BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- About
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
2001 PhD, Thrombosis & Vascular Biology; University of Aberdeen
1997 BSc (Hons) Molecular Biology; University of Aberdeen
Employment
2022- Cardiometabolic Disease Theme Lead, University of Aberdeen
2021- Personal Chair, University of Aberdeen
2017-2021 Reader, University of Aberdeen
2016- 2017 Senior Lecturer, University of Aberdeen
2011– 2016 British Heart Foundation Fellow, Senior Research Fellow, University of Aberdeen
2010-2011 British Heart Foundation Fellow, Lecturer, University of Aberdeen
2007-2010 Independent Research Fellow in cardiovascular medicine, University of Leeds, UK
2004-2006 Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA
Qualifications
- BSc hons Molecular Biology1997 - University of Aberdeen
- PhD Thrombosis & Vascular Biology2001 - University of Aberdeen
External Memberships
2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)
2024-2026: Vice-Chair of the Education Committee of the ISTH
2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee
2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)
2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH
2023 onwards: Steering Committee of UK Thrombosis Research Network
2024: Faculty Member of the CAS-AM course on anticoagulation management
Latest Publications
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
Molecular MedicineContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/S10020-026-01485-6
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
Blood Advances, vol. 10, no. 7, pp. 2173-2181Contributions to Journals: ArticlesColchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
European Journal of Pharmacology, vol. 1020, 178725Contributions to Journals: ArticlesEndothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: ArticlesAcute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V
Blood Advances, vol. 9, no. 11, pp. 2751-2762Contributions to Journals: Articles
Prizes and Awards
2024: ISTH Esteemed Career Award
2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis
- Research
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Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Supervision
My current supervision areas are: Biomedical Sciences.
Current PhD Students
Kieran Pocknell Co-Supervisors Dr Claire Whyte, Dr Dana Huskens (The Synapse Research Institute, The Netherlands)
- Funded by Medical Research Scotland
Jack Partridge, Co-Supervisors Dr Claire Whyte, Dr Mairead Black
- Funded by John Shivas Trust
Tarek Al Tarawni, Co-Supervisors Dr Claire Whyte, Prof Mary Joan Macleod
- Funded by Aqaba Medical Sciences University
Sara Sharaf, Principal supervisor Prof Karolin Hijazi, Co-Supervisors Prof Dana Dawson, Prof Nicola J Mutch
- Funded by Elphinstone Scholarship
Graduated PhD Students
Dr Joanne Mitchell, Funded by University of Aberdeen Development Trust and Friends of Anchor. Graduated 2016
Dr Mohammad Jalal: Funded by the Saudi Arabian Government. Graduated 2017
Dr Gael Morrow: Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood, Graduated, 2018
Dr Paraskevi Untiveros: Funded by the Chief Scientist Office. Clinical Fellow, Graduated 2018
Dr Maria-Louise Williams: Funded by the Institute of Medical Sciences, University of Aberdeen. Graduated, 2023
Dr Um-May Sumya, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2023
Dr Fahad Alshehri, Funded by Royal Embassy of Saudi Arabia Cultural Bureau, Graduated
Dr Steven Humphrey, Funded by BHF-NC3R's, Graduated 2025
Dr Anuj Narwal, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2026
Dr Madeline Rhodes, Funded by Marie-Curie Fellowship, Graduated, 2026
Funding and Grants
2026 Medical Research Scotland. Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. £147,385.31. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Dr Dana Huskens.
2026 Chief Scientist Office. Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. PI Prof NJ Mutch, Co-I, Dr Lucy de Lyold, Dr Sarah Bell, Dr Mairead Black Dr Claire Whyte, Prof Peter Collins.
2025 Heart Research UK. Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. £225,000. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog.
2025 BHF. Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. £309,764.10., PI: Dr Claire Whyte, Co-I Prof NJ Mutch, Co-I Prof Valerie Speirs
2024 BHF. S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. £289,206. PI Prof NJ Mutch, Co-I Dr Julie Rayes, Dr Claire Whyte and Dr Alexander Brill.
2024 Friends of Anchor. Development of an endothelialised model of deep vein thrombosis. PI Prof NJ Mutch, Co-I Dr Claire Whyte Mr Steven Humphreys. £15,000.
2023 Heart Research UK. Aetiology of impaired fibrinolysis in acute coronary syndrome and appropriate treatment strategies. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog. £199,970.
2022 Medical Research Scotland PhD Studentship. The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. £122,011. PI, Prof NJ Mutch Co-I Dr Claire Whyte.
2022 NC3Rs-BHF PhD studentship. Modelling of thrombus dynamics in a microfluidic ‘vasculature’. PI, Prof NJ Mutch, Co-I Dr Claire Whyte. £90,000
- Teaching
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Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
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Page 1 of 9 Results 1 to 10 of 88
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
Molecular MedicineContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/S10020-026-01485-6
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
Blood Advances, vol. 10, no. 7, pp. 2173-2181Contributions to Journals: ArticlesColchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
European Journal of Pharmacology, vol. 1020, 178725Contributions to Journals: ArticlesEndothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: ArticlesAcute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V
Blood Advances, vol. 9, no. 11, pp. 2751-2762Contributions to Journals: ArticlesActivated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, vol. 8, no. 19, pp. 5072–5085.Contributions to Journals: ArticlesStandardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.001
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5cb7441a-bc85-4e41-8f20-2688b11f3c70/download
- [ONLINE] View publication in Scopus
Fibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596Contributions to Journals: ArticlesThe Fibrinolysis Renaissance
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3304-3316Contributions to Journals: Articles
