Dr Hai Deng
Room 019, Meston Building, Meston Walk, Old Aberdeen AB24 3UE
08/2018 - Reader, University of Aberdeen, UK
08/2014- 07/2018 Senior Lecturer, University of Aberdeen, UK
10/2008-07/2014 Lecturer, University of Aberdeen, UK
06/2002-09/2008 Postdoctoral fellow, University of St Andrews, UK
1999-2002 Ph.D. University of Wales Swansea, UK
Memberships and Affiliations
- Internal Memberships
CM2514 course coordinator
- External Memberships
External reviewer for a series of peer-reviewed journals within my area of interest, including Chem. Sci., Chem Comm., ACS Chem. Biol., ChemBioChem, Marine Biotechnology, Org & Biomol. Chem, FEMS Microbiology Ecology, Chemistry today, Marine Drugs, Fish and Shellfish Immunology, and Virulence.
A reviewer of research councils, BBSRC (UK) and FCT (Fundação para a Ciência e a Tecnologia in the field of Chemistry and Biochemistry, 2010-2011), Fonds de recherche du Québec - Nature et technologies, Québec, Canada (2015-2016) and charities, Leverhulme Trust (UK).
My research carries on the great tradition of UK natural product biosynthesis activity. We have all the required skills to succeed in such an enterprise, involving discovery of new families of specialised metabolites, bacterial genomics, chemical synthesis and the associated molecular biology to manipulate genomes to enzymology and the reconstruction of biochemistry. All of this is focussed on understanding the molecular basis and mechanism of natural products assembly.
Recent contributions involve the understanding of a group of unsaturated amino acids called dehydroamino acids (dhAAs). dhAAs are key components in many peptidyl therapeutics and versatile building blocks in peptide chemistry where organic chemists generate peptidyl derivatives through Michael additions, cross couplings and cycloaddition. They are used as bio-orthogonal handles for later stage modification of biomolecules. However, accessing dhAAs in structurally complex molecules presents a synthetic challenge, often resulting in poor atomic economy.
Among approximately 40 dhAAs found in the natural product inventory, only two, dehydroalanine (Dha) and (Z)-dehydrobutyrine (ZDhb), are well-studied. In this context our lab has elucidated the formation of several understudied dhAAs in newly discovered bacterial peptide-related metabolites, such as pyrrolizidine alkaloids (PAs) (Angew Chem. Int. Ed. 2015, 54, 12697, Nat. Comm. 2022, 13, 62), short dehydrated non-ribosomal peptides (Angew Chemie. Int. Ed. 2021, 60, 3229) and a new family of ribosomally synthesized and posttranslationally modified peptides (RiPPs) (Nat. Comm. 2022, 13, 5044) as shown below. Apart from this, we have also accumulated an outstanding body of work from bioactive natural product discovery to new enzymology as evidenced in our publication profile.
The discovery we made offers an alternative to rational engineering of pathways to generate bioactive peptides. As such we have obtained grants from various funding bodies (i.e. UKRI, Leverhulm Trust, Royal Society, Royal Society of Edinburgh, IBIOIC, EC) to further investigate potential applications of novel enzymes identified in these pathways towards the development of pharmaceuticals.
Biological and Environmental Sciences
- Industrial Biotechnology
- Organic Chemistry
- Applied Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
My team has accumulated a good body of work on bioactive natural product discovery (from polyketides and peptides to alkaloids) and their biosynthesis, and new enzyme investigation as shown below. Collectively it is a combination of both its range and illustration and these new organic molecules and new enzymes my team has discovered will find applications for the development of pharmaceuticals and agrochemicals or new ways to biosciences.
Professor Mathew Jenner, Department of Chemistry, University of Warwick, UK
Professor Steven Cobb, Department of Chemistry, University of Durham, UK
Dr Jioji Tabudravu, School of Natural Sciences, University of Central Lancashire, UK
Dr David Clarke, EastChem, School of Chemistry, University of Edinburgh, Edinburgh, EH9 3FJ, UK
Professor Bruce Milne, Department of Physics, University of Coimbra, Rua Larga, 3004-516, Coimbra, Portugal
Professor Yi Yu, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Professor Kwaku Kyeremeh, Department of Chemistry, University of Ghana, Ghana
NCIMB Ltd and Ingenza Ltd
Funding and Grants
We gratefully thank the funding bodies below for financial supports of our research
MRC, BBSRC, Leverhulm Trust, EC, IBIOIC, The Royal Society and The Royal Society of Edinburgh.
CM4518 Biological origin of natural products
CM1020 Chemistry for Biosciences 1
CM1512 Chemistry for Biosciences 2
CM3534 Organic and Biological Chemistry
Page 1 of 10 Results 1 to 10 of 93
Chemoenzymatic Synthesis of Indole-Containing Acyloin DerivativesMolecules, vol. 28, 354Contributions to Journals: Articles
Digyalipopeptide A, an antiparasitic cyclic peptide from the Ghanaian Bacillus sp. strain DE2B.Beilstein journal of organic chemistry, vol. 18, pp. 1763-1771Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3762/bjoc.18.185
Identification of genes essential for fluorination and sulfamylation within the nucleocidin gene clusters of Streptomyces calvus and Streptomyces virensChemBioChemContributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/cbic.202200684
Deletion of the accramycin pathway-specific regulatory gene accJ activates the production of unrelated polyketide metabolitesNatural Product ResearchContributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.6084/m9.figshare.21166201.v1
- [ONLINE] View publication in Scopus
A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motifNature Communications, vol. 13, no. 1, 5044Contributions to Journals: Articles
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal TherapyJournal of Medicinal Chemistry, vol. 65, no. 3, pp. 2225-2237Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acs.jmedchem.1c01736
- [ONLINE] View publication in Scopus
Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapyJournal of Controlled Release, vol. 342, pp. 157-169Contributions to Journals: Articles
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetaseNature Communications, vol. 13, no. 1, 62Contributions to Journals: Articles
Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosisRSC Advances, vol. 12, no. 17, pp. 10540-10544Contributions to Journals: Articles
The chemical profile of activated secondary metabolites by overexpressing LaeA in Aspergillus nigerMicrobiological Research, vol. 248, 126735Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.micres.2021.126735