Professor John Storey
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Professor John Storey
BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
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External Memberships
Head Chemist for TauRx Therapeutics
- Research
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Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Page 1 of 14 Results 1 to 10 of 131
Molecular Shape, Electronic Factors and the Ferroelectric Nematic Phase
Chemistry : a European Journal, e202300073Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/chem.202300073
Using lateral substitution to control conformational preference and phase behaviour of benzanilide-based liquid crystal dimers
ChemPhysChem, e202200758Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cphc.202200758
Intrinsically Chiral Twist-Bend Nematogens: Interplay of Molecular and Structural Chirality in the NTB Phase
ChemPhysChem, e202200807Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cphc.202200807
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Frontiers in Neuroscience, vol. 16, 988074Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnins.2022.988074
- [ONLINE] View publication in Scopus
Syntheses and Crystal Structures of Three Chiral Oxazolidinones with Different Ring Conformations
Crystals, vol. 12, no. 11, 1598Contributions to Journals: ArticlesThe effect of a lateral alkyloxy chain on the ferroelectric nematic phase
RSC Advances, vol. 12, no. 45, pp. 29482-29490Contributions to Journals: ArticlesNovel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography
International journal of analytical chemistry, vol. 2022, 9171836Contributions to Journals: ArticlesLiquid Crystal Dimers and Smectic Phases from the Intercalated to the Twist-Bend
Crystals, vol. 12, no. 9, 1245Contributions to Journals: Review articlesIntrinsically chiral ferronematic liquid crystals: An inversion of the helical twist sense at the chiral nematic – Chiral ferronematic phase transition
Journal of molecular liquids, vol. 361, 119532Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molliq.2022.119532
- [ONLINE] View publication in Scopus
New patterns of twist-bend liquid crystal phase behaviour: the synthesis and characterisation of the 1-(4-cyanobiphenyl-4′-yl)-10-(4-alkylaniline-benzylidene-4′-oxy)decanes (CB10O·m)
Soft matter, vol. 18, no. 25, pp. 4679-4688Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/d2sm00162d
- [ONLINE] View publication in Scopus