We collaborate with basic scientists to translate science from bench to clinical practice. Notable collaboration work we developed recently involved MRI physicists, platelet biology experts, and experts in brain markers of pathologies of dementia.
Proof of concept study of the role of MRI in assessing falls risk
Funded by the NHS Grampian Endowment grant, this study examines the role of MRI in accessing the quantity and quality of slow muscle fibers and their differences between three groups of older participants (1) those without any previous falls, (2) those with recurrent falls and (3) those with frequent falls.
Platelet-derived extracellular vesicles as biomarkers of microvascular ageing
In this Scottish ARUK network funded translational research we examined the potential role of platelet-derived extracellular vesicles (microparticles) in microvascular ageing by comparing their activities between two groups of health ageing participants with low and high cerebrovascular disease burden. The participants were drawn from the existing ABC-1936 cohort.
Figure: Effect of time incubation in production of microparticles. The trend line for microparticles is represented by the dotted line (MSc Clinical Pharmacology Thesis work by Ioana Alexandra Andrioae: Risk factors and biomarkers for treatment of vascular dementia)
Figure: (a). Study sample with small numbers of CD41b and CD61 positive events. (b). Study sample with elevated levels of CD41b and CD61 positive signals. (c). Analysis of EMPs in a study sample; positive events for CD62E and CD105. (MSc Clinical Pharmacology Thesis work by Federico Zerbinato: Platelet aggregation and microparticles in cerebrovascular disease: biomarkers of cognitive decline?)
Figure: Platelet aggregation in response to ADP and arachidonic acid. Differences whether taking aspirin or not. (MSc Clinical Pharmacology Thesis work by Federico Zerbinato: Platelet aggregation and microparticles in cerebrovascular disease: biomarkers of cognitive decline?)
Aberdeen Birth Cohorts Brain Ageing Research
In collaboration with the research groups led by Professors Alison Murray and David Lurie at the Aberdeen Biomedical Imaging Centre, we are continuing innovative imaging research. We aim to conduct translational research though this multidisciplinary work which will have major impact on understanding of brain ageing, cognitive resilience and pathophysiology of dementias.