- Email Address
- Telephone Number
- +44 (0)1224 437536
- Office Address
Berndt Müller PhD
Institute of Medical Sciences (Room 4:35)
University of Aberdeen Foresterhill
Aberdeen AB25 2ZD Scotland, UK
- School of Medicine, Medical Sciences and Nutrition
1978-1988: Berndt graduated with a Diploma in Natural Sciences (Biology) from the Swiss Federal Institute of Technology, Zurich. He then joined the group of Professor Theodor Koller at the Institute for Cell Biology at the Swiss Federal Institute of Technology for postgraduate studies. The degree of Dr. sc. nat. (PhD) was awarded for work on the DNA recombination protein RecA executed under the supervision of Professor Koller and Dr Andrzej Stasiak, and with Dr Elisabeth Di Capua.
1988-1993: Postdoctoral Researcher in the group of Dr Stephen West at the ICRF (now CRUK) Clare Hall Laboratories investigating DNA recombination enzymes.
1993-1999: Junior group leader in the Laboratory for Developmental Biology at the Institute for Cell Biology of Bern University led by Professor Daniel Schümperli, investigating the control of animal histone gene expression brought about by RNA 3' end formation.
since 1999: Senior Lecturer, Reader and Professor at the University of Aberdeen leading work on RNA processing. We have developed a strong research program that focuses on understanding the molecular machinery involved in mRNA 5' end formation by spliced leader trans-splicing. Visit The Aberdeen Worm Laboratory site for more information.
- Privatdozent Molecular Cell Biology1999 - University of Bern
- PhD Cell Biology1988 - Swiss Federal Institute of Technology, Zürich
- Diploma Natural Sciences1983 - Swiss Federal Institute of Technology, Zürich
Member of the Biochemical Society
Member of the Genetics Society
Member of the RNA Society
The lab has a long-standing interest in the control of gene expression at the level of mRNA. This started in 1993, when Berndt joined the University of Bern where he worked with Prof Daniel Schümperli.
Prior to that he did his PhD in the group of Prof Theo Koller at the Institute of Cell Biology of the ETH in Zürich, with Dr Andrzej Stasiak and Dr Elisabeth Di Capua, analysing the interaction of the recombination protein RecA protein with DNA. He then spent 5 years in the lab of Dr Stephen West at ICRF (now Cancer Research UK) studying the Biochemistry of Genetic Recombination.
Subsequently, at Bern University, he identified factors that turn histone pre-mRNAs into mRNA by a unique 3' end formation process. This work was continued at the University of Aberdeen and has led to insight into the molecular function of these factors.
At Aberdeen, he also linked the key translation factor eIF4E to autism, and explored how RNA stability is implicated in the aetiology of neurodevelopmental disorders.
More recently he has focused on understanding the molecular mechanism of spliced leader trans-splicing in gene expression in nematodes. Have a look at https://www.aberdeenwormlab.org/ for latest news.
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
The current research focuses on understanding the mechanism of spliced leader trans-splicing in gene expression in nematodes. This is an unusual RNA splicing reaction, dependent on a set of specialised RNAs and proteins. The function of these molecules is being investigated using genome engineering, RNAseq, proteomics and high resolution microscopy combined with biochemistry and molecular biology.
For more information visit The Aberdeen Worm Lab.
Biochemistry Pogramme Coordinator
Course co-ordination of BC3503 (The Molecular Control of Cell Function) and BC4314 (Honours Biochemistry Option 2)
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CMTr mediated 2`-O-ribose methylation status of cap adjacent-nucleotides across animalsRNA , vol. 28, no. 10, pp. 1377-1390Contributions to Journals: Articles
A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complexNucleic Acids Research, vol. 50, no. 13, pp. 7591-7607Contributions to Journals: Articles
A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate ReceptorBioluminescence: Methods and Protocols, Volume 1. Kim, S. (ed.). Humana Press, pp. 197-207, 11 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
SLIDR and SLOPPR: flexible identification of spliced leader trans-splicing and prediction of eukaryotic operons from RNA-Seq dataBMC Bioinformatics, vol. 22, 140Contributions to Journals: Articles
Resolution of polycistronic RNA by SL2 trans-splicing is a widely-conserved nematode traitRNA , vol. 26, no. 12, pp. 1891-1904Contributions to Journals: Articles
A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate ReceptorMolecular Neurobiology, vol. 56, no. 10, pp. 7074-7084Contributions to Journals: Articles
A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicingInternational Journal for Parasitology: Drugs and Drug Resistance, vol. 10, pp. 28-37Contributions to Journals: Articles
An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assemblyNucleic Acids Research, vol. 45, no. 14, pp. 8474-8483Contributions to Journals: Articles
Modelling Robust Feedback Control Mechanisms That Ensure Reliable Coordination of Histone Gene Expression with DNA ReplicationPloS ONE, vol. 11, no. 10, e0165848Contributions to Journals: Articles
Mutation of genes controlling mRNA metabolism and protein synthesis predisposes to neurodevelopmental disordersBiochemical Society Transactions, vol. 43, no. 6, pp. 1259-1265Contributions to Journals: Articles
Full UPF3B function is critical for neuronal differentiation of neural stem cellsMolecular brain, vol. 8, 33Contributions to Journals: Articles
Operons Are a Conserved Feature of Nematode GenomesGenetics, vol. 197, no. 4, pp. 1201-1211Contributions to Journals: Articles
Replication stress-induced alternative mRNA splicing alters properties of the histone RNA-binding protein HBP/SLBP: a key factor in the control of histone gene expressionBioscience Reports, vol. 33, no. 5, e00066Contributions to Journals: Articles
The control of histone gene expressionBiochemical Society Transactions, vol. 40, no. 4, pp. 880-885Contributions to Journals: Literature Reviews
SL2-like spliced leader RNAs in the basal nematode Prionchulus punctatus: new insight into the evolution of nematode SL2 RNAsRNA , vol. 16, no. 8, pp. 1500-1507Contributions to Journals: Articles
The evolution of spliced leader trans-splicing in nematodesBiochemical Society Transactions, vol. 38, no. 4, pp. 1125-1130Contributions to Journals: Articles
Deregulation of EIF4E: a novel mechanism for autismJournal of Medical Genetics, vol. 46, no. 11, pp. 759-765Contributions to Journals: Articles
Treatment and Diagnosis of Behavioural DisordersPatents: Patents
Post-transcriptional control of animal histone gene expression: not so different after all...Molecular BioSystems, vol. 4, no. 7, pp. 721-725Contributions to Journals: Articles
Spliced leader trans-splicing in the nematode Trichinella spiralis uses highly polymorphic, noncanonical spliced leadersRNA , vol. 14, no. 4, pp. 760-770Contributions to Journals: Articles
DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replicationJournal of Cell Biology, vol. 179, no. 7, pp. 1385-1398Contributions to Journals: Articles
Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegansBMC Molecular Biology, vol. 8, 51Contributions to Journals: Articles
Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?Biochemical Society Transactions, vol. 35, no. 5, pp. 1369-1371Contributions to Journals: Letters
The stem-loop binding protein stimulates histone translation at an early step in the initiation pathwayRNA , vol. 11, no. 7, pp. 1030-1042Contributions to Journals: Articles
The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cellsJournal of Cell Science, vol. 117, no. 25, pp. 6043-6051Contributions to Journals: Articles
The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell divisionJournal of Cell Science, vol. 115, no. 4, pp. 857-866Contributions to Journals: Articles
Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expressionRNA , vol. 8, no. 1, pp. 29-46Contributions to Journals: Articles
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like proteinEMBO Journal, vol. 20, no. 19, pp. 5470-5479Contributions to Journals: Articles
Assembly of U7 small nuclear ribonucleoprotein particle and histone RNA 3 ' processing in Xenopus egg extractsThe Journal of Biological Chemistry, vol. 275, no. 32, pp. 24284-24293Contributions to Journals: Articles
Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid systemNucleic Acids Research, vol. 28, no. 7, pp. 1594-1603Contributions to Journals: Articles
Specificities of Caenorhabditis elegans and human hairpin binding proteins for the first nucleotide in the histone mRNA hairpin loopRNA , vol. 6, no. 11, pp. 1539-1550Contributions to Journals: Articles
A 5 '-3 ' exonuclease activity involved in forming the 3 ' products of histone pre-mRNA processing in vitroRNA , vol. 4, no. 9, pp. 1034-1046Contributions to Journals: Articles
The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolismSeminars in Cell & Developmental Biology, vol. 8, no. 6, pp. 567-576Contributions to Journals: Literature Reviews
Characterization of the calf thymus hairpin-binding factor involved in histone pre-mRNA 3' end processingThe Journal of Biological Chemistry, vol. 272, no. 16, pp. 10435-10441Contributions to Journals: Articles
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding proteinEMBO Journal, vol. 16, no. 4, pp. 769-778Contributions to Journals: Articles
Processing of Holliday Junctions by the Escherichia-Coli RuvA, RuvB, RuvC and RECG ProteinsExperientia, vol. 50, no. 3, pp. 216-222Contributions to Journals: Literature Reviews
An assay for in vitro recombination between duplex DNA moleculesDNA-Protein Interactions: Principles and Protocols. Kneale, G. (ed.). Humana Press, pp. 413-423Chapters in Books, Reports and Conference Proceedings: Chapters
Branch Migration of Holliday Junctions Promoted by the Escherichia coli RuvA and RuvB Proteins: 2. Interaction of RuvB with DNAThe Journal of Biological Chemistry, vol. 268, no. 23, pp. 17185-17189Contributions to Journals: Articles
Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins: I. Comparison of RuvAB- and RuvB-mediated reactionsThe Journal of Biological Chemistry, vol. 268, no. 23, pp. 17179-17184Contributions to Journals: Articles
Unusual Stability of Recombination Intermediates made by Escherichia coli RecA ProteinEMBO Journal, vol. 11, no. 7, pp. 2685-2693Contributions to Journals: Articles
ATP-dependent branch migration of Holliday junctions promoted by the RuvA and RuvB proteins of E. coliCell, vol. 69, no. 7, pp. 1171-1180Contributions to Journals: Articles
Action of RecBCD enzyme on Holliday structures made by RecAThe Journal of Biological Chemistry, vol. 266, no. 28, pp. 19028-19033Contributions to Journals: Articles
RecA-mediated annealing of single-stranded DNA and its relation to the mechanism of homologous recombinationJournal of Molecular Biology, vol. 221, no. 1, pp. 131-145Contributions to Journals: Articles
T7 endonuclease I resolves Holliday junctions formed in vitro by RecA proteinNucleic Acids Research, vol. 18, no. 19, pp. 5633-5636Contributions to Journals: Articles
Characterization of the DNA binding activity of stable RecA-DNA complexes : Interaction between the two DNA binding sites within RecA helical filamentsJournal of Molecular Biology, vol. 212, no. 1, pp. 97-112Contributions to Journals: Articles
Enzymatic formation and resolution of Holliday junctions in vitroCell, vol. 60, no. 2, pp. 329-336Contributions to Journals: Articles
Intermediates in genetic recombination : formation and resolution of Holliday junctions in vitroStructure and Methods: Volume I: Human genome initiative & DNA Recombination. Sama, R., Sama, M. (eds.). Adenine Press, pp. 193-202Chapters in Books, Reports and Conference Proceedings: Chapters
Molecular mechanism of post-replication repairProgress in Clinical & Biological Research, vol. 340A, pp. 121-133Contributions to Journals: Literature Reviews
Molecular mechanism of post-replicational repair: formation and resolution of recombination intermediatesMutation and the Environment: 5th International conference on environmental mutagens : Papers. Mendelsohn, M., Albertini, R. (eds.). Wiley/Lyss Inc, pp. 121-133Chapters in Books, Reports and Conference Proceedings: Chapters
Resolution of Holliday Junctions Within RECA Helical FilamentsIonizing Radiation Damage to DNA: Molecular Aspects. Wallace, S. S., Painter, R. B. (eds.). Wiley-Liss, pp. 163-171, 9 pagesChapters in Books, Reports and Conference Proceedings: Chapters