- Further Info
In our research we are investigating how different foods and their constituents inform fullness and satiety to the brain. The objectives are to identify how cells of the gut respond differently to different nutrients, so that we may be able to recommend and inform food formulations for optimal health and weight management. We are also interested in signals that drive seasonal models to alter their body weight dramatically in response to photoperiod change, since the genes involved may encode neuropeptides or receptors that have potential relevance to human energy balance and thus may be therapeutic targets for weight loss. Currently this part of our work is focussed on vitamin A signalling in the hypothalamus. We use molecular biology approaches including microarray, Next Generation Sequencing and in situ hybridization to identify target genes and exploit novel in vivo siRNA, agonist/antagonist or antibody delivery in techniques aimed at addressing functional responses.