Professor Nicola Mutch | The University of Aberdeen

Professor Nicola Mutch

BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis

Personal Chair

Email Address

Telephone Number

Office Address

Lab 1.33 01224 437417

Office 5.16 01224 437492

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences

University of Aberdeen

Foresterhill

Aberdeen

AB25 2ZD

School/Department

School of Medicine, Medical Sciences and Nutrition

Biography

Education

2001 PhD, Thrombosis & Vascular Biology; University of Aberdeen

1997 BSc (Hons) Molecular Biology; University of Aberdeen

Employment

2022- Cardiometabolic Disease Theme Lead, University of Aberdeen

2021- Personal Chair, University of Aberdeen

2017-2021 Reader, University of Aberdeen

2016- 2017 Senior Lecturer, University of Aberdeen

2011– 2016 British Heart Foundation Fellow, Senior Research Fellow, University of Aberdeen

2010-2011 British Heart Foundation Fellow, Lecturer, University of Aberdeen

2007-2010 Independent Research Fellow in cardiovascular medicine, University of Leeds, UK

2004-2006 Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA

Qualifications

BSc hons Molecular Biology
1997 - University of Aberdeen
PhD Thrombosis & Vascular Biology
2001 - University of Aberdeen

External Memberships

2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)

2024-2026: Vice-Chair of the Education Committee of the ISTH

2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee

2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)

2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH

2023 onwards: Steering Committee of UK Thrombosis Research Network

2024: Faculty Member of the CAS-AM course on anticoagulation management

Latest Publications

ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP
2026 - E-pub ahead of print
Xue, Y., Roest, M., Humphreys, S. J., van der Vorm, L. N., Konings, J., Meijer, P., Whyte, C. S., de Groot, P. G., Arce, N. A., Li, R., Mutch, N. J., de Laat, B., Huskens, D.
Journal of Thrombosis and Haemostasis
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2026.09.002
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
2026 - E-pub ahead of print
Whyte, C., Kavanagh, D., Watson, S. P., Parmer, R., Miles, L., Mutch, N.
Molecular Medicine
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/S10020-026-01485-6
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
2026 - Published
Ilich, A., Whyte, C. S., Moonla, C., Berkowitz, C., Pawlinski, I., Goraya, S., Lionikiene, A. S., Jenkins, P. V., de Lloyd, L., Bell, S. F., Collis, R. E., Collins, P. W., Mutch, N. J., Key, N. S.
Blood Advances, vol. 10, no. 7, pp. 2173-2181
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2025018775
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ab43e7f7-a5a7-45e7-a01f-1a77fff1cc3f/download
- [ONLINE] View publication in Scopus
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
2026 - Published
Sovakova, M., Phair, I. R., Gutierrez-Lara, E., Nisr, R. B., Whyte, C. S., Smyth, D., Alqurashi, N., Yap, S., McSorley, H., Lamont, D., Mutch, N. J., McNeilly, A., Rena, G.
European Journal of Pharmacology, vol. 1020, 178725
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2026.178725
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/afed039a-88cc-48e7-8b1f-3628d6d8cfb0/download
- [ONLINE] View publication in Scopus
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
2025 - Published
Humphreys, S. J., Mutch, N. J., Whyte, C. S.
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.rpth.2025.102929
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/12d6284b-5300-47b9-9035-36f7c055c66d/download

View My Publications

Prizes and Awards

2024: ISTH Esteemed Career Award

2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis

Research

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs

View Research Area

Research Specialisms

Biological Sciences
Human Biology
Cardiology
Cell Biology
Immunology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Supervision

My current supervision areas are: Biomedical Sciences.

Current PhD Students

Kieran Pocknell Co-Supervisors Dr Claire Whyte, Dr Dana Huskens (The Synapse Research Institute, The Netherlands)

- Funded by Medical Research Scotland

Jack Partridge, Co-Supervisors Dr Claire Whyte, Dr Mairead Black

- Funded by John Shivas Trust

Tarek Al Tarawni, Co-Supervisors Dr Claire Whyte, Prof Mary Joan Macleod

- Funded by Aqaba Medical Sciences University

Sara Sharaf, Principal supervisor Prof Karolin Hijazi, Co-Supervisors Prof Dana Dawson, Prof Nicola J Mutch

- Funded by Elphinstone Scholarship

Graduated PhD Students

Dr Joanne Mitchell, Funded by University of Aberdeen Development Trust and Friends of Anchor. Graduated 2016

Dr Mohammad Jalal: Funded by the Saudi Arabian Government. Graduated 2017

Dr Gael Morrow: Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood, Graduated, 2018

Dr Paraskevi Untiveros: Funded by the Chief Scientist Office. Clinical Fellow, Graduated 2018

Dr Maria-Louise Williams: Funded by the Institute of Medical Sciences, University of Aberdeen. Graduated, 2023

Dr Um-May Sumya, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2023

Dr Fahad Alshehri, Funded by Royal Embassy of Saudi Arabia Cultural Bureau, Graduated

Dr Steven Humphrey, Funded by BHF-NC3R's, Graduated 2025

Dr Anuj Narwal, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2026

Dr Madeline Rhodes, Funded by Marie-Curie Fellowship, Graduated, 2026

Funding and Grants

2026 Medical Research Scotland. Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. £147,385.31. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Dr Dana Huskens.

2026 Chief Scientist Office. Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. PI Prof NJ Mutch, Co-I, Dr Lucy de Lyold, Dr Sarah Bell, Dr Mairead Black Dr Claire Whyte, Prof Peter Collins.

2025 Heart Research UK. Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. £225,000. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog.

2025 BHF. Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. £309,764.10., PI: Dr Claire Whyte, Co-I Prof NJ Mutch, Co-I Prof Valerie Speirs

2024 BHF. S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. £289,206. PI Prof NJ Mutch, Co-I Dr Julie Rayes, Dr Claire Whyte and Dr Alexander Brill.

2024 Friends of Anchor. Development of an endothelialised model of deep vein thrombosis. PI Prof NJ Mutch, Co-I Dr Claire Whyte Mr Steven Humphreys. £15,000.

2023 Heart Research UK. Aetiology of impaired fibrinolysis in acute coronary syndrome and appropriate treatment strategies. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog. £199,970.

2022 Medical Research Scotland PhD Studentship. The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. £122,011. PI, Prof NJ Mutch Co-I Dr Claire Whyte.

2022 NC3Rs-BHF PhD studentship. Modelling of thrombus dynamics in a microfluidic ‘vasculature’. PI, Prof NJ Mutch, Co-I Dr Claire Whyte. £90,000

Teaching

Courses

The Molecular Control Of Cell Function BC3503
Advanced Molecules, Membranes And Cells BM4004
Advanced Molecules Membranes And Cells (Stem Cells And Regeneration) BM4010
Cardiovascular Health and Disease BM5003
Advanced Immunology IM4005
Exercise And Health SR2501
MT5524/MT5024 - Molecular Pharmacology
BDS - Cardiovascular System
BDS - Endocrinology

Teaching Responsibilities

Course coordinator for BM5003 Cardiovascular Health and Disease

Publications

Page 1 of 2 Results 1 to 50 of 89

ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP
2026 - E-pub ahead of print
Xue, Y., Roest, M., Humphreys, S. J., van der Vorm, L. N., Konings, J., Meijer, P., Whyte, C. S., de Groot, P. G., Arce, N. A., Li, R., Mutch, N. J., de Laat, B., Huskens, D.
Journal of Thrombosis and Haemostasis
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2026.09.002
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
2026 - E-pub ahead of print
Whyte, C., Kavanagh, D., Watson, S. P., Parmer, R., Miles, L., Mutch, N.
Molecular Medicine
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/S10020-026-01485-6
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
2026 - Published
Ilich, A., Whyte, C. S., Moonla, C., Berkowitz, C., Pawlinski, I., Goraya, S., Lionikiene, A. S., Jenkins, P. V., de Lloyd, L., Bell, S. F., Collis, R. E., Collins, P. W., Mutch, N. J., Key, N. S.
Blood Advances, vol. 10, no. 7, pp. 2173-2181
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2025018775
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ab43e7f7-a5a7-45e7-a01f-1a77fff1cc3f/download
- [ONLINE] View publication in Scopus
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
2026 - Published
Sovakova, M., Phair, I. R., Gutierrez-Lara, E., Nisr, R. B., Whyte, C. S., Smyth, D., Alqurashi, N., Yap, S., McSorley, H., Lamont, D., Mutch, N. J., McNeilly, A., Rena, G.
European Journal of Pharmacology, vol. 1020, 178725
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2026.178725
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/afed039a-88cc-48e7-8b1f-3628d6d8cfb0/download
- [ONLINE] View publication in Scopus
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
2025 - Published
Humphreys, S. J., Mutch, N. J., Whyte, C. S.
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.rpth.2025.102929
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/12d6284b-5300-47b9-9035-36f7c055c66d/download
Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V
2025 - Published
Collins, P. W., Whyte, C., de Lloyd, L., Narwal, A., Bell, S. F., Gill, N., Collis, R. E., Jenkins, P. V., Mutch, N.
Blood Advances, vol. 9, no. 11, pp. 2751-2762
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2024015514
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/6a28ecb9-4a6c-4e6a-9817-01872492cecd/download
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
2024 - Published
Sang, Y., Lee, R. H., Luong, A., Katona, ?., Whyte, C. S., Smith, N. L., Mast, A. E., Flick, M. J., Mutch, N. J., Bergmeier, W., Wolberg, A. S.
Blood Advances, vol. 8, no. 19, pp. 5072–5085.
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2024012979
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/2d073bd7-779c-4aa1-95bd-f44c52f15e5d/download
- [ONLINE] View publication in Scopus
Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
2024 - Published
Baker, R. I., Choi, P., Curry, N., Gebhart, J., Gomez, K., Henskens, Y., Heubel-Moenen, F., James, P., Kadir, R. A., Kouides, P., Lavin, M., Lordkipanidze, M., Lowe, G., Mumford, A., Mutch, N., Nagler, M., Othman, M., Pabinger, I., Sidonio, R., Thomas, W., O'Donnell, J. S., ISTH SSC Von Willebrand Factor, Platelet Physiology, and Women's Health Issues in Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
2024 - Published
Morrow, G. B., Flannery, S., Charles, P. D., Heilig, R., Feller, T., McQuilten, Z., Wake, E., Ariens, R. A. S., Winearls, J., Mutch, N. J., Fischer, R., Laffan, M. A., Curry, N.
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.001
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/5cb7441a-bc85-4e41-8f20-2688b11f3c70/download
- [ONLINE] View publication in Scopus
Fibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
2023 - Published
Simpson, M., Narwal, A., West, E., Martin, J., Bagot, C. N., Page, A. R., Watson, H. G., Whyte, C. S., Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2023.09.007
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ad53adb9-f096-478f-aecd-0144a647ad24/download
The Fibrinolysis Renaissance
2023 - Published
Mutch, N. J., Medcalf, R. L.
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3304-3316
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S1538783623007146
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2023.09.012
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/9e147852-4fd1-4417-bb81-d8532c28f117/download
Fibrinolytic pathophysiologies: still the poor cousin of hemostasis?
2023 - Published
Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 21, no. 10, pp. 2645-2647
Contributions to Journals: Editorials
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2023.08.001
Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial
2023 - Published
Chowdary, P., Agarwal, B., Peralta, M. R., Bhagani, S., Lee, S., Goldring, J., Lipman, M., Waqif, E., Phillips, M., Philippou, H., Foley, J. H., Mutch, N. J., Ariëns, R. A. S., Stringer, K. A., Ricciardi, F., Watissée, M., Hughes, D., Nathwani, A., Riddell, A., Patch, D., Buckley, J., De Neef, M., Dimber, R., Diaz-Garcia, C., Patel, H., Nandani, A., Dissanayake, U., Chadwick, N., Alkhatip, A. A. A. M. M., Watkinson, P., Raith, E., Singh, S., Wolff, T., Jha, R., Brill, S. E., Bakhai, A., Evans, A., Gilani, F., Gomez, K.
Journal of Clinical Medicine, vol. 12, no. 18, 5848
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/jcm12185848
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/3b99490a-d00c-403d-b4a5-c1907eda50d1/download
Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability
2023 - Published
Mitchell, J. L., Little, G., Bye, A. P., Gaspar, R. S., Unsworth, A. J., Kriek, N., Sage, T., Stainer, A., Sangowawa, I., Morrow, G. B., Bastos, R. N., Shapiro, S., Desborough, M. J., Curry, N., Gibbins, J. M., Whyte, C. S., Mutch, N. J., Jones, C. I.
Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 5, 100200
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.rpth.2023.100200
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/b81ba3a8-6bed-444a-9c39-f7fc1dd4328c/download
- [ONLINE] View publication in Scopus
“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions
2023 - Published
Humphreys, S. J., Whyte, C. S., Mutch, N. J.
Frontiers in cardiovascular medicine, vol. 10, 1146833
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fcvm.2023.1146833
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/8aeb01d3-6508-4394-be48-37bbe6decd7e/download
Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study
2023 - Published
de Lloyd, L., Jenkins, P. V., Bell, S. F., Mutch, N. J., Martins Pereira, J. F., Badenes, P. M., James, D., Ridgeway, A., Cohen, L., Roberts, T., Field, V., Collis, R. E., Collins, P. W.
Journal of Thrombosis and Haemostasis, vol. 21, no. 4, pp. 862-879
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2022.11.036
- [ONLINE] View publication in Scopus
Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)
2023 - Published
Morrow, G. B., Mutch, N. J.
Seminars in Thrombosis and Hemostasis, vol. 49, no. 3, pp. 305-313
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1055/s-0042-1758791
Cellular FXIII in Human Macrophage-Derived Foam Cells
2023 - Published
Somodi, L., Horváth, E., Bárdos, H., Baráth, B., Pethő, D., Katona, ?., Balla, J., Mutch, N. J., Muszbek, L.
International Journal of Molecular Sciences, vol. 24, no. 5, 4802
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms24054802
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/7aba3eb0-d502-44af-bc33-fd269434bf4f/download
- [ONLINE] View publication in Scopus
Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi
2023 - Published
Narwal, A., Whyte, C. S., Mutch, N. J.
Contributions to Journals: Short Survey
- [ONLINE] DOI: https://doi.org/10.3389/fcvm.2022.1070502
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/26a45e2b-df0e-4217-b20a-722aa8b3cf3c/download
- [ONLINE] View publication in Scopus
Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure
2023 - Published
Jalal, M. M., Whyte, C. S., Coxon, F. P., Mutch, N. J.
Platelets, vol. 34, no. 1, 2206921
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1080/09537104.2023.2206921
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ca86c900-ce8a-4f44-beae-0b07b9c50442/download
S100A8/A9 drives the formation of procoagulant platelets through GPIbα
2022 - Published
Colicchia, M., Schrottmaier, W. C., Perrella, G., Reyat, J. S., Begum, J., Slater, A., Price, J., Clark, J. C., Zhi, Z., Simpson, M. J., Bourne, J. H., Poulter, N. S., Khan, A. O., Nicolson, P. L., Pugh, M., Harrison, P., Iqbal, A. J., Rainger, G. E., Watson, S. P., Thomas, M. R., Mutch, N. J., Assinger, A., Rayes, J.
Blood, vol. 140, no. 24, pp. 2626-2643
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/blood.2021014966
- [ONLINE] View publication in Scopus
“Going with the flow” in modeling fibrinolysis
2022 - Published
Whyte, C. S., Mutch, N. J.
Frontiers in cardiovascular medicine, vol. 9, 1054541
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.3389/fcvm.2022.1054541
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/28665a50-ab45-4171-b31e-30066d4a3448/download
- [ONLINE] View publication in Scopus
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
2022 - Published
Kanji, R., Gue, Y. X., Farag, M. F., Spencer, N. H., Mutch, N. J., Gorog, D. A.
JACC: Basic to Translational Science, vol. 7, no. 11, pp. 1069-1082
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jacbts.2022.05.007
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/a4a31d9f-a142-4163-b063-8c879e5b27a7/download
- [ONLINE] View publication in Scopus
COVID-19 disease is associated with a hypofibrinolytic state driven by elevated plasminogen activator inhibitor-1 and its cofactor vitronectin.
2022 - Published
Simpson, M., Whyte, C., Morrow, G. B., Wallace, C., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J., Mutch, N.
International Society of Thrombosis and Haemostasis, PB0605
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1002/rth2.12788
The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1
2022 - Published
Whyte, C. S., Simpson, M., Morrow, G. B., Wallace, C. A., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J. G., Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 20, no. 10, pp. 2394-2406
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.15806
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/1c568a11-43a3-492f-8bff-5aac87da9ce2/download
Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial
2022 - Published
Morrow, G. B., Feller, T., McQuilten, Z., Wake, E., Ariëns, R. A. S., Winearls, J., Mutch, N. J., Laffan, M. A., Curry, N.
Critical Care, vol. 26, no. 1, 290
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13054-022-04167-x
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/75a4a599-aea2-4ac8-9997-04f775646ad4/download
Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH
2022 - Published
Mutch, N., Walters, S., Gardiner, E. E., McCarty, O. J., De Meyer, S. F., Schroeder, V., Meijers, J. C.
Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1496-1506
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.15718
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/06fec13a-791c-459a-870c-57ccc386139a/download
Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
2022 - Published
Somodi, L., Debreceni, I. B., Kis, G., Cozzolino, M., Kappelmayer, J., Antal, M., Panyi, G., Bárdos, H., Mutch, N., Muszbek, L.
Journal of Thrombosis and Haemostasis, vol. 20, no. 5, pp. 1223–1235
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.15668
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/94cd13a1-6803-4167-a104-8ad1f3ed81e6/download
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ea1077a4-cdd5-41cd-960c-914f3241a7fb/download
The Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis
2022 - Published
Whyte, C. S., Rastogi, A., Ferguson, E., Donnarumma, M., Mutch, N. J.
International Journal of Molecular Sciences, vol. 23, no. 6, 2944
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms23062944
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/ec2d2aa0-48a5-42d7-b411-4277bf1a872d/download
Removing plasmin from the equation - Something to chew on ...
2022 - Published
Morrow, G. B., Mutch, N.
Journal of Thrombosis and Haemostasis, vol. 20, no. 2, pp. 280-284
Contributions to Journals: Editorials
- [ONLINE] DOI: https://doi.org/10.1111/jth.15590
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/6ee2c1b3-3155-4200-9302-67045a2bbf4d/download
Plasminogen Activator Inhibitor-1 and its cofactor vitronectin induce a hypofibrinolytic state in COVID-19 disease which correlates with disease severity.
2022 - Published
Simpson, M., Whyte, C., Morrow, G. B., Wallace, C., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J., Mutch, N.
British Society of Thrombosis and Haemostasis
Contributions to Conferences: Abstracts
- [ONLINE] https://bsht.org.uk/wp-content/uploads/2022/02/04-BSHT2022-Scientists-in-Training-1-5-abstracts.pdf
- [ONLINE] https://bsht.org.uk/meetings-events/previous-meetings/
Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation
2021 - Published
Alshehri, F. S. M., Whyte, C. S., Tuncay, A., Williams, M., Wilson, H. M., Mutch, N. J.
International Journal of Molecular Sciences, vol. 22, no. 12, 6591
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms22126591
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/e7f755b7-85e3-44db-aaf9-9dfa2300f75b/download
Trauma-induced coagulopathy
2021 - Published
Moore, E. E., Moore, H. B., Kornblith, L. Z., Neal, M. D., Hoffman, M., Mutch, N., Schöchl, H., Hunt, B. J., Sauaia, A.
Nature reviews. Disease primers, vol. 7, 30
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41572-021-00264-3
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/c0abfa91-1896-4e45-8abc-e7042cee2fce/download
A serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease
2021 - Published
Morrow, G. B., Whyte, C., Mutch, N. J.
Frontiers in cardiovascular medicine, vol. 8, 653655
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fcvm.2021.653655
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/eab2f88e-591c-447a-8760-29bfa2249696/download
Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
2021 - Published
Alshehri, F. S. M., Whyte, C., Mutch, N.
International Journal of Molecular Sciences, vol. 22, no. 6, 3055
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms22063055
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/25d5b827-6672-46e5-a3ba-71c5b0fc1629/download
- [ONLINE] View publication in Scopus
Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?
2021 - Published
Morrow, G. B., Carlier, M. S. A., Dasgupta, S., Craigen, F. B., Mutch, N. J., Curry, N.
International Journal of Molecular Sciences, vol. 22, no. 4, 2185
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms22042185
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/772f8a97-962b-4a9e-bf4f-2cd8204100fe/download
- [ONLINE] View publication in Scopus
Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi
2021 - Published
Whyte, C. S., Mostefai, H. A., Baeten, K. M., Lucking, A. J., Newby, D. E., Booth, N. A., Mutch, N. J.
International Journal of Molecular Sciences, vol. 22, no. 4, 2115
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms22042115
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/b918060b-7509-48f1-b24e-74e431b9b5ad/download
- [ONLINE] View publication in Scopus
uPA-mediated plasminogen activation is enhanced by polyphosphate
2021 - Published
Whyte, C. S., Mutch, N. J.
Haematologica, vol. 106, no. 2, pp. 522-531
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3324/haematol.2019.237966
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/697374e7-61ff-432e-a444-6cd054b2a700/download
- [ONLINE] View publication in Scopus
Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets
2021 - Published
Whyte, C. S., Morrow, G. B., Baik, N., Booth, N. A., Jalal, M. M., Parmer, R., Miles, L., Mutch, N. J.
Blood, vol. 137, no. 2, pp. 248–257
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/blood.2020007263
- [ONLINE] View publication in Scopus
Physiology of haemostasis: Plasmin-antiplasmin system
2020 - Published
Mutch, N. J., Whyte, C. S.
Trauma Induced Coagulopathy. Moore, H., Neal, M., Moore, E. (eds.). Springer, pp. 53-74, 22 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
- [ONLINE] DOI: https://doi.org/10.1007/978-3-030-53606-0_5
- [ONLINE] View publication in Scopus
Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery
2020 - Published
Kaira, B., Slater, A., McCrae, K., Dreveny, I., Ummay, S., Mutch, N., Searle, M., Emsley, J.
Blood, vol. 136, no. 14, pp. 1685-1697
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1182/blood.2020004818
- [ONLINE] https://ashpublications.org/blood/pages/rights-permissions
- [ONLINE] View publication in Scopus
A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency
2020 - Published
Westbury, S. K., Whyte, C. S., Stephens, J., Downes, K., Turro, E., Claesen, K., Mertens, J. C., Hendriks, D., Latif, A., Leishman, E. J., NIHR BioResource, Mutch, N. J., Campbell Tait, R., Mumford, A. D.
Journal of Thrombosis and Haemostasis, vol. 18, no. 9, pp. 2209-2214
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.14990
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/cd4b6702-ece4-492e-ba6e-90c1effa45f1/download
- [ONLINE] View publication in Scopus
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19
2020 - Published
Whyte, C. S., Morrow, G. B., Mitchell, J. L., Chowdary, P., Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 18, no. 7, pp. 1548-1555
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.14872
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/3ec643dc-6c96-4d9c-a043-8d6a21a80c23/download
- [ONLINE] View publication in Scopus
Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH
2020 - Published
Moore, H., Gando, S., Iba, T., Kim, P. Y., Yeh, C. H., Brohi, K., Hunt, B. J., Levy, J. H., Draxler, D. F., Stanworth, S. J., Görlinger, K., Neal, M. D., Schreiber, M. A., Barrett, C. D., Medcalf, R. L., Moore, E. E., Mutch, N. J., Thachil, J., Urano, T., Thomas, S., Scărlătescu, E., Walsh, M.
Journal of Thrombosis and Haemostasis, vol. 18, no. 3, pp. 740-747
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.14690
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/d756493a-f31f-4ec5-99e3-2a4b4013df8f/download
- [ONLINE] View publication in Scopus
Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation
2019 - Published
Morrow, G., Whyte, C. S., Mutch, N. J.
Haematologica, vol. 105, no. 5
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3324/haematol.2019.230367
- [ONLINE] Open Access license
Regulation of fibrinolysis by platelets
2019 - Published
Mutch, N. J.
Platelets. Elsevier, pp. 417-431, 15 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-813456-6.00023-0
- [ONLINE] View publication in Scopus
Let's cross-link: diverse functions of the promiscuous cellular transglutaminase, factor XIII-A
2019 - Published
Mitchell, J. L., Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 19-30
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.14348
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/c4109e1a-f1a3-44d6-879f-3c7e3068a215/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: Communication from the SSC of the ISTH
2018 - Published
Pieters, M., Philippou, H., Undas, A., de Lange, Z., Rijken, D. C., Mutch, N. J.
Journal of Thrombosis and Haemostasis, vol. 16, no. 5, pp. 1007-1012
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jth.14002
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/cb543564-1b44-451a-95f3-3d626d992d24/download
- [ONLINE] View publication in Scopus
Defective α2antiplasmin cross-linking and thrombus stability in a case of acquired factor XIII deficiency
2017 - Published
Mitchell, J. L., Wright, S., Kazi, S., Watson, H. G., Mutch, N. J.
British Journal of Haematology, vol. 178, no. 5, pp. 794-799
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/bjh.14759
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/c1b24987-7459-4fe8-9dd6-f303b82612c0/download
Platelet-Mediated Modulation of Fibrinolysis
2017 - Published
Whyte, C. S., Mitchell, J. L., Mutch, N. J.
Seminars in Thrombosis and Hemostasis, vol. 43, no. 2, pp. 115-128
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1055/s-0036-1597283
- [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/d4839d5e-dda1-40af-a128-8d650726edc6/download

Show 10 | 25 | 50 | 100 results per page

Refine

Chapters in Books, Reports and Conference Proceedings

Chapters (4)

Contributions to Conferences

Abstracts (1)

Contributions to Journals

Abstracts (3)

Articles (68)

Reviews of Books, Films and Articles (3)

Editorials (5)

Letters (1)

Short Survey (1)

Review articles (3)

Update

Biography

Qualifications

External Memberships

Latest Publications

ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP

Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice

Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay

Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood

Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment

Prizes and Awards

Research Areas

Accepting PhDs

Biomedical Sciences

Research Specialisms

Supervision

Funding and Grants

Courses

Teaching Responsibilities

ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP

Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice

Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay

Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood

Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment

Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V

Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation

Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH

A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma

Fibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)

The Fibrinolysis Renaissance

Fibrinolytic pathophysiologies: still the poor cousin of hemostasis?

Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial

Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions

Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study

Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

Cellular FXIII in Human Macrophage-Derived Foam Cells

Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

S100A8/A9 drives the formation of procoagulant platelets through GPIbα

“Going with the flow” in modeling fibrinolysis

Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

COVID-19 disease is associated with a hypofibrinolytic state driven by elevated plasminogen activator inhibitor-1 and its cofactor vitronectin.

The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial

Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles

The Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis

Removing plasmin from the equation - Something to chew on ...

Plasminogen Activator Inhibitor-1 and its cofactor vitronectin induce a hypofibrinolytic state in COVID-19 disease which correlates with disease severity.

Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation

Trauma-induced coagulopathy

A serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease

Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?

Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi

uPA-mediated plasminogen activation is enhanced by polyphosphate

Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets

Physiology of haemostasis: Plasmin-antiplasmin system

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery

A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH

Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

Regulation of fibrinolysis by platelets

Let's cross-link: diverse functions of the promiscuous cellular transglutaminase, factor XIII-A

An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: Communication from the SSC of the ISTH

Defective α2antiplasmin cross-linking and thrombus stability in a case of acquired factor XIII deficiency

Platelet-Mediated Modulation of Fibrinolysis

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals