Search Menu
The Rowett Institute

Professor Jules Griffin

Professor Jules Griffin
Professor Jules Griffin
Professor Jules Griffin

Director of the Rowett Institute

About

Biography

My research focuses on the application of analytical chemistry to study metabolism at a global level in metabolic diseases. We have developed and applied metabolomics and lipidomics tools to investigate aspects of the metabolic syndrome and how nutrition interacts with health across the life course. This has included studies based on cell culture, model organisms, human diet intervention studies and epidemiology. At the centre of this research has been a desire to understand why fat metabolism can be so detrimental to the cell.    

I received my D.Phil. in Biochemistry from the University of Oxford, where I used 13C NMR spectroscopy to study metabolism in the brain. My first Post-doctoral position applied similar approaches to study cardiac metabolism at Harvard Medical School and Massachusetts General Hospital. Returning to the UK I took up a second post-doctoral position at Imperial College London, joining during the early stages of the development of metabolomics/metabonomics. Here, I applied these new omic tools to understanding how fat metabolism impairs cell function and have been studying this subject ever since.

I was awarded a Royal Society University Research Fellowship and set up my own research group at the Department of Biochemistry, University of Cambridge in 2002. In 2011, I took up a joint position with MRC Human Nutrition Research and the University of Cambridge as a programme leader. This was a transformative appointment, allowing my group to move our focus from model systems into human nutrition and experimental medicine. We also developed a number of high throughput metabolomics and lipidomics tools for cohort studies to examine the metabolic syndrome. In 2019 I took up the Chair of Biological Chemistry at Imperial College London, joining the Imperial College Dementia Research Institute to study the contribution of lipid metabolism to neurodegenerative diseases. In July 2021 I joined the Rowett Institute, University of Aberdeen as Director.

Memberships and Affiliations

Internal Memberships

Member of Aberdeen Cardiovascular and Diabetes Centre

Member of the Rowett Institute EDIT Committee

Chair of the Rowett Institute Executive Committee

External Memberships

Fellow of the Royal Society of Chemistry.

Director and Secretary to the Metabolic Profiling Forum (metabomeeting).

Editorial board member for Genome Medicine and Metabolites. 

Former President of the Metabolomics Society (2016-2020).

Latest Publications

  • Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)

    Mocciaro, G., Allison, M., Jenkins, B., Azzu, V., Huang-Doran, I., Herrera-Marcos, L. V., Hall, Z., Murgia, A., Susan, D., Frontini, M., Vidal-Puig, A., Koulman, A., Griffin, J. L., Vacca, M.
    Molecular Metabolism, vol. 73, 101728
    Contributions to Journals: Articles

  • Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial

    Hundertmark, M. J., Adler, A., Antoniades, C., Coleman, R., Griffin, J. L., Holman, R. R., Lamlum, H., Lee, J., Massey, D., Miller, J. J. J. J., Milton, J. E., Monga, S., Mózes, F. E., Nazeer, A., Raman, B., Rider, O., Rodgers, C. T., Valkovič, L., Wicks, E., Mahmod, M., Neubauer, S.
    Circulation
    Contributions to Journals: Articles

  • A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK)

    Sarmad, S., Viant, M. R., Dunn, W. B., Goodacre, R., Wilson, I. D., Chappell, K. E., Griffin, J. L., O'Donnell, V. B., Naicker, B., Lewis, M. R., Suzuki, T., UK Consortium on Metabolic Phenotyping (MAP/UK)
    Nature Protocols, pp. 1017-1027
    Contributions to Journals: Review articles

  • Pathway-based integration of multi-omics data reveals lipidomics alterations validated in an Alzheimer´s Disease mouse model and risk loci carriers

    Garcia-Segura, M. E., Durainayagam, B. R., Liggi, S., Graça, G., Jimenez, B., Dehghan, A., Tzoulaki, I., Karaman, I., Elliott, P., Griffin, J. L.
    Journal of Neurochemistry, vol. 164, no. 1, pp. 57-76
    Contributions to Journals: Articles

  • Creatine Deficiency Syndromes: Comparison of Screening Methods and Characterization of Four Novel Intronic Variants

    Mustafa, N. M., Elabd, N. E., Selim, L. A., Abdou, D. M., Griffin, J. L.
    Clinica Chimica Acta, vol. 536, pp. 70-76
    Contributions to Journals: Articles

View My Publications

Prizes and Awards

Trapnell Research Fellow, King's College, Cambridge, 2003-2007.

Recipient of Agilent Thought Leader Award. 2016. 

Honorary Professor at Imperial College London (2022-)

Visiting Professor at the University of Cagliari, Sardinia, Italy (2011-2012; 2015-2016; 2021-22).

Publications

Page 1 of 3 Results 1 to 10 of 23

  • Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)

    Mocciaro, G., Allison, M., Jenkins, B., Azzu, V., Huang-Doran, I., Herrera-Marcos, L. V., Hall, Z., Murgia, A., Susan, D., Frontini, M., Vidal-Puig, A., Koulman, A., Griffin, J. L., Vacca, M.
    Molecular Metabolism, vol. 73, 101728
    Contributions to Journals: Articles

  • Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial

    Hundertmark, M. J., Adler, A., Antoniades, C., Coleman, R., Griffin, J. L., Holman, R. R., Lamlum, H., Lee, J., Massey, D., Miller, J. J. J. J., Milton, J. E., Monga, S., Mózes, F. E., Nazeer, A., Raman, B., Rider, O., Rodgers, C. T., Valkovič, L., Wicks, E., Mahmod, M., Neubauer, S.
    Circulation
    Contributions to Journals: Articles

  • A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK)

    Sarmad, S., Viant, M. R., Dunn, W. B., Goodacre, R., Wilson, I. D., Chappell, K. E., Griffin, J. L., O'Donnell, V. B., Naicker, B., Lewis, M. R., Suzuki, T., UK Consortium on Metabolic Phenotyping (MAP/UK)
    Nature Protocols, pp. 1017-1027
    Contributions to Journals: Review articles

  • Pathway-based integration of multi-omics data reveals lipidomics alterations validated in an Alzheimer´s Disease mouse model and risk loci carriers

    Garcia-Segura, M. E., Durainayagam, B. R., Liggi, S., Graça, G., Jimenez, B., Dehghan, A., Tzoulaki, I., Karaman, I., Elliott, P., Griffin, J. L.
    Journal of Neurochemistry, vol. 164, no. 1, pp. 57-76
    Contributions to Journals: Articles

  • Creatine Deficiency Syndromes: Comparison of Screening Methods and Characterization of Four Novel Intronic Variants

    Mustafa, N. M., Elabd, N. E., Selim, L. A., Abdou, D. M., Griffin, J. L.
    Clinica Chimica Acta, vol. 536, pp. 70-76
    Contributions to Journals: Articles

  • Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease

    Dehghan, A., Pinto, R. C., Karaman, I., Huang, J., Durainayagam, B. R., Ghanbari, M., Nazeer, A., Zhong, Q., Liggi, S., Whiley, L., Mustafa, R., Kivipelto, M., Solomon, A., Ngandu, T., Kanekiyo, T., Aikawa, T., Radulescu, C. I., Barnes, S. J., Graça, G., Chekmeneva, E., Camuzeaux, S., Lewis, M. R., Kaluarachchi, M. R., Ikram, M. A., Holmes, E., Tzoulaki, I., Matthews, P. M., Griffin, J. L., Elliott, P.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 43, e2206083119
    Contributions to Journals: Articles

  • Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome

    Mocciaro, G., D’amore, S., Jenkins, B., Kay, R., Murgia, A., Herrera‐marcos, L. V., Neun, S., Sowton, A. P., Hall, Z., Palma‐duran, S. A., Palasciano, G., Reimann, F., Murray, A., Suppressa, P., Sabbà, C., Moschetta, A., Koulman, A., Griffin, J. L., Vacca, M.
    International Journal of Molecular Sciences, vol. 23, no. 12, 6786
    Contributions to Journals: Articles

  • Reply

    Hall, Z., Oakley, F., Vacca, M., Griffin, J. L.
    Hepatology, vol. 75, no. 5, pp. 1347-1348
    Contributions to Journals: Comments and Debates

  • Gene and metabolite expression dependence on body mass index in human myocardium

    Adebayo, A. S., Roman, M., Zakkar, M., Yusoff, S., Gulston, M., Joel-David, L., Anthony, B., Lai, F. Y., Murgia, A., Eagle-Hemming, B., Sheikh, S., Kumar, T., Aujla, H., Dott, W., Griffin, J. L., Murphy, G. J., Woźniak, M. J.
    Scientific Reports, vol. 12, no. 1, 1425
    Contributions to Journals: Articles

  • Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure

    Piedrafita, G., Varma, S. J., Castro, C., Messner, C. B., Szyrwiel, L., Griffin, J. L., Ralser, M.
    PLoS Biology, vol. 19, no. 12, e3001468
    Contributions to Journals: Articles
Show 10 | 25 | 50 | 100 results per page

Refine

Contributions to Journals

Working Papers

Update