Dr Berndt Muller

Dr Berndt Muller
Dr Berndt Muller

Dr Berndt Muller

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Accepting PhDs

About

Berndt Müller PhD

Institute of Medical Sciences (Room 4:35)

University of Aberdeen Foresterhill

Aberdeen AB25 2ZD Scotland, UK

 

Biography

1978-1988:  Undergraduate and the postgraduate studies at the Swiss Federal Institute of Technology, Zurich.  The degree of Dr. sc. nat. (PhD) was awarded for work on the recombination protein RecA under the supervision of Dr Andrzej Stasiak and Dr Elisabeth Di Capua in the group of Prof Theo Koller at the Institute for Cell Biology at the Swiss Federal Institute of Technology in Zurich.

1988-1993: Postdoctoral Researcher in the group of Dr Stephen West at the ICRF (now CRUK) Clare Hall Laboratories investigating recombination enzymes. 

1993-1999: Junior group leader in the Laboratory for Developmental Biology at the Institute for Cell Biology of Bern University led by Prof Daniel Schümperli investigating 3' end formation of histone mRNAs.  

since 1999:  Senior Lecturer, then Reader at the University of Aberdeen leading work on RNA processing.  We have developed a strong research program that focuses on understanding the molecular machinery involved in mRNA 5' end formation by spliced leader trans-splicing.  Visit The Aberdeen Worm Laboratory site for more information.

Qualifications

  • PhD Cell Biology 
    1988 - Swiss Federal Institute of Technology, Zürich 
  • Diploma Natural Sciences 
    1983 - Swiss Federal Institute of Technology, Zürich 
  • Privatdozent Molecular Cell Biology 
    1999 - University of Bern 

External Memberships

Member of the Biochemical Society

Member of the Genetics Society

Member of the RNA Society

Research

Research Overview

The lab has a long-standing interest in the control of gene expression at the level of mRNA.  This started in 1993, when Berndt joined the University of Bern where he worked with Prof Daniel Schümperli. 

Prior to that he did his PhD in the group of Prof Theo Koller at the Institute of Cell Biology of the ETH in Zürich, with Dr Andrzej Stasiak and Dr Elisabeth Di Capua, analysing the interaction of the recombination protein RecA protein with DNA.  He then spent 5 years in the lab of Dr Stephen West at ICRF (now Cancer Research UK) studying the Biochemistry of Genetic Recombination.

Subsequently, at Bern University, he identified factors that turn histone pre-mRNAs into mRNA by a unique 3' end formation process.  This work was continued at the University of Aberdeen and has led to insight into the molecular function of these factors.

At Aberdeen, he also linked the key translation factor eIF4E to autism, and explored how RNA stability is implicated in the aetiology of neurodevelopmental disorders.  

More recently he has focused on understanding the molecular mechanism of spliced leader trans-splicing in gene expression in nematodes.

 

 

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.


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Biomedical Sciences

Supervising
Accepting PhDs

Research Specialisms

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Genetic Engineering

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

The current research focuses on understanding the mechanism of spliced leader trans-splicing in gene expression in nematodes. This is an unusual RNA splicing reaction, dependent on a set of specialised RNAs and proteins. The function of these molecules is being investigated  using genome engineering, RNAseq, proteomics and high resolution microscopy combined with biochemistry and molecular biology.

For more information visit The Aberdeen Worm Lab.

 

Teaching

Teaching Responsibilities

Biochemistry Pogramme Coordinator

Course co-ordination of BC3503 (The Molecular Control of Cell Function) and BC4314 (Honours Biochemistry Option 2) 

 

Publications

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