Professor Claude Wischik
Chair in Mental Health (Clin)
- About
-
- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
-
Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
- Publications
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Page 2 of 4 Results 26 to 50 of 96
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19Contributions to Journals: ArticlesTau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Frontiers in Neurology, vol. 11, 590754Contributions to Journals: ArticlesPaired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesMechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296Contributions to Journals: ArticlesCholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
Brain Communications, vol. 2, no. 1, fcaa033Contributions to Journals: ArticlesTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
FEBS LETTERS, vol. 594, no. 5, pp. 944-950Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesPhospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645Contributions to Journals: ArticlesCortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
International Journal of Neural Systems, vol. 29, no. 6, 1850055Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11981/3/Cortical_Thickness_and_Surface_Area_Networks_in_Healthy_Aging_Alzheimer_s_Disease_and_Behavioral_Variant_Fronto_Temporal_Dementia.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12993/1/ACSChemNsci_Konig.pdf
- [ONLINE] View publication in Mendeley
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131Contributions to Journals: ArticlesModeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303Contributions to Journals: ArticlesAlpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
Behavioural Brain Research, vol. 339, pp. 153-168Contributions to Journals: ArticlesA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
Frontiers in Molecular Neuroscience, vol. 10, 447Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457Contributions to Journals: Articles- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665Contributions to Journals: ArticlesThe effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks
Medical Research Archives , vol. 5, no. 9, 1298Contributions to Journals: ArticlesOrganisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
6th Cambridge Neuroscience SymposiumContributions to Conferences: AbstractsMethod and system for determining network connections
Patents: PatentsLMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE
Alzheimer's and Dementia, vol. 13, no. 7 Suppl., pp. P945-P945Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.jalz.2017.06.1854
Monoaminergic Neuropathology in Alzheimer's disease
Progress in Neurobiology, vol. 151, pp. 101-138Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pneurobio.2016.04.001
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8480/1/ProgN_Simic.pdf
Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study
Alzheimer Research UK (2017)Contributions to Conferences: AbstractsAssays for the Screening and Characterization of Tau Aggregation Inhibitors
Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer, pp. 129-140, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-6598-4_8