Analytical Facility Manager
With over 40 years experience in the use of chromatographic techniques, I now find myself managing the Rowett Analytical Facility, in the institute where, in 1952, Richard Lawrence Millington Synge was awarded the Nobel Prize for Chemistry (along with Archer Martin) for the invention of partition chromatography.
I began my chromatographic journey in the 'very' early 80s using GLC and then HPLC, in the lab of Gabrielle Hawksworth, and I continued to work with Gay until her passing in 2012. Initially, I used these platforms as tools in understanding the underlying mechanisms of drug metabolism and toxicology, especially the roles of the cytochrome P450s and UDP-glucuronosyltransferases in these processes. As the technologies developed, I concentrated more on developing new analytical methods for the research staff and students in the group and then beyond, becoming a specialised 'core facility' for the quantitative analysis of endogenous compounds and xenobiotics and their metabolites. In recent years, I have been focused on developing new quantitative LC-MS/MS methods and have collaborated on a wide range of projects with colleagues within the University of Aberdeen and elsewhere.
The Rowett Analytical Facility has a suite of labs, a wide range of state of the art equipment and a highly-skilled team, working in support of research in the Rowett, the wider university community and with external stakeholders.
Glucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infectionPLoS Pathogens, vol. 19, no. 7, pp. e1011505Contributions to Journals: Articles
Comprehensive study of antiretroviral drug permeability at the cervicovaginal mucosa via an in vitro modelPharmaceutics, vol. 14, no. 9, 1938Contributions to Journals: Articles
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogasterCannabis and Cannabinoid Research, vol. 6, no. 2, pp. 119-136Contributions to Journals: Articles
Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older PatientsPharmaceutical and Biomedical Research, vol. 6, no. 2, pp. 151-156Contributions to Journals: Articles
Melatonin in doctors and nurses working nightshifts-the MIDNIGHT trialMeeting of the BJA-Research-Forum, pp. E50-E51Contributions to Journals: Abstracts
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The use of finger-prick rather than venous blood samples to determine the pharmacokinetics of paracetamolBritish Journal of Clinical Pharmacology, vol. 68, no. 2, pp. 298Contributions to Journals: Articles
Proinflammatory markers in prediction of post-traumatic psychological symptoms: a prospective cohort studyMediators of Inflammation, vol. 2008, 640659Contributions to Journals: Articles
Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cellsHepatology, vol. 40, no. 1, pp. 232-242Contributions to Journals: Articles
Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitroBiochemical Journal, vol. 370, no. 3, pp. 763-769Contributions to Journals: Articles
Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomesXenobiotica, vol. 28, no. 3, pp. 219-23Contributions to Journals: Articles
Interaction of metoprolol with lorazepam and bromazepamEuropean Journal of Clinical Pharmacology, vol. 40, no. 4, pp. 405-9Contributions to Journals: Articles