-165
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S0304-3940(01)02458-2
Inhibition of tau-tau-association
2002 - Published
Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.
Patents: Patents
Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002055720
2002 - Published
Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4354/1/WO2002055720.pdf
Neurofibrillary labels
2002 - Published
Wischik, C. M., Harrington, C. R., Rickard, J. E., Horsley, D.
Patents: Patents
Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease
2001 - Published
Garcia-Sierra, F., Wischik, C. M., Harrington, C. R., Luna-Munoz, J., Mena, R.
Journal of Chemical Neuroanatomy, vol. 22, no. 1-2, pp. 65-77
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S0891-0618(01)00096-5
Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia
2001 - Published
Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.
Schizophrenia Research, vol. 49, no. Suppl. 1, pp. 55
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1016/S0920-9964(01)00159-1
The molecular basis of tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias
2001 - Published
Wischik, C. M., Theuring, F., Harrington, C. R.
Neurobiology of Alzheimer’s Disease. Dawbarn, D., Allen, S. (eds.). 2 edition. Oxford University Press
Chapters in Books, Reports and Conference Proceedings: Chapters
Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease
2000 - Published
Mukaetova-Ladinska, E. B., Garcia-Siera, F., Hurt, J., Gertz, H. J., Xuereb, J. H., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M.
American Journal of Pathology, vol. 157, no. 2, pp. 623-636
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S0002-9440(10)64573-7
α-Synuclein inclusions in Alzheimer and Lewy body diseases
2000 - Published
Mukaetova-Ladinska, E. B., Hurt, J., Jakes, R., Xuereb, J., Honer, W. G., Wischik, C. M.
Journal of Neuropathology and Experimental Neurology, vol. 59, no. 5, pp. 408-417
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/jnen/59.5.408
- [ONLINE] View publication in Scopus
The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old
2000 - Published
Garcia-Sierra, F., Hauw, J. J., Duyckaerts, C., Wischik, C. M., Luna-Munoz, J., Mena, R.
Acta Neuropathologica, vol. 100, pp. 29-35
Contributions to Journals: Articles
alpha-synuclein inclusions in Alzheimer and Lewy body diseases
2000 - Published
Mukaetova-Ladinska, E. B., Hurt, J., Jakes, R., Xuereb, J., Honer, W. G., Wischik, C. M.
Journal of Neuropathology and Experimental Neurology, vol. 59, pp. 408-417
Contributions to Journals: Articles

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Research Overview

Assays for the Screening and Characterization of Tau Aggregation Inhibitors

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis

Phenothiazine compounds for treating mild cognitive impairment

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

Tau-aggregation inhibitor therapy for Alzheimer's disease

TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease

3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

Stripline resonator and preamplifier for preclinical magnetic resonance imaging at 4.7 T

3,6-Disubstituted xanthylium salts

Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

Ligands for aggregated tau molecules: WO2010034982

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

Therapeutic Use of Diaminophenothiazines: WO2009044127

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Methods of synthesis and/or purification of diaminophenothiazinium compounds

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

Inhibitors of protein aggregation: WO2007110629

A55 A rCBF study of hallucinations in dementia.

Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

Inhibition of tau-tau-association

Alzheimer's disease

Naphthoquinone-type inhibitors of protein aggregation

Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002059150

Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

Inhibition of tau-tau-association

Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002055720

Neurofibrillary labels

Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease

Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia

The molecular basis of tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias

Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease

α-Synuclein inclusions in Alzheimer and Lewy body diseases

The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old

alpha-synuclein inclusions in Alzheimer and Lewy body diseases

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