Professor Marcel Jaspars
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Professor Marcel Jaspars
FRSE, FRSC, CChem, BA Hons (Cantab), PhD (Dublin), ScD (Cantab)
Chair in Chemistry
- About
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Meston Building Room G21
Biography
Previous Positions
- Head of the Department of Chemistry, University of Aberdeen 2016-2019
- Scientific Project Leader of the EU FP7 Project ‘PharmaSea’ (€ 9.5 M, 24 partners from 14 countries) 2012-2017
- Visiting Professor for Senior International Scientists of the Chinese Academy of Sciences 2012-2013
- Visiting Professor (20%) at the University of Tromsø, Norway to provide advice for their £14 M marine biodiscovery programme. 2007-2017
- Sabbatical at the Australian Institute of Marine Science, 2004
- Professor of Organic Chemistry, University of Aberdeen, 2003-
- Senior Lecturer in Organic Chemistry, University of Aberdeen, 2000-2003
- Lecturer in Organic Chemistry, University of Aberdeen, 1995-2000
- Post-Doc, Crews Lab, University of California, Santa Cruz, 1993-1995
- Post-Doc, Burgess Lab, Texas A & M University, 1992-1993
Qualifications
- BA Hons (Cantab) Natural Sciences (Chemistry)1987 - University of Cambridge
- PhD Organic Chemistry1992 - Trinity College, DublinElectrophilic Catalysis of the Sakurai Reaction
- ScD (Cantab) Organic Chemistry2018 - University of CambridgeInvestigating the Chemical Structures, Bioactivity and Biosynthesis of Marine and Desert Natural Products
External Memberships
On the scientific advisory board for the EU Horizon 2020 ATLAS Project (Coordinator, Murray Roberts, University of Edinburgh) 2018-
Co-lead of the Deep Sea Genetic Resources Working Group of the Deep Ocean Stewardship Initiative. 2018-
On the Scientific Advisory Board of the Center for Microbial Secondary Metabolites, Danish Technical University, Copenhagen, Denmark 2018-
Management board of NPRONET, a BBSRC network in industrial biotechnology and biosciences. 2014-2018
Governing board member of Industrial Biotechnology Innovation Centre, Strathclyde 2014-2016
Policy Work:
Contributing author to “Science in Small Island Developing States: Capacity Challenges and Options relating to Marine Genetic Resources of Areas Beyond National Jurisdiction”
Co-author of Blue Paper on the Ocean Genome for the High Level Panel for a Sustainable Ocean Economy 2020
Co-author of study for the United Nations Convention on Biological Diversity on Digital Sequence Information on Genetic Resources: Concept, Scope and Current Use. CBD/DSI/AHTEG/2020/1/3 2020
Special advisor on Marine Genetic Resources to the International Union for the Conservation of Nature at the United Nations process on the Conservation and Sustainable Use of Biodiversity of Areas Beyond National Jurisdiction. 2019-
Member of Royal Society working group writing a policy briefing for the Government Office of Science entitled “Future Ocean Resources: Metal-Rich Minerals and Genetics” Released July 2017.
Chair of advisory panel of policy and legal experts (Part of the PharmaSea EU FP7 consortium lead by Marcel Jaspars 2012-17) bringing together policymakers (United Nations, European Commission) with NGOs (International Union for the Conservation of Nature, Convention on Biodiversity Secretariat, International Seabed Authority) with international marine biotechnology companies and academic and legal/policy experts to shape the policy debate on intellectual property derived from marine genetic resources in areas beyond national jurisdiction (United Nations process on the Conservation and Sustainable Use of Biodiversity of Areas Beyond National Jurisdiction). Contributions recorded on our BBNJ Page and our Song of the Ocean page
UK member of the Marine Biotechnology working group of the European Science Foundation’s Marine Board Marine Biotechnology Working Group to assist in the revision of the White Paper “Marine Biotechnology – A European Strategy” 2009-2010
Prizes and Awards
Biotechnology and Biological Sciences Research Council Research Development Fellow, 2006-2009
American Society of Pharmacognosy Matt Suffness Award for young investigators, 2003
Fellow of the Royal Society of Chemistry, Chartered Chemist
Fellow of the Royal Society of Edinburgh
- Research
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Research Overview
Tour the lab and find out what we do
Introduction:
My research involves the discovery of new compounds with potential pharmaceutical use from marine and desert environments, their structure determination and biosynthesis. Translation of bioactive natural compounds into preclinical evaluation is exemplified by with sponge derived compounds/analogues that have activity in animal models for Alzheimer’s disease or epilepsy or are able to deliver proteins into animal brains to generate a model of Alzheimer’s disease.
Natural Product Structure Determination:
Structural work involves the use of complementary NMR and theoretical methods to solve the relative stereochemistry of complex natural products, particularly the use of NOE data to constrain conformational searches and the comparison of predicted and experimental CD spectra. A combination of analytical and spectroscopic methods was used to define a metal complex present in the extract of a seasquirt, giving insight into its ecological role.Together with Leo Gross at IBM Research, I started original work on organic structure determination using a combination of spectroscopy and atomic force microscopy (AFM). First we showed how Ångstrom-resolution AFM images may be used to solve the structure of a simple planar molecule and how this process might be generalised. Subsequently we applied the combined methods to an unknown molecule with a NMR silent region (no H atoms). In a book chapter, we propose the developments needed so that AFM may become invaluable in the rapid structure determination of complex organic molecules in the future.
Biosynthesis:
The isolation and structural characterisation of modified cyclic peptides of marine origin was driven by an interest in their chemical structure in solution and their interaction with metal ions. A major problem with these bioactive cyclic compounds was a sustainable supply. In 2004, I worked together with Dr Paul Long at the London School of Pharmacy and scientists from the Australian Institute of Marine Science to effect the first shotgun cloning of the patellamide biosynthetic pathway resulting in low level production of these compounds.Subsequent collaboration with Professor Jim Naismith at St Andrews succeeded in overexpressing and structurally characterising the main enzymes involved in the biosynthesis of the patellamides and related cyanobactins. Working together, we defined the main proteases involved including the macrocyclase that circularises a linear peptide without inclusion of a signal sequence, thus making it a very exciting prospect for biotechnological application. We have defined a unique enzyme that forms the heterocycles – the first crystal structure of this type of enzyme. Engineering of this enzyme allowed short synthetic peptide sequences to be processed to form heterocycles in the chain. These enzymes are extremely permissive, and natural and non-natural substrates can be processed using them resulting in the formation milligram quantities of complex, modified cyclic peptides. The starting sequences may include non-natural amino acids and even non-amino acid segments such as fatty acids, aromatics and sugars, with a minimum of three residues required for this to work.
Spinout Company - GyreOx Therapeutics
GyreOx uses an automated chemoenzymatic process to design compounds to treat complex diseases to hit ‘undruggable’ targets. The GyreOx combination of computational design, automation and unique engineered enzymes allows them to deliver novel drugs in the chemical space beyond the 'rule of 5'. Focussed library design enables better compound-target interaction and the tuning of important drug properties. No other technology offers GyreOx's degree of flexibility in design and production.
The company was founded in late 2019 together with Prof Jim Naismith at the University of Oxford and Dr Bill Primrose, Entrepreneur, with funding from Innovate UK and other investors.
Research Areas
Chemistry
MARBLES EU Project
Harnessing marine microbes for drug discovery and sustainable production of fish and crops
Knowledge Exchange
Policy Work:
Protecting the Oceans Using Chemistry
Professor Marcel Jaspars has been advising the UN to develop a new law to protect marine biodiversity. The UN is working to conserve and sustainably use marine biodiversity in areas beyond national jurisdiction – about 60% of the oceans and 40% of the entire planet. The Song of the Oceans brings together science, the arts and humanities to publicise the urgent need to conserve the oceans.
Policy Input
Marcel provided scientific leadership for a large EU FP7 consortium ‘PharmaSea’, running from 2012-2017 with the contribution of 24 partners from 14 countries. Part of this project was to engage with stakeholders, NGOs and policy makers to provide sound scientific advice on major issues affecting the conservation and sustainable use of marine biodiversity. His major role was to translate scientific information and provide options on this topic to senior policy makers at the EU and UN, making visits to Brussels and New York to present information in a digestible format and answer questions, paying particular attention to the legal and policy requirements.
Marcel has been active at national and international levels to develop the science, its applications/industrial uptake and associated policy involved in marine biodiscovery and biotechnology. Since 2014 Marcel has been involved in the BBNJ process, providing scientific input and co-authoring the Mare Geneticum proposal which provides building blocks based on good scientific practice towards a solution for the MGR aspects of the BBNJ process. Also see our work to bring this to a wider audience with our 'Song of the Oceans'.
At EU level he was involved in coordinating the authoring the health section of a European Science Foundation position paper on the Future of Marine Biotechnology informing the blue growth agenda of the European Commission through a number of concrete and measurable recommendations. In 2017 he was a member of the UK Marine Foresight Committee’s Royal Society Working group that wrote a report entitled ‘Future Ocean Resources: Metal-Rich Minerals and Genetics’ on the UN BBNJ issue and he has since provided advice on this topic to the UK’s Foreign and Commonwealth Office. More recently he was a co-author on a report on the Ocean Genome for the High Level Panel for a Sustainable Ocean Economy and a lead author on a study for the United Nations Convention on Biological Diversity on Digital Sequence Information on Genetic Resources: Scope, Concept and Current Use.
Marcel Jaspars speaking at UN HQ in New York as advisor to the International Union for the Conservation of Nature at the Second Intergovernmental Conference on the UN process on the Conservation and Sustainable Use of Biodiversity in Areas Beyond National Jurisdiction
- Teaching
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Courses
Non-course Teaching Responsibilities
Professor Jaspars is:
Year 3 Coordinator
Erasmus Officer for Chemistry
Coordinator for SX3002 'Science and Society'
- Publications
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Page 1 of 3 Results 1 to 100 of 248
Arabinofuranosyl Thymine Derivatives—Potential Candidates against Cowpox Virus: A Computational Screening Study
International Journal of Molecular Sciences, vol. 24, no. 2, 1751Contributions to Journals: ArticlesAntiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria
Antibiotics, vol. 12, no. 1, 109Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/antibiotics12010109
- [ONLINE] https://www.mdpi.com/2079-6382/12/1/109
Digyalipopeptide A, an antiparasitic cyclic peptide from the Ghanaian Bacillus sp. strain DE2B.
Beilstein journal of organic chemistry, vol. 18, pp. 1763-1771Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3762/bjoc.18.185
Can Crude Oil Exploration Influence the Phytochemicals and Bioactivity of Medicinal Plants? A Case of Nigerian Vernonia amygdalina and Ocimum gratissimum
Molecules, vol. 27, no. 3, 8372Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/molecules27238372
Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore Study
International Journal of Molecular Sciences, vol. 23, no. 22, 14287Contributions to Journals: ArticlesMutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert
Molecules, vol. 27, no. 21, pp. 7185Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/molecules27217185
- [ONLINE] https://www.mdpi.com/1420-3049/27/21/7185
A structure-activity relationship analysis of anthraquinones with antifouling activity against marine biofilm-forming bacteria
Frontiers in Natural Products, vol. 1, 990822Contributions to Journals: ArticlesWhat Should We Mean by ‘Open Access’?
Access and Benefit Sharing of Genetic Resources. Lawson, C., Humphries, F., Rourke, M. (eds.). Routledge, 23 pagesChapters in Books, Reports and Conference Proceedings: ChaptersThe Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study.
Molecules, vol. 27, no. 18Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/molecules27186016
Metabolic Profiling of Inga Species with Antitumor Activity.
Molecules, vol. 27, no. 15, 4695Contributions to Journals: ArticlesInhibition of the Quorum Sensing System, Elastase Production and Biofilm Formation in Pseudomonas aeruginosa by Psammaplin A and Bisaprasin
Molecules, vol. 27, no. 5, 1721Contributions to Journals: ArticlesBringing access and benefit sharing into the digital age
Plants people planet, vol. 4, no. 1, pp. 5-12Contributions to Journals: ArticlesIsolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B
Beilstein journal of organic chemistry, vol. 17, pp. 2390-2398Contributions to Journals: ArticlesDermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1 T
Marine Drugs, vol. 19, no. 6, e325Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/md19060325
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16688/1/marinedrugs-19-00325-v2.pdf
Marine Genetic Resources in Areas Beyond National Jurisdiction: Promoting Marine Scientific Research and Enabling Equitable Benefit Sharing
Frontiers in Marine Science, vol. 8, 667274Contributions to Journals: Review articlesTraceability Approaches for Marine Genetic Resources Under the Proposed Ocean (BBNJ) Treaty
Frontiers in Marine Science, vol. 8, 661313Contributions to Journals: ArticlesBiotechnological and Ecological Potential of Micromonospora provocatoris sp. nov., a Gifted Strain Isolated from the Challenger Deep of the Mariana Trench
Marine Drugs, vol. 19, no. 5, 243Contributions to Journals: ArticlesAntiviral drug discovery: preparing for the next pandemic
Chemical Society Reviews, vol. 50, no. 6, pp. 3647-3655Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/d0cs01118e
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15878/1/d0cs01118e.pdf
- [ONLINE] View publication in Scopus
Combining Intellectual Property, Trade Secrets, Science and an Ecosystem-Focused Approach
Marine Biodiversity of Areas beyond National Jurisdiction. Nordquist, M., Long, R. (eds.). Brill, pp. 97-130, 34 pagesChapters in Books, Reports and Conference Proceedings: ChaptersIron-meditated fungal starvation by lupine rhizosphere-associated and extremotolerant Streptomyces sp. S29 desferrioxamine production
Molecular Omics, vol. 17, no. 1, pp. 95-107Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/D0MO00084A
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15611/2/Jarmush_etal_Iron_meditated_fungal_VOR.pdf
- [ONLINE] View publication in Scopus
Unlocking the potential of marine biodiscovery
Natural Product Reports, vol. 38, no. 7, pp. 1235-1242Contributions to Journals: ArticlesA tiered approach to the marine genetic resource governance framework under the proposed UNCLOS agreement for biodiversity beyond national jurisdiction (BBNJ)
Marine Policy, vol. 122, 103910Contributions to Journals: ArticlesWhole genome sequencing of four bacterial strains from South Shetland Trench revealing biosynthetic and environmental adaptation gene clusters
Marine Genomics, vol. 54, 100782Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.margen.2020.100782
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16889/1/Manuscript.pdf
- [ONLINE] View publication in Scopus
Cutting the Gordian knot: early and complete amino acid sequence confirmation of class II lasso peptides by HCD fragmentation
The Journal of antibiotics, vol. 73, pp. 772-779Contributions to Journals: ArticlesAntiparasitic Activity of Bromotyrosine Alkaloids and New Analogues Isolated from the Fijian Marine Sponge Aplysinella rhax
Chemistry & Biodiversity, vol. 17, no. 10, 2000335Contributions to Journals: ArticlesIntellectual Property Rights: Implications for Deep-Ocean Stewardship
Contributions to Specialist Publications: ReportsNovel South African Rare Actinomycete Kribbellaspeibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners
Molecules, vol. 25, no. 13, 2979Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/molecules25132979
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14708/1/molecules_25_02979_v2_1.pdf
- [ONLINE] View publication in Scopus
A cell-based assay system for activators of the environmental cell stress response
Analytical Biochemistry, vol. 592, 113583Contributions to Journals: ArticlesWhole Genome Sequence of Dermacoccus abyssi MT1.1 Isolated from the Challenger Deep of the Mariana Trench Reveals Phenazine Biosynthesis Locus and Environmental Adaptation Factors
Marine Drugs, vol. 18, no. 3, 131Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/md18030131
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13857/1/Abdel_Mageed_WholeGenomeSequence_VOR.pdf
- [ONLINE] View publication in Scopus
Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide
Molecules, vol. 25, no. 4, 922Contributions to Journals: ArticlesDownsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle
Journal of Organic Chemistry, vol. 85, no. 3, pp. 1661-1667Contributions to Journals: ArticlesBenefit sharing: combining intellectual property, trade secrets, science and an ecosystem focussed approach
Working Papers: Working PapersMS Dereplication for Rapid Discovery of Structurally New or Novel Natural Products
Marine Drugs, vol. 18, no. 40, pp. 56-57Contributions to Journals: Articles- [ONLINE] http://clok.uclan.ac.uk/31403/
- [ONLINE] DOI: https://doi.org/10.3390/md18010040
Heterologous expression of a cryptic gene cluster from Streptomyces leeuwenhoekii C34T yields a novel lasso peptide, leepeptin
Applied and Environmental Microbiology, vol. 85, no. 23, e01752-19Contributions to Journals: ArticlesPaenidigyamycin g: 1-acetyl-2,4-dimethyl-3-phenethyl-1H-imidazol-3-ium
MolBank, vol. 2019, no. 4, M1094Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.3390/M1094
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13483/1/Molbank_PaenidigyamycinG_VOR.pdf
- [ONLINE] View publication in Scopus
Inclusive innovation: Enhancing global participation in and benefit sharing linked to the utilization of marine genetic resources from areas beyond national jurisdiction
Marine Policy, vol. 109, 103696Contributions to Journals: ArticlesDigyaindoleacid A: 2-(1-(4-hydroxyphenyl)-3-oxobut-1-en-2-yloxy)-3-(1H-indol-3-yl)propanoic acid, a novel indole alkaloid
MolBank, vol. 2019, no. 3, pp. 1-10Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/M1080
- [ONLINE] View publication in Scopus
Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae
Marine Drugs, vol. 17, no. 7, 385Contributions to Journals: Articlesα-D-glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β-D-fructofuranoside]
MolBank, vol. 2019, no. 2, M1066Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/M1066
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13123/1/Kveremeh_ADGlucoyranosyl_VOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Making North-South Collaborations Work: Facilitating Natural Product Drug Discovery in Africa
Africa and the sustainable development goals. Ramutsindela, M., Mickler, D. (eds.). Springer International Publishing AG, pp. 257-266, 10 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-030-14857-7_24
Simplified immunosuppressive and neuroprotective agents based on gracilin A
Nature Chemistry, vol. 11, pp. 342-350Contributions to Journals: Articles- [ONLINE] https://www.ncbi.nlm.nih.gov/pubmed/30903037
- [ONLINE] DOI: https://doi.org/10.1038/s41557-019-0230-0
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
Scientific Reports, vol. 9, 4678Contributions to Journals: ArticlesLegonoxamines A-B, two new hydroxamate siderophores from the soil bacterium, Streptomyces sp. MA37
Tetrahedron Letters, vol. 60, no. 1, pp. 75-79Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tetlet.2018.11.063
- [ONLINE] View publication in Scopus
LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products
Journal of Natural Products, vol. 82, no. 2, pp. 211-220Contributions to Journals: ArticlesHyphenated LC-ICP-MS/ESI-MS identification of halogenated metabolites in South African marine ascidian extracts
South African Journal of Chemistry, vol. 71, no. 1, pp. 111-117Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.17159/0379-4350/2018/v71a14
- [ONLINE] View publication in Scopus
Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian Paenibacillus sp. DE2SH
Marine Drugs, vol. 17, no. 1, 9Contributions to Journals: ArticlesAntibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives
Marine Drugs, vol. 16, no. 10, 355Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.3390/md16100355
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11317/1/marinedrugs_16_00355.pdf
Natural product diversity of actinobacteria in the Atacama Desert
Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, vol. 111, no. 8, pp. 1467-1477Contributions to Journals: ArticlesThe Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
PLoS Pathogens, vol. 14, no. 5, e1006978Contributions to Journals: ArticlesMare Geneticum: Balancing Governance of Marine Genetic Resources in International Waters
International Journal of Marine and Coastal Law, vol. 33, no. 1, pp. 3-33Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1163/15718085-13310030
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10390/1/Mare_Geneticum.pdf
- [ONLINE] View publication in Scopus
Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil
The Journal of antibiotics, vol. 71, pp. 425-431Contributions to Journals: ArticlesZebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A
ACS Chemical Neuroscience, vol. 9, no. 7, pp. 1652-1662Contributions to Journals: ArticlesCyclic Peptides – A Look to the Future
Cyclic Peptides. Koehnke, J., Naismith, J., van der Donk, W. A. (eds.). Royal Society of Chemistry (Great Britain), pp. 340-373, 34 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1039/9781788010153-00340
Bypassing the proline/thiazoline requirement of the macrocyclase PatG
Chemical Communications, vol. 53, no. 91, pp. 12274-12277Contributions to Journals: ArticlesCyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants
Chemical Communications, vol. 53, no. 77, pp. 10656-10659Contributions to Journals: ArticlesDual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation
Frontiers in Microbiology, vol. 8, pp. 1-10Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fmicb.2017.01284
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9041/1/fmicb_08_01284.pdf
Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time
Journal of Natural Products, vol. 80, no. 5, pp. 1370-1377Contributions to Journals: ArticlesA Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize
The Journal of Physical Chemistry Letters, vol. 8, no. 10, pp. 2310-2315Contributions to Journals: ArticlesPseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
Tetrahedron, vol. 73, no. 18, pp. 2633-2637Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tet.2017.03.051
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10213/1/Manuscript_reviewed_JTdocx.docx
- [ONLINE] View publication in Scopus
Increased Biological Activity of Aneurinibacillus migulanus Strains Correlates with the Production of New Gramicidin Secondary Metabolites
Frontiers in Microbiology, vol. 8, pp. 1-11Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fmicb.2017.00517
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8392/3/fmicb_08_00517.pdf
Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil
The Journal of antibiotics, vol. 70, pp. 448-453Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ja.2016.78
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7915/1/Manuscript_JA_22453_Accepted.pdf
Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization
ChemistryOpen, vol. 6, no. 1, pp. 11-14Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1002/open.201600134
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8221/1/Oueis_et_al_2017_ChemistryOpen.pdf
- [ONLINE] View publication in Scopus
Accurate quantification of modified cyclic peptides without the need for authentic standards
Tetrahedron, vol. 72, no. 52, pp. 8603-8609Contributions to Journals: ArticlesNew cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.
Tetrahedron, vol. 72, no. 44, pp. 6929-6934Contributions to Journals: ArticlesStructure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD
Acta Crystallographica Section D: Structural Biology, vol. 72, no. 11, pp. 1174-1180Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2059798316015850
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7736/1/ag5003.pdf
Evaluation of the Antioxidant Activity of the Marine Pyrroloiminoquinone Makaluvamines
Marine Drugs, vol. 14, no. 11, 197Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/md14110197
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7737/1/marinedrugs_makaluvamines.pdf
Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation
Frontiers in Immunology, vol. 7, 452Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fimmu.2016.00452
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7735/1/fimmu_07_00452.pdf
Inside Cover: The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac (Chem. Eur. J. 37/2016)
Chemistry : a European Journal, vol. 22, no. 37, pp. 12946Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/chem.201603742
- [ONLINE] View publication in Scopus
The Catalytic Mechanism of the Marine-Derived Macrocyclase, PATGmac
Chemistry : a European Journal, vol. 22, no. 37, pp. 13089-13097Contributions to Journals: ArticlesEnzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics
Angewandte Chemie International Edition, vol. 55, no. 19, pp. 5842-5845Contributions to Journals: ArticlesIdentification of Spongionella compounds as cyclosporine A mimics
Pharmacological Research, vol. 107, pp. 407-414Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.phrs.2016.03.029
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8589/1/Manuscript.doc
Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica)
Marine Drugs, vol. 14, no. 5, pp. 1-14Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/md14050083
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6149/1/marinedrugs_14_00083.pdf
A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway
Angewandte Chemie International Edition, vol. 55, no. 11, pp. 3596-3599Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/anie.201509920
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8296/1/paper.pdf
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