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The School of Medicine, Medical Sciences and Nutrition

Professor Mark Vickers

Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

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  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

    Ball, R. J., Avenell, A., Aucott, L., Hanlon, P., Vickers, M. A.
    Arthritis Research & Therapy, vol. 17, pp. 274
    Contributions to Journals: Articles

  • Intraoperative cell salvage may damage erythrocytes as indicated by macrophage uptake

    Chakravarty, P. D., Porter, C., Cao, H., Cairns, L., Barker, R. N., Moss, M., Duthie, R., Jeffrey, R. P., Ashcroft, G. P., Gibson, G., Buchan, K., Erwig, L., Vickers, M. A.
    Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, pp. 31-31
    Contributions to Journals: Abstracts

  • How do immune responses differ against senescent and damaged erythrocytes: profiling sugar and protein changes on the cell surface

    Cao, H., Tampakis, D., Moss, M., Pickford, W. J., Hall, L. S., Crocker, P. R., Erwig, L. P., Vickers, M. A., Barker, R. N.
    Immunology, vol. 143, no. s2, pp. 118-119
    Contributions to Journals: Abstracts

  • Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease

    Vickers, M. A., Wilkie, G. M., Robinson, N., Rivera, N., Haque, T., Crawford, D. H., Barry, J., Fraser, N., Turner, D. M., Robertson, V., Dyer, P., Flanagan, P., Newlands, H. R., Campbell, J., Turner, M.
    British Journal of Haematology, vol. 167, no. 3, pp. 402-410
    Contributions to Journals: Articles

  • Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A

    Forrester, M. A., Robertson, L., Bayoumi, N., Keavney, B. D., Barker, R. N., Vickers, M. A.
    Clinical and Experimental Immunology, vol. 178, no. 2, pp. 373-383
    Contributions to Journals: Articles

  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Vickers, M. A., Hall, L. S., Hall, A. M., Pickford, W. J., Urbaniak, S. J., Barker, R. N.
    54th Annual Scientific Meeting of the British-Society-for-Haematology, pp. 12-12
    Contributions to Journals: Abstracts

  • Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge

    Whibley, N., Maccallum, D. M., Vickers, M. A., Zafreen, S., Waldmann, H., Hori, S., Gaffen, S. L., Gow, N. A. R., Barker, R. N., Hall, A. M.
    European Journal of Immunology, vol. 44, no. 4, pp. 1069-1083
    Contributions to Journals: Articles

  • The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak

    Visser, E., Milne, D., Collacott, I., McLernon, D., Counsell, C., Vickers, M.
    BMC Infectious Diseases, vol. 14, 151
    Contributions to Journals: Articles

  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Hall, L. S., Hall, A. M., Pickford, W., Vickers, M. A., Urbaniak, S. J., Barker, R. N.
    Haematologica, vol. 99, no. 3, pp. 588-596
    Contributions to Journals: Articles

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus

    Hanlon, P., Avenell, A., Aucott, L., Vickers, M. A.
    Arthritis Research & Therapy, vol. 16, no. 1, R3
    Contributions to Journals: Articles

  • Quantitative variation in plasma angiotensin-i converting enzyme activity shows allelic heterogeneity in the ABO blood group locus

    Terao, C., Bayoumi, N., McKenzie, C. A., Zelenika, D., Muro, S., Mishima, M., Connell, J. M. C., Vickers, M. A., Mark Lathrop, G., Farrall, M., Matsuda, F., Keavney, B. D., The Nagahama Cohort Research Group
    Annals of Human Genetics, vol. 77, no. 6, pp. 465-471
    Contributions to Journals: Articles

  • The soluble isoform of CTLA-4 as a regulator of T-cell responses

    Ward, F. J., Dahal, L. N., Wijisekera, S. K., Abdul-Jawad, S. K., Kaewarpai, T., Xu, H., Vickers, M. A., Barker, R. N.
    European Journal of Immunology, vol. 43, no. 5, pp. 1274-1285
    Contributions to Journals: Articles

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis

    Almohmeed, Y. H., Avenell, A., Aucott, L., Vickers, M. A.
    PloS ONE, vol. 8, no. 4, e61110
    Contributions to Journals: Articles

  • Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms

    Lawrie, A., Stevenson, D. A. J., Doig, T., Vickers, M., Culligan, D. J.
    Cancer Genetics and Cytogenetics, vol. 205, no. 11, pp. 599-602
    Contributions to Journals: Articles

  • Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia

    Hall, A. M., Zamzami, O. M., Whibley, N., Hampsey, D. P., Haggart, A. M., Vickers, M. A., Barker, R. N.
    Haematologica, vol. 97, no. 10, pp. 1494-1500
    Contributions to Journals: Articles

  • Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses

    Whibley, N. W., MacCallum, D. M., Vickers, M. A., Waldmann, H., Hori, S., Gow, N. A. R., Barker, R. N., Hall, A. M.
    European Congress of Immunology, pp. 206-206
    Contributions to Journals: Abstracts

  • Identification, immunomodulatory activity, and immunogenicity of the major helper T-cell epitope on the K blood group antigen

    Stephen, J., Cairns, L. S., Pickford, W. J., Vickers, M. A., Urbaniak, S. J., Barker, R. N.
    Blood, vol. 119, no. 23, pp. 5563-5574
    Contributions to Journals: Articles

  • Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

    Milliken, S. V. I., Wassall, H., Lewis, B. J., Logie, J., Barker, R. N., Macdonald, H., Vickers, M. A., Ormerod, A. D.
    Journal of Allergy and Clinical Immunology, vol. 129, no. 6, pp. 1554-1561
    Contributions to Journals: Articles

  • Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells

    Whibley, N., MacCallum, D. M., Vickers, M. A., Gow, N. A., Barker, R. N., Hall, A. M.
    Immunology, vol. 135, no. Suppl. 1, pp. 161
    Contributions to Journals: Abstracts

  • Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults

    Crowther, M., Chan, Y. T., Garbett, I. K., Lim, W., Vickers, M. A., Crowther, M. A.
    Blood, vol. 118, no. 15, pp. 4036-4040
    Contributions to Journals: Articles

  • Foundation Years Journal

    Vickers, M.
    .
    Other Contributions: Other Contributions

  • The doctor's dilemma: stimulating T cells

    Vickers, M.
    Blood, vol. 114, no. 16, pp. 3361-3362
    Contributions to Journals: Comments and Debates

  • Helper T cells point the way to specific immunotherapy for autoimmune disease

    Hall, A. M., Vickers, M. A., Barker, R. N., Erwig, L. P.
    Cardiovascular & Hematological Disorders - Drug Targets, vol. 9, no. 3, pp. 159-166
    Contributions to Journals: Articles

  • A case of apples and pears?

    Crowther, M., Vickers, M. A., Avenell, A.
    Blood, vol. 113, no. 24, pp. 6259-6260
    Contributions to Journals: Letters

  • Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes

    Cunnington, M. S., Mayosi, B. M., Hall, D. H., Avery, P. J., Farrall, M., Vickers, M. A., Watkins, H., Keavney, B.
    Atherosclerosis, vol. 203, no. 1, pp. 41-44
    Contributions to Journals: Articles
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