Professor John Storey
BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
Head Chemist for TauRx Therapeutics
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
Professor Storey teaches in the following courses:Â
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
Page 1 of 13 Results 1 to 10 of 128
Using lateral substitution to control conformational preference and phase behaviour of benzanilide-based liquid crystal dimersChemPhysChemContributions to Journals: Articles
Intrisically Chiral Twist-Bend Nematogens: Interplay of Molecular and Structural Chirality in the NTB PhaseChemPhysChemContributions to Journals: Articles
Syntheses and Crystal Structures of Three Chiral Oxazolidinones with Different Ring ConformationsCrystals, vol. 12, no. 11, 1598Contributions to Journals: Articles
Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid ChromatographyInternational journal of analytical chemistry, vol. 2022, 9171836Contributions to Journals: Articles
Liquid Crystal Dimers and Smectic Phases from the Intercalated to the Twist-BendCrystals, vol. 12, no. 9, 1245Contributions to Journals: Review articles
Intrinsically chiral ferronematic liquid crystals: An inversion of the helical twist sense at the chiral nematic – Chiral ferronematic phase transitionJournal of molecular liquids, vol. 361, 119532Contributions to Journals: Articles
New patterns of twist-bend liquid crystal phase behaviour: the synthesis and characterisation of the 1-(4-cyanobiphenyl-4′-yl)-10-(4-alkylaniline-benzylidene-4′-oxy)decanes (CB10O·m)Soft matter, vol. 18, no. 25, pp. 4679-4688Contributions to Journals: Articles
Controlling spontaneous chirality in achiral materials: liquid crystal oligomers and the heliconical twist-bend nematic phaseChemical Communications, vol. 58, no. 34, pp. 5285-5288Contributions to Journals: Articles
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of RivastigmineBiomedicines, vol. 10, no. 4, 867Contributions to Journals: Articles
Flexoelectric Polarization in a Nematic Liquid Crystal Enhanced by Dopants with Different Molecular Shape PolaritiesACS Omega, vol. 7, no. 11, pp. 9785-9795Contributions to Journals: Articles