BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
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- Email Address
- j.storey@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272926
- Office Address
- Meston Room G106
- School/Department
- School of Natural and Computing Sciences
External Memberships
Head Chemist for TauRx Therapeutics
- Research
-
Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Page 5 of 15 Results 41 to 50 of 148
Phase transitions in a high magnetic field of an odd, symmetric liquid crystal dimer having two nematic phases, N U and NTB, studied by NMR spectroscopy
Physical Review E, vol. 102, no. 4, 042706Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.102.042706
- [ONLINE] View publication in Scopus
Supramolecular liquid crystals exhibiting a chiral twist-bend nematic phase
Materials Advances, vol. 1, no. 6, pp. 1622-1630Contributions to Journals: ArticlesMolecular structure and the twist-bend nematic phase: the role of terminal chains
Liquid Crystals, vol. 47, no. 8, pp. 1232–1245Contributions to Journals: ArticlesConcentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesTemperature dependence of bend elastic constant in oblique helicoidal cholesterics
Physical Review Research, vol. 2, no. 1, 013248Contributions to Journals: ArticlesHydrogen bonding and the design of twist-bend nematogens
Journal of molecular liquids, vol. 303, 112630Contributions to Journals: ArticlesTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
FEBS LETTERS, vol. 594, no. 5, pp. 944-950Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf
- [ONLINE] View publication in Scopus
Twist-Bend Nematogenic Supramolecular Dimers and Trimers Formed by Hydrogen Bonding
Crystals, vol. 10, no. 3, 175Contributions to Journals: Articles- [ONLINE] https://www.mdpi.com/2073-4352/10/3/175
- [ONLINE] DOI: https://doi.org/10.3390/cryst10030175
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13847/1/Walker_etal_crystals_Twist_Bend.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesHigh-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
Journal of visualized experiments : JoVE, no. 152, e60433Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3791/60433