Dr Alan Sneddon

Dr Alan Sneddon

Research Fellow

Dr Alan Sneddon
Dr Alan Sneddon

Contact Details

work +44 (0)1224 438671
The University of Aberdeen Metabolic Health Group
Rowett Institute
University of Aberdeen
Aberdeen. AB25 2ZD
Tel: +44(0)1224 438671   
Fax: +44(0)1224 438629

External Memberships and Affiliations

  • Deputy Editor for British Journal of Nutrition
  • First Editor for Journal of Nutritional Science.
  • Member of Editorial Board for Preventive Nutrition and Food Science
  • Member of the Nutrition Society

Research Overview

Micronutrients and heavy metals and health

My research interests lie primarily in identifying the role of micronutrients in health and disease. This work involves accurately quantifying micronutrient levels within different food products within the diet and also in developing tools to assess their bioavailability within the body.

I have also recently developed an interest in heavy metals and their effects on health. Heavy metals including mercury, cadmium and lead can be ingested from the diet and evidence suggests that certain micronutrients play a role in alleviating their toxicity within the body.

This research will help the food industry to make healthier products and provide information on how micronutrients act to promote health.

Current Research

We have been investigating the function of dietary fatty acids and micronutrients in human health and disease and in particular cardiovascular disease (CVD). Using a model of heart disease we have shown that consuming a high fat diet lacking one micronutrient (selenium) increases heart disease more compared to consumption of the same diet containing selenium. Furthermore, these effects correlated with the levels of ‘bad’ fatty acids within the bloodstream. Additionally, other studies have shown that selenium has an anti-inflammatory effect both within immune cells and endothelial cells (which line the inside of blood vessels) and that it can reduce the interaction between these cell types, which is an important early step in heart disease development. More recent work has involved investigating nutrient-nutrient interactions relevant to CVD.

Currently, we are investigating the effects of seasonality and location on shellfish micronutrient levels and the effect of regular shellfish consumption on modulating micronutrient status in humans. These studies have ranged from measuring conventional markers of nutrient intake, to developing tools to assess micronutrient bioavailability as well as developing improved markers to assess micronutrient status and have encompassed work at both cellular and tissue level and intervention studies within animal models and in humans.

The objective of this work has been to obtain evidence for the involvement of specific nutrients in promoting health and alleviating disease in order to provide more informed dietary advice on their optimum requirements within the population. Previous work has focused on how the changing composition of feedstuffs within the aquaculture and dairy industries driven by issues of sustainability, impact on ultimate product nutritional quality and the likely influence on health for the consumer. Funding from the Wellcome Trust and British Heart Foundation have also investigated the influence of genotype and chemical speciation on micronutrient function, bioavailability and health.

Research Funding and Grants

  • RESAS (Scottish Government): Improving primary produce; Food Safety; Improvement of livestock.
  • Industrial Funding: ‘Crab consumption, cadmium and health; do crabmeat consumers have a greater cadmium burden compared to non-crabmeat consumers?
  • IMMANA: Aquatic Food for Health and Nutrition (AQN): A metric for assessing the impacts on nutrition and health of agroecosystems producing farmed seafood.
  • Elphinstone PhD studentship:‘The effect of selected micronutrients on endothelial cell function with relevance to atherosclerosis’
  • Encompass Kick-start Award: Developing bioactive mapping in seaweeds as a quality assurance tool” (co-applicant)
  • Fraserburgh Moonlight Prowl PhD studentship: ‘Omega-3 endocannabinoids: novel anticancer lipid ethanolamides’.
  • RESAS (Scottish Government), Healthy and safe diets
  • British Heart Foundation: ‘Atherosclerosis: the effect of selenium speciation and dose’.
  • Wellcome Trust Project Grant: ‘Interaction of selenium, fatty acids and a polymorphism in GPX4 in modulating vascular function’.  

Teaching Responsibilities

Course Co-ordinator for RN5507 'Nutrition and Health' 

Course contributor to RN5003 'Foundations of Nutrition'; RN5001 'Fundamentals of Human Nutrition and Metabolism'; RR5502 'Molecular Nutrition'



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  • Linkages of agroecosystems producing farmed seafood on food security, nutritional status and adolescent health in Bangladesh

    de Roos, B., Roos, N., Ara, G., Ahmed, T., Mamun, A., Sneddon, A., Murray, F., Grieve, E., Little, D. C.

    Maternal and Child Nutrition, vol. 16, no. Suppl 3, 13017

    Contributions to Journals: Articles

  • The nutritional and cardiovascular health benefits of rapeseed oil-fed farmed salmon in humans are not decreased compared with those of traditionally farmed salmon: a randomized controlled trial

    de Roos, B., Wood, S., Bremner, D., Bashir, S., Betancor, M. B., Fraser, W. D., Duthie, S. J., Horgan, G. W., Sneddon, A. A.

    European Journal of Nutrition, pp. 1-13

    Contributions to Journals: Articles

  • Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

    Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W., Rotondo, D., Heys, S. D.

    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 156, pp. 102024

    Contributions to Journals: Articles

  • Linking agroecosystems producing farmed seafood with food security and health status to better address the nutritional challenges in Bangladesh

    de Roos, B., Roos, N., Mamun, A., Ahmed, T., Sneddon, A. A., Murray, F., Grieve, E., Little, D. C.

    Public Health Nutrition, vol. 22, no. 16, pp. 2941-2949

    Contributions to Journals: Articles

  • Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study)

    Donadio, J. L., Rogero, M. M., Guerra-Shinohara, E. M., Barbosa Jr., F., Desmarchelier, C., Borel, P., Sneddon, A., Hesketh, J., Cozzolino, S. M.

    Clinical Nutrition, vol. 38, no. 2, pp. 539-548

    Contributions to Journals: Articles

  • Regular crabmeat consumers do not show increased urinary cadmium or beta-2-microglobulin levels compared to non-crabmeat consumers

    Dyck, K. N., Bashir, S., Horgan, G., Sneddon, A. A.

    Journal of Trace Elements in Medicine and Biology, vol. 52, pp. 22-28

    Contributions to Journals: Articles

  • The potential impact of compositional changes in farmed fish on its health-giving properties: is it time to reconsider current dietary recommendations?

    de Roos, B., Sneddon, A. A., Sprague, M., Horgan, G., Brouwer, I. A.

    Public Health Nutrition, vol. 20, no. 11, pp. 2042-2049

    Contributions to Journals: Articles

  • Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

    Zhang, X., McGeoch, S. C., Johnstone, A. M., Holtrop, G., Sneddon, A. A., Macrury, S. M., Megson, I. L., Pearson, D. W. M., Abraham, P., De Roos, B., Lobley, G. E., O'Kennedy, N.

    Journal of Thrombosis and Thrombolysis, vol. 37, no. 4, pp. 455-463

    Contributions to Journals: Articles

  • The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function: Interaction with selenium and fatty acids

    Crosley, L. K., Bashir, S., Nicol, F., Arthur, J. R., Hesketh, J. E., Sneddon, A. A.

    Molecular Nutrition & Food Research, vol. 57, no. 12, pp. 2185-2194

    Contributions to Journals: Articles

  • Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids

    Song, H., Sneddon, A. A., Heys, S. D., Wahle, K. W. J.

    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 87, no. 6, pp. 197-203

    Contributions to Journals: Articles

  • Selenium nutrition and its impact on health

    Sneddon, A. A.

    Food and Health Innovation Service. 6 pages

    Books and Reports: Other Reports

  • Fish as a dietary source of healthy long chain n-3 polyunsaturated fatty acids (LCn-3 PUFA) and vitamin D: A Review of the current literature

    De Roos, B., Sneddon, A. A., Macdonald, H. M.

    Food and Health Innovation Service

    Books and Reports: Commissioned Reports

  • A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

    Gautrey, H., Nicol, F., Sneddon, A. A., Hall, J., Hesketh, J.

    Biochimica et Biophysica Acta, vol. 1810, no. 6, pp. 584-591

    Contributions to Journals: Articles

  • Intervention with fish oil, but not with docosahexaenoic acid, results in lower levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice

    Mavrommatis, Y., Ross, K., Rucklidge, G., Reid, M., Duncan, G. J., Gordon, M. J., Thies, F., Sneddon, A. A., De Roos, B.

    British Journal of Nutrition, vol. 103, no. 1, pp. 16-24

    Contributions to Journals: Articles

  • Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid

    Tsofliou, F., Fyfe, C., Matheson, I., Jackson, D., Horgan, G. W., Wahle, K. W. J., Ahren, B., Williams, L., Sneddon, A. A.

    Journal of Food Lipids, vol. 16, no. 4, pp. 499-513

    Contributions to Journals: Articles

  • Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men

    Ahren, B., Mari, A., Fyfe, C., Tsofliou, F., Sneddon, A. A., Wahle, K. W. J., Winzell, M. S., Pacini, G., Williams, L.

    European Journal of Clinical Nutrition, vol. 63, no. 6, pp. 778-786

    Contributions to Journals: Articles

  • Clenbuterol increases muscle fiber size and GATA-2 protein in rat skeletal muscle in utero

    Downie, D., Delday, M. I., Maltin, C. A., Sneddon, A. A.

    Molecular Reproduction and Development, vol. 75, no. 5, pp. 785-794

    Contributions to Journals: Articles

  • Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin

    Sneddon, A. A., Tsofliou, F., Fyfe, C., Matheson, I., Jackson, D., Horgan, G. W., Winzell, M. S., Wahle, K. W. J., Ahren, B., Williams, L.

    Obesity, vol. 16, no. 5, pp. 1019-1024

    Contributions to Journals: Articles

  • Effects of age and obesity on 24-hour heart rate variability in healthy lean and obese, young and older men

    Tsofliou, F., Jackson, D., Fyfe, C., Sneddon, A. A., Wahle, K. W. J., Williams, L.

    International Journal of Obesity, vol. 32, no. Supplement 1, pp. S112

    Contributions to Journals: Articles

  • Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: Involvement of the transcription factor NF-κB?

    Goua, M., Mulgrew, S., Frank, J., Rees, D., Sneddon, A. A., Wahle, K. W. J.

    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 78, no. 1, pp. 33-43

    Contributions to Journals: Articles

  • The effects of fish oil and DHA on soluble epoxide hydrolase in apoE-/- mice

    Mavrommatis, Y. I., Thies, F., Ross, K., Gordon, M. J., McLeod, E., Sneddon, A. A., Rucklidge, G. J., Reid, M. D., Duncan, G. J., Mayer, C., Horgan, G., Arthur, J., De Roos, B.

    Proceedings of the Nutrition Society, vol. 66, no. Supplement OCA-B , 103A

    Contributions to Journals: Abstracts

  • Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid

    Sneddon, A. A., McLeod, E., Wahle, K. W. J., Arthur, J.

    Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, vol. 1761, no. 7, pp. 793-801

    Contributions to Journals: Articles

  • Induction of apoptosis and inhibition of NF-kappa B activation in human prostate cancer cells by the cis-9, trans-11 but not the trans-10, cis-12 isomer of conjugated linoleic acid

    Song, H. J., Sneddon, A. A., Heys, S. D., Wahle, K. W. J.

    The Prostate, vol. 66, no. 8, pp. 839-846

    Contributions to Journals: Articles

  • Platelet-activating factor mediates cytokine-induced monocyte adhesion to endothelium: Suppression by conjugated linoleic acid

    Sneddon, A. A., McLeod, E., Wahle, K. W. J., Arthur, J.

    Atherosclerosis Supplements, vol. 7, no. 3, pp. 222-223

    Contributions to Journals: Articles

  • Plasma adiponectin levels after a high-fat meal and a standard mixed meal in lean and obese, young and older men.

    Tsofliou, F., Fyfe, C., Matheson, C. I., Sneddon, A. A., Jackson, D., Wahle, K. W. J., Williams, L.

    Proceedings of the Nutrition Society, vol. 65, no. Suppl. S, pp. 98A

    Contributions to Journals: Articles

  • Moderate maternal vitamin A deficiency alters myogenic regulatory protein expression and perinatal organ growth in the rat

    Downie, D., Antipatis, C., Delday, M. I., Maltin, C., Sneddon, A. A.

    American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 288, no. 1, pp. R73-R79

    Contributions to Journals: Articles

  • Conjugated linoleic acid regulates basal and inducible cytokine expression in endothelial cells

    Sneddon, A. A., McLeod, E., Wahle, K. W. J., Arthur, J.

    Scientific Meeting of the Nutrition Society (2004), pp. 59A

    Contributions to Journals: Abstracts

  • ICAM-1 and VCAM-1 regulation by conjugated linoleic acids in human umbilical vein endothelial cells: involvement of the NFK kappa B pathway

    Goua, M., Sneddon, A. A., Mulgrew, S., Wahle, K. W. J.

    45th International Conference on the Bioscience of Lipids, pp. 38-38

    Contributions to Journals: Abstracts

  • Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells

    Song, H. J., Sneddon, A. A., Barker, P. A., Bestwick, C., Choe, S. N., McClinton, S., Grant, I., Rotondo, D., Heys, S. D., Wahle, K. W. J.

    Nutrition and Cancer, vol. 49, pp. 100-108

    Contributions to Journals: Articles

  • Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants

    Sneddon, A. A., Wu, H. C., Farquharson, A., Grant, I., Arthur, J., Rotondo, D., Choe, S. N., Wahle, K. W. J.

    Atherosclerosis, vol. 171, no. 1, pp. 57-65

    Contributions to Journals: Articles

  • Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle

    Sneddon, A. A., Koll, M., Wallace, M. C., Jones, J., Miell, J. P., Garlick, P. J., Preedy, V. R.

    American Journal of Physiology: Endocrinology and Metabolism, vol. 284, pp. 874-882

    Contributions to Journals: Articles

  • The importance of alcohol-induced muscle disease

    Preedy, V. R., Ohlendieck, K., Adachi, J., Koll, M., Sneddon, A. A., Hunter, R., Rajendram, R., Mantle, D., Peters, T.

    Journal of Muscle Research and Cell Motility, vol. 24, no. 1, pp. 55-63

    Contributions to Journals: Articles

  • Elevated IGF-II mRNA and phosphorylation of 4E-BP1 and p70(S6k) in muscle showing clenbuterol-induced anabolism

    Sneddon, A. A., Delday, M. I., Steven, J., Maltin, C.

    American Journal of Physiology: Endocrinology and Metabolism, vol. 281, no. 4, pp. 676-682

    Contributions to Journals: Articles

  • Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle

    Maltin, C., Delday, M. I., Sinclair, K. D., Steven, J., Sneddon, A. A.

    Reproduction, vol. 122, no. 3, pp. 359-374

    Contributions to Journals: Literature Reviews

  • Fatty Acid Regulation of Protein Kinase C Isoforms in Prostate Cancer Cells

    Pandian, S., Sneddon, A. A., Bestwick, C., McClinton,, S., Grant, I., Wahle, K. W. J., Heys, S.

    Biochemical and Biophysical Research Communications, vol. 283, no. 4, pp. 806-812

    Contributions to Journals: Articles

  • Amelioration of denervation-induced atrophy by clenbuterol is associated with increased PKC-alpha activity

    Sneddon, A. A., Delday, M. I., Maltin, C.

    American Journal of Physiology: Endocrinology and Metabolism, vol. 279, no. 1, pp. 188-196

    Contributions to Journals: Articles

  • Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases

    Dowd, S., Sneddon, A. A., Keyse, S. M.

    Journal of Cell Science, vol. 111 ( Pt 22), pp. 3389-99

    Contributions to Journals: Articles

  • Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

    Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., Keyse, S. M.

    EMBO Journal, vol. 15, no. 14, pp. 3621-32

    Contributions to Journals: Articles

  • A regulated MET3-GLC7 gene fusion provides evidence of a mitotic role for Saccharomyces cerevisiae protein phosphatase 1

    Black, S., Andrews, P. D., Sneddon, A. A., Stark, M. J.

    Yeast, vol. 11, no. 8, pp. 747-59

    Contributions to Journals: Articles

  • XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus laevis: its role in MAP kinase inactivation in differentiated cells and its expression during early development

    Lewis, T., Groom, L. A., Sneddon, A. A., Smythe, C., Keyse, S. M.

    Journal of Cell Science, vol. 108 ( Pt 8), pp. 2885-96

    Contributions to Journals: Articles

  • Genetic analyses of yeast protein serine/threonine phosphatases

    Stark, M. J., Black, S., Sneddon, A. A., Andrews, P. D.

    FEMS Microbiology Letters, vol. 117, no. 2, pp. 121-30

    Contributions to Journals: Articles

  • Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae

    van Zyl, W., Huang, W., Sneddon, A. A., Stark, M., Camier, S., Werner, M., Marck, C., Sentenac, A., Broach, J. R.

    Molecular and Cellular Biology, vol. 12, no. 11, pp. 4946-4959

    Contributions to Journals: Articles

  • Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes

    Sneddon, A. A., Cohen, P. T., Stark, M. J.

    EMBO Journal, vol. 9, no. 13, pp. 4339-46

    Contributions to Journals: Articles

  • The transcriptional control regions of the copia retrotransposon

    Sneddon, A., Flavell, A. J.

    Nucleic Acids Research, vol. 17, no. 11, pp. 4025-35

    Contributions to Journals: Articles

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