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The Institute of Medical Sciences

Professor Cosimo De Bari

Professor Cosimo De Bari
Professor Cosimo De Bari
Professor Cosimo De Bari

MD PhD FRCP, Hon Consultant Rheumatologist

Clinical Chair in Experimental Medicine and Rheumatology

About
Email Address
c.debari@abdn.ac.uk
Office Address

School of Medicine, Medical Sciences and Nutrition

University of Aberdeen

Aberdeen Centre for Arthritis and Musculoskeletal Health

Arthritis and Regenerative Medicine Laboratory

Institute of Medical Sciences

Foresterhill, Aberdeen AB25 2ZD

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
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Biography

Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.

Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.

Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.

External Memberships

Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.

Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.

Research

Research Overview

The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.

The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.

The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.

Publications

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  • Yap is a novel regulator of C2C12 myogenesis

    Watt, K. I., Judson, R., Medlow, P., Reid, K., Kurth, T. B., Burniston, J. G., Ratkevicius, A., De Bari, C., Wackerhage, H.
    Biochemical and Biophysical Research Communications, vol. 393, no. 4, pp. 619-624
    Contributions to Journals: Articles

  • Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table

    Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., De Bari, C., De Waele, P., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., Hess, D. C., Lanzoni, G., Liu, B., Marongiu, F., McGuckin, C., Mohr, S., Nolli, M. L., Ofir, R., Ponsaerts, P., Romagnoli, L., Solomon, A., Soncini, M., Strom, S., Surbek, D., Venkatachalam, S., Wolbank, S., Zeisberger, S., Zeitlin, A., Zisch, A., Borlongan, C. V.
    Stem Cells and Development, vol. 19, no. 2, pp. 143-154
    Contributions to Journals: Articles

  • Distinct mesenchymal progenitor cell subsets in the adult human synovium

    Karystinou, A., Dell'Accio, F., Kurth, T. B. A., Wackerhage, H., Khan, I. M., Archer, C. W., Jones, E. A., Mitsiadis, T. A., De Bari, C.
    Rheumatology, vol. 48, no. 9, pp. 1057-1064
    Contributions to Journals: Articles

  • Mesenchymal stem cells find their niches in skeletal regenerative medicine

    de Bari, C.
    European Cells and Materials, vol. 18, no. SUPPL. 1
    Contributions to Journals: Articles

  • A novel in vivo murine model of cartilage regeneration: Age and strain-dependent outcome after joint surface injury

    Eltawil, N. M., De Bari, C., Achan, P., Pitzalis, C., Dell'accio, F.
    Osteoarthritis and Cartilage, vol. 17, no. 6, pp. 695-704
    Contributions to Journals: Articles

  • Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources

    Guillot, P. V., De Bari, C., Dell'Accio, F., Kurata, H., Polak, J., Fisk, N. M.
    Differentiation: Research in Biological Diversity, vol. 76, no. 9, pp. 946-957
    Contributions to Journals: Articles

  • A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination

    Mitsiadis, T. A., Tucker, A. S., De Bari, C., Cobourne, M. T., Rice, D. P. C.
    Developmental Biology, vol. 320, no. 1, pp. 39-48
    Contributions to Journals: Articles

  • The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing organs: The rodent incisor as a model

    Mitsiadis, T. A., Caton, J., De Bari, C., Bluteau, G.
    Developmental Biology, vol. 320, no. 1, pp. 256-266
    Contributions to Journals: Articles

  • Stem cells for tooth engineering

    Bluteau, G., Luder, H. U., De Bari, C., Mitsiadis, T. A.
    European Cells & Materials, vol. 16, no. 1, pp. 1-9
    Contributions to Journals: Articles

  • Identification of the molecular response of articular cartilage to injury, by microarray screening

    Dell'Accio, F., De Bari, C., Eltawil, N. A., Vanhummelen, P., Pitzalis, C.
    Arthritis & Rheumatism, vol. 58, no. 5, pp. 1410-1421
    Contributions to Journals: Articles

  • Apoptosis in developmental and repair-related human tooth remodeling: a view from the inside

    Mitsiadis, T. A., De Bari, C., About, I.
    Experimental Cell Research, vol. 314, no. 4, pp. 869-877
    Contributions to Journals: Articles

  • Cell therapy: a challenge in modern medicine

    De Bari, C., Dell'accio, F.
    3rd International Meeting on Medical Engineering and Therapy, pp. 11-17
    Contributions to Journals: Special Issues

  • A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells

    De Bari, C., Dell'Accio, F., Karystinou, A., Guillot, P. V., Fisk, N. M., Jones, E. A., McGonagle, D., Khan, I. M., Archer, C. W., Mitsiadis, T. A., Donaldson, A. N., Luyten, F. P., Pitzalis, C.
    Arthritis & Rheumatism, vol. 58, no. 1, pp. 240-250
    Contributions to Journals: Articles

  • Mesenchymal stem cells in rheumatology: A regenerative approach to joint repair

    De Bari, C., Dell'accio, F.
    Clinical Science, vol. 113, no. 8, pp. 339-348
    Contributions to Journals: Articles

  • Stem cell niches in mammals

    Mitsiadis, T. A., Barrandon, O., Rochat, A., Barrandon, Y., De Bari, C.
    Experimental Cell Research, vol. 313, no. 16, pp. 3377-3385
    Contributions to Journals: Articles

  • Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development

    McGonagle, D., De Bari, C., Arnold, P., Jones, E.
    Arthritis & Rheumatism, vol. 56, no. 3, pp. 714-721
    Contributions to Journals: Articles

  • Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis

    Lories, R. J. U., Derese, I., De Bari, C., Luyten, F. P.
    Arthritis & Rheumatism, vol. 56, no. 2, pp. 489-497
    Contributions to Journals: Articles

  • Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

    Tyndall, A., Walker, U. A., Cope, A., Dazzi, F., De Bari, C., Fibbe, W., Guiducci, S., Jones, S., Jorgensen, C., Le Blanc, K., Luyten, F., McGonagle, D., Martin, I., Bocelli-Tyndall, C., Pennesi, G., Pistoia, V., Pitzalis, C., Uccelli, A., Wulffraat, N., Feldmann, M.
    Arthritis Research & Therapy, vol. 9, no. 1, pp. 301
    Contributions to Journals: Articles

  • Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells

    Van Damme, A., Thorrez, L., Ma, L., Vandenburgh, H., Eyckmans, J., Dell'Accio, F., De Bari, C., Luyten, F., Lillicrap, D., Collen, D., VandenDriessche, T., Chuah, M. K. L.
    Stem Cells, vol. 24, no. 4, pp. 896-907
    Contributions to Journals: Articles

  • Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

    De Bari, C., Dell'Accio, F., Vanlauwe, J., Eyckmans, J., Khan, I. M., Archer, C. W., Jones, E. A., Mcgonagle, D., Mitsiadis, T. A., Pitzalis, C., Luyten, F. P.
    Arthritis & Rheumatism, vol. 54, no. 4, pp. 1209-1221
    Contributions to Journals: Articles

  • Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury

    Dell'Accio, F., De Bari, C., El Tawil, N. M. F., Barone, F., Mitsiadis, T. A., O'Dowd, J., Pitzalis, C.
    Arthritis Research & Therapy, vol. 8, no. 5, pp. R139
    Contributions to Journals: Articles

  • Reparative medicine: from tissue engineering to joint surface regeneration

    De Bari, C., Pitzalis, C., Dell'Accio, F.
    Regenerative Medicine, vol. 1, no. 1, pp. 59-69
    Contributions to Journals: Articles

  • Increased Bcl-2/p53 ratio in human osteoarthritic cartilage: a possible role in regulation of chondrocyte metabolism

    Iannone, F., De Bari, C., Scioscia, C., Patella, V., Lapadula, G.
    Annals of the Rheumatic Diseases, vol. 64, no. 2, pp. 217-221
    Contributions to Journals: Articles

  • Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo

    Dell'Accio, F., De Bari, C., Luyten, F. P.
    Experimental Cell Research, vol. 287, no. 1, pp. 16-27
    Contributions to Journals: Articles

  • In vitro growth rate of fibroblast-like synovial cells is reduced by methotrexate treatment

    Lories, R. J. U., Derese, I., De Bari, C., Luyten, F. P.
    Annals of the Rheumatic Diseases, vol. 62, no. 6, pp. 568-571
    Contributions to Journals: Articles

  • Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane

    Vandenabeele, F., De Bari, C., Moreels, M., Lambrichts, I., Dell'Accio, F., Lippens, P. L., Luyten, F. P.
    Archives of Histology and Cytology, vol. 66, no. 2, pp. 145-153
    Contributions to Journals: Articles

  • Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats

    Van Damme, A., Chuah, M. K. L., Dell'accio, F., De Bari, C., Luyten, F., Collen, D., VandenDriessche, T.
    Haemophilia, vol. 9, no. 1, pp. 94-103
    Contributions to Journals: Articles

  • Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation

    Dell'Accio, F., Vanlauwe, J., Bellemans, J., Neys, J., De Bari, C., Luyten, F. P.
    Journal of Orthopaedic Research, vol. 21, no. 1, pp. 123-131
    Contributions to Journals: Articles

  • Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes

    Iannone, F., De Bari, C., Dell'Accio, F., Covelli, M., Patella, V., Lo Bianco, G., Lapadula, G.
    Rheumatology, vol. 41, no. 12, pp. 1413-1418
    Contributions to Journals: Articles

  • Skeletal tissue engineering: opportunities and challenges

    Luyten, F. P., Dell'Accio, F., De Bari, C.
    Best Practice & Research Clinical Rheumatology, vol. 15, no. 5, pp. 759-769
    Contributions to Journals: Articles

  • Multipotent mesenchymal stem cells from adult human synovial membrane

    De Bari, C., Dell'Accio, F., Tylzanowski, P., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 8, pp. 1928-1942
    Contributions to Journals: Articles

  • Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo

    Dell'Accio, F., De Bari, C., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 7, pp. 1608-1619
    Contributions to Journals: Articles

  • Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age

    De Bari, C., Dell'Accio, F., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 1, pp. 85-95
    Contributions to Journals: Articles

  • Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes

    Iannone, F., De Bari, C., Dell'Accio, F., Covelli, M., Cantatore, F. P., Patella, V., Lo Bianco, G., Lapadula, G.
    Clinical and Experimental Rheumatology, vol. 19, no. 2, pp. 139-145
    Contributions to Journals: Articles

  • Coexisting psoriatic arthritis, gout, and chondrocalcinosis

    De Bari, C., Lapadula, G., Cantatore, F. P.
    Scandinavian Journal of Rheumatology, vol. 27, no. 4, pp. 306-309
    Contributions to Journals: Articles

  • Isolated thrombocytopenia associated with low dose methotrexate therapy

    Lapadula, G., De Bari, C., Acquista, C. A., Dell'Accio, F., Covelli, M., Iannone, F.
    Clinical Rheumatology, vol. 16, no. 4, pp. 429-430
    Contributions to Journals: Articles

  • Anti-bacterial antibodies in Behçet's disease

    Iannone, F., De Bari, C., Pipitone, V., Lapadula, G., Covelli, M.
    Clinical and Experimental Rheumatology, vol. 15, no. 4, pp. 451-452
    Contributions to Journals: Articles
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