Dr Hai Deng
Reader
- About
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Room 019, Meston Building, Meston Walk, Old Aberdeen AB24 3UE
Biography
08/2018 - Reader, University of Aberdeen, UK
08/2014- 07/2018 Senior Lecturer, University of Aberdeen, UK
10/2008-07/2014 Lecturer, University of Aberdeen, UK
06/2002-09/2008 Postdoctoral fellow, University of St Andrews, UK
1999-2002 Ph.D. University of Wales Swansea, UK
Memberships and Affiliations
- Internal Memberships
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PGR coordinator
CM2514 course coordinator
- External Memberships
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External reviewer for a series of peer-reviewed journals within my area of interest, including Chem. Sci., Chem Comm., ACS Chem. Biol., ChemBioChem, Marine Biotechnology, Org & Biomol. Chem, FEMS Microbiology Ecology, Chemistry today, Marine Drugs, Fish and Shellfish Immunology, and Virulence.
A reviewer of research councils, BBSRC (UK) and FCT (Fundação para a Ciência e a Tecnologia in the field of Chemistry and Biochemistry, 2010-2011), Fonds de recherche du Québec - Nature et technologies, Québec, Canada (2015-2016) and charities, Leverhulme Trust (UK).
- Research
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Research Overview
The projects in my group mainly lie on the interface of chemistry and biology. I have expertise in bioinformatics/biochemistry/genetics/organic chemistry. As such I am interested in identifying novel enzymes in secondary metabolism and exploring novel enzymatic mechanisms (J. Biol. Chem. 2013; ChemBioChem 2014; Chem. Sci. 2015; Chem. Biol. 2015; Angew Chemie Int. Ed. 2015, Org. Biomol. Chem. 2016 and 2017), tracing biosynthesis pathways using bioinformatics and genetic manipulations (Org. Biomol. Chem. 2014; Chem. Biol. 2015; Angew Chemie Int. Ed. 2015), characterizing novel natural product scaffold (Tetrahedron, 2013 and Org. Biomol. Chem., 2015, 2016 and 2017). These interests inevitably take us towards designing novel substrates for enzymes (industrial biotechnology/ biotransformation/synthetic biology), inhibiting enzymes (medicinal chemistry), applying these biocatalysts to industrial biotechnology and synthetic biology. The expertise established in my laboratory is:
- Using chemical tools for enzymology studies;
- Synthetic biology enabling industrial biological application;
- Chemical synthesis of small molecules;
- Biotransformation of novel enzymes for lead compound discovery.
- Genome mining of biosynthetic genes from microbial genomes for natural product discovery;
- Genetic manipulation of microbial biosynthetic genes;
- Microbiology, especially cultivation and fermentation of marine-derived and terrestrial actinobacteria for analysis of secondary metabolite profiles.
- Molecular taxonomy of new actinobacteria.
Research Areas
Biological and Environmental Sciences
Chemistry
Research Specialisms
- Industrial Biotechnology
- Biochemistry
- Organic Chemistry
- Applied Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Supervision
Supervisees
Funding and Grants
We gratefully thank the funding bodies below for financial supports of our research
MRC, BBSRC, Leverhulm Trust, EU FP7, Tenuvas.
- Teaching
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Teaching Responsibilities
CM4518 Biological origin of natural products
CM1020 Chemistry for Biosciences 1
CM1512 Chemistry for Biosciences 2
CM3534 Organic and Biological Chemistry
- Publications
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Page 1 of 9 Results 1 to 10 of 87
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy
Journal of Medicinal Chemistry, vol. 65, no. 3, pp. 2225-2237Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acs.jmedchem.1c01736
- [ONLINE] View publication in Scopus
Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy
Journal of Controlled Release, vol. 342, pp. 157-169Contributions to Journals: ArticlesAminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase
Nature Communications, vol. 13, no. 1, 62Contributions to Journals: ArticlesCharacterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis
RSC Advances, vol. 12, no. 17, pp. 10540-10544Contributions to Journals: ArticlesThe chemical profile of activated secondary metabolites by overexpressing LaeA in Aspergillus niger
Microbiological Research, vol. 248, 126735Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.micres.2021.126735
Peculiarities of promiscuous l-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids
Applied Microbiology and Biotechnology, vol. 105, pp. 3507–3520Contributions to Journals: ArticlesBacterial Pathogens: Threat or Treat? (a review on bioactive natural products from bacterial pathogens)
Natural Product Reports, vol. 38, no. 4, pp. 782-821Contributions to Journals: Review articlesGenomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid
Synthetic and Systems Biotechnology, vol. 6, no. 1, pp. 12-19Contributions to Journals: ArticlesDiscovery and biosynthetic investigation of a new antibacterial dehydrated non‐ribosomal tripeptide
Angewandte Chemie International Edition, vol. 60, no. 6, pp. 3229-3237Contributions to Journals: ArticlesUpconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy
Nature Communications, vol. 11, 6183Contributions to Journals: Articles
