Professor Cosimo De Bari
MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
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Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolutionAnnals of the Rheumatic DiseasesContributions to Journals: Articles
Cellular therapy and tissue engineering for cartilage repairOsteoarthritis and CartilageContributions to Journals: Review articles
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exerciseCell Stem Cell, vol. 29, no. 4, pp. 528-544.e9Contributions to Journals: Articles
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritisAnnals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224Contributions to Journals: Articles
Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury ModelCells, vol. 10, no. 8, 1999Contributions to Journals: Articles
IL-6 ACTIVATES YES-ASSOCIATED PROTEIN (YAP) IN FIBROBLASTS AND INDUCES YAP-SNAIL COMPLEX FORMATION TO DRIVE SYNOVIAL LINING PATHOLOGY IN INFLAMMATORY ARTHRITISEuropean Congress of Rheumatology, pp. 19-19Contributions to Journals: Abstracts
Evaluation of Adjunctive Mycophenolate for Large Vessel Giant Cell ArteritisRheumatology Advances in Practice, vol. 4, no. 2, rkaa069Contributions to Journals: Articles
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritisAnnals of the Rheumatic Diseases, vol. 79, no. 12, pp. 1625-1634Contributions to Journals: Articles
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesisScience translational medicine, vol. 12, no. 559, eaax9086Contributions to Journals: Articles
Stem and progenitor cells in synoviumEncyclopedia of Bone Biology. Zaidi, M. (ed.). Elsevier, pp. 96-108, 13 pagesChapters in Books, Reports and Conference Proceedings: Chapters