Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

Email Address
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
AB25 2ZD

School of Medicine, Medical Sciences and Nutrition


I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  


  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here


Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.


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  • Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply

    Jansen, J. O., MacLennan, G. S., Campbell, M. K.
    JAMA, vol. 331, no. 11, pp. 981-982
    Contributions to Journals: Comments and Debates
  • Reply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4

    Heer, R., Tan, W. S., Gravestock, P., Vadiveloo, T., Lewis, R., Penegar, S., Vale, L., MacLennan, G., Hall, E., PHOTO Trial Team
    European Urology, vol. 85, no. 3, pp. 309-312
    Contributions to Journals: Comments and Debates
  • SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

    Long, M. B., Abo-Leyah, H., Giam, Y. H., Vadiveloo, T., Hull, R. C., Keir, H. R., Pembridge, T., De Lima, D. A., Delgado, L., Inglis, S. K., Hughes, C., Gilmour, A., Gierlinski, M., New, B. J., Maclennan, G., Dinkova-Kostova, A. T., Chalmers, J. D.
    ERJ Open Research, vol. 10, no. 2, 00917-2023
    Contributions to Journals: Articles
  • Three-year cost utility analysis of mini versus standard slings: A trial based economic evaluation

    Kilonzo, M., Boyers, D., Cooper, D., Davidson, T., Bhal, K., N'Dow, J., MacLennan, G., Norrie, J., Abdel-Fattah, M.
    BJUI Compass, vol. 5, no. 2, pp. 230-239
    Contributions to Journals: Articles
  • Effects of socioeconomic status on baseline values and outcomes at 24 months in the Treatment of Advanced Glaucoma Study randomised controlled Trial

    King, A. J., Hudson, J., Azuara-Blanco, A., Kirwan, J. F., Goyal, S., Lim, K. S., Maclennan, G., TAGS Research Group
    British Journal of Ophthalmology, vol. 108, no. 2, pp. 203-210
    Contributions to Journals: Articles
  • Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    King, A. J., Hudson, J., Azuara-Blanco, A., Burr, J., Kernohant, A., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., Davidson, T., Vale, L., MacLennan, G., TAGS Study Group
    Contributions to Journals: Articles
  • Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial

    Ahmed, I., Hudson, J., Innes, K., Hernández, R., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    BMJ, vol. 383, e075383
    Contributions to Journals: Articles
  • Cost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases

    Chong, H. Y., McNamee, P., Bachmair, E., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., Macfarlane, G., Basu, N., LIFT study group
    Rheumatology, vol. 62, no. 12, pp. 3819-3827
    Contributions to Journals: Articles
  • Development of an intervention to manage benzodiazepine dependence and high-risk use in the context of escalating drug related deaths in Scotland: an application of the MRC framework

    Berry, K., Matheson, C., Schofield, J., Dumbrell, J., Parkes, T., Hill, D., Kilonzo, M., MacLennan, G., Stewart, D., Ritchie, T., Turner, M.
    BMC Health Services Research, vol. 23, no. 1, 1205
    Contributions to Journals: Articles
  • Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

    Jansen, J. O., Hudson, J., Cochran, C., MacLennan, G., Lendrum, R., Sadek, S., Gillies, K., Cotton, S., Kennedy, C., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., Aylwin, C., Bew, D., Brooks, A., Chinery, J., Cowlam, T., Frith, D., George, A., Hudson, A., Johnstone, P., Mahmood, A., Novak, A., O'Meara, M., Reid, S., Sattout, A., Smith, C., Stansfield, T., Thompson, J., UK-REBOA Study Group
    JAMA, vol. 330, no. 19, pp. 1862-1871
    Contributions to Journals: Articles
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Books and Reports

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals