Dr Karen Scott
Senior Research Fellow
I gained my BSc (Hons 2:i) in Biochemistry from the University of Aberdeen before continuing to my PhD (Molecular Biology of plant viruses) at what was then the Scottish Crop Research Institute in Invergowrie, Dundee. After my PhD I returned to Aberdeen to the Rowett Institute and have been been an active researcher here ever since.
Memberships and Affiliations
- Internal Memberships
I am co-lead of the Rowett Athena Swan, Equality and Diversity Team.
I am co-director of the University of Aberdeen Centre for Bacteria in Health and Disease.
I am the Institute Biological Safety Advisor.
I am the primary supervisor for 3 PhD students and the co-supervisor for a further 2 PhD students.
- External Memberships
- I am one of the Board of Durectors of ISAPP (International Scientific Association for Probiotics and Prebiotics), the foremost organisation in the world promoting the science behind probiotics and prebiotics (https://isappscience.org/). Served as President from 2016-2019.
Chair of organising committee for the biennial International Gut Microbiology symposium [Rowett/INRAE conference] 2016- present
- Member of the organising committee for the Wellcome Trust Gut Microbiome annual conference (2014-2018); International Human Microbiome Conference (2020-2022)
- Member of ILSI Prebiotic Expert Groups on "short chain fatty acids" and "gut microbiota and nutrients" 2016-2019
- Global Grant for Gut Health Grant Panel committee member 2018- present; Editor of Microbiology journal (2016 - 2018)
- External PhD student examiner (1 - 2 students per year) for various universities within UK or Europe.
- Regularly invited to review grant proposals submitted to International award bodies, and scientific manuscripts
Investigations into the development and evolution of the gut microbiota
The human large intestine is home to the largest and most diverse group of bacteria in the human body. These bacteria play an important role in maintaining human health, fermenting plant fibres and other non-digestible carbohydrates, and releasing compounds that have direct or indirect benefits to human health. Understanding the impact of specific dietary components on gut bacteria will help us to formulate health advice for the general population.
Key Research Interests are:
- the molecular mechanisms by which specific bacteria utilise different dietary components including prebiotics and fibre
- the importance of diet in modulating both the composition and activity of the microbiota
- understanding the sequential colonisation and longitudinal development of the microbiota through life
- investigating the health benefits that can be derived from increased consumption of oats and barley. The impact of these dietary components are assessed in vitro using bacterial mono- and co-culture, aswell as using mixed batch culture and fermentor systems. Human studies have also been done to ascertain the effects in vivo.
the role of the gut microbiota in the carriage, evolution and dissemination of antimicrobial resistance genes
- co-localisation of antimicrobial and other resistance genes on transmissible conjugative transposons. These resistance genes are also useful genetic markers to investigate gene function in key gut anaerobes, and to perfrom genetic manipulation experiments.
identifying new commensal bacteria suitable for development as next generation probiotics
Biological and Environmental Sciences
Nutrition and Health
1. Assessing the prevalence and evolution of antibiotic resistance genes in bacteria resident in the gut, and entering from the food chain
2. Effect of different cereals as dietary components on the gut microbiota.
3. Manipulation of anaerobic gut bacteria
4. investigating possible members of the gut microbiota as potential probiotics
Through the RESAS work I collaborate with scientists at JHI (Kelly Houston, Nicola Holden), the Moredun (Eleanor Watson), SRUC (Nicola Holden, Judith Evans) and UHI (Peter Martin).
I also collaborate on various projects with other scientists from different Universities (UK and EU) who have mutual interests in the activity of the gut microbiota, or in the prevalence and spread of antibiotic resistance genes.
PhD student supervision:
2010 – 2014 Joint studentship with University College Cork, Genetic Manipulation of anaerobic gut bacteria
2011-2015 RESAS cereal SP, Realizing the potential of cereal products to benefit human health
2011 – 2015 GTbiologics/Sulsa, The role of the gut microbiota in inflammatory bowel disease
2017 – 2020 Elphinstone award, Spread of antibiotic resistance through the food chain
2017 – 2021 A Vogel, Prebiotic treatment to alleviate IBS
2017 – 2021 Jordanian govt, Impact of antibiotic treatment on the evolution of mosaic genes
2018 – 2021 Kuwait govt, Health impacts of B-glucan
2020 – 2023 EastBio PhD student, Impact of bile salt hydrolase activities of specific gut bacteria on energy balance
2021-2025 Eastbio PhD student, Carriage of antimicrobial resistance genes by Campylobacter isolates from wildlife
Funding and Grants
- Scottish Government funded HEI Partnership grant - A systems wide approach to the control of Campyobacter in the food chain (focussing on the presence of antibiotic resistance genes)
- Scottish Government theme funding for RI
- Commercial funding from Vogel to investigate the effect of a specific prebiotic on gut health
- Commercial funding to perform anaerobic bacterial isolations
- Several foreign government funded PhD studentships
- Tenovus and NHS Endowment trust funding for various collaborative projects
I am responsible for teaching various units on the composition and function of the gut microbiota to MSc students and undergraduate 2nd year Medical students. I am also involved in supporting the general science and microbiology undergraduate teaching in the University, contributing to both lecturing and practical course teaching. I also contribute a section on Gut Microbiology to the successful Nutrition and Wellbeing MOOC, accessible learning for anyone interested.
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Comparison of microbial signatures between paired faecal and rectal biopsy samples from healthy volunteers using next-generation sequencing and culturomicsMicrobiome, vol. 10, no. 1, 171Contributions to Journals: Articles
Higher total faecal short chain fatty concentrations correlate with increasing proportions of butyrate and decreasing proportions of branched chain fatty acids across multiple human studiesGut Microbiome, vol. 3, e2Contributions to Journals: Articles
Changes in the gut microbiota of Nigerian infants within the first year of lifePloS ONE, vol. 17, no. 3, e0265123Contributions to Journals: Articles
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbioticsNature Reviews Gastroenterology & Hepatology, vol. 17, no. 11, pp. 687-701Contributions to Journals: Articles
Daily Fermented Whey Consumption Alters the Fecal Short-Chain Fatty Acid Profile in Healthy AdultsFrontiers in Nutrition, vol. 7, pp. 165Contributions to Journals: Articles
Conjugation Protocol Optimised for Roseburia inulinivorans and Eubacterium rectaleBio-protocol, vol. 10, no. 7, e3575Contributions to Journals: Articles
Developments in understanding and applying prebiotics in research and practice: an ISAPP conference paperJournal of Applied Microbiology, vol. 128, no. 4, pp. 934-949Contributions to Journals: Articles
Increased wholegrain intake does not reduce blood pressure and other markers of cardiovascular disease risk in unmedicated pre-hypertensive/stage 1 hypertensive volunteersNutrition Society Live 2020, E789Contributions to Journals: Abstracts
Short chain fatty acids in human gut and metabolic healthBeneficial Microbes, vol. 11, no. 5, pp. 411-455Contributions to Journals: Articles
Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmidsAnaerobe, vol. 59, pp. 131-140Contributions to Journals: Articles