Health Economics Research Unit (HERU)

Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Comparing the clinical and cost-effectiveness of various washout policies in preventing catheter associated complications in adults living with long-term catheters: synopsis of the CATHETER II RCT

    Johnson, D., Tripathee, S., Cooper, D., Constable, L., Omar, M. I., MacLennan, S., Cotton, S., Dimitropoulos, K., Evans, S., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, G., Murchie, P., Kyaw Myint, P., N'Dow, J., Norrie, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A., Abdel-fattah, M.
    Health Technology Assessment, vol. 30, no. 26
    Contributions to Journals: Articles

  • PARTIAL: study protocol for a clinical and cost-effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma randomised trial

    Johnson, D., Thomas, R., Cotton, S., Newlands, R., Cooper, D., McCann, S., Vale, L., Gillies, K., Bex, A., Challacombe, B., Falloon, J., MacLennan, G., Narahari, K., Nicol, D., Sheerin, N., Stewart, G. D., Tran, M., Heer, R., Soomro, N.
    Trials
    Contributions to Journals: Articles

  • Ten Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement

    Beard, D. J., Davies, L. J., Cook, J. A., MacLennan, G., Hudson, J., Price, A. J., Carr, A. J., Little, M., Leal, J., Fitzpatrick, R., Murray, D. W., Campbell, M., TOPKAT Study Group
    The Lancet Rheumatology, vol. 8, no. 2, pp. e116-e126
    Contributions to Journals: Articles

  • Clinical and cost-effectiveness of medical management versus surgery for deep infiltrating endometriosis: synopsis from the DIAMOND RCT

    Cooper, K., Constable, L., Vadiveloo, T., Matuluko, A., Kennedy, C., McCann, S., Cotton, S., Gillies, K., Bruce, R., Smith, P., MacLennan, G., Clark, T. J.
    Health Technology Assessment
    Contributions to Journals: Articles

  • Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data

    Morrison, A. P., Pyle, M., Law, H., Emsley, R., MacLennan, G., Hudson, J.
    Schizophrenia Bulletin, vol. 52, no. 1, sbaf121
    Contributions to Journals: Articles

  • A feasibility study of a co-designed intervention to manage benzodiazepine dependence and high-risk use in those receiving opioid agonist treatment

    Matheson, C., Berry, K., Kilonzo, M., Galea-Singer, S., Hill, D., Ritchie, T., Schofield, J., Stewart, D., Turner, M., MacLennan, G.
    Pilot and Feasibility Studies, vol. 12, no. 1, 4
    Contributions to Journals: Articles

  • Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial

    Parkes, T., Carver, H., Boyd, J., Cotton, S., Breeman, S., Cooper, D., Forrest, M., Foster, R., Hawthorn, J., Hunt, K., Kilonzo, M., Matheson, C., Maxwell, M., Mercer, S. W., Pauly, B., Scotland, G., Steele, W., Sumnall, H., Wallace, J., Macaulay, L., MacLennan, G.
    Trials, vol. 27, 18
    Contributions to Journals: Articles

  • Reply to Zhihao Lei’s Letter to the Editor re: Oliver Wiseman, Daron Smith, Kathryn Starr, et al. The PUrE Randomised Controlled Trial 1: Clinical and Cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for Lower Pole Stones ≤10 mm. Eur Urol 2025;88:179–89

    Wiseman, O., Smith, D., Starr, K., Aucott, L., Hernández, R., Thomas, R., MacLennan, S., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology, vol. 89, no. 1, pp. e23-e24
    Contributions to Journals: Letters

  • Patient engagement and shared decision-making in trial recruitment intervention studies: a systematic review

    Morgan, T. L., Hudek, N., Carroll, K., Yee, M., Inglis, J., Fergusson, D. A., Gillies, K., Richards, D. P., Semchishen, S. N., Presseau, J., Grimshaw, J., Graham, I. D., Rodger, M., Taljaard, M., Marlin, S., Weijer, C., MacLennan, G., Brehaut, J. C.
    Research Involvement and Engagement, vol. 11, no. 1, 142
    Contributions to Journals: Articles

  • ColoCap: determining the diagnostic accuracy of colon capsule endoscopy compared with standard colonoscopy in patients at risk of colorectal disease: a study protocol

    Ibrahim, H., Haritakis, M., Ballantine, L., McCormack, K., Cotton, S., Hudson, J., Atkin, K., Rogers, S., Nixon, L. S., Verghese, A., Holmes, H., Treweek, S., MacLennan, G., Dolwani, S., Gardner, G., Hurt, C., Watson, A. J. M., Turvill, J. L.
    BMJ Open, vol. 15, no. 9, e104661
    Contributions to Journals: Articles
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