Publications | The School of Biological Sciences

Graded calorie restriction causes graded slowing of epigenetic aging in mice

2025 - Accepted/In press

Speakman, J., Chen, E., Moulds, T., Mitchell, S., Guo, W., Yang, X., Adams, P.

Aging Cell

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1111/acel.70342

Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice

2025

Mitchell, S., Heib, L., Green, C. L., Derous, D., Hambly, C., Speakman, J.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 80, no. 11, glaf168

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/gerona/glaf168
Open Access: http://aura.abdn.ac.uk/bitstreams/3ab5e65f-aea9-4def-a762-cb885acca2bc/download

Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

2025

Bajunaid, R., Niu, C., Hambly, C., Liu, Z., Yamada, Y., Aleman-Mateo, H., Anderson, L. J., Arab, L., Baddou, I., Bandini, L., Bedu-Addo, K., Blaak, E. E., Bouten, C. V. C., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Casper, R., Close, G. L., Cooper, J. A., Cooper, R., Das, S. K., Davies, P. S. W., Dabare, P., Dugas, L. R., Eaton, S., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Gillingham, M., Goris, A. H., Gurven, M., El Hamdouchi, A., Haisma, H. H., Hoffman, D., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kimura, M., Kraus, W. E., Kriengsinyos, W., Kuriyan, R., Kushner, R. F., Lambert, E. V., Lanerolle, P., Larsson, C. L., Leonard, W. R., Lessan, N., Löf, M., Martin, C. K., Matsiko, E., Medin, A. C., Morehen, J. C., Morton, J. P., Must, A., Neuhouser, M. L., Nicklas, T. A., Nyström, C. D., Ojiambo, R. M., Pietiläinen, K. H., Pitsiladis, Y. P., Plange-Rhule, J., Plasqui, G., Prentice, R. L., Racette, S. B., Raichlen, D. A., Ravussin, E., Redman, L. M., Reilly, J. J., Reynolds, R., Roberts, S. B., Samaranayakem, D., Sardinha, L. B., Silva, A. M., Sjödin, A. M., Stamatiou, M., Stice, E., Urlacher, S. S., Van Etten, L. M., van Mil, E. G. A. H., Wilson, G., Yanovski, J. A., Yoshida, T., Zhang, X., Murphy-Alford, A. J., Sinha, S., Loechl, C. U., Luke, A. H., Pontzer, H., Rood, J., Sagayama, H., Schoeller, D. A., Westerterp, K. R., Wong, W. W., Speakman, J. R.

Nature Food, vol. 6, pp. 58-71

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s43016-024-01089-5
Open Access: http://aura.abdn.ac.uk/bitstreams/ce0bc095-8b09-476f-a7fc-0bf61dcb1a65/download

Improving quality control procedures for the measurement of total daily energy expenditure using the two-point doubly labeled water method

2024

Breit, M. J., Duncan, N. M., Dahle, J. H., Catenacci, V. A., Creasy, S. A., Berman, E. S., Speakman, J. R., Melanson, E. L.

Rapid Communications in Mass Spectrometry, vol. 38, no. 19, e9886

Contributions to Journals: Articles

Online: https://pmc.ncbi.nlm.nih.gov/articles/PMC12084875/
Digital Object Identifier: https://doi.org/10.1002/rcm.9886
Additional Links: View publication in Scopus

Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory

2024

Mitchell, S. E., Simpson, M., Coulet, L., Gouedard, S., Hambly, C., Morimoto, J., Allison, D. B., Speakman, J. R.

Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 42, e2408682121

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1073/pnas.2408682121
Open Access: http://aura.abdn.ac.uk/bitstreams/77f23679-e0a5-490b-82bb-5e2e7155f0f0/download
Additional Links: View publication in Scopus

Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake

2024

Smith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., Allison, D. B., Speakman, J. R., Nagy, T. R.

GeroScience, vol. 46, pp. 4809–4826

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1007/s11357-024-01166-4
Open Access: http://aura.abdn.ac.uk/bitstreams/ef4c69c8-cb7d-458d-b8fb-bf535850e3ef/download

On the pathogenesis of obesity: causal models and missing pieces of the puzzle

2024

Magkos, F., Sørensen, T. I., Raubenheimer, D., Dhurandhar, N. V., Loos, R. J., Bosy-Westphal, A., Clemmensen, C., Hjorth, M. F., Allison, D. B., Taubes, G., Ravussin, E., Friedman, M. I., Hall, K. D., Ludwig, D. S., Speakman, J. R., Astrup, A.

Nature Metabolism, vol. 6, no. 10, pp. 1856-1865

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s42255-024-01106-8
Additional Links: View publication in Scopus

Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.

2024

Osorio Mendoza, J., Mitchell, S., Hambly, C., Allison, D. B., Speakman, J.

Appetite, vol. 200, 107421

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.appet.2024.107421
Open Access: http://aura.abdn.ac.uk/bitstreams/c7e4825a-7182-4cb1-9b94-a26dd88f996f/download

Validity of dietary assessment methods compared with doubly labeled water in children: A systematic review and meta-analysis

2024

Mehranfar, S., Jalilpiran, Y., Jafari, A., Jayedi, A., Shab-bidar, S., Speakman, J. R., Djafarian, K.

Obesity Reviews, vol. 25, no. 9, e13768

Contributions to Journals: Review articles

Digital Object Identifier: https://doi.org/10.1111/obr.13768
Additional Links: View publication in Scopus

Energy expenditure, intake and availability in female soccer players via doubly labelled water: Are we misrepresenting low energy availability?

2024 - E-pub ahead of print

McHaffie, S. J., Langan-Evans, C., Strauss, J. A., Areta, J. L., Rosimus, C., Evans, M., Waghorn, R., Grant, J., Cuthbert, M., Hambly, C., Speakman, J. R., Morton, J. P.

Experimental Physiology

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1113/EP091589
Additional Links: View publication in Scopus

Daily energy expenditure and water turnover in female netball players from the Netball Super League: A doubly labeled water observation study

2024

Costello, N., Jones, B., Roe, S., Blake, C., Clark, A., Chantler, S., Owen, C., Wilson, L., Wilson, O., Stavropoulos-Kalinoglou, A., Janse van Rensburg, D. C., Hambly, C., Speakman, J. R., Backhouse, S., Whitehead, S.

European Journal of Sport Science, vol. 24, no. 8, pp. 1130-1142

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1002/ejsc.12160
Open Access: http://aura.abdn.ac.uk/bitstreams/cef55f3c-08f2-49dd-9dce-404ea1265ebb/download
Additional Links: View publication in Scopus

Validity of predictive equations for total energy expenditure against doubly labeled water

2024

Prado-Nóvoa, O., Howard, K. R., Laskaridou, E., Zorrilla-Revilla, G., Reid, G. R., Marinik, E. L., Davy, B. M., Stamatiou, M., Hambly, C., Speakman, J. R., Davy, K. P.

Scientific Reports, vol. 14, 15754

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s41598-024-66767-7
Open Access: http://aura.abdn.ac.uk/bitstreams/8677aacf-430e-459d-afb4-02a86b3dfa99/download
Additional Links: View publication in Scopus

The carbohydrate insulin model is always correct: a point worth reiterating even when commenting on studies that do not concern it

2024

Speakman, J. R., Gao, L., Hu, S.

Obesity, vol. 32, no. 7, pp. 1229-1230

Contributions to Journals: Letters

Digital Object Identifier: https://doi.org/10.1002/oby.24053
Additional Links: View publication in Scopus

Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction

2024

Gutierrez, E., Mitchell, S., Hambly, C., Sayle, K. l., Von kriegsheim, A., Speakman, J. r., Britton, K.

iScience, vol. 27, no. 6, 110059

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.isci.2024.110059
Open Access: http://aura.abdn.ac.uk/bitstreams/ed1dc7b3-9204-44a7-9301-062fb4d8b983/download

Results of the Second Life Metabolism Travel Awards 2024

2024

Speakman, J. R.

Life metabolism, vol. 3, no. 3, loae007

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/lifemeta/loae007
Open Access: http://aura.abdn.ac.uk/bitstreams/46575609-7de1-4d8c-a37b-6e1e67289425/download

Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

2024

Leeson-Payne, A., Iyinikkel, J., Malcolm, C., Lam, B. Y. H., Sommer, N., Dowsett, G. K. C., Blanco Martinez de Morentin, P., Thompson, D., MacKenzie, A., Chianese, R., Kentistou, K. A., Gardner, E. J., Perry, J. R., Grassmann, F., Speakman, J., Rochford, J., Yeo, G. S. H., Murray, F., Heisler, L.

Cell Metabolism, vol. 36, no. 5, pp. 1076-1087

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.cmet.2024.03.016
Open Access: http://aura.abdn.ac.uk/bitstreams/a4df5e6e-2e39-4d4b-9f5b-ca50333bb251/download

Turmeric shortens lifespan in houseflies

2024

Laurie, S., Ainslie, L., Mitchell, S., Morimoto, J.

Frontiers in Insect Science, vol. 4, 1376011

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.3389/finsc.2024.1376011
Open Access: http://aura.abdn.ac.uk/bitstreams/2c9bcab3-98c8-43a3-aa96-33b89e11842f/download
Additional Links: View publication in Scopus

Case-study: Energy expenditure of a world class male wheelchair tennis player during training, Grand Slam and British open tournaments measured by doubly labelled water

2024

Ellis, D. G., Speakman, J., Hambly, C., Cockram, A., Morton, J. P., Close, G. L., Donovan, T. F.

International Journal of Sports Science and Coaching, vol. 19, no. 2, pp. 857 - 863

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1177/17479541231169033
Open Access: http://aura.abdn.ac.uk/bitstreams/b42aa800-6271-4676-92f1-bf6d3b42971f/download
Additional Links: View publication in Scopus

The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice

2024

Gao, L., Hu, S., Yang, D., Wang, L., Togo, J., Wu, Y., Li, B., Li, M., Wang, G., Zhang, X., Li, L., Xu, Y., Mazidi, M., Couper, E., Whittington-Davies, A., Niu, C., Speakman, J.

Obesity, vol. 32, no. 4, pp. 733-742

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1002/oby.23991
Open Access: http://aura.abdn.ac.uk/bitstreams/c26a8d46-7e83-43a7-b8f7-982e046d1006/download

Links between energy budgets, somatic condition, and life history reveal heterogeneous energy management tactics in a group-living mesocarnivore

2024

Bright Ross, J. G., Markham, A., Buesching, C. D., Hambly, C., Speakman, J. R., Macdonald, D. W., Newman, C.

Movement Ecology, vol. 12, 24

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1186/s40462-024-00453-1
Open Access: http://aura.abdn.ac.uk/bitstreams/32dd1aef-edeb-4883-b315-b34af929bc99/download

Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

2024

Huang, Y., Wang, A., Zhou, W., Li, B., Zhang, L., Rudolf, A. M., Jin, Z., Hambly, C., Wang, G., Speakman, J. R.

Nature Communications, vol. 15, 2382

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s41467-024-46589-x
Open Access: http://aura.abdn.ac.uk/bitstreams/8c5adf29-546c-4892-bc9c-55b9998a8bd6/download
Additional Links: View publication in Scopus

Behavioural variability, physical activity, rumination time, and milk characteristics of dairy cattle in response to regrouping

2024

Marumo, J. L., Lusseau, D., Speakman, J. R., Mackie, M., Byar, A. Y., Cartwright, W., Hambly, C.

Animal , vol. 18, no. 3, 101094

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.animal.2024.101094
Open Access: http://aura.abdn.ac.uk/bitstreams/bc17c30d-6f8c-4847-b03b-15fc0f1c74fc/download
Additional Links: View publication in Scopus

Limits to sustained energy intake. XXXIV.: Can the heat dissipation limit (HDL) theory explain reproductive aging?

2024

Grosiak, M., Koteja, P., Hambly, C., Speakman, J. R., Sadowska, E. T.

The Journal of experimental biology, vol. 227, no. 4, jeb246592

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1242/jeb.246592
Open Access: http://aura.abdn.ac.uk/bitstreams/67195986-6b95-40cf-b2a2-45d34c2a32ca/download

Wearable Sensors Based Human Core Body Temperature Computing Method

2023

Jiang, L., Wang, Y., Li, Y., Tao, B., Sun, F., Speakman, J.

Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

Digital Object Identifier: https://doi.org/10.1109/DASC/PiCom/CBDCom/Cy59711.2023.10361403
Additional Links: View publication in Scopus

Daily energy requirements of male academy soccer players are greater than age-matched non-academy soccer players: A doubly labelled water investigation

2023

Stables, R. G., Hannon, M. P., Jacob, A. D., Topping, O., Costello, N. B., Boddy, L. M., Hambly, C., Speakman, J. R., Sodhi, J. S., Close, G. L., Morton, J. P.

Journal of Sports Sciences, vol. 41, no. 12, pp. 1218-1230

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1080/02640414.2023.2263707
Open Access: http://aura.abdn.ac.uk/bitstreams/02302ed9-aa69-4acc-84aa-331fd7b1e395/download