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  • Graded calorie restriction causes graded slowing of epigenetic aging in mice

    Speakman, J., Chen, E., Moulds, T., Mitchell, S., Guo, W., Yang, X., Adams, P.

    Aging Cell

    Contributions to Journals: Articles

  • Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice

    Mitchell, S., Heib, L., Green, C. L., Derous, D., Hambly, C., Speakman, J.

    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 80, no. 11, glaf168

    Contributions to Journals: Articles

  • Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

    Bajunaid, R., Niu, C., Hambly, C., Liu, Z., Yamada, Y., Aleman-Mateo, H., Anderson, L. J., Arab, L., Baddou, I., Bandini, L., Bedu-Addo, K., Blaak, E. E., Bouten, C. V. C., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Casper, R., Close, G. L., Cooper, J. A., Cooper, R., Das, S. K., Davies, P. S. W., Dabare, P., Dugas, L. R., Eaton, S., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Gillingham, M., Goris, A. H., Gurven, M., El Hamdouchi, A., Haisma, H. H., Hoffman, D., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kimura, M., Kraus, W. E., Kriengsinyos, W., Kuriyan, R., Kushner, R. F., Lambert, E. V., Lanerolle, P., Larsson, C. L., Leonard, W. R., Lessan, N., Löf, M., Martin, C. K., Matsiko, E., Medin, A. C., Morehen, J. C., Morton, J. P., Must, A., Neuhouser, M. L., Nicklas, T. A., Nyström, C. D., Ojiambo, R. M., Pietiläinen, K. H., Pitsiladis, Y. P., Plange-Rhule, J., Plasqui, G., Prentice, R. L., Racette, S. B., Raichlen, D. A., Ravussin, E., Redman, L. M., Reilly, J. J., Reynolds, R., Roberts, S. B., Samaranayakem, D., Sardinha, L. B., Silva, A. M., Sjödin, A. M., Stamatiou, M., Stice, E., Urlacher, S. S., Van Etten, L. M., van Mil, E. G. A. H., Wilson, G., Yanovski, J. A., Yoshida, T., Zhang, X., Murphy-Alford, A. J., Sinha, S., Loechl, C. U., Luke, A. H., Pontzer, H., Rood, J., Sagayama, H., Schoeller, D. A., Westerterp, K. R., Wong, W. W., Speakman, J. R.

    Nature Food, vol. 6, pp. 58-71

    Contributions to Journals: Articles

  • Improving quality control procedures for the measurement of total daily energy expenditure using the two-point doubly labeled water method

    Breit, M. J., Duncan, N. M., Dahle, J. H., Catenacci, V. A., Creasy, S. A., Berman, E. S., Speakman, J. R., Melanson, E. L.

    Rapid Communications in Mass Spectrometry, vol. 38, no. 19, e9886

    Contributions to Journals: Articles

  • Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory

    Mitchell, S. E., Simpson, M., Coulet, L., Gouedard, S., Hambly, C., Morimoto, J., Allison, D. B., Speakman, J. R.

    Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 42, e2408682121

    Contributions to Journals: Articles

  • Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake

    Smith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., Allison, D. B., Speakman, J. R., Nagy, T. R.

    GeroScience, vol. 46, pp. 4809–4826

    Contributions to Journals: Articles

  • On the pathogenesis of obesity: causal models and missing pieces of the puzzle

    Magkos, F., Sørensen, T. I., Raubenheimer, D., Dhurandhar, N. V., Loos, R. J., Bosy-Westphal, A., Clemmensen, C., Hjorth, M. F., Allison, D. B., Taubes, G., Ravussin, E., Friedman, M. I., Hall, K. D., Ludwig, D. S., Speakman, J. R., Astrup, A.

    Nature Metabolism, vol. 6, no. 10, pp. 1856-1865

    Contributions to Journals: Articles

  • Validity of dietary assessment methods compared with doubly labeled water in children: A systematic review and meta-analysis

    Mehranfar, S., Jalilpiran, Y., Jafari, A., Jayedi, A., Shab-bidar, S., Speakman, J. R., Djafarian, K.

    Obesity Reviews, vol. 25, no. 9, e13768

    Contributions to Journals: Review articles

  • Energy expenditure, intake and availability in female soccer players via doubly labelled water: Are we misrepresenting low energy availability?

    McHaffie, S. J., Langan-Evans, C., Strauss, J. A., Areta, J. L., Rosimus, C., Evans, M., Waghorn, R., Grant, J., Cuthbert, M., Hambly, C., Speakman, J. R., Morton, J. P.

    Experimental Physiology

    Contributions to Journals: Articles

  • Daily energy expenditure and water turnover in female netball players from the Netball Super League: A doubly labeled water observation study

    Costello, N., Jones, B., Roe, S., Blake, C., Clark, A., Chantler, S., Owen, C., Wilson, L., Wilson, O., Stavropoulos-Kalinoglou, A., Janse van Rensburg, D. C., Hambly, C., Speakman, J. R., Backhouse, S., Whitehead, S.

    European Journal of Sport Science, vol. 24, no. 8, pp. 1130-1142

    Contributions to Journals: Articles

  • Validity of predictive equations for total energy expenditure against doubly labeled water

    Prado-Nóvoa, O., Howard, K. R., Laskaridou, E., Zorrilla-Revilla, G., Reid, G. R., Marinik, E. L., Davy, B. M., Stamatiou, M., Hambly, C., Speakman, J. R., Davy, K. P.

    Scientific Reports, vol. 14, 15754

    Contributions to Journals: Articles

  • The carbohydrate insulin model is always correct: a point worth reiterating even when commenting on studies that do not concern it

    Speakman, J. R., Gao, L., Hu, S.

    Obesity, vol. 32, no. 7, pp. 1229-1230

    Contributions to Journals: Letters

  • Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

    Leeson-Payne, A., Iyinikkel, J., Malcolm, C., Lam, B. Y. H., Sommer, N., Dowsett, G. K. C., Blanco Martinez de Morentin, P., Thompson, D., MacKenzie, A., Chianese, R., Kentistou, K. A., Gardner, E. J., Perry, J. R., Grassmann, F., Speakman, J., Rochford, J., Yeo, G. S. H., Murray, F., Heisler, L.

    Cell Metabolism, vol. 36, no. 5, pp. 1076-1087

    Contributions to Journals: Articles

  • Case-study: Energy expenditure of a world class male wheelchair tennis player during training, Grand Slam and British open tournaments measured by doubly labelled water

    Ellis, D. G., Speakman, J., Hambly, C., Cockram, A., Morton, J. P., Close, G. L., Donovan, T. F.

    International Journal of Sports Science and Coaching, vol. 19, no. 2, pp. 857 - 863

    Contributions to Journals: Articles

  • Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

    Huang, Y., Wang, A., Zhou, W., Li, B., Zhang, L., Rudolf, A. M., Jin, Z., Hambly, C., Wang, G., Speakman, J. R.

    Nature Communications, vol. 15, 2382

    Contributions to Journals: Articles

  • Behavioural variability, physical activity, rumination time, and milk characteristics of dairy cattle in response to regrouping

    Marumo, J. L., Lusseau, D., Speakman, J. R., Mackie, M., Byar, A. Y., Cartwright, W., Hambly, C.

    Animal , vol. 18, no. 3, 101094

    Contributions to Journals: Articles

  • Daily energy requirements of male academy soccer players are greater than age-matched non-academy soccer players: A doubly labelled water investigation

    Stables, R. G., Hannon, M. P., Jacob, A. D., Topping, O., Costello, N. B., Boddy, L. M., Hambly, C., Speakman, J. R., Sodhi, J. S., Close, G. L., Morton, J. P.

    Journal of Sports Sciences, vol. 41, no. 12, pp. 1218-1230

    Contributions to Journals: Articles

  • Great tits (Parus major) in a west European temperate forest show little seasonal variation in metabolic energy requirements

    Pacioni, C., Sentís, M., Hambly, C., Speakman, J. R., Kerimov, A., Bushuev, A., Lens, L., Strubbe, D.

    Journal of Thermal Biology, vol. 118, pp. 103748

    Contributions to Journals: Articles

  • The bioelectrical impedance analysis (BIA) international database: aims, scope, and call for data

    Silva, A. M., Campa, F., Stagi, S., Gobbo, L. A., Buffa, R., Toselli, S., Silva, D. A. S., Gonçalves, E. M., Langer, R. D., Guerra-Júnior, G., Machado, D. R. L., Kondo, E., Sagayama, H., Omi, N., Yamada, Y., Yoshida, T., Fukuda, W., Gonzalez, M. C., Orlandi, S. P., Koury, J. C., Moro, T., Paoli, A., Kruger, S., Schutte, A. E., Andreolli, A., Earthman, C. P., Fuchs-Tarlovsky, V., Irurtia, A., Castizo-Olier, J., Mascherini, G., Petri, C., Busert, L. K., Cortina-Borja, M., Bailey, J., Tausanovitch, Z., Lelijveld, N., Ghazzawi, H. A., Amawi, A. T., Tinsley, G., Kangas, S. T., Salpéteur, C., Vázquez-Vázquez, A., Fewtrell, M., Ceolin, C., Sergi, G., Ward, L. C., Heitmann, B. L., da Costa, R. F., Vicente-Rodriguez, G., Cremasco, M. M., Moroni, A., Shepherd, J., Moon, J., Knaan, T., Müller, M. J., Braun, W., García-Almeida, J. M., Palmeira, A. L., Santos, I., Larsen, S. C., Zhang, X., Speakman, J. R., Plank, L. D., Swinburn, B. A., Ssensamba, J. T., Shiose, K., Cyrino, E. S., Bosy-Westphal, A., Heymsfield, S. B., Lukaski, H., Sardinha, L. B., Wells, J. C., Marini, E.

    European Journal of Clinical Nutrition, vol. 77, pp. 1143–1150

    Contributions to Journals: Articles

  • The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice

    Mitchell, S. E., Togo, J., Green, C. L., Derous, D., Hambly, C., Speakman, J. R.

    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 78, no. 11, pp. 1953-1963

    Contributions to Journals: Articles

  • Validation of the 2 × 24 h recall method and a 7-d web-based food diary against doubly labelled water in Danish adults

    Biltoft-Jensen, A., Ygil, K. H., Knudsen, L., Matthiessen, J., Fagt, S., Trolle, E., Nielsen, T. H., Hansen, D. M., Licht, C. L., Martens, M., Hambly, C., Speakman, J. R., Christensen, T.

    British Journal of Nutrition, vol. 130, no. 8, pp. 1444-1457

    Contributions to Journals: Articles

  • Greater male variability in daily energy expenditure develops through puberty

    Halsey, L. G., Careau, V., Ainslie, P. N., Alemán-Mateo, H., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bandini, L., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Brage, S., Buchowski, M. S., Butte, N., Camps, S. G., Casper, R., Close, G. L., Colbert, L. H., Cooper, J. A., Cooper, R., Dabare, P., Das, S. K., Davies, P. S. W., Deb, S., Nyström, C. D., Dietz, W., Dugas, L. R., Eaton, S., Ekelund, U., Hamdouchi, A. E., Entringer, S., Forrester, T., Fudge, B. W., Gillingham, M., Goris, A. H., Gurven, M., Haisma, H., Hambly, C., Hoffman, D., Hoos, M. B., Hu, S., Joonas, N., Joosen, A., Katzmarzyk, P., Kempen, K. P., Wood, B., IAEA DLW Database Consortium

    Biology Letters, vol. 19, no. 9, 20230152

    Contributions to Journals: Articles

  • A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

    Semerciöz-Oduncuoğlu, A. S., Mitchell, S. E., Özilgen, M., Yilmaz, B., Speakman, J. R.

    Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 37, e2300624120

    Contributions to Journals: Articles

  • Quantifying physical activity energy expenditure based on doubly labelled water and basal metabolism calorimetry: what are we actually measuring?

    Speakman, J. R., Pontzer, H.

    Current Opinion in Clinical Nutrition and Metabolic Care, vol. 26, no. 5, pp. 401-408

    Contributions to Journals: Review articles

  • Unanswered questions about the causes of obesity: Obesity is now a global pandemic, but there is little consensus about the causes.

    Speakman, J. R., Sørensen, T. I., Hall, K. D., Allison, D. B.

    Science (New York, N.Y.), vol. 381, no. 6661, pp. 944-946

    Contributions to Journals: Articles

  • GDF15 promotes weight loss by enhancing energy expenditure in muscle

    Wang, D., Townsend, L. K., DesOrmeaux, G. J., Frangos, S. M., Batchuluun, B., Dumont, L., Kuhre, R. E., Ahmadi, E., Hu, S., Rebalka, I. A., Gautam, J., Jabile, M. J. T., Pileggi, C. A., Rehal, S., Desjardins, E. M., Tsakiridis, E. E., Lally, J. S., Juracic, E. S., Tupling, A. R., Gerstein, H. C., Paré, G., Tsakiridis, T., Harper, M. E., Hawke, T. J., Speakman, J. R., Blondin, D. P., Holloway, G. P., Jørgensen, S. B., Steinberg, G. R.

    Nature, vol. 619, no. 7968, pp. 143-150

    Contributions to Journals: Articles

  • The effects of graded levels of calorie restriction: XIX. Impact of graded calorie restriction on protein expression in the liver

    Wang, L., Derous, D., Huang, X., Mitchell, S. E., Douglas, A., Lusseau, D., Wang, Y., Speakman, J. R.

    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 78, no. 7, pp. 1125-1134

    Contributions to Journals: Articles

  • An Observational Case Series Measuring the Energy Expenditure of Elite Tennis Players During Competition and Training by Using Doubly Labeled Water

    Ellis, D. G., Speakman, J., Hambly, C., Morton, J. P., Close, G. L., Donovan, T. F.

    International journal of sports physiology and performance, vol. 18, no. 5, pp. 547-552

    Contributions to Journals: Articles

  • Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure

    Speakman, J. R., de Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., Das, S. K., Davies, P. S. W., Dugas, L. R., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Gillingham, M., Ghosh, S., Goris, A. H., Gurven, M., Halsey, L. G., Hambly, C., Haisma, H. H., Hoffman, D., Hu, S., Joosen, A. M., Kaplan, J. L., Katzmarzyk, P., Kraus, W. E., Kushner, R. F., Leonard, W. R., Löf, M., Martin, C. K., Matsiko, E., Medin, A. C., Meijer, E. P., Neuhouser, M. L., Nicklas, T. A., Ojiambo, R. M., Pietiläinen, K. H., Plange-Rhule, J., Plasqui, G., Prentice, R. L., Racette, S. B., Raichlen, D. A., Ravussin, E., Redman, L. M., Roberts, S. B., Rudolph, M. C., Sardinha, L. B., Schuit, A. J., Silva, A. M., Stice, E., Urlacher, S. S., Valenti, G., Van Etten, L. M., Van Mil, E. A., Wood, B. M., Yanovski, J. A., Yoshida, T., Zhang, X., Murphy-Alford, A. J., Loechl, C. U., Kurpad, A., Luke, A. H., Pontzer, H., Rodeheffer, M. S., Rood, J., Schoeller, D. A., Wong, W. W.

    Nature Metabolism, vol. 5, no. 4, pp. 579-588

    Contributions to Journals: Articles

  • Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

    Krol, E., Turner, F., Derous, D., Mitchell, S. E., Martin, S., Douglas, A., Speakman, J.

    Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, pp. 171-192

    Contributions to Journals: Articles

  • Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

    Kentistou, K. A., Luan, J., Wittemans, L. B. L., Hambly, C., Klaric, L., Kutalik, Z., Speakman, J. R., Wareham, N. J., Kendall, T. J., Langenberg, C., Wilson, J. F., Joshi, P. K., Morton, N. M.

    Nature Communications, vol. 14, 307

    Contributions to Journals: Articles

  • The energy balance model of obesity: beyond calories in, calories out

    Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J., Mangelsdorf, D. J., O'Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., Speakman, J. R., Tobias, D. K.

    American Journal of Clinical Nutrition, vol. 115, no. 5, pp. 1243-1254

    Contributions to Journals: Articles

  • Variation in human water turnover associated with environmental and lifestyle factors

    Yamada, Y., Zhang, X., Henderson, M. E. T., Sagayama, H., Pontzer, H., Watanabe, D., Yoshida, T., Kimura, M., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G., Close, G. L., Cooper, J. A., Cooper, R., Das, S. K., Dugas, L. R., Eaton, S., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Goris, A. H., Gurven, M., Halsey, L. G., Hambly, C., El Hamdouchi, A., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kempen, K. P., Kraus, W. E., Kriengsinyos, W., Kushner, R. F., Lambert, E. V., Leonard, W. R., Lessan, N., Speakman, J. R., International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

    Science, vol. 378, no. 6622, pp. 909-915

    Contributions to Journals: Articles

  • Focus on diet and exercise

    Speakman, J., Johnstone, A., Moholdt, T., Panda, S., Klein, S., Parker, B. L., Goodyear, L.

    Contributions to Journals

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