MB ChB MRCP(UK)
Honorary Chair
- About
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- Email Address
- r.l.soiza@abdn.ac.uk
- Office Address
c/o Ageing Clinical & Experimental Research, University of Aberdeen, Room 1:128, Polwarth Building, Aberdeen AB25 2ZD United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Edinburgh University in 2000 and became a Member of the Royal College of Physicians in 2003. Later that year, I joined the North of Scotland training programme as a Specialist Registrar in Geriatric Medicine and General Internal Medicine. In 2006, I joined the University of Aberdeen as Clinical Lecturer in Elderly Medicine.
I was a Consultant Geriatrician with NHS Grampian from 2008 to 2018, before joining the General Medicine Department at Aberdeen Royal Infirmary, returning to Geriatric Medicine in 2023. I have held numerous roles in postgraduate medical training, including Training Programme Director for Core Medical Training and Geriatric Medicine and serving as Associate Postgraduate Dean from 2015-2017.
I was awarded an NRS Career Researcher Fellowship in 2012. Having previous held roles of Honorary Senior Lecturer and Honorary Reader, I was awarded an Honorary Chair in 2024.
External Memberships
- Consultant Physician, NHS Grampian
- Senior Editor, Age & Ageing 2020-
- Associate Editor, Therapeutic Advances in Drug Safety 2010-, SAGE Open Medicine and SAGE Open Medical Reports 2012-,
- Editorial Board Member, American Journal of Cardiovascular Disease 2011-, BMC Health Services Research 2014-
- Growing Older in Scotland Report, Reference Group Member
- Reviewer, for numerous international medical journals and grant-awarding bodies including MRC, CSO, NIHR, Research Council of Norway, South African Medical Research Council and Italian Ministry of Education, Universities & Research
Other Recent Roles
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Associate Postgraduate Dean (Medicine), NES, 1st Feb 2015 – 31st Aug 2017
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NRS Career Research Fellow 2012-5
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Treasurer, Scottish Society of Physicians, 2014-8
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Executive Committee Member, Scottish Society of Physicians, 2012-8
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Scottish Intercollegiate Guideline Network (SIGN), Delirium Guideline Development Group Member 2016-9, Dementia Guideline Group Member 2020-
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Chair, Organising Committee, RCPE Geriatric Medicine Symposium 2019
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Faculty Member, Faculty Development Alliance (formerly SCOTS Supervisor Training Courses), 2010-7
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Electives Adviser, University of Aberdeen Medical School, 2010-8
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Training Programme Director, North of Scotland Deanery
Core Medical Training 2010-3
Geriatric Medicine 2011-5
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Educational Supervisor, Foundation Programme, GP and Specialty Registrars, 2008-
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Chair, Medical Specialties Training Committee, North of Scotland Deanery 2013-2015
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Member, RCP/BGS Geriatric Medicine Specialty Certificate Exam (SCE) Question Writing Group, 2009-14
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Advisory Board Member, Otsuka Pharmaceuticals (UK), 2010-12
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External Examiner, MSc (Hons) research theses, Dundee University and Flinders University 2012-6
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Clinical Supervisor, Physician Associate course, University of Aberdeen 2013-5
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‘Hospital to Home’ National Project Advisory Group Member, Institute for Research and Innovation in Social Services (IRISS), 2013-6
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Expert panellist, for a number of Delphi expert panels, e.g. for the FORTA, OPERAM and PERFECTED clinical trials
- Research
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Research Overview
I am interested in all aspects of health and disease in old age. My chief interests are hyponatraemia in older people and clinical pharmacology in old age. More recently, I have been working on COVID-19 therapy trials, and leading on vaccine trials. I have also researched polypharmacy, whole body vibration exercise, vascular ageing and cognitive ageing. I run clinical trials in older people but have wide experience in epidemiological and mechanistic studies, as well as systematic reviews.
Current Research
I am the Aberdeen Principal Investigator for the NOVAVAX, MODERNA P-305 (omicron), Medicago, BiCARB, K-SWAY, LACE, RAINDROP and SENATOR randomised controlled trials.
I have an ongoing interest in hyponatraemia, most recently investigating the causes of hyponatraemia after head injury.
I also led Wave 4 of the Aberdeen 1936 Birth Cohort (ABC36) Study, a longitudinal cohort study of cognitive ageing.
Supervision
I have supervised numerous undergraduate and postgraduate students from medical elective students to PhD candidates.
Funding and Grants
Current Grants
- ‘An evidence synthesis suite to inform a a future randomised trial of reducing anticholinergic related harm in older adults’, PK Myint, RL Soiza et al (6 co-investigators), Dunhill Medical Trust Ref No RPGF180666, £99,165
- ‘Oral iron, intravenous iron or discontinuation of therapy for older adults with treatment unresponsive iron deficiency anaemia- a pilot randomised controlled trial’, PK Myint, RL Soiza et al (7 co-investigators), CSO Grant Ref No HIPS/17/15, £283,555
- ‘Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older persons (SENATOR)’, EU FP7 Project Grant, D O’Mahony, RL Soiza et al (12 co-investigators), €5,938,947
- ‘Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial’ NIHR HTA Grant 10/71, MD Witham, RL Soiza et al (10 co-investigators), £1,471,735
- ‘Vitamin K supplementation to reduce falls in older people – a multicentre trial’ CSO Grant CZH/4/1100, MD Witham, M McMurdo, P Donnan, P Mc Namee, RL Soiza, V Cvoro, £213,493
- ‘Assessment of association between slow muscle fibres of calf and postural integrity between elderly fallers and non fallers using MRI techniques – a proof of concept study’ NHS Grampian Endowment Fund Research Grant 14/19, PK Myint, SR Gray, J He, RL Soiza,£11,936
- Vascular ageing and hyponatraemia, NRS Career Researcher Fellowship, £123,010
- ‘Association of White Matter Lesions with Endothelial Dysfunction and Postural Blood Pressure Instability (ENDOW Study)’ NHS Grampian Endowment Fund Research Grant, £16,000, GE Hoyle, RL Soiza, DJP Williams, DG Seymour, AD Murray
- ‘Aberdeen 1936 Birth Cohort Study: Wave 4’ Development Trust Alzheimer’s Research Fund, £41,382, AD Murray, RL Soiza, LJ Whalley
- 'Association of Postural Blood Pressure Instability with Arterial Stiffness and Endothelial Dysfunction' NHSG Endowments No. 08/26 £8,667, RL Soiza, S Saha, GE Hoyle, DJP Williams
- ‘The role of serum urate in cognitive decline’ Tenovus Scotland Project Grant G09/20 £9,456, RL Soiza, AD Murray, L Phillips, RT Staff
- ‘The association between plasma nitrite levels and degree of endothelial function measured by pulse wave analysis’ 50% NHSG Endowments No. 09/19 & 50% British Geriatrics Society SpR Start-up Grant - £13,704, RL Soiza, S Saha, DJP Williams, IJ Megson
- ‘Arginine Methylation: the missing link between vascular risk and Alzheimer’s disease severity’. NHS Grampian Endowments Research Grant 11/08, £9,084 AA Mangoni, RL Soiza, D Mowat
- ‘Can asymmetric dimethylarginine (ADMA) predict cognitive decline?’ NHS Grampian Endowments Research Grant No 11/07, £11,789, AA Mangoni, F Thies, RL Soiza, RT Staff
- Publications
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Page 3 of 6 Results 51 to 75 of 150
Dexamethasone in Hospitalized Patients with Covid-19: Preliminary Report
The New England Journal of MedicineContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa2021436
Prevention of Adverse Drug Reactions in Hospitalized Older Patients with Multi-morbidity and Polypharmacy: the SENATOR randomized controlled clinical trial
Age and Ageing, vol. 49, no. 4, pp. 605-614Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afaa072
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/3/SENATOR_Trial_AgeandAgeing_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/1/Figure1_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/2/Figure2_AAM.pdf
- [ONLINE] View publication in Scopus
COVID-19 position statement: Presentations and management of COVID-19 in older people in acute care
Scottish Government. 14 pagesBooks and Reports: Commissioned ReportsThe prognostic value of anticholinergic burden measures in relation to mortality in older individuals: a systematic review and meta-analysis
Frontiers in Pharmacology, vol. 11, 570Contributions to Journals: ArticlesClinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial
BMC medicine , vol. 18, 91Contributions to Journals: ArticlesClinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis: The BiCARB randomised controlled trial
Health Technology Assessment, vol. 18, 91Contributions to Journals: ArticlesAssessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Annals of Family Medicine, vol. 18, no. 2, pp. 148-155Contributions to Journals: Articles- [ONLINE] http://www.AnnFamMed.org/content/18/2/148/suppl/DC1/
- [ONLINE] DOI: https://doi.org/10.1370/afm.2501
- [ONLINE] Deposit in University of Glasgow repository
- [ONLINE] View publication in Scopus
Non-pharmacological, non-surgical interventions for urinary incontinence in older persons: A systematic review of systematic reviews. The SENATOR project ONTOP series
Maturitas, vol. 133, pp. 42-48Contributions to Journals: ArticlesAssociation between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review
Age and Ageing, vol. 49, no. 2, pp. 184-192Contributions to Journals: Review articlesEffect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial
Journal of the American Geriatrics Society, vol. 67, no. 10, pp. 2102-2107Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jgs.16024
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13134/1/Witham_et_al_JAGS_Effect_of_vitamin_K2_VoR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Nonpharmacologic Management of Orthostatic Hypotension in Older People: A Systematic Review. The SENATOR ONTOP Series
Journal of the American Medical Directors Association, vol. 20, no. 9, pp. 1065-1073.e3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jamda.2019.03.032
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14323/1/Revision2_JAMDA_D_19_00103R2.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
The Scottish Intercollegiate Guidelines Network (SIGN) 157: Guidelines on Risk Reduction and Management of Delirium: Communication
Medicina, vol. 55, no. 8, 491Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/medicina55080491
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12723/1/Soiza_Myint_Medicina_SIGN157_VOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
SCoOP Acute Hospital Outcomes Report: An overview of outcomes of acute geriatric medicine services in Scotland
University of Aberdeen. 36 pagesBooks and Reports: Commissioned ReportsNon-pharmacological interventions for the improvement of post-stroke quality of life amongst older stroke survivors: a systematic review (The SENATOR ONTOP series)
European Geriatric Medicine, vol. 10, no. 3, pp. 359-386Contributions to Journals: Articles- [ONLINE] https://link.springer.com/epdf/10.1007/s41999-019-00180-6?author_access_token=cT_8ebDtsBoiP4tzRaWDs_e4RwlQNchNByi7wbcMAY4dboH4TWmlnz_LYoOJPSmuq1JmAzXleWCflVZHt3IN0XRu5ju_6CddJZSLYe0BRNqslvdonGTIdcj2Gk_pnQMcKadHJ9n2KbLS9RhpnTAzkg%3D%3D
- [ONLINE] DOI: https://doi.org/10.1007/s41999-019-00180-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13948/1/EGEM_D_18_00317_R1.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
SIGN 157: Risk reduction and management of delirium
Scottish Intercollegiate Guidelines Network (Online).Other Contributions: Other ContributionsPrevalence and documented causes of hyponatraemia among geriatric patients attending a primary care clinic
The Medical Journal of Malaysia, vol. 74, no. 2, pp. 121-127Contributions to Journals: Articles- [ONLINE] http://www.e-mjm.org/
- [ONLINE] Publisher copyright on deposition
- [ONLINE] View publication in Scopus
The effect of SENATOR (Software ENgine for the Assessment and optimisation of drug and non-drug Therapy in Older peRsons) on incident adverse drug reactions (ADRs) in an older hospital cohort: Trial Protocol
BMC Geriatrics, vol. 19, 40Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12877-019-1047-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11920/1/The_effect_of_SENATOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Oral Bicarbonate Therapy in Non-Haemodialysis Dependent Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Journal of Clinical Medicine, vol. 8, no. 2, 208Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/jcm8020208
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11880/1/jcm_08_00208.pdf
- [ONLINE] View publication in Mendeley
Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project
Ageing Research Reviews, vol. 49, pp. 27-48Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.arr.2018.10.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13213/1/ONTOP_Nutrition_Review.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Variability in the clinical management of iron deficiency anaemia in older adults: results from a survey of UK specialists in the care of older people
Therapeutic Advances in Drug Safety, vol. 10, pp. 1-10Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/2042098619854870
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12431/1/Variability_in_the_clinical_management_of_iron_deficiency_anaemia_in_older_adultspdf.pdf
- [ONLINE] http://journals.sagepub.com/doi/10.1177/2042098619854870
- [ONLINE] View publication in Mendeley
Effect of two different participant information sheets on recruitment to a falls trial: An embedded randomised recruitment trial
Clinical Trials, vol. 15, no. 6, pp. 551-556Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1740774518803558
Non-pharmacological interventions for the improvement of post-stroke activities of daily living and disability amongst older stroke survivors: A systematic review
PloS ONE, vol. 13, no. 10, 0204774Contributions to Journals: ArticlesThe pale evidence for treatment of iron-deficiency anaemia in older people
Therapeutic Advances in Drug Safety, vol. 9, no. 6, pp. 259-261Contributions to Journals: EditorialsManagement of acute coronary syndromes in older people
Age and Ageing, vol. 47, no. 1, pp. 2-3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afx160
Serum sodium level variability as a prognosticator in older adults
Scandinavian Journal of Clinical & Laboratory Investigation, vol. 78, no. 7-8, pp. 632-638Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/00365513.2018.1543893