Publications | The School of Biological Sciences

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

2023

Kentistou, K. A., Luan, J., Wittemans, L. B. L., Hambly, C., Klaric, L., Kutalik, Z., Speakman, J. R., Wareham, N. J., Kendall, T. J., Langenberg, C., Wilson, J. F., Joshi, P. K., Morton, N. M.

Nature Communications, vol. 14, no. 1, pp. 307

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s41467-022-35563-0

Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

2023 - E-pub ahead of print

Krol, E., Turner, F., Derous, D., Mitchell, S. E., Martin, S., Douglas, A., Speakman, J.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1007/s00360-023-01474-9
Open Access: http://aura.abdn.ac.uk/bitstream/2164/19855/1/Krol_etal_JCPB_Fur_Removal_Promotes_VoR.pdf

Variation in human water turnover associated with environmental and lifestyle factors

2022

Yamada, Y., Zhang, X., Henderson, M. E. T., Sagayama, H., Pontzer, H., Watanabe, D., Yoshida, T., Kimura, M., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G., Close, G. L., Cooper, J. A., Cooper, R., Das, S. K., Dugas, L. R., Eaton, S., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Goris, A. H., Gurven, M., Halsey, L. G., Hambly, C., El Hamdouchi, A., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kempen, K. P., Kraus, W. E., Kriengsinyos, W., Kushner, R. F., Lambert, E. V., Leonard, W. R., Lessan, N., Speakman, J. R., International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

Science, vol. 378, no. 6622, pp. 909-915

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1126/science.abm8668
Additional Links: View publication in Scopus

Focus on diet and exercise

2022

Speakman, J., Johnstone, A., Moholdt, T., Panda, S., Klein, S., Parker, B. L., Goodyear, L.

Contributions to Journals

Digital Object Identifier: https://doi.org/10.1016/j.cmet.2022.09.011

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

2022

Zhao, Z., Yang, R., Li, M., Bao, M., Huo, D., Cao, J., Speakman, J. R.

Molecular Metabolism, vol. 64, 101551

Contributions to Journals: Review articles

Digital Object Identifier: https://doi.org/10.1016/j.molmet.2022.101551
Open Access: http://aura.abdn.ac.uk/bitstream/2164/19279/1/Zhao_et_al_Effects_ambient_Molecular_metabolism_vor.pdf

Variability in energy expenditure is much greater in males than females

2022

Halsey, L. G., Careau, V., Pontzer, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., Cooper, J. A., Das, S. K., Cooper, R., Dugas, L. R., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Goris, A. H., Gurven, M., Hambly, C., Hamdouchi, A. E., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kempen, K. P., Kimura, M., Kraus, W. E., Kushner, R. F., Lambert, E. V., Leonard, W. R., Lessan, N., Martin, C. K., Medin, A. C., Meijer, E. P., Morehen, J. C., Morton, J. P., Neuhouser, M. L., Nicklas, T. A., Ojiambo, R. M., Pietiläinen, K. H., Pitsiladis, Y. P., Plange-Rhule, J., Plasqui, G., Prentice, R. L., Rabinovich, R. A., Racette, S. B., Raichlen, D. A., Ravussin, E., Reynolds, R. M., Roberts, S. B., Schuit, A. J., Sjödin, A. M., Stice, E., Urlacher, S. S., Valenti, G., Van Etten, L. M., Van Mil, E. A., Wilson, G., Wood, B. M., Yanovski, J., Yoshida, T., Zhang, X., Murphy-Alford, A. J., Loechl, C. U., Luke, A. H., Rood, J., Sagayama, H., Schoeller, D. A., Westerterp, K. R., Wong, W. W., Yamada, Y., Speakman, J. R.

Journal of Human Evolution, vol. 171, pp. 103229

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.jhevol.2022.103229

Human total, basal and activity energy expenditures are independent of ambient environmental temperature

2022

Zhang, X., Yamada, Y., Sagayama, H., Ainslie, P. N., Blaak, E. E., Buchowski, M. S., Close, G. L., Cooper, J. A., Das, S. K., Dugas, L. R., Gurven, M., El Hamdouchi, A., Hu, S., Joonas, N., Katzmarzyk, P., Kraus, W. E., Kushner, R. F., Leonard, W. R., Martin, C. K., Meijer, E. P., Neuhouser, M. L., Ojiambo, R. M., Pitsiladis, Y. P., Plasqui, G., Prentice, R. L., Racette, S. B., Ravussin, E., Redman, L. M., Reynolds, R. M., Roberts, S. B., Sardinha, L. B., Silva, A. M., Stice, E., Urlacher, S. S., Van Mil, E. A., Wood, B. M., Murphy-Alford, A. J., Loechl, C., Luke, A. H., Rood, J., Schoeller, D. A., Westerterp, K. R., Wong, W. W., Pontzer, H., Speakman, J. R., IAEA DLW Database Consortium

iScience, vol. 25, no. 8, 104682

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.isci.2022.104682
Open Access: http://aura.abdn.ac.uk/bitstream/2164/19320/1/Zhang_et_al_HUman_total_iScience_vor.pdf

Obesity: an evolutionary context

2022

Speakman, J. R., Elmquist, J. K.

Life metabolism, vol. 1, no. 1, pp. 10-24

Contributions to Journals: Review articles

Digital Object Identifier: https://doi.org/10.1093/lifemeta/loac002

The usage of different types of food outlets was not significantly associated with body mass index during the third COVID-19 national lockdown in the United Kingdom

2022

Albalawi, A., Hambly, C., Speakman, J. R.

Obesity Science & Practice, vol. 8, no. 4, pp. 411-422

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1002/osp4.579
Open Access: https://pure.abdn.ac.uk/ws/files/219081926/Albalawi_et_al_usage_different_Obesity_science_and_practice_vor.pdf

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults

2022 - E-pub ahead of print

Hu, S., Zhang, X., Stamatiou, M., Hambly, C., Huang, Y., Ma, J., Li, Y., Speakman, J. R.

Cell Metabolism

Contributions to Journals: Letters

Digital Object Identifier: https://doi.org/10.1016/j.cmet.2022.05.012

Interspecific coprophagia by wild red foxes: DNA metabarcoding reveals a potentially widespread form of commensalism among animals

2022

Navarro Waggershauser, C., Taberlet, P., Coissac, E., Kortland, K., Hambly, C., Lambin, X.

Ecology and Evolution, vol. 12, no. 7, e9029

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1002/ece3.9029
Open Access: http://aura.abdn.ac.uk/bitstream/2164/18776/1/Waggershauser_etal_E_E_Interspecific_coprophagia_by_VOR.pdf

Consumption of takeaway and delivery meals is associated with increased BMI and percent fat among UK Biobank participants

2022

Speakman, J., Albalawi, A. A. A., Hambly, C.

The American Journal of Clinical Nutrition, vol. 116, no. 1, pp. 173-188

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/ajcn/nqac078
Open Access: http://aura.abdn.ac.uk/bitstream/2164/18919/1/Albalawi_etal_AJCN_Consumption_Of_Takeaway_VoR.pdf

The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction

2022 - E-pub ahead of print

Phillips, D., Mathers, H., Mitchell, S. E., Speakman, J. R.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/gerona/glac110

Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression

2022

Liu, X., Jin, Z., Summers, S., Derous, D., Li, M., Li, B., Li, L., Speakman, J.

Cell Reports, vol. 39, no. 7

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.celrep.2022.110835
Open Access: http://aura.abdn.ac.uk/bitstream/2164/19340/1/Liu_etal_CR_Calorie_Restriction_And_VOR.pdf

Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

2022

Wu, Y., Green, C. L., Wang, G., Yang, D., Li, L., Li, B., Wang, L., Li, M., Li, J., Xu, Y., Zhang, X., Niu, C., Hu, S., Togo, J., Mazidi, M., Derous, D., Douglas, A., Speakman, J.

Aging Cell, vol. 21, no. 4, e13585

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1111/acel.13585
Open Access: http://aura.abdn.ac.uk/bitstream/2164/18425/1/Wu_etal_AC_Effects_of_dietary_VOR.pdf

Social associations in lactating dairy cows housed in a robotic milking system

2022

Marumo, J. L., Fisher, D. N., Lusseau, D., Mackie, M., Speakman, J. R., Hambly, C.

Applied Animal Behaviour Science, vol. 249, 105589

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.applanim.2022.105589
Additional Links: View publication in Scopus

Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

2022

Wu, Y., Hu, S., Yang, D., Li, L., Li, B., Wang, L., Li, M., Wang, G., Li, J., Xu, Y., Zhang, X., Niu, C., Speakman, J. R.

Frontiers in Nutrition, vol. 9, 835536

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.3389/fnut.2022.1049766

Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals

2022

Zhao, Z., Cao, J., Niu, C., Bao, M., Xu, J., Huo, D., Liao, S., Liu, W., Speakman, J. R.

Nature Metabolism, vol. 4, no. 3, pp. 320-326

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s42255-022-00545-5
Additional Links: View publication in Scopus

A Mesocosm Experiment in Ecological Physiology: The Modulation of Energy Budget in a Hibernating Marsupial under Chronic Caloric Restriction

2022

Nespolo, R. F., Fonturbel, F. E., Mejias, C., Contreras, R., Gutierrez, P., Oda, E., Sabat, P., Hambly, C., Speakman, J. R., Bozinovic, F.

Physiological and Biochemical Zoology, vol. 95, no. 1, pp. 66-81

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1086/717760

Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice

2021

Li, M., Li, L., Li, B., Hambly, C., Wang, G., Wu, Y., Jin, Z., Wang, A., Niu, C., Wolfrum, C., Speakman, J. R.

Nature Communications, vol. 12, no. 1, 4725

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s41467-021-24659-8
Open Access: http://aura.abdn.ac.uk/bitstream/2164/17520/1/Li_etal_NC_Brown_adipose_tissue_VOR.pdf
Additional Links: View publication in Scopus

Energy compensation and adiposity in humans

2021

Careau, V., Halsey, L. G., Pontzer, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., Cooper, J. A., Das, S. K., Cooper, R., Dugas, L. R., Eaton, S. D., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Goris, A. H., Gurven, M., Hambly, C., El Hamdouchi, A., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kempen, K. P., Kimura, M., Kraus, W. E., Kushner, R. F., Lambert, E., Leonard, W. R., Lessan, N., Martin, C. K., Medin, A. C., Meijer, E. P., Morehen, J. C., Morton, J. P., Neuhouser, M. L., Nicklas, T. A., Ojiambo, R. M., Pietilainen, K. H., Pitsiladis, Y. P., Plange-Rhule, J., Plasqui, G., Prentice, R. L., Rabinovich, R. A., Racette, S. B., Raichlen, D. A., Ravussin, E., Reilly, J. J., Reynolds, R. M., Roberts, S. B., Schuit, A. J., Sjodin, A. M., Stice, E., Urlacher, S. S., Valenti, G., Van Etten, L. M., Van Mil, E. A., Wells, J. C. K., Wilson, G., Wood, B. M., Yanovski, J., Yoshida, T., Zhang, X., Murphy-Alford, A. J., Loechl, C. U., Luke, A. H., Rood, J., Sagayama, H., Schoeller, D. A., Wong, W. W., Yamada, Y., Speakman, J. R.

Current Biology, vol. 31, no. 20, pp. 4659-4666

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.cub.2021.08.016
Open Access: http://aura.abdn.ac.uk/bitstream/2164/17522/1/Careau_etal_CB_Energy_compensation_and_VOR.pdf

Determinants of heart rate in Svalbard reindeer reveal mechanisms of seasonal energy management

2021

Trondrud, L. M., Pigeon, G., Albon, S., Arnold, W., Evans, A. L., Irvine, R. J., Król, E., Ropstad, E., Stien, A., Veiberg, V., Speakman, J. R., Loe, L. E.

Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1831, 20200215

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1098/rstb.2020.0215
Open Access: http://aura.abdn.ac.uk/bitstream/2164/16961/1/Trondrud_etal_rstb_Determinants_of_heart_VOR.pdf
Additional Links: View publication in Scopus

Daily energy expenditure through the human life course

2021

Pontzer, H., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G., Close, G. L., Cooper, J. A., Cooper, R., Das, S. K., Dugas, L. R., Ekelund, U., Entringer, S., Forrester, T., Fudge, B. W., Goris, A. H., Gurven, M., Hambly, C., El Hamdouchi, A., Hoos, M. B., Hu, S., Joonas, N., Joosen, A. M., Katzmarzyk, P., Kempen, K. P., Kimura, M., Kraus, W. E., Kushner, R. F., Lambert, E. V., Leonard, W. R., Lessan, N., Martin, C., Medin, A. C., Meijer, E. P., Morehen, J. C., Morton, J. P., Neuhouser, M. L., Zhang, X., Speakman, J. R., IAEA DLW Database Consortium, Luke, A. H., Rood, J., Schoeller, D. A., Westerterp, K. R., Wong, W. W.

Science, vol. 373, no. 6556, pp. 808-812

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1126/science.abe5017
Additional Links: View publication in Scopus

The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways

2021

García-Flores, L. A., Green, C. L., Mitchell, S. E., Promislow, D. E., Lusseau, D., Douglas, A., Speakman, J. R.

Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 31, e2101977118

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1073/pnas.2101977118
Additional Links: View publication in Scopus

Surviving winter on the Qinghai-Tibetan Plateau: Pikas suppress energy demands and exploit yak feces to survive winter

2021

Speakman, J. R., Chi, Q., Ołdakowski, �., Fu, H., Fletcher, Q. E., Hambly, C., Togo, J., Liu, X., Piertney, S. B., Wang, X., Zhang, L., Redman, P., Wang, L., Tang, G., Li, Y., Cui, J., Thomson, P. J., Wang, Z., Glover, P., Robertson, O. C., Zhang, Y., Wang, D.

Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 30, e2100707118

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1073/pnas.2100707118
Additional Links: View publication in Scopus