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The School of Natural and Computing Sciences

Dr Thomas Baddeley

Dr Thomas Baddeley
Dr Thomas Baddeley
Dr Thomas Baddeley

Senior Research Fellow

About
Telephone Number
+44 (0)1224 274238
School/Department
School of Natural and Computing Sciences
Research

Research Overview

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The synthesis and study of novel organic compounds for use as potential drug candiates and excipients.

The study of the physical properties of novel oligosaccharides

Publications

Page 2 of 4 Results 11 to 20 of 33

  • In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

    Steven, J., Müller, M. R., Carvalho, M. F., Ubah, O. C., Kovaleva, M., Donohoe, G., Baddeley, T., Cornock, D., Saunders, K., Porter, A. J., Barelle, C. J.
    Frontiers in Immunology, vol. 8, 1361
    Contributions to Journals: Articles

  • Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

    Nogueira, T. C. M., Pinheiro, A. C., de Souza, M. V. N., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1128, pp. 579-589
    Contributions to Journals: Articles

  • Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

    Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
    Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
    Contributions to Journals: Articles

  • Tautomers and polymorphs of pyrazolinone derivatives, generated from reactions of arylhydrazines, ArNHNH2, with 1,3-dicarbonyl compounds

    Baddeley, T. C., Howie, R. A., De Lima, G. M., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 228, no. 2, pp. 77-91
    Contributions to Journals: Articles

  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents

  • Variation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe=NNHC6H4X (X = H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines

    Howie, R. A., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1020, pp. 16-22
    Contributions to Journals: Articles

  • 1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one

    Baddeley, T., Wardell, S. M. S., Tiekink, E., Wardell, J.
    Acta Crystallographica Section E: Structure Reports Online, vol. E68, pp. o1016-o1017
    Contributions to Journals: Articles

  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • (Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions

    Baddeley, T. C., Alan Howie, R., Da Silva Lima, C. H., Kaiser, C. R., De Souza, M. V., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 224, no. 10, pp. 506-514
    Contributions to Journals: Articles

  • 2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions

    Baddeley, T. C., Franca, L. d. S., Howie, R. A., de Lima, G. M., Skakle, J., de Souza, J. D., Wardell, J. L., Wardell, S. M. S. V.
    Zeitschrift für Kristallographie, vol. 224, no. 4, pp. 213-224
    Contributions to Journals: Articles
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