The methodological expertise of the team covers a wide range of topics including, but not limited to the following. Examples of recent publications using the methods are provided.

School of Medicine and Dentistry

Longitudinal data analysis/mixed models

  1. N Tagieva-Milne, G Devereux, S Fielding, S Turner, G Douglas. Outcomes of childhood asthma and wheezy bronchitis – a 50 year cohort study. Am J Respir Crit Care Med. Published online 09 Sep 2015 DOI: 10.1164/rccm.201505-0870OC

  2. Kuan Ken Lee, Raja EA, Amanda J Lee, Sohinee Bhattacharya, Siladitya Bhattacharya, Jane E Norman, Rebecca M Reynolds. Maternal obesity during pregnancy associates with premature mortality and major cardiovascular events in later life.  Hypertension 2015; (in press)
  3. P Murchie, EA Raja, DH Bewster, NC Campbell, LD Ritchie, R Robertson, L Samuel, N Gray and AJ Lee. Time from first presentation in primary care to treatment of symptomatic colorectal cancer: effect on disease stage and survival. British Journal of Cancer 2014: 1-9: doi 10.1038/bjc.2014.352
  4. Murchie P, Raja E-A, Lee AJ, Brewster DH, Campbell NC, Gray N, Ritchie LD, Robertson R, Samual L.  Effect of longer health service provider delays on stage at diagnosis and mortality in symptomatic breast cancer.  Breast 2015; 24: 248-255.
  5. Beasley M, Prescott GJ, Scotland G, McBeth J, Lovell K, Keeley P, Hannaford P, Symmons D, Woby S, Macfarlane GJ, on behalf of the MUSICIAN Study team. Patient-reported improvements in health are maintained two-years after completing a short course of cognitive behaviour therapy, exercise or both treatments for chronic widespread pain: long-term results from the MUSICIAN randomised controlled trial. Rheumatic and Musculoskeletal Diseases (RMD) Open 2015 (In press).
  6. S Turner, S Fielding, D Mullane, D Cox, J Goldblatt, L Landau, P LeSouef A longitudinal study of lung function from one month to 18 years of age. Thorax 2014; 69(11): 1015-20.
  7. Devereux G, Steele S, Jagelman T, Fielding S, Muirhead R, Brady J, Grierson C, Brooker R, Winter J, Fardon T, McCormick J, Huang JT, Miller D. An observational study of matrix metalloproteinase (MMP)-9 in Cystic Fibrosis. J Cyst Fibros 2014. 13(5): 557-563.
  8. Ian McKay, Isobel Ford, Shona Fielding, Paul Bachoo, Julie Brittenden Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function  in patients with peripheral arterial disease. Atherosclerosis 221 (2012) 514-520.

Multilevel/hierarchical modelling

  1. Denison F, Norwood P, Bhattacharya S, Duffy A, Mahmood T, Morris C, Raja EA, Norman J, Lee A, Scotland G. Association between maternal body mass index during pregnancy, short-term morbidity, and increased health service costs: a population-based study. BJOG 2014; 121(1):72-82.
  2. Smith JL, Sivasubramaniam S, Rabiu MM, Kyari F, Solomon AW, Gilbert C. Multilevel Analysis of Trachomatous Trichiasis and Corneal Opacity in Nigeria: The Role of Environmental and Climatic Risk Factors on the Distribution of Disease.PLoS Negl Trop Dis. 2015 Jul 29;9(7):e0003826.
  3. Denison, FC., Norwood, P., Bhattacharya, S., Duffy, A., Mahmood, T., Morris, C., Raja, EA., Norman, JE., Lee, AJ. & Scotland, G. (2014). 'Association between maternal body mass index during pregnancy, short-term morbidity and increased health service costs: a population based study'. BJOG-An International Journal of Obstetrics and Gynaecology, vol 121, no. 1, pp. 72-82.
  4. Long-Acting Beta-Agonists prescribing in asthma among children and adults in primary care: a cross-sectional observational study. Morales DR, Jackson C, Fielding S, et al. Thorax 2013; 68:192-194.
  5. Macdonald, H.M.; Wood, Adrian; Aucott, Dr Lorna S.; Black, A.J.; William Fraser (MED); Mavroeidi, A.; Reid, David M.; Secombes, Karen; Simpson William; Thies, F.  ‘Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1 year double-blind RCT in postmenopausal women’ J Bone Miner Res. Oct 2013; 28(10):2202-13. doi: 10.1002/jbmr.1959.
  6. L A Frassetto, A C Hardcastle,, A Sebastian,, L Aucott,, W D Fraser,D M Reid1 and H M MacdonaldNo evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake” European Journal of Clinical Nutrition (2012) 66, 1315–1322; doi:10.1038/ejcn.2012.151.
  7. Liam Hill, Justin HG Williams, Lorna Aucott, Jenny Thomson, Mark Mon-Williams "How does exercise benefit performance on cognitive tests in primary-school pupils?"  Developmental Medicine & Child Neurology. (2011) Published on-line 24 MAR 2011, DOI: 10.1111/j.1469-8749.2011.03954.x
  8. Dr Helen Macdonald, Dr Alexandra M. Mavroeidi, Dr Lorna S Aucott, Brian Diffey, Bill Fraser Dr Anthony Ormerod, Professor David M Reid. "Skin colour change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study." JCEM 2011, 96: 1677-1686. 
  9. Murchie P, Raja EA, Lee AJ, Campbell NC.  Mortality and morbidity after initial diagnostic excision biopsy of cutaneous melanoma in primary versus secondary care.  British Journal of General Practice 2013, 63: e563-e572.

Missing values and imputation

  1. S Fielding, PM Fayers, CR Ramsay. Analysing randomised controlled trials with missing data: Choice of approach affects conclusions, Contemporary Clinical Trial (2012) 33; 3: 461-469. doi:10.1016/j.cct.2011.12.002.
  2. S Fielding, P Fayers, C Ramsay. Predicting missing quality of life data that was later recovered: an empirical comparison of approaches. Clinical Trials 2010; 7: 333–342.
  3. S Fielding, P M Fayers, C R Ramsay. Investigating the missingness mechanism in quality of life data: A comparison of approaches. Health and Quality of Life Outcomes 2009, 7: 57.
  4. S Fielding, G MacLennan, J A Cook, C R Ramsay. A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes. Trials 2008, 9: 51.
  5. S Fielding, P M Fayers, A McDonald, G McPherson, M K Campbell for the RECORD study group. Simple imputation methods were inadequate for missing not at random (MNAR) quality of life data. Health and Quality of Life Outcomes 2008, 6: 57.

Systematic reviews and IPD meta-analyses

  1. Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD009566.
  2. Bawa FM, Mercer SW, Atherton R, Clague F, Scott N, Bond CM.   Systematic review of ECHO outcomes of mindfulness-based Interventions for adults with chronic pain.  British Journal of General Practice 2015,65,635,387-400.
  3. Lamont K, Scott NW, Jones GT, Bhattacharya S.  Recurrence risk of unexplained stillbirth: systematic review and meta-analysis.  BMJ 2015,350,3080.
  4. Spiteri Cornish K, Lois N, Scott N, Burr J, Cook J, Boachie C, Tadayoni R, la Cour M, Christensen U, Kwok A.  Vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with no peeling for idiopathic full-thickness macular hole (FTMH).  Cochrane database of systematic reviews, 2013; 6, CD009306.
  5. Spiteri Cornish K, Lois N, Scott N, Burr J, Cook J, Boachie C, Tadayoni R, la Cour M, Christensen U, Kwok A.  Vitrectomy with internal limiting membrane peeling versus vitrectomy with no peeling for idiopathic full-thickness macular hole.  Ophthalmology 2014, 121,3,649-655.
  6. Lorna Aucott; Denise Gray; Helen Rothnie; Mohan Thapa; Charles Waweru: For the PROGRESS group.  “Effects of lifestyle interventions and Long-term weight loss on lipid outcomes -A systematic review” Obesity Reviews (2011) 12,5:e412-e425
  7. Almohmeeed, Y H.m.h, Avenell, A; Vickers, M.A.; Aucott, L.S. ‘Systematic Review and Meta-analysis of The Sero-epidemiological Association Between Epstein Barr Virus and Multiple Sclerosis’ PLOS ONE (2013). DOI: 10.1371/journal.pone.0061110.
  8. McLernon DJ, Harrild K, Bergh C, Davies MJ, de Neubourg D, Dumoulin JCM, Gerris J, Kremer JAM, Martikainen H, Mol BW, Norman RJ, Thurin-Kjellberg A, Tiitinen A, van Montfoort APA, Van Peperstraten A, Van Royen E, Bhattacharya S. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ 2010;341:c6945.

Differential item functioning

  1. Cameron I, Scott N, Adler M, Reid IC.  A comparison of three methods of assessing differential item functioning (DIF) in the Hospital Anxiety Depression Scale: ordinal logistic regression, Rasch analysis and the Mantel chi-square procedure. Quality of Life Research 2014,23,10,2883-2888.
  2. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG on behalf of the EORTC Quality of Life Group and the Quality of Life Cross-Cultural Meta-Analysis Group. Differential item functioning (DIF) analyses of health-related quality of life instruments using logistic regression.  Health and Quality of Life Outcomes 2010,8:81.
  3. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG on behalf of the EORTC Quality of Life Group and the Quality of Life Cross-Cultural Meta-Analysis Group. Interpretation of differential item functioning (DIF) analyses using external review.  Expert Reviews in Pharmacoeconomics and Outcomes Research 2010;10:3:253-258.
  4. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG on behalf of the EORTC Quality of Life Group and the Quality of Life Cross-Cultural Meta-Analysis Group. A simulation study provided sample size guidance for differential item functioning (DIF) studies using short scales. Journal of Clinical Epidemiology 2009;62;288-295.
  5. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG on behalf of the EORTC Quality of Life Group and the Quality of Life Cross-Cultural Meta-Analysis Group. Differential item functioning (DIF) in the EORTC QLQ-C30: a comparison of baseline, on-treatment and off-treatment data.  Quality of Life Research 2009;18:381-388.
  6. Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, Gundy C, Koller M, Petersen MA, Sprangers MAG on behalf of the EORTC Quality of Life Group and the Quality of Life Cross-Cultural Meta-Analysis Group. The practical impact of differential item functioning (DIF) analyses.  Quality of Life Research 2009;18:1125-1130.

Variable reduction: Factor analysis/Principal components

  1. AD Wood, AA Strachan, F Thies, LS Aucott, DM Reid, AC Hardcastle, A Mavroeidi, WG Simpson, GG Duthie, HM Macdonald. ‘Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk.’  British Journal Of Nutrition 10/2014; 112(8):1341-1352.
  2. K Rothnie, S Cotton, S Fielding, N Gray, J Little, M Cruickshank, L Walker, M Avis, L Smart, L Sharp. Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM).  Health and Quality of Life Outcomes 2014, 12: 154.
  3. AC Hardcastle, L Aucott, WD Fraser, DM Reid and HM Macdonald. "Dietary patterns, bone resorption and bone mineral density in early postmenopausal Scottish women", European Journal of Clinical Nutrition (EJCN). 2011, 65, 378-385.

Clinical prediction modelling

  1. Dawson DK, McLernon DJ, Raj VJ, Maceira AM, Prasad S, Frenneaux MP, Pennell DJ, Kilner PJ. Cardiovascular magnetic resonance determinants of left ventricular noncompaction. Am J Cardiol 2014; 114: 456-462. doi:10.1016/j.amjcard.2014.05.017.
  2. McLernon DJ, Donnan PT, Sullivan FM, Roderick P, Rosenberg WM, Ryder S, Dillon JF.  Prediction of liver disease in patients whose liver function tests have been checked in primary care: model development and validation using population-based observational cohorts.  BMJ Open 2014;4:e004837. doi:10.1136/bmjopen-2014-004837.
  3. McLernon DJ, DillonJF, Sullivan FM, Roderick P, Rosenberg WM, Ryder S, Donnan PT.  The utility of liver function tests for mortality prediction within one year in primary care using the Algorithm for Liver Function Investigations (ALFI).  PLoS ONE 2012; 7(12): e50965. doi:10.1371/journal.pone.0050965.
  4. FGR Fowkes, GD Murray, I Butcher, AR Folsom, AT Hirsch, DJ Cooper, G DeBacker, M Komitzer, AB Newman, KCSutton-Tyrell, M Cushman, AJ Lee, et al. Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. European Journal of Preventive Cardiology. 2014 21(3): 310-320.

Advanced survival analysis

  1. Marks A, Fluck N, Prescott GJ, Robertson L, Simpson WG, Smith WCS, Black C. Looking to the future: Predicting renal replacement outcomes in a large community cohort with chronic kidney disease. Nephrology Dialysis Transplantation 2015 (In press) DOI: http://dx.doi.org/10.1093/ndt/gfv089
  2. Marks A, MacLeod C, McAteer A, Murchie P, Fluck N, Smith WCS, Prescott GJ, Clark L, Ali T, Black C. Definitions of progression in chronic kidney disease – predictors and relationship to renal replacement therapy in a population cohort with six years follow-up. Nephrology Dialysis Transplantation 2014; 29(2): 333-341.
  3. McLernon DJ, Donnan PT, Sullivan FM, Roderick P, Rosenberg WM, Ryder S, Dillon JF.  Prediction of liver disease in patients whose liver function tests have been checked in primary care: model development and validation using population-based observational cohorts.  BMJ Open 2014;4:e004837. doi:10.1136/bmjopen-2014-004837.
  4. L Iversen, S Fielding, P Hannaford. Smoking in young women in Scotland and future risk of hospital admission and death: cohort evidence from the Royal College of General Practitioners’ Oral Contraception Study. Br J Gen Pract 2013 63(613):e523-33. DOI: 10.3399/bjgp13X670651. 
  5. Bhattacharya S, Prescott GJ, Iversen L, Campbell DM, Smith WCS, Hannaford PC. Hypertensive disorders of pregnancy and future health and mortality: a record linkage study. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 2012; 2(10): 1–7.
  6. McLernon DJ, Dillon JF, Sullivan FM, Roderick P, Rosenberg WM, Ryder S, DonnanPT.  The utility of liver function tests for mortality prediction within one year in primary care using the Algorithm for Liver Function Investigations (ALFI).  PLoS ONE 2012; 7(12): e50965. doi:10.1371/journal.pone.0050965.
  7. Reynolds RM, Allan KM, Raja EA, Bhattacharya S, McNeill G, Hannaford PC, Sarwar N, Lee AJ, Bhattacharya S, Norman JE. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1,323,275 person years. BMJ. 2013 Aug 13; 347: f4539. doi: 10.1136/bmj.f4539.

Health Technology Assessment including network meta-analysis

  1. Moira Cruickshank, Neil Scott, Miriam Brazelli, Pawana Sharma, David Cooper, Graham Scotland, William Simpson, Craig R Ramsay, Cynthia Fraser, Mehdi Javanbakht, Graeme Maclennan. Ezetimibe for the treatment of primary (heterozygous-familial and non-familial) hypercholesterolaemia: a single technology appraisal. Aberdeen HTA Group, 2015.
  2. Clare Robertson, Ewen Cummins, Shona Fielding, Thomas Lam, Cynthia Fraser, Craig R Ramsay. Enzalutamide for treating metastatic hormone-relapsed prostate cancer not previously treated with chemotherapy. Aberdeen HTA Group, 2015.
  3. Cummins E, Scott N, Cruickshank M, Fraser C, Ormerod A, Brazzelli M. Secukinumab for treating moderate to severe plaque psoriasis: a single technology appraisal. Aberdeen HTA Group, 2015.
  4. Robertson C, Lam T, Stewart F, Scott NW, Cummins E, Ramsay CR. Radium-223 for the treatment of bone metastases in hormone relapsed prostate cancer Aberdeen HTA Group, Institute of Applied Health Sciences, University of Aberdeen, 2013, 2014 and 2015.
  5. Cummins E, Scott N, Rothnie K, Waugh N, Fraser C, Philip S, Brazzelli M. Dapagliflozin for the treatment of type 2 diabetes. Aberdeen HTA Group, Institute of Applied Health Sciences, University of Aberdeen, 2012.
  6. Shona Fielding, Ewen Cummins, Moira Cruickshank, Cynthia Fraser, Noemi Lois, Miriam Brazelli. Aflibercept for treating diabetic macular oedema: a single technology appraisal. Aberdeen HTA Group, 2014.
  7. Ewen Cummins, Shona Fielding, Moira Cruickshank, Cynthia Fraser, Neomi Lois, Miriam Brazelli. Ranibizumab for the treatment of choroidal neovascularisation associated with pathological myopia: a single technology appraisal. Aberdeen HTA Group, 2013.
  8. Ewen Cummins, Shona Fielding, Rhona Johnston, Kieran Rothnie, Fiona Stewart, Noemi Lois, Jennifer Burr,Miriam Brazelli. Aflibercept solution for injection for the treatment of wet age-related macular degeneration: a single technology appraisal. Aberdeen HTA Group, 2013.
  9. Cummins Ewen, Shona Fielding, Neil Scott, Kieran Rothnie, Mark Crowther, Cynthia Fraser, and Miriam Brazzelli. "Eltrombopag for the treatment of chronic immune thrombocytopenic purpura (ITP): a single technology appraisal. Aberdeen HTA Group, 2012.
School of Biological Sciences

Content to follow... http://www.abdn.ac.uk/biologicalsci/