Professor David St Clair

Professor David St Clair

Chair in Applied Medicine

Overview

Contact Details

Research

Research Overview

Psychiatric Genetics, particularly of schizophrenia.

Publications

Publications 

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  • HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

    Lang, B., Alrahbeni, T. M. A., St Clair, D., Blackwood, D. H., McCaig, C. D., Shen, S.

    American Journal of Stem Cells, vol. 1, no. 1, pp. 31-41

    Contributions to Journals: Articles

  • Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

    Shi, Y., Li, Z., Xu, Q., Wang, T., Li, T., Shen, J., Zhang, F., Chen, J., Zhou, G., Ji, W., Li, B., Xu, Y., Liu, D., Wang, P., Yang, P., Liu, B., Sun, W., Wan, C., Qin, S., He, G., Steinberg, S., Cichon, S., Werge, T., Sigurdsson, E., Tosato, S., Palotie, A., Nöthen, M. M., Rietschel, M., Ophoff, R. A., Collier, D. A., Rujescu, D., St Clair, D., Stefansson, H., Stefansson, K., Ji, J., Wang, Q., Li, W., Zheng, L., Zhang, H., Feng, G., He, L.

    Nature Genetics, vol. 43, pp. 1224-1227

    Contributions to Journals: Articles

  • GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

    Chen, X., Lee, G., Maher, B. S., Fanous, A. H., Chen, J., Zhao, Z., Guo, A., Van Den Oord, E., Sullivan, P. F., Shi, J., Levinson, D. F., Gejman, P. V., Sanders, A., Duan, J., Owen, M. J., Craddock, N. J., O'Donovan, M. C., Blackman, J., Lewis, D., Kirov, G. K., Qin, W., Schwab, S., Wildenauer, D., Chowdari, K., Nimgaonkar, V., Straub, R. E., Weinberger, D. R., O'Neill, F. A., Walsh, D., Bronstein, M., Darvasi, A., Lencz, T., Malhotra, A. K., Rujescu, D., Giegling, I., Werge, T., Hansen, T., Ingason, A., Nöethen, M. M., Rietschel, M., Cichon, S., Djurovic, S., Andreassen, O. A., Cantor, R. M., Ophoff, R., Corvin, A., St Clair, D., Crombie, C., Fraser, G., Kuan, S. L., St Clair, D., Genetic Risk and Outcome in Psychosis (GROUP), The International Schizophrenia Consortium (ISC)

    Molecular Psychiatry, vol. 16, no. 11, pp. 1117-1129

    Contributions to Journals: Articles

  • Common variants at VRK2 and TCF4 conferring risk of schizophrenia

    Steinberg, S., de Jong, S., Andreassen, O. A., Werge, T., Børglum, A. D., Mors, O., Mortensen, P. B., Gustafsson, O., Costas, J., Pietiläinen, O. P. H., Demontis, D., Papiol, S., Huttenlocher, J., Mattheisen, M., Breuer, R., Vassos, E., Giegling, I., Fraser, G., Walker, N., Tuulio-Henriksson, A., Suvisaari, J., Lönnqvist, J., Paunio, T., Agartz, I., Melle, I., Djurovic, S., Strengman, E., Jürgens, G., Glenthøj, B., Terenius, L., Hougaard, D. M., Ørntoft, T., Wiuf, C., Didriksen, M., Hollegaard, M. V., Nordentoft, M., van Winkel, R., Kenis, G., Abramova, L., Kaleda, V., Arrojo, M., Sanjuán, J., Arango, C., Sperling, S., Rossner, M., Ribolsi, M., Magni, V., Siracusano, A., Christiansen, C., St Clair, D., Irish Schizophrenia Genomics Consortium

    Human Molecular Genetics, vol. 20, no. 20, pp. 4076-4081

    Contributions to Journals: Articles

  • Genome-wide association study identifies five new schizophrenia loci

    Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., St Clair, D., Corvin, A., Gurling, H., Werge, T., Rujescu, D., Blackwood, D. H. R., Pato, C. N., Malhotra, A. K., Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P. H., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium

    Nature Genetics, vol. 43, no. 10, pp. 969-976

    Contributions to Journals: Articles

  • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

    Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., Guan, W., Mattingsdal, M., McQuillin, A., Kwan, P., Wienker, T. F., Daly, M., Dudbridge, F., Holmans, P. A., Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Li, J., Breen, G., St Clair, D., Psychiatric GWAS Consortium Bipolar Disorder Working Group

    Nature Genetics, vol. 43, no. 10, pp. 977-983

    Contributions to Journals: Articles

  • Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia

    Chen, J., Lee, G., Fanous, A. H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K. S., Chen, X., The International Schizophrenia Consortium (ISC), St Clair, D.

    Schizophrenia Research, vol. 131, no. 1-3, pp. 43-51

    Contributions to Journals: Articles

  • At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia

    Hansen, T., Ingason, A., Djurovic, S., Melle, I., Fenger, M., Gustafsson, O., Jakobsen, K. D., Rasmussen, H. B., Tosato, S., Rietschel, M., Frank, J., Owen, M., Bonetto, C., Suvisaari, J., Thygesen, J. H., Pétursson, H., Lönnqvist, J., Sigurdsson, E., Giegling, I., Craddock, N., O'Donovan, M. C., Ruggeri, M., Cichon, S., Ophoff, R. A., Pietiläinen, O., Peltonen, L., Nöthen, M. M., Rujescu, D., St Clair, D., Collier, D. A., Andreassen, O. A., Werge, T.

    Biological Psychiatry, vol. 70, no. 1, pp. 59-63

    Contributions to Journals: Articles

  • DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls

    Green, E. K., Grozeva, D., Sims, R., Raybould, R., Forty, L., Gordon-Smith, K., Russell, E., St. Clair, D., Young, A. H., Ferrier, I. N., Kirov, G., Jones, I., Jones, L., Owen, M. J., O'Donovan, M. C., Craddock, N.

    American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156, no. 4, pp. 490-492

    Contributions to Journals: Articles

  • Evidence of sex-modulated association of ZNF804A with schizophrenia

    Zhang, F., Chen, Q., Ye, T., Lipska, B. K., Straub, R. E., Vakkalanka, R., Rujescu, D., St Clair, D., Hyde, T. M., Bigelow, L., Kleinman, J. E., Weinberger, D. R.

    Biological Psychiatry, vol. 69, no. 10, pp. 914-917

    Contributions to Journals: Articles

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