Dr Fiona Campbell

Dr Fiona Campbell
Dr Fiona Campbell
Dr Fiona Campbell

Advanced Research Fellow

About

Biography

I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.

 

External Memberships

Member of the Nutrition Society,

Member of Biochemical Society,

Member of British Society for Proteome Resarch (BSPR).

Latest Publications

View My Publications

Research

Research Overview

A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.

Current Research

Current research in my laboratory is focused on  investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.

During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia.  We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.

In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.

This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.

This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies. 

Teaching

Teaching Responsibilities

Programme coordinator for MSc Human Nutrition

Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.

Publications

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  • Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta

    Campbell, F. M., Dutta-Roy, A. K.
    Biochemical Society Transactions, vol. 24, no. 2, pp. 249S
    Contributions to Journals: Articles
  • Platelet membrane glycoprotein IV (CD36) is involved in arachidonic acid induced-platelet aggregation

    Dutta-Roy, A. K., Crosbie, L., Gordon, M. J., Campbell, F. M.
    Biochemical Society Transactions, vol. 24, no. 2, pp. 167S
    Contributions to Journals: Articles
  • alpha-Tocopherol-binding protein in the cytosol of the human placenta

    Gordon, M. J., Campbell, F. M., Dutta-Roy, A. K.
    Biochemical Society Transactions, vol. 24, no. 2, pp. 202S
    Contributions to Journals: Articles
  • Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes

    Campbell, F. M., Gordon, M. J., DuttaRoy, A. K.
    Molecular & Cellular Biochemistry, vol. 155, no. 1, pp. 77-83
    Contributions to Journals: Articles
  • Arachidonic acid uptake by human platelets is mediated by CD36

    DuttaRoy, A. K., Gordon, M. J., Campbell, F. M., Crosbie, L.
    Platelets, vol. 7, no. 5-6, pp. 291-295
    Contributions to Journals: Articles
  • Plasma-membrane fatty-acid-binding protein (FABP(PM)) is exclusively located in the maternal facing membranes of the human placenta

    Campbell, F. M., Duttaroy, A. K.
    FEBS Letters, vol. 375, no. 3, pp. 227-230
    Contributions to Journals: Articles
  • Plasma-membrane fatty-acid-binding protein in human placenta-identification and characterization

    Campbell, F. M., Taffesse, S., Gordon, M. J., Duttaroy, A. K.
    Biochemical and Biophysical Research Communications, vol. 209, no. 3, pp. 1011-1017
    Contributions to Journals: Articles
  • Characterization of a novel alpha-tocopherol-binding-protein from bovine heart cytosol

    Gordon, M. J., Campbell, F. M., Duthie, G. G., Dutta-Roy, A. K.
    Archives of Biochemistry and Biophysics, vol. 318, no. 1, pp. 140-146
    Contributions to Journals: Articles
  • Vitamin-E requirements, transport, and metabolism: role of alpha-tocopherol-binding proteins

    Duttaroy, A. K., Gordon, M. J., Campbell, F. M., Duthie, G. G., James, W. P. T.
    The Journal of Nutritional Biochemistry, vol. 5, no. 12, pp. 562-570
    Contributions to Journals: Literature Reviews
  • Plasma-membrane fatty-acid-binding protein (FABP(PM)) of the sheep placenta

    Campbell, F. M., Gordon, M. J., Duttaroy, A. K.
    Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, vol. 1214, no. 2, pp. 187-192
    Contributions to Journals: Articles
  • Identification and partial characterization of Fatty-Acid-Binding Sites in Sheep Placental Membranes

    Campbell, F. M., Gordon, M. J., Dutta-Roy, A. K.
    Biochemical Society Transactions, vol. 22, no. 2, pp. S117
    Contributions to Journals: Articles
  • Identification of a low molecular mass (14.2 kDa) a-tocopherol-binding protein in the cytosol of rat liver and heart

    Duttaroy, A. K., Leishman, D. J., Gordon, M. J., Campbell, F. M., Duthie, G. G.
    Biochemical and Biophysical Research Communications, vol. 196, no. 3, pp. 1108-1112
    Contributions to Journals: Articles
  • A low molecular weight (12-15kDa) protein fraction in rat liver binds alpha-tocopherol

    Leishman, D. J., Campbell, F. M., Gordon, M. J., Duthie, G. G., Dutta-Roy, A. K.
    Biochemical Society Transactions, vol. 21, no. 4, pp. 408S
    Contributions to Journals: Abstracts
  • Alpha-Tocopherol-Binding Protein in Bovine Heart Cytosol

    Gordon, M. J., Campbell, F. M., Duthie, G. G., Dutta-Roy, A. K.
    The FASEB Journal, vol. 7, no. 3
    Contributions to Journals: Abstracts
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