Dr Thomas Baddeley

Dr Thomas Baddeley

Senior Research Fellow

School of Natural and Computing Sciences

Research Overview

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The synthesis and study of novel organic compounds for use as potential drug candiates and excipients.

The study of the physical properties of novel oligosaccharides

Publications

Page 1 of 3 Results 1 to 10 of 29

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
2022 - Published
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
Biomedicines, vol. 10, no. 4, 867
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biomedicines10040867
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/18559/1/Santos_et_al_HMTM_Mediated_Biomedicines_vor.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14427/2/Shiells_et_al_JAD_ConcentrationDependentActivity_VoR.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13339/1/Schelter_et_al_JoAD_ConcentrationDependentActivity_VoR.pdf
N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry
2019 - Published
Baddeley, T. C., de Souza, M. V. N., Wardell, J. L., Jotani, M. M., Tiekink, E. R. T.
Acta Crystallographica Section E: Crystallographic Communications, vol. 75, no. 4, pp. 516-523
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S2056989019003980/hb7809Isup3.cml
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12442/1/hb7809.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives
2019 - Published
Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V., Wardell, J. L.
Journal of Molecular Structure, vol. 1178, pp. 655-668
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2018.10.030
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements
2018 - Published
Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C., Wardell, J. L.
Steroids, vol. 140, pp. 92-103
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.steroids.2018.09.010
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
2018 - Published
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2018.08.010
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11249/1/1_s2.0_S0022283618305606_main.pdf
A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
2018 - Published
Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
Frontiers in Molecular Neuroscience, vol. 10, 447
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development
2017 - Published
Steven, J., Müller, M. R., Carvalho, M. F., Ubah, O. C., Kovaleva, M., Donohoe, G., Baddeley, T., Cornock, D., Saunders, K., Porter, A. J., Barelle, C. J.
Frontiers in Immunology, vol. 8, 1361
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fimmu.2017.01361
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9601/1/fimmu_08_01361.pdf
Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
2017 - Published
Nogueira, T. C. M., Pinheiro, A. C., de Souza, M. V. N., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
Journal of Molecular Structure, vol. 1128, pp. 579-589
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2016.09.021

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Dr Thomas Baddeley

Research Overview

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

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Contributions to Journals

Patents

Dr Thomas Baddeley

Telephone

Dr Thomas Baddeley

Research Overview

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

N′-(1,3-Benzo­thia­zol-2-yl) benzene­sulfono­hydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

Refine

Contributions to Journals

Patents

N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry