Dr Alexander Ross
In our research we are investigating how different foods and their constituents inform fullness and satiety to the brain. The objectives are to identify how cells of the gut and liver respond differently to different nutrients, and also how these nutrients may differentially affect metabolism to promote improved health. We are also interested in how diet-induced differences in the gut microbiome may alter host metabolism and health. The research results should provide evidence which, after validation in human trials, may be released as advice to the general public, or as product formulation advice to the food or drug industry aimed at healthy weight management.
We use molecular biology and biochemical approaches including Next Generation Sequencing, Real-time PCR, in situ hybridization and Western blotting to identify target genes and exploit novel in vivo agonist/antagonist or antibody delivery in techniques aimed at addressing functional responses.
Lynn Thomson - Research assistant
Karen Hislop - Research assistant
Swang Shallangwa - PhD student
Funding and Grants
Biotechnology and Biological Science Research Council (BBSRC) grant number BB/K001043/1 entitled: Inflammatory signals regulate neuroendocrine control of growth and energy balance through re-modelling of mammalian hypothalamus.
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Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3NScientific Reports, vol. 8, 15648Contributions to Journals: Articles
Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in MiceCell Reports, vol. 21, no. 6, pp. 1521-1533Contributions to Journals: Articles
Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasisBrain Structure and Function, vol. 221, no. 6, pp. 3315-3326Contributions to Journals: Articles
A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balanceScientific Reports, vol. 6, 26830Contributions to Journals: Articles
Effects of Dietary Fibre (Pectin) and/or Increased Protein (Casein or Pea) on Satiety, Body Weight, Adiposity and Caecal Fermentation in High Fat Diet-Induced Obese RatsPloS ONE, vol. 11, no. 5, e0155871Contributions to Journals: Articles
Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese RatsPloS ONE, vol. 10, no. 10, e0140392Contributions to Journals: Articles
Photoperiod Regulates Lean Mass Accretion, but Not Adiposity, in Growing F344 Rats Fed a High Fat DietPloS ONE, vol. 10, no. 3, 0119763Contributions to Journals: Articles
Photoperiodic effects on seasonal physiology, reproductive status and hypothalamic gene expression in young male F344 ratsJournal of Neuroendocrinology, vol. 27, no. 2, pp. 79-87Contributions to Journals: Articles
Dose-dependent effects of a soluble dietary fibre (pectin) on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in ratsPloS ONE, vol. 10, no. 1, 0115438Contributions to Journals: Articles
A Thyroid Hormone Challenge in Hypothyroid Rats Identifies T3 Regulated Genes in the Hypothalamus and in Models with Altered Energy Balance and Glucose HomeostasisThyroid : official journal of the American Thyroid Association, vol. 24, no. 11, pp. 1575-1593Contributions to Journals: Articles