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The Institute of Medical Sciences

Professor Bettina Platt

Professor Bettina Platt
Professor Bettina Platt
Professor Bettina Platt

PhD (Dr rer. nat.), Dipl. Biol., FRSB

Chair in Translational Neuroscience

Accepting PhDs

About
Email Address
b.platt@abdn.ac.uk
Telephone Number
+44 (0)1224 437402
Office Address

Room 6.28; School of Medicine, Medical Sciences & Nutrition University of Aberdeen Institute of Medical Sciences Foresterhill ABERDEEN AB25 2ZD Scotland, UK

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

Bettina Platt graduated with distinction from the University of Mainz, Germany and received her PhD from the University of Düsseldorf, Germany. After completing a prestigious personal European Fellowship at the University of Leeds, Prof Platt joined the University of Aberdeen in 1997, initially within the Department of Biomedical Sciences. Since 2009, Prof Platt holds the Chair in Translational Neuroscience within the School of Medical Sciences. She heads a multi-disciplinary research team that investigates aspects of brain function and malfunction from the single molecule to the systems level. Prof Platt has acted as Research Director for a number of large research initiatives, some of which were co-funded by the pharmaceutical industry and the Scottish government. Her national and international collaborations have brought together novel research strategies, technologies and disciplines such as imaging, drug discovery, electronics, and computer science. Prof Platt is a Fellow of the Society of Biology and a founding member of the Scottish Dementia Research Consortium (SDRC). Additionally, Prof Platt was a member of the SDRC executive board until 2016 and previously sat on the Alzheimer’s Society funding board. She currently is a member of the Scottish Alzheimer Research UK (ARUK) network board, and the ARUK Scientific Advisory Board.

 

External Memberships

Executive Board member, Scottish Dementia Research Consortium

North-East of Scotland Alzheimer Research UK (ARUK) network coordinator (preclinical)

Member of the ARUK Scientific Advisory Board

Alzheimer’s Society Grant Advisory Board.

Editorial Advisory Board, Recent Patents on CNS Drug Discovery

Latest Publications

View My Publications

Research

Research Overview

Research interests: Alzheimer's disease and other dementias, mechanisms of neuronal plasticity, neurodegeneration and neuroprotection.

The amazing ability of the nervous system to learn and adapt to changing conditions forms the basis of our cognitive and intellectual abilities as humans, and how crucially we depend on this is demonstrated in patients suffering from neurodegenerative diseases such as Alzheimer's disease (AD).

We are currently combining various procedures, from standard histology and immunocytochemistry, to cell death essays and more functional techniques based on electrophysiological and imaging techniques, as well as behavioural studies. Latest developments include the use of EEG recordings, and PET/CT applications. Together, we cover aspects from the systems to the single cell level, and even to single receptors / channels, for disease target identification, drug development and testing within the sector of CNS diseases.

The main projects currently under investigation can be summarised as follows:

1)      Alzheimer’s disease and neurodegeneration: causes, biomarkers and treatments.

2)      Mechanisms of neuronal plasticity.

3)      Therapeutics in CNS disorders.

4)      Translational technologies.

 

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs
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Research Specialisms

  • Biomedical Sciences
  • Neuroscience
  • Animal Physiology
  • Dementia Studies

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

Alzheimer's disease, FTD, dementia, cognition, neurodegeneration, neurotoxicity, neuroprotection, neuronal plasticity, EEG, imaging, Ca signalling, plasticity.

Techniques and Skills:

  • Models of dementia: transgenic, pharmacological & viral models in vivo and in vitro (beta amyloid, tau, PS1, BACE; single / double & triple combinations; siRNA).
  • Drug discovery
  • Translational Technologies
  • In vitro electrophysiological recording techniques in brain slices, neuronal cultures, and isolated neurones (patch-clamping and field recordings).
  • In vivo electrophysiological recordings (evoked potentials and EEG recordings (wireless).
  • In vivo imaging (PET/CT & MRI)
  • Behavioural assessments (Cognition & Phenotyper).
  • Immunocytochemical and histological techniques, ELISAs, Western Blots.
  • Confocal  / fluorescent microscopy.
  • Time-lapse imaging
  • Cell culture, brain slice, cell lines
  • Assays for cell death / neuroprotection  / viability

Collaborations

1)      Within Aberdeen University:

Prof Gernot Riedel (animal models / behaviour); Prof Roger Pertwee (cannabinoids); Prof Matteo Zanda (novel PET ligands); Dr Rod Scott  & Prof Marcel Jaspars (natural toxins and cell transfection); Dr Derryck Shewan (neurite outgrowth / time lapse); Prof Andy Welch (PET/CT); Dr Hugh Seton (MRI); Dr Thiel, Dr Schelter & Prof Grebogi (Computer Science & Modelling); Dr Delibegovic & Dr Mody (phosphatases; diabetes and AD)

2)      External Collaborators:

Prof Peer Wulff (viral strategies); Prof Jim Austin (University of York): EEG and image analyses, data sharing; Prof. Thanos Salifoglou (University of Crete, Greece): Aluminium speciation and toxicity; Prof. J. Micheau (Univ. Bordeaux II): CREB and hippocampal function, cell transfection, siRNA; Dr. Grazina Niewadomska (Univ. Warsaw, Poland): Tau pathology; Dr K. Bruce (U Penn., USA) and Dr Neel (U Ontario): Phosphatase knock-out mice.

3)      Industry-based collaborators

Dr Karsten Wicke (Abbott / AbbVie), B Cruts (BrainMarker, The Netherlands), Dr Hong Wan (Pfizer), J McAvoy (Cybula) and Prof Hugh Marston (Lilly).

Teaching

Courses

Teaching Responsibilities

Course co-ordinator for AN4002/AN4003 (Brain function & malfunction)

Publications

Page 2 of 3 Results 51 to 100 of 114

  • 18f-labelled barbiturate compounds for use as positron emission imaging agents

    Greig, I. R., Zanda, M., Platt, B., Calamai, E.
    Patents: Patents

  • BACE1: The missing link between Alzheimer’s disease, diabetes and obesity?

    Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G., Platt, B.
    Alzheimer Research UK
    Contributions to Conferences: Posters

  • Store-operated Ca(2+) entry in hippocampal neurons: regulation by protein tyrosine phosphatase PTP1B

    Koss, D. J., Riedel, G., Bence, K., Platt, B.
    Cell Calcium, vol. 53, no. 2, pp. 125-138
    Contributions to Journals: Articles

  • 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

    Calamai, E., Dall'Angelo, S., Koss, D., Domarkas, J., McCarthy, T. J., Mingarelli, M., Riedel, G., Schweiger, L. F., Welch, A. E., Platt, B., Zanda, M.
    Chemical Communications, vol. 49, no. 8, pp. 792-794
    Contributions to Journals: Articles

  • Social Transmission of Food Preference in C57BL/6 mice

    Plucinska, K., Robinson, L., Peters, D., Platt, B., Riedel, G.
    Measuring Behaviour
    Contributions to Conferences: Posters

  • Generation and characterization of a novel BACE1 knock-in mouse, PLB4

    Plucinska, K., Platt, B., Riedel, G.
    Alzheimer Research UK (2012)
    Contributions to Conferences: Posters

  • Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

    Deiana, S., Watanabe, A., Yamasaki, Y., Amada, N., Arthur, M., Fleming, S., Woodcock, H., Dorward, P., Pigliacampo, B., Close, S., Platt, B., Riedel, G.
    Psychopharmacology, vol. 219, no. 3, pp. 859-873
    Contributions to Journals: Articles

  • Inference of Granger causal time-dependent influences in noisy multivariate time series

    Sommerlade, L., Thiel, M., Platt, B., Plano, A., Riedel, G., Grebogi, C., Timmer, J., Schelter, B. O.
    Journal of Neuroscience Methods, vol. 203, no. 1, pp. 173-185
    Contributions to Journals: Articles

  • A pilot study into the effects of the CB1 cannabinoid receptor agonist, WIN55,212-2 or the antagonist/inverse agonist AM251 on sleep in rats

    Goonawardena, A. V., Plano, A., Robinson, L., Platt, B., Hampson, R. E., Riedel, G.
    Sleep Disorders, vol. 2011, 178469
    Contributions to Journals: Articles

  • Cholinomimetic actions of memantine on learning and hippocampal plasticity

    Drever, B., Anderson, W., Johnson, H., O'Callaghan, M., Seo, S., Choi, D. Y., Riedel, G., Platt, B.
    Handbook of Animal Models in Alzheimer's Disease, pp. 297-316, 20 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1

    Platt, B., Drever, B., Koss, D., Stoppelkamp, S., Jyoti, A., Plano, A., Utan, A., Merrick, G., Ryan, D., Melis, V., Wan, H., Mingarelli, M., Porcu, E., Scrocchi, L., Welch, A., Riedel, G.
    PloS ONE, vol. 6, no. 11, e27068
    Contributions to Journals: Articles

  • Acetylcholine: Future research and perspectives

    van der Zee, E., Platt, B., Riedel, G.
    Behavioural Brain Research, vol. 221, no. 2, pp. 583-586
    Contributions to Journals: Articles

  • Involvement of the cholinergic system in conditioning and perceptual memory

    Robinson, L., Platt, B., Riedel, G.
    Behavioural Brain Research, vol. 221, no. 2, pp. 443-465
    Contributions to Journals: Articles

  • The cholinergic system, EEG and sleep

    Platt, B., Riedel, G.
    Behavioural Brain Research, vol. 221, no. 2, pp. 499-504
    Contributions to Journals: Articles

  • FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

    Platt, B., Welch, A., Riedel, G.
    Biochemical Society Transactions, vol. 39, no. 4, pp. 874-880
    Contributions to Journals: Articles

  • The cholinergic system and hippocampal plasticity

    Platt, B., Drever, B. D., Riedel, G.
    Behavioural Brain Research, vol. 221, no. 2, pp. 505-514
    Contributions to Journals: Articles

  • Genetic differences in anxiety-like behaviour in mice: 5 strain comparison

    Plucinska, K., Platt, B., Riedel, G.
    Scottish Neuroscience Group Meeting (2011)
    Contributions to Conferences: Posters

  • Acetylcholine has mulitple facets in brain function and disease

    Riedel, G., Platt, B., van der Zee, E.
    Behavioural Brain Research, vol. 221, pp. 333
    Contributions to Journals: Articles

  • CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases

    Williamson, R., van Aalten, L., Mann, D. M. A., Platt, B., Plattner, F., Bedford, L., Mayer, J., Howlett, D., Usardi, A., Sutherland, C., Cole, A. R.
    Journal of Alzheimer's Disease, vol. 27, no. 3, pp. 615-625
    Contributions to Journals: Articles

  • Multivariate Analysis of Dynamical Processes with Applications to the Neurosciences

    Schelter, B., Sommerlade, L., Platt, B., Plano, A., Thiel, M., Timmer, J.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

  • Multivariate Analysis of Dynamical Processes with applications in the Neurosciences

    Schelter, B., Sommerlade, L., Platt, B., Plano, A., Thiel, M., Timmer, J.
    Contributions to Conferences: Papers

  • Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

    Mody, N., Agouni, A., McIlroy, G., Platt, B., Delibegovic, M.
    Diabetologia, vol. 54, no. 8, pp. 2143-2151
    Contributions to Journals: Articles

  • The Cholinergic system and spatial learning

    Deiana, S., Platt, B., Riedel, G.
    Behavioural Brain Research, vol. 221, pp. 389-411
    Contributions to Journals: Articles

  • Culturing conditions determine neuronal and glial excitability

    Stoppelkamp, S., Riedel, G., Platt, B.
    Journal of Neuroscience Methods, vol. 194, no. 1, pp. 132-138
    Contributions to Journals: Articles

  • EEG, activity, and sleep architecture in a transgenic AβPPSWE/PSEN1A246E Alzheimer's disease mouse

    Jyoti, A., Plano, A., Riedel, G., Platt, B.
    Journal of Alzheimer's Disease, vol. 22, no. 3, pp. 873-887
    Contributions to Journals: Articles

  • Aluminum does not enhance β-amyloid toxicity in rat hippocampal cultures

    Nday, C. M., Drever, B. D., Salifoglou, T., Platt, B.
    Brain Research, vol. 1352, pp. 265-276
    Contributions to Journals: Articles

  • Aluminium interferes with hippocampal calcium signaling in a species-specific manner

    Nday, C. M., Drever, B. D., Salifoglou, T., Platt, B.
    Journal of Inorganic Biochemistry, vol. 104, no. 9, pp. 919-927
    Contributions to Journals: Articles

  • WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R., Platt, B., Riedel, G.
    Behavioural Brain Research, vol. 208, no. 2, pp. 584-592
    Contributions to Journals: Articles

  • Bi-directional alterations of LTP after acute homocysteine exposure

    Christie, L. A., Riedel, G., Platt, B.
    Behavioural Brain Research, vol. 205, no. 2, pp. 559-563
    Contributions to Journals: Articles

  • Scopolamine-induced deficits in social memory in mice: Reversal by donepezil

    Riedel, G., Kang, S. H., Choi, D. Y., Platt, B.
    Behavioural Brain Research, vol. 204, no. 1, pp. 217-225
    Contributions to Journals: Articles

  • Sleep and hippocampus: Do we search for the right things?

    Brankačk, J., Platt, B., Riedel, G.
    Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 5, pp. 806-812
    Contributions to Journals: Review articles

  • Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons

    Koss, D. J., Riedel, G., Platt, B.
    Cell Calcium, vol. 46, no. 1, pp. 39-48
    Contributions to Journals: Articles

  • Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

    Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B., Robinson, L.
    British Journal of Pharmacology, vol. 156, no. 7, pp. 1154-1166
    Contributions to Journals: Articles

  • Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels

    Ryan, D., Drysdale, A. J., Lafourcade, C., Pertwee, R. G., Platt, B.
    Journal of Neuroscience, vol. 29, no. 7, pp. 2053-2063
    Contributions to Journals: Articles

  • The seed extract of Cassia obtusifolia offers neuroprotection to mouse hippocampal cultures

    Drever, B. D., Anderson, W. G. L., Riedel, G., Kim, D. H., Ryu, J. H., Choi, D., Platt, B.
    Journal of Pharmacological Sciences, vol. 107, no. 4, pp. 380-392
    Contributions to Journals: Articles

  • Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

    Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B., Riedel, G.
    Psychopharmacology, vol. 198, no. 4, pp. 551-563
    Contributions to Journals: Articles

  • Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

    Park, H., Min, K., Kwak, H., Koo, K. D., Lim, D., Seo, S., Choi, J., Platt, B., Choi, D.
    Bioorganic & Medicinal Chemistry, vol. 18, no. 9, pp. 2900-2904
    Contributions to Journals: Articles

  • Memantine acts as a cholinergic stimulant in the mouse hippocampus

    Drever, B. D., Anderson, W. G., Johnson, H. L., O'Callaghan, M., Seo, S., Choi, D., Riedel, G., Platt, B.
    Journal of Alzheimer's Disease, vol. 12, no. 4, pp. 319-333
    Contributions to Journals: Articles

  • Dissociation of cholinergic function in spatial and procedural learning in rats

    Roloff, E. V., Harbaran, D. V., Micheau, J., Platt, B., Riedel, G.
    Neuroscience, vol. 146, no. 3, pp. 875-889
    Contributions to Journals: Articles

  • Differential toxicity of novel aluminium compounds in hippocampal culture

    Platt, B., Drysdale, A. J., Nday, C., Roloff, E. V., Drever, B. D., Salifoglou, A.
    Neurotoxicology, vol. 28, no. 3, pp. 576-586
    Contributions to Journals: Articles

  • A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones

    Koss, D. J., Hindley, K. P., David, K. C., Mancini, I., Guella, G., Sepčić, K., Turk, T., Rebolj, K., Riedel, G., Platt, B., Scott, R. H.
    BMC Pharmacology, vol. 7, 1
    Contributions to Journals: Articles

  • Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

    Ryan, D., Drysdale, A. J., Pertwee, R. G., Platt, B.
    Neuroscience Letters, vol. 408, no. 3, pp. 236-241
    Contributions to Journals: Articles

  • Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease

    Platt, B.
    Journal of Alzheimer's Disease, vol. 10, no. 2-3, pp. 203-213
    Contributions to Journals: Articles

  • Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

    Drysdale, A. J., Ryan, D., Pertwee, R. G., Platt, B.
    Neuropharmacology, vol. 50, no. 5, pp. 621-631
    Contributions to Journals: Articles

  • Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity

    Algaidi, S. A., Christie, L., Jenkinson, A. M., Whalley, L. J., Riedel, G., Platt, B.
    Experimental Neurology, vol. 197, no. 1, pp. 8-21
    Contributions to Journals: Articles

  • Enhanced hippocampal long-term potentiation in rats after chronic exposure to homocysteine

    Christie, L. A., Riedel, G., Algaidi, S. A., Whalley, L. J., Platt, B.
    Neuroscience Letters, vol. 373, no. 2, pp. 119-124
    Contributions to Journals: Articles

  • Cannabinoids: mechanisms and therapeutic applications in the CNS

    Drysdale, A. J., Platt, B.
    Current Medicinal Chemistry, vol. 10, no. 24, pp. 1241-1253
    Contributions to Journals: Articles

  • Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels

    White, A. M., Kylanpaa, R. A., Christie, L. A., McIntosh, S. J., Irving, A. J., Platt, B.
    British Journal of Pharmacology, vol. 140, no. 8, pp. 1421-1433
    Contributions to Journals: Articles

  • Glutamate receptor function in learning and memory

    Riedel, G., Platt, B., Micheau, J.
    Behavioural Brain Research, vol. 140, no. 1-2, pp. 1-47
    Contributions to Journals: Articles

  • Sometimes you see them, sometimes you don't: IPSCs in the rat superficial superior colliculus

    Edwards, M. D., Platt, B.
    Experimental Brain Research, vol. 149, no. 3, pp. 331-339
    Contributions to Journals: Articles
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