BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
-
- Email Address
- j.storey@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272926
- Office Address
- Meston Room G106
- School/Department
- School of Natural and Computing Sciences
External Memberships
Head Chemist for TauRx Therapeutics
- Research
-
Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Page 3 of 6 Results 51 to 75 of 148
The Chiral Twist-Bend Nematic Phase (N*TB)
Chemistry : a European Journal, vol. 25, no. 58, pp. 13329-13335Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/chem.201903014
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15077/1/Accepted_Manuscript_The_Chiral_Twist_Bend_Nematic_Phasel.pdf
- [ONLINE] https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201903014
- [ONLINE] View publication in Mendeley
- [ONLINE] http://dx.doi.org/10.1002/chem.201903014
- [ONLINE] View publication in Scopus
Sulfur-linked cyanobiphenyl-based liquid crystal dimers and the twist-bend nematic phase
Liquid Crystals, vol. 46, no. 10, pp. 1595-1609Contributions to Journals: ArticlesDistinct differences in the nanoscale behaviors of the twist-bend liquid crystal phase of a flexible linear trimer and homologous dimer
Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 22, pp. 10698-10704Contributions to Journals: Articles- [ONLINE] http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1821372116/-/DCSupplemental.
- [ONLINE] DOI: https://doi.org/10.1073/pnas.1821372116
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12332/1/Distinct_differences_in_the_nanoscale_behaviors_of_the_twist_bend_liquid_crystal_phase_of_a_flexible_linear_trimer_and_homologous_dimer.pdf
- [ONLINE] View publication in Scopus
Fast-and-Giant Photorheological Effect in a Liquid Crystal Dimer
Advanced Materials Interfaces, vol. 6, no. 9, 1802032Contributions to Journals: ArticlesMulti-level chirality in liquid crystals formed by achiral molecules
Nature Communications, vol. 10, 1922Contributions to Journals: ArticlesMolecular curvature, specific intermolecular interactions and the twist-bend nematic phase: the synthesis and characterisation of the 1-(4-cyanobiphenyl-4-yl)-6-(4-alkylanilinebenzylidene-4-oxy)hexanes (CB6O.m)
Soft matter, vol. 15, pp. 3188-3197Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/c9sm00026g
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13856/1/manuCB6Omsm_rev.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
- [ONLINE] http://dx.doi.org/10.1039/c9sm00026g
Augmenting Bragg Reflection with Polymer-sustained Conical Helix
Scientific Reports, vol. 9, 5468Contributions to Journals: ArticlesSpherical-cap droplets of a photo-responsive bent liquid crystal dimer
Soft matter, vol. 15, no. 5, pp. 989-998Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/c8sm01751d
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13468/1/cti_rev_maintext_180725.pdf
- [ONLINE] View publication in Mendeley
Structure-property relationships in azobenzene-based twist-bend nematogens
Liquid Crystals, vol. 46, no. 13-14, pp. 2102-2114Contributions to Journals: ArticlesCritical behavior of the optical birefringence at the nematic to twist bend nematic phase transition
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 98, no. 5, pp. 1-5Contributions to Journals: ArticlesCysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131Contributions to Journals: ArticlesCholesteric Metronomes with Flexoelectrically Programmable Amplitude
Advanced Optical Materials, vol. 6, no. 12, 1800013Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/adom.201800013
- [ONLINE] View publication in Scopus
Color smart window based on polymer-sustained conical helix of cholesteric
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1002/sdtp.12389
- [ONLINE] View publication in Scopus
Giant flexoelectro-optic effect with bimesogen in vertical standing helix
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1002/sdtp.12376
- [ONLINE] View publication in Scopus
Spontaneous chirality through mixing achiral components: A twist-bend nematic phase driven by hydrogen-bonding between unlike components
Chemical Communications, vol. 54, no. 27, pp. 3383-3386Contributions to Journals: ArticlesModeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303Contributions to Journals: ArticlesCholesteric metronomes with flexoelectrically programmable amplitude
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1117/12.2291544
- [ONLINE] View publication in Scopus
Heliconical smectic phases formed by achiral molecules
Nature Communications, vol. 9, 228Contributions to Journals: ArticlesA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
Frontiers in Molecular Neuroscience, vol. 10, 447Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
The role of a terminal chain in promoting the twist-bend nematic phase: the synthesis and characterisation of the 1-(4-cyanobiphenyl-4′-yl)-6-(4-alkyloxyanilinebenzylidene-4′-oxy)hexanes
Liquid Crystals, vol. 45, no. 13-15, pp. 2341-2351Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/02678292.2018.1525503
- [ONLINE] View publication in Scopus
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457Contributions to Journals: Articles- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665Contributions to Journals: ArticlesAzobenzene-based liquid crystal dimers and the twist-bend nematic phase
Liquid Crystals, vol. 44, no. 12-13, pp. 2060-2078Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/02678292.2017.1366075
- [ONLINE] View publication in Scopus
Fast Flexoelectro-optic Response of Bimesogen-doped Polymer Stabilized Cholesteric Liquid Crystals in Vertical Standing Helix Mode
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1002/SDTP.12051
- [ONLINE] View publication in Scopus
Formation of periodic zigzag patterns in the twist-bend nematic liquid crystal phase by surface treatment
Liquid Crystals, vol. 44, no. 1, pp. 168-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/02678292.2016.1274283
- [ONLINE] View publication in Scopus