Professor James N'Dow
Chair in Surgery (Clin)
James N’Dow is Director of the Academic Urology Unit since its establishment in 2001. His research activity spans across evidence synthesis, trials, guideline development, implementation science and the use of big data to complement traditional trial data. He has consistently secured significant funding for research totalling over £43 million over the past 20 years; including being the Coordinator of two large EU IMI funded big data for better outcomes projects. He is Coordinator of the €12M EU IMI funded 5 year project on prostate cancer big data (https://prostate-pioneer.eu/), a large European Multidisciplinary Consortium of 35 partners from 9 countries to harness the power of Big data to inform clinical practice recommendations. He recently successfully coordinated a second €21.3M EU IMI funded large consortium of 36 partners called OPTIMA researching three solid cancers (Prostate, Breast and Lung cancers).
He was Coordinating Editor of the Cochrane Incontinence Review Group and has a track record in delivering NIHR funded national trials in urology. He is co-lead for the recently funded British Association of Urological Surgeons TUF Trials Unit awarded to CHaRT. Appointed Chair of European Association of Urology Guideline Office Board in 2014. Under his leadership, the EAU Guidelines have become the most comprehensive and trusted urological surgical practice guidelines globally, endorsed by 75 countries.
Co-founder and MD of UCAN. UCAN has led 3 fundraising campaigns over the past 15 years, raising over £7 million in philanthropic contributions (cash and in-kind) galvanising the support of the local business community. UCAN funded the opening of the first Urological Cancer Care Centre in Scotland, brought the first robotics surgical system to Scotland as well as contributing £2,517,000 to University of Aberdeen for urological cancer related research. He is also Founder and trustee for Horizons Trust UK charitable trust.
- MB ChB Medicine1990 - University of Aberdeen
- FRCS (Ed) Surgery1994 - Royal College of Surgeons of Edinburgh
- MD Medicine1999 - University of NewcastleWith Commendation
- FRCS (Urol) Urology1999 - Royal College of Surgeons of Edinburgh
Memberships and Affiliations
- Internal Memberships
University of Aberdeen (2001 onwards)
University of Newcastle (1994 – 2001)
- External Memberships
Fellow, Royal College of Surgeons of Edinburgh
Fellow, Royal College of Surgeons of England
British Association of Urological Surgeons
Medical and Dental Defence Union
European Association of Urology
Association of Academic European Urologist
About Urology Trials:
Urology (AUU) has a strong track record of delivering NIHR funded multicentre randomised trials in collaboration with other urologists across the UK as well as uro-gynaecologists and forms a significant proportion of CHaRT’s trial portfolio. Some examples of Urology trials are:
James N’Dow (AUU Director) and Graeme MacLennan (CHaRT Director) are co-Lead for the British Association of Urological Surgeons TUF Trials Unit 3 year award (starting 2021).
A unique strength has always been AUU’s willingness to support other clinical academic surgeons as aspiring trialists to develop and lead trials themselves thereby building capacity of senior academic surgeons as Chief Investigators. The BAUS TUF Trials Unit allows AUU and CHaRT to support the Urological Community to mentor and develop the next generation of Urological Surgeon trialists.
A €12M EU IMI funded 5 year project on prostate cancer big data (https://prostate-pioneer.eu/), a large European Multidisciplinary Consortium of 35 partners from 9 countries to encourage the global urological community to harness the power of real world (Big) data to inform clinical practice recommendations in the field of Prostate Cancer.
Nature Reviews Urology Publication – Introducing PIONEER https://rdcu.be/cqUmi
PIONEER presents a unique opportunity to contribute to critical patient focussed Pan-European Prostate Cancer research. PIONEER has prioritised 56 unanswered research questions using Delphi consensus methodology with all key stakeholders involved in the prioritisation exercise. Prostate Cancer patients from Grampian, across the UK and from the EU countries were involved.
The EAU Prostate Cancer Guideline panel and other prostate cancer Key Opinion Leaders were consulted to propose the most critical questions in the field of prostate cancer to be answered using big data. A two round Delphi survey including 73 healthcare professionals and 57 patients participated in round one followed by 49 healthcare professionals and 169 patients (including 53 English; 19 French; 31 German; 53 Italian; 13 Spanish) in round two, twelve additional questions were proposed during this first round. 56 questions were finally prioritised to be “critically important”.
Over the next 5 years, we expect to answer 10 prioritised research questions using federated analytics methodologies. To do this, PIONEER has had to map datasets to a common data model (OMOP) to allow reliable comparisons of outcomes across different datasets and countries (PIONEER has over 90 datasets in the pipeline for onboarding onto the PIONEER platform).
PIONEER is also exploring inclusion of hospital EHR data with Grampian (DaSH) being an early pilot centre. Researchers will only access pseudonymised data and no patient level data will be released from the DaSH environment. The results of this research will inform European Prostate cancer clinical practice guidelines.
OPTIMA is a € 21.3 million European Commission Innovative Medicines Initiative funded research on patients with solid tumours leveraging the power of real world data analytics and artificial intelligence (AI). It is a five-year project, involving 36 partners across 13 countries. OPTIMA’s mission is to design, develop and deliver the first interoperable and GDPR-compliant European real-world oncology data and evidence generation platform. To achieve this ambitious goal OPTIMA will:
- Establish a harmonised large scale real-world evidence data platform for prostate, breast and lung cancer with real-world date covering > 200 million people. The platform will be secure, sustainable and interoperable hosting datasets, data analysis tools, federated learning tools, AI algorithms, and electronic decision support tools.
- Drive new knowledge generation through advanced analytics and AI-models. OPTIMA will identify and prioritise the main knowledge gaps in prostate, breast and lung cancer. Based on the key unanswered questions in each of the 3 cancer types, OPTIMA will develop specific AI-models to fill knowledge gaps and propose improved guideline recommendations.
- Develop electronic shared decision support tools. These tools will be based on computer-interpretable guidelines developed by combining declarative AI and clinical care pathways developed from the leading clinical practice guidelines for prostate, breast and lung cancer. The electronic decision support tools will be interfaced with patient electronic health records (EHR).
OPTIMA aims at personalisation of treatment, encompassing the richness of available data by processing high-dimensional data across datasets and sources, and using deep learning to identify the decisive factors that enable personalised, real-time decisions for each individual patient based on the most accurate and complete weighing of available knowledge. If successful in its objectives OPTIMA will also inform policy on a European level when it comes to the clinical deployment of AI algorithms in healthcare.
As academic coordinator for both PIONEER and OPTIMA, there are unique opportunities to expand evidence generation to include incorporation of real world evidence into the evidence profiles underpinning clinical practice guidelines development. This would further cement the Academic Urology Unit and the EAU as leaders in the methodologies of Clinical Practice Guidelines development by incorporating real world data analytics and new evidence informed by AI models.
About Clinical Practice Guidelines and Implementation Science:
Whilst the development and global dissemination of evidence based guidelines was transformative for urological practice, it was clear that adherence to guideline recommendations was still suboptimal and there were potentially a myriad of reasons for non-adherence:
IMAGINE (IMpact Assessment of Guidelines Implementation and Education):
IMAGINE is a Pan-European National Urological Society Implementation Science Collaborative established to monitor clinical practice variation across over 40 European countries, to monitor baseline adherence to guideline recommendations and to identify determinants of non-adherence. IMAGINE will go on to develop knowledge transfer interventions geared to improve adherence. The first pilot has seen adherence data capture relating to treatment of over 6000 patients. To find out more on IMAGINE’s objectives, please see the following editorial and a recent publication.
Improving guideline adherence in urology 2021 - Accepted/In press European Urology Focus
MacLennan, S., Duncan, E., Skolarus, T. A., Roobol, M. J., Kasivisvanathan, V., Gallagher, K. M., Gandaglia, G., Sakalis, V., Smith, E. J., Plass, K., Ribal, M. J., N'Dow, J., Briganti, A.:
Applied Health SciencesSupervising
Extensive collaborations across the world.
National – well connected with Urologists across the UK and strong links with the British Association of Urological Surgeons.
International – having spearheaded the engagement and endorsement of the European Urological clinical practice guidelines by National Urological Societies in 75 countries between 2014 – 2021, a strong network exists across all continents around the globe. As adjunct Secretary General of the EAU responsible for Education, I meet with representatives of all European National Urological Societies few times a year to discuss shared interests and collaborative opportunities.
STICHTING EUROPEAN UROLOGICAL FOUNDATION
UNIVERSITA VITA-SALUTE SAN RAFFAELE
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
TAMPEREEN KORKEAKOULUSAATIO SR
KING'S COLLEGE LONDON
EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT LTD
EUROPEAN CANCER PATIENT COALITION
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
THE HYVE BV
EUROPEAN ALLIANCE FOR PERSONALISED MEDICINE ASBL
PINSENT MASONS LLP
WEIZMANN INSTITUTE OF SCIENCE
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
TECHNISCHE UNIVERSITAET DRESDEN
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
STICHTING RADBOUD UNIVERSITEIT
IHE, INSTITUTET FOR HALSOOCH SJUKVARDSEKONOMI AKTIEBOLAG
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
ASTELLAS PHARMA EUROPE BV
NV SAS INSTITUTE SA
JANSSEN PHARMACEUTICA NV
COVANCE LABORATORIES LTD
IMS INFORMATION SOLUTIONS MEDICAL RESEARCH LIMITED
THE ECANCER GLOBAL FOUNDATION
JULIUS CLINICAL RESEARCH BV
HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV
1. Stichting EAU Foundation for Urological Research (EAU) NL
2. Lund University (LU) SE
3. Erasmus Universitair Medisch Centrum Rotterdam (EMC) NL
4. Association EISBM (EISBM) FR
5. The University Court of the University of Aberdeen (UoA) UK
6. Tartu Ülikool (TU) EE
7. Universita Vita-Salute San Raffaele (UNISR) IT
8. Queen Mary University of London (QMUL) UK
9. CASUS, Helmholtz-Zentrum Dresden - Rossendorf (HZDR) DE
10. Helios Klinikum Emil von Behring (HC) DE
11. Uppsala University (UU) SE
12. Oxford University (UOXF) UK
13. University of Vienna (UNIVIE) AT
14. European Institute of Oncology (IEO) IT
15.Ludwig-Maximilians-University Munich (LMU) DE
16. University College London (UCL) UK
17. European Organisation for Research and Treatment of Cancer (EORTC) BE
18. Institut de Cancerologie de l’Ouest (ICO) FR
19. Maastricht University (MU) NL
20. Institut Universitari d’Investigacio en Atencio Primaria (IDIAPJGol) ES
21. European Respiratory Society (ERS) CH
22. German Cancer Society (DKG) DE
23. European Lung Foundation (ELF) UK
24. European Cancer Patient Coalition (ECPC) BE
25. ttopstart (TTOP) NL
26. GMV Soluciones Globales de Internet SAU (GMV) ES
27. Information Technology for Translational Medicine (ITTM) LU
28. SmartReporting GMBH (SR) DE
29. Owkin (OWK) FR
30. Arttic Innovation (ART) DE
31. YDEAL software PT
32. Pfizer UK
33. Bayer AG DE
34. Amgen CH
35. Roche CH
36. Abbvie US
Funding and Grants
2004 – 2009
Conservative treatment for urinary incontinence in men after prostate surgery (MAPS Trial)
2004 – 2007
Prospective collaborative study of patients with intestinal segments transposed into the urinary tract following surgery for bladder cancer or benign end-stage bladder disease (OTIS Study)
2005 – 2006
Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement (BPE)
2006 - 2009
Types of urethral catheter for reducing symptomatic urinary tract infections in hospitalised adults requiring short-term catheterisation: multicentre randomised controlled trial of antibiotic and antiseptic impregnated urethral catheters.
2007 - 2009
Systematic review and economic modelling of the effectiveness and efficiency of non-surgical treatments of women with stress urinary incontinence (SUI)
2010 – 2013
'Use of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre placebo controlled randomised trial of a calcium channel blocker (nifedipine) and an alpha blocker (tamsulosin)' (SUSPEND)
2010 – 2015
Cochrane Incontinence Review Group Editorial Base Funding
2012 – 2015
Systematic review and economic modelling of ablative therapy for men with localised prostate cancer
2012 – 2015
Development of core outcomes for surgical management of localised prostate cancer to support decision-making by patients, clinicians and policy makers
2013 – 2015
Macmillan Cancer Support
Cancer Survival, Work and Working Life: Developing a Patient Advice & Information System for Scotland
2013 – 2016
Prostate Cancer UK
Extending the UCAN model of patient information and support to remote and rural communities
2013 – 2016
TISU Trial: A multicentre randomised controlled trial of extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic retrieval, for ureteric stones
2012 – 2017
OPEN Trial: A multicentre randomised controlled trial of urethroplasty versus optical urethrotomy for recurrent bulbar urethral stricture disease
2013 – 2016
ANTIC Trial: A multicentre randomised controlled trial of antibiotic prophylaxis for clean intermittent self catheterisation
2014 – 2020
PHOTO Trial: A multicentre randomised controlled trial of Photodynamic guided treatment for bladder cancer
2018 – 2023
CATHETER II Trial: Randomised Controlled Trial CompAring THE Clinical And CosT-Effectiveness Of VaRious Washout Policies Versus No Washout Policy In Preventing Catheter Associated Complications In Adults Living With Long-Term Catheters
2018 – 2023
2021 - 2026
European Commission Innovative Medicines Initiative
European Commission Innovative Medicines Initiative
PIONEER: European Network of Excellence for Big Data in Prostate Cancer
Optimal treatment for patients with solid tumours in Europe through Artificial Intelligence
Non-course Teaching Responsibilities
Trainer of East of Scotland Urology Specialist Registrars.
Provide research training to medical students as part of the Aberdeen Summer Research Scholarship programme (ASRS).
Trainer and mentor of young academic urological surgeons in evidence synthesis methodology and real world data analytics.
Responsible for Education portfolio of European Association of Urology that has a membership of 19,000 urological surgeons.
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Enabling mutual helping?: Examining variable needs for facilitated peer supportPatient Education and Counseling, vol. 85, no. 2, pp. e120-e125Contributions to Journals: Articles
Assessing risk of bias in non-randomised studies and incorporating GRADE: Initial experience with a new Cochrane ‘risk of bias’ tool under developmentContributions to Conferences: Papers
Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trialsThe Lancet, vol. 378, no. 9788, pp. 328-337Contributions to Journals: Articles
Defining a patient-reported outcome measure for urethral stricture surgeryEuropean Urology, vol. 60, no. 1, pp. 60-68Contributions to Journals: Articles
The future of clinical practice guidelines in urologyEuropean Urology, vol. 60, no. 1, pp. 72-74Contributions to Journals: Editorials
Conservative treatment for urinary incontinence in Men After Prostate Surgery (MAPS): two parallel randomised controlled trialsHealth Technology Assessment, vol. 15, no. 24, pp. 1-290Contributions to Journals: Articles
Conservative treatment for urinary incontinence in Men After Prostate Surgery (MAPS): two parallel randomised controlled trialsHealth Technology Assessment, vol. 15, no. 24, pp. 1-296Contributions to Journals: Articles
Urological cancer care pathways: development and use in the context of systematic reviews and clinical practice guidelinesWorld Journal of Urology, vol. 29, no. 3, pp. 291-301Contributions to Journals: Articles
Concepts of information provision in cancer care: a critical interpretive synthesis of literatureMedical Encounter, vol. 25, no. 3, pp. 63Contributions to Journals: Articles
Photodynamic diagnosis of bladder cancer compared with white light cystoscopy: Systematic review and meta-analysisInternational Journal of Technology Assessment in Health Care, vol. 27, no. 1, pp. 3-10Contributions to Journals: Articles
Transurethral Resection of the Prostate (TURP): Gold standard in an uncertain environmentUrology News, pp. 6Contributions to Journals: Articles
'They're doing surgery on two people': a meta-ethnography of the influences on couples' treatment decision making for prostate cancerHealth Expectations, vol. 13, no. 4, pp. 335-349Contributions to Journals: Articles
Quality of life with urinary diversionEuropean Urology Supplements, vol. 9, no. 10, pp. 763-771Contributions to Journals: Articles
The importance of patient-reported outcome measures in reconstructive urologyCurrent Opinion in Urology, vol. 20, no. 6, pp. 495-499Contributions to Journals: Review articles
Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinenceHealth Technology Assessment, vol. 14, no. 40, pp. 1-506Contributions to Journals: Articles
Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinenceHealth Technology Assessment, vol. 14, no. 40, pp. 1-215Contributions to Journals: Articles
Evidence-based urology in practice: heterogeneity in a systematic review meta-analysisBJU International, vol. 105, no. 6, pp. 770-773Contributions to Journals: Articles
The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trialsWorld Journal of Urology, vol. 28, no. 1, pp. 23-32Contributions to Journals: Articles
The fate of conference abstracts: systematic review and meta-analysis of surgical treatments for men with benign prostatic enlargementWorld Journal of Urology, vol. 28, no. 1, pp. 63-69Contributions to Journals: Articles
Systematic review of the clinical and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer.Health Technology Assessment, vol. 14, no. 4, pp. 1-353Contributions to Journals: Articles
Management of lower urinary tract symptoms in men: summary of NICE guidanceBMJ (Clinical research ed.), vol. 340, c2354Contributions to Journals: Articles
How close are we to knowing whether orthotopic bladder replacement surgery is the new gold standard?: Evidence from a systematic review updateUrology, vol. 74, no. 6, pp. 1331-1339Contributions to Journals: Articles
Quality of life and body image for bladder cancer patients undergoing radical cystectomy and urinary diversion: a prospective cohort study with a systematic review of literatureUrology, vol. 74, no. 5, pp. 1138-1143Contributions to Journals: Articles
Surgical treatments for men with benign prostatic enlargement: cost effectiveness studyBritish Medical Journal, vol. 338, no. -, b1288Contributions to Journals: Articles
Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargementHealth Technology Assessment, vol. 12, no. 35, pp. 1-168Contributions to Journals: Literature Reviews
Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trialsBritish Medical Journal, vol. 337, a1662Contributions to Journals: Articles
Alternative approaches to endoscopic ablation for benign enlargement of the prostate: systematic review of randomised controlled trialsBritish Medical Journal, vol. 337Contributions to Journals: Articles
Surgical management of localised prostate cancerCochrane Database of Systematic Reviews, no. 2, CD007021Contributions to Journals: Review articles
Body Image and Health are Not the Most Important Determinants of Quality of Life (QoL) for Bladder Cancer Patients Facing Major SurgeryEuropean Urology, vol. 7, no. 3, pp. 221Contributions to Journals: Abstracts
Benign prostatic hyperplasia: Part 2-managementBritish Medical Journal, vol. 336, no. 7637, pp. 206-210Contributions to Journals: Articles
Benign prostatic hyperplasia: Part 1- diagnosisBritish Medical Journal, vol. 336, no. 7636, pp. 146-149Contributions to Journals: Articles
Benign prostatic hyperplasia: Part 1 - DiagnosisBritish Medical Journal, vol. 336, pp. 146-149Contributions to Journals: Literature Reviews
Benign prostatic hyperplasia. Part 2 - ManagementBritish Medical Journal, vol. 336, pp. 206-210Contributions to Journals: Literature Reviews
Duloxetine, a serotonin and noradrenaline reuptake inhibitor (SNRI) for the treatment of stress urinary incontinence: a systematic reviewEuropean Urology, vol. 51, no. 1, pp. 67-74Contributions to Journals: Articles
Outcomes of stenting after uncomplicated ureteroscopy: systematic review and meta-analysisBMJ (Clinical research ed.), vol. 334, no. 7593, pp. 572Contributions to Journals: Articles
Herpetiform cutaneous metastases from transitional cell carcinoma of urinary bladder: Immunohistochemical profile of cytokeratin expressionJournal of Clinical Pathology, vol. 59, no. 12, pp. 1331-1333Contributions to Journals: Articles
Mechanical devices for urinary incontinence in womenCochrane Database of Systematic Reviews, no. 3, CD001756Contributions to Journals: Articles
Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement (BPE)Unknown PublisherBooks and Reports: Commissioned Reports
Does retrograde balloon dilation compromise outcome of secondary open pyeloplasty: 17 Years' experience at a single centerUrology, vol. 66, no. 6, pp. 1172-1175Contributions to Journals: Articles
Adrenergic drugs for urinary incontinence in adultsCochrane Database of Systematic Reviews, no. 3, CD001842Contributions to Journals: Articles
Is orthotopic bladder replacement the new gold standard?: Evidence from a systematic reviewJournal of Urology, vol. 174, no. 1, pp. 21-28Contributions to Journals: Articles
The bladder does not appear to have a dynamic secreted continuous mucous gel layerJournal of Urology, vol. 173, no. 6, pp. 2025-2031Contributions to Journals: Articles
The role of mucus and protein biomarkers in intestinal segments transposed into the urinary tractBJU International, vol. 95, no. Suppl. 5, pp. 43Contributions to Journals: Articles
Proteomic analysis of urine in patients with intestinal segments transposed into the urinary tractProteomics, vol. 5, no. 6, pp. 1729-1733Contributions to Journals: Articles
Serotonin and noradrenaline reuptake inhibitors (SNRI) for stress urinary incontinence in adultsCochrane Database of Systematic Reviews, no. 3, pp. CD004742Contributions to Journals: Articles
Membrane bound mucins MUC1, MUC4 and MUC16/CA125 are preferentially expressed in muscle invasive bladder cancer.Journal of Urology, vol. 171, pp. 259-259Contributions to Journals: Articles
Membrane-bound mucin expression in bladder cancer.European Journal of Surgical Oncology, vol. 30, pp. 1027-1028Contributions to Journals: Articles
Mucus production after transposition of intestinal segments into the urinary tractWorld Journal of Urology, vol. 22, no. 3, pp. 178-185Contributions to Journals: Articles
Mucin gene expression in superficial bladder cancer: identifying novel mucin tumour markersBritish Journal of Cancer, vol. 88, no. Suppl. 1, pp. S46Contributions to Journals: Abstracts
A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestationContraception, vol. 68, no. 5, pp. 335-338Contributions to Journals: Articles