Analytical Facility Manager
With over 40 years experience in the use of chromatographic techniques, I now find myself managing the Rowett Analytical Facility, in the institute where, in 1952, Richard Lawrence Millington Synge was awarded the Nobel Prize for Chemistry (along with Archer Martin) for the invention of partition chromatography.
I began my chromatographic journey in the 'very' early 80s using GLC and then HPLC, in the lab of Gabrielle Hawksworth, and I continued to work with Gay until her passing in 2012. Initially, I used these platforms as tools in understanding the underlying mechanisms of drug metabolism and toxicology, especially the roles of the cytochrome P450s and UDP-glucuronosyltransferases in these processes. As the technologies developed, I concentrated more on developing new analytical methods for the research staff and students in the group and then beyond, becoming a specialised 'core facility' for the quantitative analysis of endogenous compounds and xenobiotics and their metabolites. In recent years, I have been focused on developing new quantitative LC-MS/MS methods and have collaborated on a wide range of projects with colleagues within the University of Aberdeen and elsewhere.
The Rowett Analytical Facility has a suite of labs, a wide range of state of the art equipment and a highly-skilled team, working in support of research in the Rowett, the wider university community and with external stakeholders.
Glucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infectionPLoS Pathogens, vol. 19, no. 7, pp. e1011505Contributions to Journals: Articles
Comprehensive study of antiretroviral drug permeability at the cervicovaginal mucosa via an in vitro modelPharmaceutics, vol. 14, no. 9, 1938Contributions to Journals: Articles
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogasterCannabis and Cannabinoid Research, vol. 6, no. 2, pp. 119-136Contributions to Journals: Articles
Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older PatientsPharmaceutical and Biomedical Research, vol. 6, no. 2, pp. 151-156Contributions to Journals: Articles
Melatonin in doctors and nurses working nightshifts-the MIDNIGHT trialMeeting of the BJA-Research-Forum, pp. E50-E51Contributions to Journals: Abstracts
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Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicansPloS ONE, vol. 10, no. 9, 0137750Contributions to Journals: Articles
The enantioselective population pharmacokinetics of intravenous ketorolac in children using a stereoselective assay suitable for microanalysisJournal of Pharmacy and Pharmacology, vol. 67, no. 9, pp. 1179-1187Contributions to Journals: Articles
Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicansPloS ONE, vol. 10, no. 6, e0126940Contributions to Journals: Articles
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signallingNature Communications, vol. 5, pp. 1-13Contributions to Journals: Articles
Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsisJournal of Pineal Research, vol. 56, no. 4, pp. 427-438Contributions to Journals: Articles
Development of an enantiomer selective microsampling assay for the quantification of ketorolac suitable for paediatric pharmacokinetic studiesBiopharmaceutics & Drug Disposition, vol. 34, no. 7, pp. 377-386Contributions to Journals: Articles
Population pharmacokinetics of single-dose intravenous paracetamol in childrenBritish Journal of Anaesthesia, vol. 108, no. 5, pp. 823-829Contributions to Journals: Articles
Cannabinoids and Bone: Endocannabinoids modulate human osteoclast function in vitroBritish Journal of Pharmacology, vol. 165, no. 8, pp. 2584-2597Contributions to Journals: Articles
Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfindingJournal of Neuroscience, vol. 30, no. 42, pp. 13992-14007Contributions to Journals: Articles
Can finger-prick sampling replace venous sampling to determine the pharmacokinetic profile of oral paracetamol?British Journal of Clinical Pharmacology, vol. 70, no. 1, pp. 52-56Contributions to Journals: Articles