
Professor John Storey
BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
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External Memberships
Head Chemist for TauRx Therapeutics
- Research
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Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Page 1 of 12 Results 1 to 10 of 120
Controlling spontaneous chirality in achiral materials: liquid crystal oligomers and the heliconical twist-bend nematic phase
Chemical Communications, vol. 58, no. 34, pp. 5285-5288Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesFlexoelectric Polarization in a Nematic Liquid Crystal Enhanced by Dopants with Different Molecular Shape Polarities
ACS Omega, vol. 7, no. 11, pp. 9785-9795Contributions to Journals: ArticlesPhoto-driven effects in twist-bend nematic phases: dynamic and memory response of liquid crystalline dimers
Journal of molecular liquids, vol. 344, 117680Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molliq.2021.117680
Multiple Polar and Non-polar Nematic Phases
ChemPhysChem, vol. 22, no. 24, pp. 2506-2510Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cphc.202100644
- [ONLINE] View publication in Scopus
Helical phases assembled from achiral molecules: Twist-bend nematic and helical filamentary B4 phases formed by mesogenic dimers
Journal of molecular liquids, vol. 346, 118180Contributions to Journals: ArticlesCombined electric and photocontrol of selective light reflection at an oblique helicoidal cholesteric liquid crystal doped with azoxybenzene derivative
Physical Review E, vol. 104, no. 4, 044702Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.104.044702
- [ONLINE] View publication in Scopus
Photonic Bandgap in Achiral Liquid Crystals—A Twist on a Twist
Advanced Materials, 2103288Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/adma.202103288
- [ONLINE] View publication in Scopus
Photocontrol of selective light reflection by oblique helicoidal cholesteric
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1117/12.2592765
- [ONLINE] View publication in Scopus
Chalcogen bonding and liquid crystallinity: Understanding the anomalous behaviour of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles (nSCB)
Journal of molecular liquids, 117094Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molliq.2021.117094
- [ONLINE] View publication in Scopus